SwePub
Sök i SwePub databas

  Extended search

Träfflista för sökning "WFRF:(HALLBERG A) "

Search: WFRF:(HALLBERG A)

  • Result 1-25 of 421
Sort/group result
   
EnumerationReferenceCoverFind
1.
  •  
2.
  •  
3.
  •  
4.
  •  
5.
  •  
6.
  •  
7.
  •  
8.
  •  
9.
  • Lawrenson, Kate, et al. (author)
  • Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus
  • 2016
  • In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 7
  • Journal article (peer-reviewed)abstract
    • A locus at 19p13 is associated with breast cancer (BC) and ovarian cancer (OC) risk. Here we analyse 438 SNPs in this region in 46,451 BC and 15,438 OC cases, 15,252 BRCA1 mutation carriers and 73,444 controls and identify 13 candidate causal SNPs associated with serous OC (P=9.2 × 10-20), ER-negative BC (P=1.1 × 10-13), BRCA1-associated BC (P=7.7 × 10-16) and triple negative BC (P-diff=2 × 10-5). Genotype-gene expression associations are identified for candidate target genes ANKLE1 (P=2 × 10-3) and ABHD8 (P<2 × 10-3). Chromosome conformation capture identifies interactions between four candidate SNPs and ABHD8, and luciferase assays indicate six risk alleles increased transactivation of the ADHD8 promoter. Targeted deletion of a region containing risk SNP rs56069439 in a putative enhancer induces ANKLE1 downregulation; and mRNA stability assays indicate functional effects for an ANKLE1 3′-UTR SNP. Altogether, these data suggest that multiple SNPs at 19p13 regulate ABHD8 and perhaps ANKLE1 expression, and indicate common mechanisms underlying breast and ovarian cancer risk.
  •  
10.
  •  
11.
  •  
12.
  •  
13.
  •  
14.
  •  
15.
  •  
16.
  • Darabi, H, et al. (author)
  • Fine scale mapping of the 17q22 breast cancer locus using dense SNPs, genotyped within the Collaborative Oncological Gene-Environment Study (COGs)
  • 2016
  • In: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 6, s. 32512-
  • Journal article (peer-reviewed)abstract
    • Genome-wide association studies have found SNPs at 17q22 to be associated with breast cancer risk. To identify potential causal variants related to breast cancer risk, we performed a high resolution fine-mapping analysis that involved genotyping 517 SNPs using a custom Illumina iSelect array (iCOGS) followed by imputation of genotypes for 3,134 SNPs in more than 89,000 participants of European ancestry from the Breast Cancer Association Consortium (BCAC). We identified 28 highly correlated common variants, in a 53 Kb region spanning two introns of the STXBP4 gene, that are strong candidates for driving breast cancer risk (lead SNP rs2787486 (OR = 0.92; CI 0.90–0.94; P = 8.96 × 10−15)) and are correlated with two previously reported risk-associated variants at this locus, SNPs rs6504950 (OR = 0.94, P = 2.04 × 10−09, r2 = 0.73 with lead SNP) and rs1156287 (OR = 0.93, P = 3.41 × 10−11, r2 = 0.83 with lead SNP). Analyses indicate only one causal SNP in the region and several enhancer elements targeting STXBP4 are located within the 53 kb association signal. Expression studies in breast tumor tissues found SNP rs2787486 to be associated with increased STXBP4 expression, suggesting this may be a target gene of this locus.
  •  
17.
  •  
18.
  •  
19.
  •  
20.
  • Couch, Fergus J., et al. (author)
  • Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer
  • 2016
  • In: Nature Communications. - : NATURE PUBLISHING GROUP. - 2041-1723. ; 7:11375, s. 1-13
  • Journal article (peer-reviewed)abstract
    • Common variants in 94 loci have been associated with breast cancer including 15 loci with genome-wide significant associations (P<5 x 10(-8)) with oestrogen receptor (ER)-negative breast cancer and BRCA1-associated breast cancer risk. In this study, to identify new ER-negative susceptibility loci, we performed a meta-analysis of 11 genome-wide association studies (GWAS) consisting of 4,939 ER-negative cases and 14,352 controls, combined with 7,333 ER-negative cases and 42,468 controls and 15,252 BRCA1 mutation carriers genotyped on the iCOGS array. We identify four previously unidentified loci including two loci at 13q22 near KLF5, a 2p23.2 locus near WDR43 and a 2q33 locus near PPIL3 that display genome-wide significant associations with ER-negative breast cancer. In addition, 19 known breast cancer risk loci have genome-wide significant associations and 40 had moderate associations (P<0.05) with ER-negative disease. Using functional and eQTL studies we implicate TRMT61B and WDR43 at 2p23.2 and PPIL3 at 2q33 in ER-negative breast cancer aetiology. All ER-negative loci combined account for similar to 11% of familial relative risk for ER-negative disease and may contribute to improved ER-negative and BRCA1 breast cancer risk prediction.
  •  
21.
  •  
22.
  •  
23.
  •  
24.
  • Pelttari, LM, et al. (author)
  • RAD51B in Familial Breast Cancer
  • 2016
  • In: PloS one. - : Public Library of Science (PLoS). - 1932-6203. ; 11:5, s. e0153788-
  • Journal article (peer-reviewed)
  •  
25.
  •  
Skapa referenser, mejla, bekava och länka
  • Result 1-25 of 421
Type of publication
journal article (333)
conference paper (61)
other publication (9)
research review (7)
book chapter (5)
doctoral thesis (4)
visa fler...
rapport (1)
bok (1)
visa färre...
Typ av innehåll
refereegranskat (336)
övrigt vetenskapligt/konstnärligt (83)
populärvet., debatt m.m. (2)
Författare/redaktör
Hallberg, A (106)
Hallberg, J (55)
Melen, E (47)
Kull, I (38)
Hallberg, B (27)
Hallberg, Anders (22)
visa fler...
Andrulis, IL (21)
Couch, FJ (21)
Easton, DF (21)
Dennis, J (20)
Wang, Q. (20)
Hall, P (20)
Czene, K (20)
Bolla, MK (20)
Chang-Claude, J (20)
Benitez, J. (19)
Southey, MC (19)
Hamann, U (19)
Schmidt, MK (19)
Fasching, PA (19)
Nevanlinna, H (19)
Chenevix-Trench, G (19)
Milne, RL (18)
Dunning, AM (18)
Shah, M (18)
Mannermaa, A (18)
Rudolph, A (18)
Brenner, H (17)
Giles, GG (17)
Hopper, JL (17)
Radice, P (17)
Bojesen, SE (17)
Garcia-Closas, M (17)
Samuelsson, B (17)
Michailidou, K (16)
Margolin, S (16)
Glendon, G (16)
Beckmann, MW (16)
Cox, A (16)
Lambrechts, D (16)
Jakubowska, A (16)
Lubinski, J (16)
Pharoah, PDP (16)
Lindblom, A (15)
Burwinkel, B (15)
Guenel, P (15)
Truong, T (15)
Haiman, CA (15)
Winqvist, R (15)
Flyger, H (15)
visa färre...
Lärosäte
Karolinska Institutet (175)
Uppsala universitet (146)
Lunds universitet (52)
Göteborgs universitet (40)
Stockholms universitet (24)
Linköpings universitet (21)
visa fler...
Umeå universitet (19)
Kungliga Tekniska Högskolan (10)
Chalmers tekniska högskola (9)
Luleå tekniska universitet (7)
Södertörns högskola (6)
Karlstads universitet (6)
Högskolan Kristianstad (5)
Högskolan i Halmstad (4)
Malmö universitet (3)
RISE (3)
Örebro universitet (2)
Högskolan Väst (1)
Högskolan i Borås (1)
Högskolan Dalarna (1)
Blekinge Tekniska Högskola (1)
Sveriges Lantbruksuniversitet (1)
visa färre...
Språk
Engelska (413)
Svenska (6)
Odefinierat språk (2)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (122)
Naturvetenskap (70)
Teknik (19)
Samhällsvetenskap (5)
Lantbruksvetenskap (3)
Humaniora (1)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy