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- Barany, George, et al.
(author)
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Poly(ethylene glycol)-containing supports for solid-phase synthesis of peptides and combinatorial organic libraries.
- 1997
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In: Poly(ethylene glycol): Chemistry and Biological Applications, ACS Symp. Series. - Washington, DC : American Chemical Society. - 9780841235373 ; 680, s. 239-264
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Book chapter (pop. science, debate, etc.)abstract
- The choice of a polymeric support is a key factor for the success of solid-phase methods for syntheses of organic compounds and biomolecules such as peptides and oligonucleotides. Classical Merrifield solid-phase peptide synthesis, performed on low cross-linked hydrophobic polystyrene (PS) beads, sometimes suffers from sequence-dependent coupling difficulties. The concept of incorporating PEG into supports for solid-phase synthesis represents a successful approach to alleviating such problems. This chapter reviews the preparation of families of poly(ethylene glycol)-polystyrene (PEG-PS)graft as well as (highly) Cross-Linked Ethoxylate Acrylate Resin (CLEAR) supports developed in our laboratories, and demonstrates their applications to the syntheses of a wide range of targets in connection with numerous research objectives.
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- Kempe, Maria, et al.
(author)
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CLEAR supports for solid-phase synthesis
- 1998
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In: Peptides 1996, Proceedings of the Twenty-Fourth European Peptide Symposium. - 9780952701125 ; , s. 533-534
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Conference paper (peer-reviewed)
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