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1.	Newton, P. T., et al. (author) A radical switch in clonality reveals a stem cell niche in the epiphyseal growth plate 2019 In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 567:7747 Journal article (peer-reviewed)abstract Longitudinal bone growth in children is sustained by growth plates, narrow discs of cartilage that provide a continuous supply of chondrocytes for endochondral ossification(1). However, it remains unknown how this supply is maintained throughout childhood growth. Chondroprogenitors in the resting zone are thought to be gradually consumed as they supply cells for longitudinal growth(1,2), but this model has never been proved. Here, using clonal genetic tracing with multicolour reporters and functional perturbations, we demonstrate that longitudinal growth during the fetal and neonatal periods involves depletion of chondroprogenitors, whereas later in life, coinciding with the formation of the secondary ossification centre, chondroprogenitors acquire the capacity for self-renewal, resulting in the formation of large, stable monoclonal columns of chondrocytes. Simultaneously, chondroprogenitors begin to express stem cell markers and undergo symmetric cell division. Regulation of the pool of self-renewing progenitors involves the hedgehog and mammalian target of rapamycin complex 1 (mTORC1) signalling pathways. Our findings indicate that a stem cell niche develops postnatally in the epiphyseal growth plate, which provides a continuous supply of chondrocytes over a prolonged period.
2.	Shin, J, et al. (author) Single-Cell RNA-Seq with Waterfall Reveals Molecular Cascades underlying Adult Neurogenesis 2015 In: Cell stem cell. - : Elsevier BV. - 1875-9777 .- 1934-5909. ; 17:3, s. 360-372 Journal article (peer-reviewed)
3.	Song, J, et al. (author) Neuronal circuitry mechanism regulating adult quiescent neural stem-cell fate decision 2012 In: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 489:7414, s. 150-U216 Journal article (peer-reviewed)

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Type of publication: journal article (3)

Type of content: peer-reviewed (3)

Author/Editor: Enikolopov, G. (3); Song, J. (2); Song, HJ (2); Ming, GL (2); Bonaguidi, MA (2); Christian, KM (2); show more...; Li, L. (1); Petersen, J. (1); Lundeberg, Joakim (1); Shin, J. (1); Meletis, K (1); Kasper, M (1); Adameyko, I (1); Fried, K (1); Gu, Y. (1); Savendahl, L (1); Hedlund, E (1); Schweingruber, C (1); Shin, JY (1); Berg, DA (1); Gritli Linde, Amel, ... (1); Bouderlique, T (1); Xie, M (1); Huang, ZJ (1); Deisseroth, K (1); Luscher, B (1); Chagin, A S (1); Qian, H. (1); Mollbrink, Annelie (1); Sandhow, L (1); Sun, X Y (1); El Shahawy, Maha (1); Dyachuk, V (1); Zhu, YH (1); Ivashkin, E (1); Newton, P. T. (1); Hovorakova, M (1); Zhong, C (1); Zhou, B. Y. (1); Artemov, A. V. (1); Suter, S. (1); Nauen, DW (1); Sun, GJ (1); Hsu, D (1); Ge, SY (1); show less...

University: Karolinska Institutet (3); University of Gothenburg (1); Royal Institute of Technology (1)

Language: English (3)

Research subject (UKÄ/SCB): Medical and Health Sciences (1)

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