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1.	Gotschalck, MA, et al. (author) Predictors for and outcomes after bone marrow biopsy in Scandinavian patients with chronic immune thrombocytopenia 2021 In: European journal of haematology. - : Wiley. - 1600-0609 .- 0902-4441. ; 107:1, s. 145-156 Journal article (peer-reviewed)
2.	Jansen, WJ, et al. (author) Prevalence Estimates of Amyloid Abnormality Across the Alzheimer Disease Clinical Spectrum 2022 In: JAMA neurology. - : American Medical Association. - 2168-6157 .- 2168-6149. Journal article (peer-reviewed)
3.	Panayidou, K, et al. (author) Global temporal changes in the proportion of children with advanced disease at the start of combination antiretroviral therapy in an era of changing criteria for treatment initiation 2018 In: Journal of the International AIDS Society. - : Wiley. - 1758-2652. ; 21:11, s. e25200- Journal article (peer-reviewed)
4.	Prause, M, et al. (author) JNK1 Deficient Insulin-Producing Cells Are Protected against Interleukin-1β-Induced Apoptosis Associated with Abrogated Myc Expression 2016 In: Journal of diabetes research. - : Hindawi Limited. - 2314-6753 .- 2314-6745. ; 2016, s. 1312705- Journal article (peer-reviewed)abstract The relative contributions of the JNK subtypes in inflammatoryβ-cell failure and apoptosis are unclear. The JNK protein family consists of JNK1, JNK2, and JNK3 subtypes, encompassing many different isoforms. INS-1 cells express JNK1α1, JNK1α2, JNK1β1, JNK1β2, JNK2α1, JNK2α2, JNK3α1, and JNK3α2 mRNA isoform transcripts translating into 46 and 54 kDa isoform JNK proteins. Utilizing Lentiviral mediated expression of shRNAs against JNK1, JNK2, or JNK3 in insulin-producing INS-1 cells, we investigated the role of individual JNK subtypes in IL-1β-inducedβ-cell apoptosis. JNK1 knockdown prevented IL-1β-induced INS-1 cell apoptosis associated with decreased 46 kDa isoform JNK protein phosphorylation and attenuated Myc expression. Transient knockdown of Myc also prevented IL-1β-induced apoptosis as well as caspase 3 cleavage. JNK2 shRNA potentiated IL-1β-induced apoptosis and caspase 3 cleavage, whereas JNK3 shRNA did not affect IL-1β-inducedβ-cell death compared to nonsense shRNA expressing INS-1 cells. In conclusion, JNK1 mediates INS-1 cell death associated with increased Myc expression. These findings underline the importance of differentiated targeting of JNK subtypes in the development of inflammatoryβ-cell failure and destruction.

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Type of publication: journal article (4)

Type of content: peer-reviewed (4)

Author/Editor: Bernard, C. (1); Chen, K. (1); Itoh, Y. (1); Aarsland, D (1); Campbell, M. (1); Ruiz, A. (1); show more...; Zetterberg, H. (1); Sonnerborg, A (1); Vandenberghe, R (1); Fladby, T (1); Kramberger, MG (1); Baker, M. (1); Fan, Y. (1); Wood, R (1); Peters, O. (1); Alam, N (1); Nordberg, A (1); Hodges, J. (1); Stephan, C (1); Hildebrandt, H. (1); Kjaer, J (1); Boada, M. (1); Hort, J (1); Phillips, A. (1); Takeda, A. (1); Hamouda, O (1); Paredes, R (1); Reiss, P (1); Soininen, H (1); Norgaard, M (1); Sorensen, HT (1); Pinto, J (1); Patel, K (1); Lim, M (1); Den Braber, A (1); Bahmanyar, S (1); Ghanima, W (1); Christiansen, CF (1); Frederiksen, H (1); Skoog, I (1); Wallin, A (1); Battegay, M (1); Thorne, C (1); Blennow, K (1); Dubois, B (1); Prins, M (1); Tsolaki, M (1); Cortes, C (1); Sabin, C. (1); Hansson, O. (1); show less...

University: Karolinska Institutet (4); Örebro University (1)

Language: English (4)

Research subject (UKÄ/SCB): Medical and Health Sciences (2)

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