| 1. |
- Kehoe, Laura, et al.
(author)
-
Make EU trade with Brazil sustainable
- 2019
-
In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 364:6438, s. 341-
-
Journal article (other academic/artistic)
|
|
| 2. |
- Englund, Davis A., et al.
(author)
-
Nutritional Supplementation With Physical Activity Improves Muscle Composition in Mobility-Limited Older Adults, The VIVE2 Study : A Randomized, Double-Blind, Placebo-Controlled Trial
- 2018
-
In: The journals of gerontology. Series A, Biological sciences and medical sciences. - : Oxford University Press (OUP). - 1079-5006 .- 1758-535X. ; 73:1, s. 95-101
-
Journal article (peer-reviewed)abstract
- Background: Nutritional supplementation and physical activity have been shown to positively influence muscle mass and strength in older adults. The efficacy of long-term nutritional supplementation in combination with physical activity in older adults remains unclear.Methods: Mobility-limited (short physical performance battery [SPPB] ≤9) and vitamin D insufficient (serum 25(OH) D 9–24 ng/mL) older adults were recruited for this study. All subjects participated in a physical activity program. Subjects were randomized to consume a daily nutritional supplement (150 kcal, 20 g whey protein, 800 IU vitamin D, 119 mL beverage) or placebo (30 kcal, nonnutritive, 119 mL). In a prespecified secondary analysis, we examined total-body composition (dual energy X-ray absorptiometry), thigh composition (computed tomography), and muscle strength, power, and quality before and after the 6-month intervention.Results: One hundred and forty-nine subjects were randomized into the study [mean (standard deviation, SD) age 78.5 (5.4) years; 46.3% female; mean (SD) short physical performance battery 7.9 (1.2); mean (SD) vitamin D 18.7 (6.4) ng/mL]. After the intervention period both groups demonstrated improvements in muscle strength, body composition, and thigh composition. Nutritional supplementation lead to further losses of intermuscular fat (p = .049) and increased normal muscle density (p = .018).Conclusions: Six months of physical activity resulted in improvements in body composition, subcutaneous fat, intermuscular fat, and strength measures. The addition of nutritional supplementation resulted in further declines in intermuscular fat and improved muscle density compared to placebo. These results suggest nutritional supplementation provides additional benefits to mobility-limited older adults undergoing exercise training.
|
|
| 3. |
|
|
| 4. |
- Haïssaguerre, Michel, et al.
(author)
-
Sudden cardiac arrest associated with early repolarization
- 2008
-
In: New England Journal of Medicine. - 0028-4793 .- 1533-4406. ; 358:19, s. 2016-2023
-
Journal article (peer-reviewed)abstract
- BACKGROUND: Early repolarization is a common electrocardiographic finding that is generally considered to be benign. Its potential to cause cardiac arrhythmias has been hypothesized from experimental studies, but it is not known whether there is a clinical association with sudden cardiac arrest.METHODS: We reviewed data from 206 case subjects at 22 centers who were resuscitated after cardiac arrest due to idiopathic ventricular fibrillation and assessed the prevalence of electrocardiographic early repolarization. The latter was defined as an elevation of the QRS-ST junction of at least 0.1 mV from baseline in the inferior or lateral lead, manifested as QRS slurring or notching. The control group comprised 412 subjects without heart disease who were matched for age, sex, race, and level of physical activity. Follow-up data that included the results of monitoring with an implantable defibrillator were obtained for all case subjects.RESULTS: Early repolarization was more frequent in case subjects with idiopathic ventricular fibrillation than in control subjects (31% vs. 5%, P<0.001). Among case subjects, those with early repolarization were more likely to be male and to have a history of syncope or sudden cardiac arrest during sleep than those without early repolarization. In eight subjects, the origin of ectopy that initiated ventricular arrhythmias was mapped to sites concordant with the localization of repolarization abnormalities. During a mean (+/-SD) follow-up of 61+/-50 months, defibrillator monitoring showed a higher incidence of recurrent ventricular fibrillation in case subjects with a repolarization abnormality than in those without such an abnormality (hazard ratio, 2.1; 95% confidence interval, 1.2 to 3.5; P=0.008).CONCLUSIONS: Among patients with a history of idiopathic ventricular fibrillation, there is an increased prevalence of early repolarization.
|
|
| 5. |
- Alfonsson, Sven, 1977-, et al.
(author)
-
Tailored Text Message Prompts to Increase Therapy Homework Adherence : A Single-Case Randomised Controlled Study
- 2019
-
In: Behaviour change. - : Cambridge University Press (CUP). - 0813-4839 .- 2049-7768. ; 36:3, s. 180-191
-
Journal article (peer-reviewed)abstract
- Background: Psychotherapy homework completion is associated with positive treatment outcomes, but many patients show low adherence to prescribed assignments. Whether text-message prompts are effective in increasing adherence to assignments is unknown. Aims: To evaluate whether tailored daily text-message prompts can increase homework adherence in a stress/anxiety treatment. Method: This study used a randomised controlled single-case alternating treatment design with parallel replication in seven participants. Participants received a five-week relaxation program for stress and anxiety with daily exercises. The intervention consisted of daily text messages tailored for each participant. Phases with or without text messages were randomly alternated over the study course. Randomisation tests were used to statistically analyse differences in mean number of completed relaxation exercises between phases. Results: There was a significant (combined p = .018) effect of daily text messages on homework adherence across participants with weak to medium effect size improvements. No negative effects of daily text messages were identified. Conclusions: Tailored text messages can marginally improve adherence to assignments for patients in CBT. Further studies may investigate how text messages can be made relevant for more patients and whether text messages can be used to increase homework quality rather than quantity.
|
|
| 6. |
- Andersson, Mattias, 1985, et al.
(author)
-
Highly Insulating Polyethylene Blends for High-Voltage Direct-Current Power Cables
- 2017
-
In: ACS Macro Letters. - : American Chemical Society (ACS). - 2161-1653. ; 6:2, s. 78-82
-
Journal article (peer-reviewed)abstract
- The insulation of state-of-the-art extruded high-voltage direct-current (HVDC) power cables is composed of cross-linked low-density polyethylene. Driven by the search for sustainable energy solutions, concepts that improve the ability to withstand high electrical fields and, ultimately, the power transmission efficiency are in high demand. The performance of a HVDC insulation material is limited by its residual electrical conductivity. Here, we demonstrate that the addition of small amounts of high-density polyethylene (HDPE) to a low-density polyethylene (LDPE) resin results in a drastic reduction in DC conductivity. An HDPE content as low as 1 wt % is found to introduce a small population of thicker crystalline lamellae, which are finely distributed throughout the material. The change in nanostructure correlates with a decrease in DC conductivity by approximately 1 order of magnitude to about 10(-15) S m(-1) at high electric fields of 30 and 40 kV mm(-1) and elevated temperature of 70 degrees C. This work opens up an alternative design concept for the insulation of HVDC power cables.
|
|
| 7. |
- Aramrattana, Maytheewat, 1988-, et al.
(author)
-
Team Halmstad Approach to Cooperative Driving in the Grand Cooperative Driving Challenge 2016
- 2018
-
In: IEEE transactions on intelligent transportation systems (Print). - Piscataway, N.J. : Institute of Electrical and Electronics Engineers Inc.. - 1524-9050 .- 1558-0016. ; 19:4, s. 1248-1261
-
Journal article (peer-reviewed)abstract
- This paper is an experience report of team Halmstad from the participation in a competition organised by the i-GAME project, the Grand Cooperative Driving Challenge 2016. The competition was held in Helmond, The Netherlands, during the last weekend of May 2016. We give an overview of our car’s control and communication system that was developed for the competition following the requirements and specifications of the i-GAME project. In particular, we describe our implementation of cooperative adaptive cruise control, our solution to the communication and logging requirements, as well as the high level decision making support. For the actual competition we did not manage to completely reach all of the goals set out by the organizers as well as ourselves. However, this did not prevent us from outperforming the competition. Moreover, the competition allowed us to collect data for further evaluation of our solutions to cooperative driving. Thus, we discuss what we believe were the strong points of our system, and discuss post-competition evaluation of the developments that were not fully integrated into our system during competition time. © 2000-2011 IEEE.
|
|
| 8. |
- Astvaldsdottir, A., et al.
(author)
-
Oral health and dental care of older persons-A systematic map of systematic reviews
- 2018
-
In: Gerodontology. - : Wiley. - 0734-0664 .- 1741-2358. ; 35:4, s. 290-304
-
Research review (peer-reviewed)abstract
- Objectives: To examine the current knowledge on oral health status and dental care of older persons through a systematic mapping of systematic reviews of low or moderate risk of bias. Background: Geriatric dentistry covers all aspects of oral health and oral care of older persons. Oral health is part of general health and contributes to a person's physical, psychological and social wellbeing. Methods: A literature search was performed in three different databases (PubMed, The Cochrane Library and Cinahl) within 12 domains: Dental caries, periodontitis, Orofacial pain and temporomandibular joint (TMJ) pain, mucosal lesions, oral motor function, dry mouth, halitosis, interaction between oral status and other medical conditions, ability to interrelate and communicate, quality of life, ethics and organisation of dental care for older persons. Systematic reviews were identified and scrutinised, highlighting scientific knowledge and knowledge gaps. Results: We included 32 systematic reviews of which 14 were judged to be of low/moderate risk of bias. Most of the domains lack systematic reviews with low or moderate risk of bias. In two of the domains evidence was identified; in institutionalised people aged 65 or older, effective oral hygiene can prevent pneumonia. Furthermore, there is an evidence of a relationship between malnutrition (protein energy-related malnutrition, PEM) and poor appetite and edentulousness. Conclusions: There is an urgent need for further research and evidence-based knowledge within most domains in geriatric dentistry and in other fields related to oral health and dental care for older persons striving for multi-disciplinary research programmes.
|
|
| 9. |
- Backman, Sofia, et al.
(author)
-
Swedish consensus reached on recording, interpretation and reporting of neonatal continuous simplified electroencephalography that is supported by amplitude-integrated trend analysis
- 2018
-
In: Acta Paediatrica. - : WILEY. - 0803-5253 .- 1651-2227. ; 107:10, s. 1702-1709
-
Journal article (peer-reviewed)abstract
- Continuous monitoring of electroencephalography (EEG), with a focus on amplitude-integrated EEG (aEEG), has been used in neonatal intensive care for decades. A number of systems have been suggested for describing and quantifying aEEG patterns. Extensive full-montage EEG monitoring is used in specialised intensive care units. The American Clinical Neurophysiology Society published recommendations for defining and reporting EEG findings in critically ill adults and infants. Swedish neonatologists and clinical neurophysiologists collaborated to optimise simplified neonatal continuous aEEG and EEG recordings based on these American documents. Conclusion: This paper describes the Swedish consensus document produced by those meetings.
|
|
| 10. |
- Blomquist, Jens, et al.
(author)
-
Structure liming reduces draught requirement on clay soil
- 2023
-
In: Soil and Tillage Research. - 0167-1987 .- 1879-3444. ; 231
-
Journal article (peer-reviewed)abstract
- Liming with ‘structure lime’, comprising approximately 80–85% ground limestone and 15–20% slaked lime, has been promoted in subsidised environmental schemes in Sweden since 2010 to increase clay aggregate stability and mitigate particulate phosphorus losses to surface waters. To date, approximately 65,000 ha have been structure-limed. Apart from stabilising aggregates, liming may also improve other physical properties, such as soil strength. This study examined the effect of increasing application rate (0–16 t ha-1) of structure lime on soil strength, approximated by horizontal (draught requirement) and vertical (penetrometer resistance) measurements, in eight field soils (clay content 26–38%) to which structure lime had been applied two, three, four or six years previously. Draught requirement when cultivating with a multipurpose cultivator significantly decreased (by 11%) with the highest application rate of structure lime (16 t ha-1) compared with an unlimed control. This reduced the wheel power requirement by 7.1 kW and diesel consumption by 1.2–1.4 L ha-1, and lowered CO2 emissions by 3–4 kg ha-1. To clarify the general effect of structure liming, the mean value of all limed treatments was compared with that of the unlimed control. This showed that structure liming in general significantly reduced the draught requirement (by 7%). However, penetrometer resistance measurements revealed no significant effects of structure liming and no relation between draught requirement and penetrometer resistance measurements. Overall, the results indicate that structure liming can reduce fuel consumption, due to easier soil tillage, and thus lower CO2 emissions.
|
|
| 11. |
- Broman, Göran, et al.
(author)
-
Introductory Optimisation Study of a Rammer Soil Compactor Machine
- 2001
-
Conference paper (peer-reviewed)abstract
- Rammer compactor machines perform dynamic soil compaction. The complexity of this machine type makes design optimisation through traditional prototype testing impractical. This has pointed to the need for a theoretical model and simulation procedure for prediction of the dynamic behaviour of the machine and a procedure for optimisation as design parameters are changed during product development. In this paper a theoretical model of the rammer machine in combination with a soil model is described. This multi-body dynamics system is solved numerically. The system is non-linear and chaotic behaviour is possible. This parameter sensitivity emphasises the need for this kind of simulations in the product development process. A fairly regular behaviour is necessary for a predictable and safe operation. Parameter combinations giving too irregular behaviour are non-feasible. The energy transfer rate from the rammer machine into the soil is used as the objective function for optimisation. Multi-start Sequential Quadratic Programming for optimum search is used. To cover the design space well a Uniform Experimental Design is used for selection of starting points. This procedure proves to work well for the problem of this introductory study. The study shows a significant potential for improved compaction capacity although considering only the three design parameters that are most easily changed in practice. Approximately the same optimum is obtained both for operation on soft soil and hard soil, so a good all-round design seems possible. Including this theoretical support in the product development process should make it much more effective in finding optimum designs, also for other machines of similar type.
|
|
| 12. |
- Capo, Eric, et al.
(author)
-
Lake sedimentary dna research on past terrestrial and aquatic biodiversity: Overview and recommendations
- 2021
-
In: Quaternary. - : MDPI. - 2571-550X. ; 4:1
-
Research review (peer-reviewed)abstract
- The use of lake sedimentary DNA to track the long-term changes in both terrestrial and aquatic biota is a rapidly advancing field in paleoecological research. Although largely applied nowadays, knowledge gaps remain in this field and there is therefore still research to be conducted to ensure the reliability of the sedimentary DNA signal. Building on the most recent literature and seven original case studies, we synthesize the state-of-the-art analytical procedures for effective sampling, extraction, amplification, quantification and/or generation of DNA inventories from sedimentary ancient DNA (sedaDNA) via high-throughput sequencing technologies. We provide recommendations based on current knowledge and best practises.
|
|
| 13. |
|
|
| 14. |
- Dell'Isola, Andrea, et al.
(author)
-
Road to Total Knee Replacement: Utilization of Knee Surgeries Up to Ten Years Before Total Knee Replacement in England and Sweden
- 2023
-
In: Arthritis Care and Research. - : Wiley. - 2151-4658 .- 2151-464X. ; 75:5, s. 1104-1112
-
Journal article (peer-reviewed)abstract
- OBJECTIVE: To compare the prevalence and timing of knee surgery (including meniscal, ligamentous, synovial, and osteotomy) in the 10 years prior to primary total knee replacement (TKR) between England and Sweden.METHODS: This was a population-based, case-control study within England and southern Sweden using electronic health care databases. Patients underwent primary TKR between 2015 and 2019. Risk-set sampling showed that general population controls matched 1:1 by age, sex, and practice/municipality. The annual prevalence and prevalence ratio of having at least 1 recorded surgery in each of the 10 years preceding TKR was estimated using Poisson regressions.RESULTS: We included 6,308 and 47,010 TKR cases in Sweden and England, respectively. Meniscal surgeries were the most frequent procedure prior to TKR in both countries; prevalence was higher in England across all time points. The prevalence of meniscal surgery increased in both countries in the years approaching TKR, reaching 33.2 (95% confidence interval [95% CI] 31.6-34.9) per 1,000 persons in England, and 9.83 (95% CI 7.66-12.61) in Sweden. In England, we observed a decrease from 2014 to 2018 in the utilization of this procedure in the 4 years preceding a TKR. The prevalence of all analyzed surgeries was consistently lower in controls.CONCLUSION: There are comparable trends in the use of knee surgery in the years preceding TKR across England and Sweden. Of note, meniscal surgeries remain common, even within the year prior to TKR, highlighting that these patients may experience low-value care. Careful consideration of knee surgery in those with late-stage disease is required.
|
|
| 15. |
- Dell'Isola, Andrea, et al.
(author)
-
Use of non-surgical treatments on the journey to knee replacement in patients with knee osteoarthritis : A 10-year population-based case-control study
- 2023
-
In: RMD Open. - 2056-5933. ; 9:3
-
Journal article (peer-reviewed)abstract
- Aim To investigate temporal trends in primary care visits, physiotherapy visits, dispensed non-steroidal anti-inflammatory drugs (NSAIDs) and opioids in knee osteoarthritis (OA) patients who have and have not undergone knee replacement. Methods We analysed 5665 OA patients from the Skåne Healthcare Register, Sweden, who underwent knee replacement between 2015 and 2019. Controls were OA patients without knee replacement, matched 1:1 by sex, age, time and healthcare level of initial OA diagnosis, and assigned a pseudo-index date corresponding to their case's knee replacement date. Annual prevalence and prevalence ratio of primary care and physiotherapy visits, dispensed NSAIDs and opioids (all for any cause) in the 10 years before knee replacement were estimated using Poisson regression. Results The annual prevalence of all-cause primary care visits, physiotherapy visits and opioid use was similar between cases and controls until 3 years before the index date when it started to increase among the cases. The year before the index date, the prevalence ratio (cases vs controls) for physiotherapy use was 1.8 (95% CI 1.7, 1.8), while for opioid use 1.6 (1.5, 1.7). NSAID use was consistently higher among cases, even 10 years before the index date when the prevalence ratio versus controls was 1.3 (1.2, 1.3), increasing to 1.8 (1.7, 1.9) in the year preceding the index date. Conclusions Management of OA patients who have and have not undergone knee replacement appears largely similar except for higher use of NSAIDs in knee replacement cases. Symptomatic treatments start to increase a few years before the surgery in knee replacement cases.
|
|
| 16. |
- Durmo, Faris, et al.
(author)
-
Brain Tumor Characterization Using Multibiometric Evaluation of MRI
- 2018
-
In: Tomography : a journal for imaging research. - : MDPI AG. - 2379-1381. ; 4:1, s. 14-25
-
Journal article (peer-reviewed)abstract
- The aim was to evaluate volume, diffusion, and perfusion metrics for better presurgical differentiation between high-grade gliomas (HGG), low-grade gliomas (LGG), and metastases (MET). For this retrospective study, 43 patients with histologically verified intracranial HGG (n = 18), LGG (n = 10), and MET (n = 15) were chosen. Preoperative magnetic resonance data included pre- and post-gadolinium contrast-enhanced T1-weighted fluid-attenuated inversion recover, cerebral blood flow (CBF), cerebral blood volume (CBV), fractional anisotropy, and apparent diffusion coefficient maps used for quantification of magnetic resonance biometrics by manual delineation of regions of interest. A binary logistic regression model was applied for multiparametric analysis and receiver operating characteristic (ROC) analysis. Statistically significant differences were found for normalized-ADC-tumor (nADC-T), normalized-CBF-tumor (nCBF-T), normalized-CBV-tumor (nCBV-T), and normalized-CBF-edema (nCBF-E) between LGG and HGG, and when these metrics were combined, HGG could be distinguished from LGG with a sensitivity and specificity of 100%. The only metric to distinguish HGG from MET was the normalized-ADC-E with a sensitivity of 68.8% and a specificity of 80%. LGG can be distinguished from MET by combining edema volume (Vol-E), Vol-E/tumor volume (Vol-T), nADC-T, nCBF-T, nCBV-T, and nADC-E with a sensitivity of 93.3% and a specificity of 100%. The present study confirms the usability of a multibiometric approach including volume, perfusion, and diffusion metrics in differentially diagnosing brain tumors in preoperative patients and adds to the growing body of evidence in the clinical field in need of validation and standardization.
|
|
| 17. |
- Durmo, Faris, et al.
(author)
-
Multivoxel 1H-MR Spectroscopy Biometrics for Preoprerative Differentiation Between Brain Tumors
- 2018
-
In: Tomography : a journal for imaging research. - : MDPI AG. - 2379-1381. ; 4:4, s. 172-181
-
Journal article (peer-reviewed)abstract
- We investigated multivoxel proton magnetic resonance spectroscopy (1H-MRS) biometrics for preoperative differentiation and prognosis of patients with brain metastases (MET), low-grade glioma (LGG) and high-grade glioma (HGG). In total, 33 patients (HGG, 14; LGG, 9; and 10 MET) were included. 1H-MRS imaging (MRSI) data were assessed and neurochemical profiles for metabolites N-acetyl aspartate (NAA) + NAAG(NAA), Cr + PCr(total creatine, tCr), Glu + Gln(Glx), lactate (Lac), myo-inositol(Ins), GPC + PCho(total choline, tCho), and total lipids, and macromolecule (tMM) signals were estimated. Metabolites were reported as absolute concentrations or ratios to tCho or tCr levels. Voxels of interest in an MRSI matrix were labeled according to tissue. Logistic regression, receiver operating characteristic, and Kaplan-Meier survival analysis was performed. Across HGG, LGG, and MET, average Ins/tCho was shown to be prognostic for overall survival (OS): low values (≤1.29) in affected hemisphere predicting worse OS than high values (>1.29), (log rank < 0.007). Lip/tCho and Ins/tCho combined showed 100% sensitivity and specificity for both HGG/LGG (P < .001) and LGG/MET (P < .001) measured in nonenhancing/contrast-enhancing lesional tissue. Combining tCr/tCho in perilesional edema with tCho/tCr and NAA/tCho from ipsilateral normal- appearing tissue yielded 100% sensitivity and 81.8% specificity (P < .002) for HGG/MET. Best single biomarker: Ins/tCho for HGG/LGG and total lipid/tCho for LGG/MET showed 100% sensitivity and 75% and 100% specificity, respectively. HGG/MET; NAA/tCho showed 75% sensitivity and 84.6% specificity. Multivoxel 1H-MRSI provides prognostic information for OS for HGG/LGG/MET and a multibiometric approach for differentiation may equal or outperform single biometrics.
|
|
| 18. |
- Emery, Carolyn A, et al.
(author)
-
Establishing outcome measures in early knee osteoarthritis
- 2019
-
In: Nature Reviews Rheumatology. - : Springer Science and Business Media LLC. - 1759-4804 .- 1759-4790. ; 15:7, s. 438-448
-
Research review (peer-reviewed)abstract
- The classification and monitoring of individuals with early knee osteoarthritis (OA) are important considerations for the design and evaluation of therapeutic interventions and require the identification of appropriate outcome measures. Potential outcome domains to assess for early OA include patient-reported outcomes (such as pain, function and quality of life), features of clinical examination (such as joint line tenderness and crepitus), objective measures of physical function, levels of physical activity, features of imaging modalities (such as of magnetic resonance imaging) and biochemical markers in body fluid. Patient characteristics such as adiposity and biomechanics of the knee could also have relevance to the assessment of early OA. Importantly, research is needed to enable the selection of outcome measures that are feasible, reliable and validated in individuals at risk of knee OA or with early knee OA. In this Perspectives article, potential outcome measures for early symptomatic knee OA are discussed, including those measures that could be of use in clinical practice and/or the research setting.
|
|
| 19. |
- Englund, Annika, et al.
(author)
-
Hodgkin lymphoma in children, adolescents and young adults - a comparative study of clinical presentation and treatment outcome.
- 2018
-
In: Acta Oncologica. - 0284-186X .- 1651-226X. ; 57:2, s. 276-282
-
Journal article (peer-reviewed)abstract
- Background: Hodgkin lymphoma (HL) treatment protocols for children, adolescents and young adults traditionally differ, but the biological and clinical justification for this remains uncertain.Material and methods: We compared age-dependent clinical presentation and treatment and outcome for 1072 classical HL patients 0–24 years diagnosed in Denmark (1990–2010) and Sweden (1992–2009) in pediatric (n = 315, Denmark <15 years, Sweden <18 years) or adult departments (n = 757). Distribution of clinical characteristics was assessed with Pearson’s chi2-test and Mantel–Haenszel trend test. The Kaplan–Meier method was used for survival analyses. Hazard ratios (HR) were used to compare the different treatment groups and calculated using Cox regression.Results: Children (0–9 years) less often presented with advanced disease than adolescents (10–17 years) and young adults (18–24 years) (stage IIB-IV: children 32% vs. adolescents 50%, and adults 55%; p < .005). No variation in overall survival (OS) was seen between pediatric and adult departments or by country. Danish pediatric patients received radiotherapy (36%) less frequently than Swedish pediatric patients (71%) (p < .0001). Ten-year event-free survival (EFS) was lower among Danish pediatric patients (0–14 years) (0.79; 95% confidence interval (CI) 0.70–0.86) than among Swedish pediatric patients (0–17 years) (0.88; 95% CI 0.83–0.92), HR (1.93; 95% CI 1.08–3.46). A similar pattern was seen between adult patients in the two countries: Denmark 10-year EFS 0.85 (95% CI 0.81–0.88), Sweden 0.88 (95% CI 0.84–0.91), adjusted HR 1.51 (95% CI 1.03–2.22).Conclusion: Adolescents and young adults shared similar clinical presentation suggesting a rationale of harmonized treatment for these groups. Both adult and pediatric protocols provided high OS with no significant difference between the departments. The less frequent use of radiotherapy in Danish pediatric patients corresponded to a lower EFS, but comparable OS in all groups confirmed effective rescue strategies for the relapsing patients.
|
|
| 20. |
|
|
| 21. |
- Englund, Håkan, et al.
(author)
-
A framework for chosen IV statistical analysis of stream ciphers
- 2007
-
In: Progress in Cryptology / Lecture Notes in Computer Science. - Berlin, Heidelberg : Springer Berlin Heidelberg. - 0302-9743 .- 1611-3349. - 9783540770251 ; 4859, s. 268-281
-
Conference paper (peer-reviewed)abstract
- Saarinen recently proposed a chosen IV statistical attack, called the $d$-monomial test, and used it to find eaknesses in several proposed stream ciphers. In this paper we generalize this idea and propose a framework for chosen IV statistical attacks using a polynomial description. We propose a few new statistical attacks, apply them on some existing stream cipher proposals, and give some conclusions regarding the strength of their IV initialization. In particular, we experimentally detected statistical weaknesses in some state bits of Grain-128 with full IV initialization as well as in the keystream of Trivium using an initialization reduced to 736 rounds from 1152 rounds. We also propose some stronger alternative initialization schemes with respect to these statistical attacks.
|
|
| 22. |
- Englund, Håkan, et al.
(author)
-
A new distinguisher for clock controlled stream ciphers
- 2005
-
In: Lecture Notes in Computer Science. - Berlin, Heidelberg : Springer Berlin Heidelberg. - 1611-3349. ; 3557, s. 181-195
-
Journal article (peer-reviewed)abstract
- In this paper we present a distinguisher targeting towards irregularly clocked filter generators. The attack is applied on the irregularly. clocked stream cipher called LILI-II. LILI-II is the successor of the cipher LILI-128 and its design was published in [1]. There have been no known attacks better than exhaustive key search on LILI-II. Our attack is-the first of this kind that distinguishes the cipher output from a random source using 2(103) bits of keystream using computational complexity of approximately 2(103) operations.
|
|
| 23. |
- Englund, Håkan, et al.
(author)
-
A new simple technique to attack filter generators and related ciphers
- 2004
-
In: Selected Areas in Cryptography. - Berlin, Heidelberg : Springer Berlin Heidelberg. - 1611-3349 .- 0302-9743. - 3540243275 ; 3357, s. 39-53
-
Conference paper (peer-reviewed)abstract
- This paper presents a new simple distinguishing attack that can be applied on stream ciphers constructed from filter generators or similar structures. We demonstrate the effectiveness by describing key recovery attacks on the stream cipher LILI-128. One attack on LILI-128 requires 247 bits of keystream and a computational complexity of roughly 253. This is a significant improvement compared to other known attacks
|
|
| 24. |
- Englund, Håkan, et al.
(author)
-
A note on distinguishing attacks
- 2007
-
In: [Host publication title missing]. - 9781424412006 ; , s. 87-90
-
Conference paper (peer-reviewed)abstract
- A new distinguishing attack scenario for stream ciphers, allowing a resynchronization collision attack, is presented. The attack can succeed if the part of the state that depends on both the key and the IV is smaller than twice the key size. It is shown that the attack is applicable to block ciphers in OFB mode. For OFB mode, the attack is more powerful than the previously known generic distinguishing attack since it will directly recover a part of the plaintext while having the same asymptotic complexity as the generic distinguishing attack. The attack is also demonstrated on the eSTREAM candidate LEX. LEX is not vulnerable to any of the previously known generic distinguishing attack but is vulnerable to the new attack. It is shown that if approximately 265.7 resynchronizations using LEX are performed for the same key, some plaintext might be recovered.
|
|
| 25. |
- Englund, Håkan, et al.
(author)
-
Correlation attacks using a new class of weak feedback polynomials
- 2004
-
In: Fast Software Encryption. Revised Papers / Lecture Notes in Computer Science. - Berlin, Heidelberg : Springer Berlin Heidelberg. - 0302-9743 .- 1611-3349. - 9783540221715 ; 3017, s. 127-142
-
Conference paper (peer-reviewed)abstract
- In 1985 Siegenthaler introduced the concept of correlation attacks on LFSR based stream ciphers. A few years later Meier and Staffelbach demonstrated a special technique, usually referred to as fast correlation attacks, that is very effective if the feedback polynomial has a special form, namely, if its weight is very low. Due to this seminal result, it is a well known fact that one avoids low weight feedback polynomials in the design of LFSR based stream ciphers. This paper identifies a new class of such weak feedback polynomials, polynomials of the form f(x) = g(1) (x) + g(2) (x)x(M1) + (...) + g(t)(x)x(Mt-1), where g(1), g(2), (...), g(t) are all polynomials of low degree. For such feedback polynomials, we identify an efficient correlation attack in the form of a distinguishing attack.
|
|
