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Search: WFRF:(Hallberg P)

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  • Fung, P. P. L., et al. (author)
  • Time to onset of bisphosphonate-related osteonecrosis of the jaws : a multicentre retrospective cohort study
  • 2017
  • In: Oral Diseases. - : WILEY. - 1354-523X .- 1601-0825. ; 23:4, s. 477-483
  • Journal article (peer-reviewed)abstract
    • Objectives: Osteonecrosis of the jaw (ONJ) is a potentially severe adverse effect of bisphosphonates (BP). Although the risk of ONJ increases with increasing duration of BP treatment, there are currently no reliable estimates of the ONJ time to onset (TTO). The objective of this study was to estimate the TTO and associated risk factors in BP-treated patients.Subjects and Methods: Retrospective analysis of data from 22 secondary care centres in seven countries relevant to 349 patients who developed BP-related ONJ between 2004 and 2012.Results: The median (95%CI) TTO was 6.0 years in patients treated with alendronate (n=88) and 2.2years in those treated with zoledronate (n=218). Multivariable Cox regression showed that dentoalveolar surgery was inversely associated, and the use of antiangiogenics directly associated, with the TTO in patients with cancer treated with zoledronate.Conclusions: The incidence of ONJ increases with the duration of BP therapy, with notable differences observed with respect to BP type and potency, route of administration and underlying disease. When data are stratified by BP type, a time of 6.0 and 2.2years of oral alendronate and intravenous zoledronate therapy, respectively, is required for 50% of patients to develop ONJ. After stratification by disease, a time of 5.3 and 2.2years of BP therapy is required for 50% of patients with osteoporosis and cancer, respectively, to develop ONJ. These findings have significant implications for the design of future clinical studies and the development of risk-reduction strategies aimed at either assessing or modulating the risk of ONJ associated with BP.
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  • Darabi, H, et al. (author)
  • Fine scale mapping of the 17q22 breast cancer locus using dense SNPs, genotyped within the Collaborative Oncological Gene-Environment Study (COGs)
  • 2016
  • In: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 6, s. 32512-
  • Journal article (peer-reviewed)abstract
    • Genome-wide association studies have found SNPs at 17q22 to be associated with breast cancer risk. To identify potential causal variants related to breast cancer risk, we performed a high resolution fine-mapping analysis that involved genotyping 517 SNPs using a custom Illumina iSelect array (iCOGS) followed by imputation of genotypes for 3,134 SNPs in more than 89,000 participants of European ancestry from the Breast Cancer Association Consortium (BCAC). We identified 28 highly correlated common variants, in a 53 Kb region spanning two introns of the STXBP4 gene, that are strong candidates for driving breast cancer risk (lead SNP rs2787486 (OR = 0.92; CI 0.90–0.94; P = 8.96 × 10−15)) and are correlated with two previously reported risk-associated variants at this locus, SNPs rs6504950 (OR = 0.94, P = 2.04 × 10−09, r2 = 0.73 with lead SNP) and rs1156287 (OR = 0.93, P = 3.41 × 10−11, r2 = 0.83 with lead SNP). Analyses indicate only one causal SNP in the region and several enhancer elements targeting STXBP4 are located within the 53 kb association signal. Expression studies in breast tumor tissues found SNP rs2787486 to be associated with increased STXBP4 expression, suggesting this may be a target gene of this locus.
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  • Pelttari, LM, et al. (author)
  • RAD51B in Familial Breast Cancer
  • 2016
  • In: PloS one. - : Public Library of Science (PLoS). - 1932-6203. ; 11:5, s. e0153788-
  • Journal article (peer-reviewed)
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  • Result 1-25 of 224
Type of publication
journal article (171)
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Type of content
peer-reviewed (173)
other academic/artistic (50)
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Author/Editor
Hallberg, J (32)
Melen, E (21)
Andrulis, IL (21)
Couch, FJ (21)
Easton, DF (21)
Dennis, J (20)
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Wang, Q. (20)
Hall, P (20)
Czene, K (20)
Bolla, MK (20)
Chang-Claude, J (20)
Benitez, J. (19)
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Hamann, U (19)
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Nevanlinna, H (19)
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Milne, RL (18)
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Shah, M (18)
Mannermaa, A (18)
Rudolph, A (18)
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Giles, GG (17)
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Radice, P (17)
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Garcia-Closas, M (17)
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Truong, T (15)
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Winqvist, R (15)
Flyger, H (15)
Peterlongo, P (14)
Tomlinson, I (14)
Brauch, H (14)
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