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Search: WFRF:(Esteve C)

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  • Krasilnikov, A., et al. (author)
  • Evidence of 9 Be + p nuclear reactions during 2ω CH and hydrogen minority ICRH in JET-ILW hydrogen and deuterium plasmas
  • 2018
  • In: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 58:2
  • Journal article (peer-reviewed)abstract
    • The intensity of 9Be + p nuclear fusion reactions was experimentally studied during second harmonic (2ω CH) ion-cyclotron resonance heating (ICRH) and further analyzed during fundamental hydrogen minority ICRH of JET-ILW hydrogen and deuterium plasmas. In relatively low-density plasmas with a high ICRH power, a population of fast H+ ions was created and measured by neutral particle analyzers. Primary and secondary nuclear reaction products, due to 9Be + p interaction, were observed with fast ion loss detectors, γ-ray spectrometers and neutron flux monitors and spectrometers. The possibility of using 9Be(p, d)2α and 9Be(p, α)6Li nuclear reactions to create a population of fast alpha particles and study their behaviour in non-active stage of ITER operation is discussed in the paper.
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  • Overview of the JET results
  • 2015
  • In: Nuclear Fusion. - : IOP Publishing. - 0029-5515 .- 1741-4326. ; 55:10
  • Journal article (peer-reviewed)
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  • Woollacott, I. O. C., et al. (author)
  • C5F glial markers are elevated in a subset of patients with genetic frontotemporal dementia
  • 2022
  • In: Annals of Clinical and Translational Neurology. - : Wiley. - 2328-9503. ; 9:11, s. 1764-1777
  • Journal article (peer-reviewed)abstract
    • Background: Neuroinflammation has been shown to be an important pathophysiological disease mechanism in frontotemporal dementia (FTD). This includes activation of microglia, a process that can be measured in life through assaying different glia-derived biomarkers in cerebrospinal fluid. However, only a few studies so far have taken place in FTD, and even fewer focusing on the genetic forms of FTD. Methods: We investigated the cerebrospinal fluid concentrations of TREM2, YKL-40 and chitotriosidase using immunoassays in 183 participants from the Genetic FTD Initiative (GENFI) study: 49 C9orf72 (36 presymptomatic, 13 symptomatic), 49 GRN (37 presymptomatic, 12 symptomatic) and 23 MAPT (16 presymptomatic, 7 symptomatic) mutation carriers and 62 mutation-negative controls. Concentrations were compared between groups using a linear regression model adjusting for age and sex, with 95% bias-corrected bootstrapped confidence intervals. Concentrations in each group were correlated with the Mini-Mental State Examination (MMSE) score using non-parametric partial correlations adjusting for age. Age-adjusted z-scores were also created for the concentration of markers in each participant, investigating how many had a value above the 95th percentile of controls. Results: Only chitotriosidase in symptomatic GRN mutation carriers had a concentration significantly higher than controls. No group had higher TREM2 or YKL-40 concentrations than controls after adjusting for age and sex. There was a significant negative correlation of chitotriosidase concentration with MMSE in presymptomatic GRN mutation carriers. In the symptomatic groups, for TREM2 31% of C9orf72, 25% of GRN, and 14% of MAPT mutation carriers had a concentration above the 95th percentile of controls. For YKL-40 this was 8% C9orf72, 8% GRN and 0% MAPT mutation carriers, whilst for chitotriosidase it was 23% C9orf72, 50% GRN, and 29% MAPT mutation carriers. Conclusions: Although chitotriosidase concentrations in GRN mutation carriers were the only significantly raised glia-derived biomarker as a group, a subset of mutation carriers in all three groups, particularly for chitotriosidase and TREM2, had elevated concentrations. Further work is required to understand the variability in concentrations and the extent of neuroinflammation across the genetic forms of FTD. However, the current findings suggest limited utility of these measures in forthcoming trials.
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  • Result 1-25 of 68
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journal article (64)
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Type of content
peer-reviewed (66)
other academic/artistic (2)
Author/Editor
Esposito, B. (23)
Jones, G. (23)
Price, D. (23)
Yao, L. (23)
Young, C. (23)
Thomas, P. (23)
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Baker, A. (23)
Martin, A. (23)
Schneider, M. (23)
Day, C. (23)
Page, A. (23)
Morris, J. (23)
Lee, S (23)
Williams, M (23)
Bowden, M. (23)
Afzal, M (23)
Silva, C. (23)
Duran, I (23)
Mayer, M. (23)
Sinha, A. (23)
Kundu, A. (23)
Lopez, J. M. (23)
Martin, Y. (23)
Godwin, J (23)
Ambrosino, G (23)
Amosov, V (23)
Anghel, M (23)
Ariola, M (23)
Arshad, S (23)
Ash, A (23)
Asunta, O (23)
Avotina, L (23)
Ayres, C (23)
Baciero, A (23)
Balboa, I (23)
Balshaw, N (23)
Barnsley, R (23)
Batistoni, P (23)
Bazylev, B (23)
Bellinger, M (23)
Bernardo, J (23)
Bieg, B (23)
Bigi, M (23)
Blanchard, P (23)
Bobkov, V (23)
Boboc, A (23)
Bolzonella, T (23)
Botrugno, A (23)
Boyce, T (23)
Braic, V (23)
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University
Karolinska Institutet (32)
Royal Institute of Technology (25)
Uppsala University (25)
Chalmers University of Technology (24)
University of Gothenburg (12)
Umeå University (2)
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Stockholm University (1)
Linköping University (1)
Lund University (1)
RISE (1)
Swedish Museum of Natural History (1)
Swedish University of Agricultural Sciences (1)
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Language
English (68)
Research subject (UKÄ/SCB)
Natural sciences (32)
Medical and Health Sciences (13)
Engineering and Technology (12)

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