| 1. |
- Niemi, MEK, et al.
(author)
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- 2021
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swepub:Mat__t
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| 2. |
- Kanai, M, et al.
(author)
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- 2023
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swepub:Mat__t
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| 3. |
- Bravo, L, et al.
(author)
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- 2021
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swepub:Mat__t
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| 4. |
- Tabiri, S, et al.
(author)
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- 2021
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swepub:Mat__t
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| 5. |
- Khatri, C, et al.
(author)
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Outcomes after perioperative SARS-CoV-2 infection in patients with proximal femoral fractures: an international cohort study
- 2021
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In: BMJ open. - : BMJ. - 2044-6055. ; 11:11, s. e050830-
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Journal article (peer-reviewed)abstract
- Studies have demonstrated high rates of mortality in people with proximal femoral fracture and SARS-CoV-2, but there is limited published data on the factors that influence mortality for clinicians to make informed treatment decisions. This study aims to report the 30-day mortality associated with perioperative infection of patients undergoing surgery for proximal femoral fractures and to examine the factors that influence mortality in a multivariate analysis.SettingProspective, international, multicentre, observational cohort study.ParticipantsPatients undergoing any operation for a proximal femoral fracture from 1 February to 30 April 2020 and with perioperative SARS-CoV-2 infection (either 7 days prior or 30-day postoperative).Primary outcome30-day mortality. Multivariate modelling was performed to identify factors associated with 30-day mortality.ResultsThis study reports included 1063 patients from 174 hospitals in 19 countries. Overall 30-day mortality was 29.4% (313/1063). In an adjusted model, 30-day mortality was associated with male gender (OR 2.29, 95% CI 1.68 to 3.13, p<0.001), age >80 years (OR 1.60, 95% CI 1.1 to 2.31, p=0.013), preoperative diagnosis of dementia (OR 1.57, 95% CI 1.15 to 2.16, p=0.005), kidney disease (OR 1.73, 95% CI 1.18 to 2.55, p=0.005) and congestive heart failure (OR 1.62, 95% CI 1.06 to 2.48, p=0.025). Mortality at 30 days was lower in patients with a preoperative diagnosis of SARS-CoV-2 (OR 0.6, 95% CI 0.6 (0.42 to 0.85), p=0.004). There was no difference in mortality in patients with an increase to delay in surgery (p=0.220) or type of anaesthetic given (p=0.787).ConclusionsPatients undergoing surgery for a proximal femoral fracture with a perioperative infection of SARS-CoV-2 have a high rate of mortality. This study would support the need for providing these patients with individualised medical and anaesthetic care, including medical optimisation before theatre. Careful preoperative counselling is needed for those with a proximal femoral fracture and SARS-CoV-2, especially those in the highest risk groups.Trial registration numberNCT04323644
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| 6. |
- Board, A., et al.
(author)
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Community-to-vehicle-to-community (C2V2C) for inter-community electricity delivery and sharing via electric vehicle : Performance evaluation and robustness analysis
- 2024
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In: Applied Energy. - : Elsevier. - 0306-2619 .- 1872-9118. ; 363
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Journal article (peer-reviewed)abstract
- Electric vehicles (EVs) possess untapped potential as mobile power banks for actively delivering electricity between different energy communities, known as Community-to-Vehicle-to-Community (C2V2C) service. While C2V2C represents an effective means of inter-community electricity sharing, limited research explores EVs' role in electricity delivery between locations. Suitable control approaches of EV charging for the C2V2C service are lacking, and it is unclear how robust the C2V2C service is and how its performance is affected by different factors. This paper aims to bridge these research gaps by developing an advanced control of EV smart charging/discharging to facilitate the C2V2C service. By comparing the power balance in the EVs' current-connecting and next-destination communities, the advanced control derives a target state-of-charge for the EVs in the current-connecting community, which can optimize the electricity delivery between the two communities. Then, the robustness of the C2V2C service is analyzed by evaluating its performances under different scenarios. Major factors like community combinations, renewable energy system (RES) configurations, EV battery capacity and numbers are examined for their impacts on C2V2C performance. The findings demonstrate that the C2V2C service significantly enhances energy balance across diverse community combinations, particularly in workplaces with substantial RES capacity. A large EV battery capacity is beneficial for performance improvements, but the impact diminishes at higher values due to limited surplus renewables availability. The increasing EV number enhances both electricity delivery capability and utilization of self-produced renewables. This study validated the effectiveness of the C2V2C service and provides valuable insights into optimizing its application across different scenarios. © 2024 The Author(s)
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| 7. |
- I. Sinning, G.J. Kleywegt, S.W. Cowan, P. Reinemer, H.W. Dirr, R. Huber, G.L. Gilliland, R.N. Armstrong, X. Ji, P.G. Board, B. Olin, B. Mannervik & T.A. Jones
(author)
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Structure determination and refinement of human alpha class glutathione transferase A1-1, and a comparison with the mu and pi class enzymes
- 1993
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In: Journal of Molecular Biology. ; 232, s. 192-212
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Journal article (peer-reviewed)
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| 8. |
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| 9. |
- Sinning, I, et al.
(author)
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Structure determination and refinement of human alpha class glutathione transferase A1-1, and a comparison with the Mu and Pi class enzymes.
- 1993
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In: J Mol Biol. - 0022-2836. ; 232:1, s. 192-212
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Journal article (peer-reviewed)abstract
- The crystal structure of human alpha class glutathione transferase A1-1 has been determined and refined to a resolution of 2.6 A. There are two copies of the dimeric enzyme in the asymmetric unit. Each monomer is built from two domains. A bound inhibitor, S-benzyl-glutathione, is primarily associated with one of these domains via a network of hydrogen bonds and salt-links. In particular, the sulphur atom of the inhibitor forms a hydrogen bond to the hydroxyl group of Tyr9 and the guanido group of Arg15. The benzyl group of the inhibitor is completely buried in a hydrophobic pocket. The structure shows an overall similarity to the mu and pi class enzymes particularly in the glutathione-binding domain". The main difference concerns the extended C terminus of the alpha class enzyme which forms an extra alpha-helix that blocks one entrance to the active site and makes up part of the substrate binding site.
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| 10. |
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