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Search: WFRF:(Boutet Robinet Elisa)

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1.
  • Boutet-Robinet, Elisa, et al. (author)
  • Detection of DNA damage by alkaline comet assay in mouse colonic mucosa
  • 2021
  • In: STAR Protocols. - : Cell Press. - 2666-1667. ; 2:4
  • Journal article (peer-reviewed)abstract
    • We recently characterized the association between DNA damage and immunoresponse in vivo in colonic mucosa of mice infected with a Salmonella Typhimurium strain expressing a genotoxin, known as typhoid toxin. In this protocol, we describe the specific steps for assessing DNA damage by the alkaline comet assay of colonic mucosal samples. The description of the comet assay protocol follows the international guidelines (Minimum Information for Reporting on the Comet Assay [Moller et al., 2020]). For complete details on the use and execution of this protocol, please refer to Martin et al. (2021).
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2.
  • Martin, Océane C.B., et al. (author)
  • Influence of the microenvironment on modulation of the host response by typhoid toxin
  • 2021
  • In: Cell Reports. - : Cell Press. - 2211-1247. ; 35:1
  • Journal article (peer-reviewed)abstract
    • Bacterial genotoxins cause DNA damage in eukaryotic cells, resulting in activation of the DNA damage response (DDR) in vitro. These toxins are produced by Gram-negative bacteria, enriched in the microbiota of inflammatory bowel disease (IBD) and colorectal cancer (CRC) patients. However, their role in infection remains poorly characterized. We address the role of typhoid toxin in modulation of the host-microbial interaction in health and disease. Infection with a genotoxigenic Salmonella protects mice from intestinal inflammation. We show that the presence of an active genotoxin promotes DNA fragmentation and senescence in vivo, which is uncoupled from an inflammatory response and unexpectedly associated with induction of an anti-inflammatory environment. The anti-inflammatory response is lost when infection occurs in mice with acute colitis. These data highlight a complex context-dependent crosstalk between bacterial-genotoxin-induced DDR and the host immune response, underlining an unexpected role for bacterial genotoxins.
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