| 1. |
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- 2017
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In: Physical Review D. - 2470-0010 .- 2470-0029. ; 96:2
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Journal article (peer-reviewed)
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| 2. |
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| 3. |
- Barausse, Enrico, et al.
(author)
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Prospects for fundamental physics with LISA
- 2020
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In: General Relativity and Gravitation. - : SPRINGER/PLENUM PUBLISHERS. - 0001-7701 .- 1572-9532. ; 52:8
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Journal article (other academic/artistic)abstract
- In this paper, which is of programmatic rather than quantitative nature, we aim to further delineate and sharpen the future potential of the LISA mission in the area of fundamental physics. Given the very broad range of topics that might be relevant to LISA,we present here a sample of what we view as particularly promising fundamental physics directions. We organize these directions through a "science-first" approach that allows us to classify how LISA data can inform theoretical physics in a variety of areas. For each of these theoretical physics classes, we identify the sources that are currently expected to provide the principal contribution to our knowledge, and the areas that need further development. The classification presented here should not be thought of as cast in stone, but rather as a fluid framework that is amenable to change with the flow of new insights in theoretical physics.
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| 4. |
- Reifarth, R., et al.
(author)
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Nuclear astrophysics with radioactive ions at FAIR
- 2016
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In: Journal of Physics: Conference Series. - : IOP Publishing. - 1742-6588 .- 1742-6596. ; 665:1
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Conference paper (peer-reviewed)abstract
- The nucleosynthesis of elements beyond iron is dominated by neutron captures in the s and r processes. However, 32 stable, proton-rich isotopes cannot be formed during those processes, because they are shielded from the s-process flow and r-process beta-decay chains. These nuclei are attributed to the p and rp process. For all those processes, current research in nuclear astrophysics addresses the need for more precise reaction data involving radioactive isotopes. Depending on the particular reaction, direct or inverse kinematics, forward or time-reversed direction are investigated to determine or at least to constrain the desired reaction cross sections. The Facility for Antiproton and Ion Research (FAIR) will offer unique, unprecedented opportunities to investigate many of the important reactions. The high yield of radioactive isotopes, even far away from the valley of stability, allows the investigation of isotopes involved in processes as exotic as the r or rp processes.
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| 5. |
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| 6. |
- De Leoz, M. L. A., et al.
(author)
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NIST Interlaboratory Study on Glycosylation Analysis of Monoclonal Antibodies: Comparison of Results from Diverse Analytical Methods
- 2020
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In: Molecular & Cellular Proteomics. - 1535-9476. ; 19:1, s. 11-30
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Journal article (peer-reviewed)abstract
- A broad-based interlaboratory study of glycosylation profiles of a reference and modified IgG antibody involving 103 reports from 76 laboratories. Glycosylation is a topic of intense current interest in the development of biopharmaceuticals because it is related to drug safety and efficacy. This work describes results of an interlaboratory study on the glycosylation of the Primary Sample (PS) of NISTmAb, a monoclonal antibody reference material. Seventy-six laboratories from industry, university, research, government, and hospital sectors in Europe, North America, Asia, and Australia submitted a total of 103 reports on glycan distributions. The principal objective of this study was to report and compare results for the full range of analytical methods presently used in the glycosylation analysis of mAbs. Therefore, participation was unrestricted, with laboratories choosing their own measurement techniques. Protein glycosylation was determined in various ways, including at the level of intact mAb, protein fragments, glycopeptides, or released glycans, using a wide variety of methods for derivatization, separation, identification, and quantification. Consequently, the diversity of results was enormous, with the number of glycan compositions identified by each laboratory ranging from 4 to 48. In total, one hundred sixteen glycan compositions were reported, of which 57 compositions could be assigned consensus abundance values. These consensus medians provide community-derived values for NISTmAb PS. Agreement with the consensus medians did not depend on the specific method or laboratory type. The study provides a view of the current state-of-the-art for biologic glycosylation measurement and suggests a clear need for harmonization of glycosylation analysis methods.
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| 7. |
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| 8. |
- Zhang, Y., et al.
(author)
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Galaxies in X-ray selected clusters and groups in Dark Energy Survey data - II. Hierarchical Bayesian modelling of the red-sequence galaxy luminosity function
- 2019
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In: Monthly notices of the Royal Astronomical Society. - : OXFORD UNIV PRESS. - 0035-8711 .- 1365-2966. ; 488:1, s. 1-17
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Journal article (peer-reviewed)abstract
- Using similar to 100 X-ray selected clusters in the Dark Energy Survey Science Verification data, we constrain the luminosity function ( LF) of cluster red-sequence galaxies as a function of redshift. This is the first homogeneous optical/X-ray sample large enough to constrain the evolution of the LF simultaneously in redshift ( 0.1 < z < 1.05) and cluster mass ( 13.5 <= log(10)( M-200crit) similar to< 15.0). We pay particular attention to completeness issues and the detection limit of the galaxy sample. We then apply a hierarchical Bayesian model to fit the cluster galaxy LFs via a Schechter function, including its characteristic break ( m*) to a faint end power-law slope ( alpha). Our method enables us to avoid known issues in similar analyses based on stacking or binning the clusters. We find weak and statistically insignificant (similar to 1.9 sigma) evolution in the faint end slope alpha versus redshift. We also find no dependence in alpha or m* with the X-ray inferred cluster masses. However, the amplitude of the LF as a function of cluster mass is constrained to similar to 20 per cent precision. As a by-product of our algorithm, we utilize the correlation between the LF and cluster mass to provide an improved estimate of the individual cluster masses as well as the scatter in true mass given the X-ray inferred masses. This technique can be applied to a larger sample of X-ray or optically selected clusters from the Dark Energy Survey, significantly improving the sensitivity of the analysis.
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| 9. |
- Horikoshi, Momoko, et al.
(author)
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New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.
- 2013
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 45:1
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Journal article (peer-reviewed)abstract
- Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood. Previous genome-wide association studies of birth weight identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes and a second variant, near CCNL1, with no obvious link to adult traits. In an expanded genome-wide association meta-analysis and follow-up study of birth weight (of up to 69,308 individuals of European descent from 43 studies), we have now extended the number of loci associated at genome-wide significance to 7, accounting for a similar proportion of variance as maternal smoking. Five of the loci are known to be associated with other phenotypes: ADCY5 and CDKAL1 with type 2 diabetes, ADRB1 with adult blood pressure and HMGA2 and LCORL with adult height. Our findings highlight genetic links between fetal growth and postnatal growth and metabolism.
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| 10. |
- Surendran, Praveen, et al.
(author)
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Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals
- 2020
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In: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 52:12, s. 1314-1332
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Journal article (peer-reviewed)abstract
- Genetic studies of blood pressure (BP) to date have mainly analyzed common variants (minor allele frequency > 0.05). In a meta-analysis of up to similar to 1.3 million participants, we discovered 106 new BP-associated genomic regions and 87 rare (minor allele frequency <= 0.01) variant BP associations (P < 5 x 10(-8)), of which 32 were in new BP-associated loci and 55 were independent BP-associated single-nucleotide variants within known BP-associated regions. Average effects of rare variants (44% coding) were similar to 8 times larger than common variant effects and indicate potential candidate causal genes at new and known loci (for example, GATA5 and PLCB3). BP-associated variants (including rare and common) were enriched in regions of active chromatin in fetal tissues, potentially linking fetal development with BP regulation in later life. Multivariable Mendelian randomization suggested possible inverse effects of elevated systolic and diastolic BP on large artery stroke. Our study demonstrates the utility of rare-variant analyses for identifying candidate genes and the results highlight potential therapeutic targets.
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| 11. |
- Snider, J. R., et al.
(author)
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Intercomparison of cloud condensation nuclei and hygroscopic fraction measurements: Coated soot particles investigated during the LACIS Experiment in November (LExNo)
- 2010
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In: Journal of Geophysical Research. - 2156-2202. ; 115, s. 11205-11205
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Journal article (peer-reviewed)abstract
- Four cloud condensation nuclei (CCN) instruments were used to sample size-selected particles prepared at the Leipzig Aerosol Cloud Interaction Simulator facility. Included were two Wyoming static diffusion CCN instruments, the continuous flow instrument built by Droplet Measurement Technologies, and the continuous flow Leipzig instrument. The aerosols were composed of ammonium sulfate, levoglucosan, levoglucosan and soot, and ammonium hydrogen sulfate and soot. Comparisons are made among critical supersaturation values from the CCN instruments and derived from measurements made with a humidified tandem differential mobility system. The comparison is quite encouraging: with few exceptions the reported critical supersaturations agree within known experimental uncertainty limits. Also reported are CCN- and hygroscopicity-based estimates of the soot particles' solute fraction. Relative differences between these are as large as 40%, but an error analysis demonstrates that agreement within experimental uncertainty is achieved. We also analyze data from the Droplet Measurement Technologies and the two Wyoming static diffusion instruments for evidence of size distribution broadening and investigate levoglucosan particle growth kinetics in the Wyoming CCN instrument.
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| 12. |
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| 13. |
- Arun, K. G., et al.
(author)
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New horizons for fundamental physics with LISA
- 2022
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In: Living Reviews in Relativity. - : Springer Science and Business Media LLC. - 1433-8351 .- 2367-3613. ; 25:1
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Research review (peer-reviewed)abstract
- The Laser Interferometer Space Antenna (LISA) has the potential to reveal wonders about the fundamental theory of nature at play in the extreme gravity regime, where the gravitational interaction is both strong and dynamical. In this white paper, the Fundamental Physics Working Group of the LISA Consortium summarizes the current topics in fundamental physics where LISA observations of gravitational waves can be expected to provide key input. We provide the briefest of reviews to then delineate avenues for future research directions and to discuss connections between this working group, other working groups and the consortium work package teams. These connections must be developed for LISA to live up to its science potential in these areas.
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| 14. |
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| 15. |
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| 16. |
- Hennig, A., et al.
(author)
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Collective excitations of Ru-96 by means of (p, p 'gamma) experiments
- 2015
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In: Physical Review C - Nuclear Physics. - 2469-9985 .- 2469-9993. ; 92:6
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Journal article (peer-reviewed)abstract
- Background: One-phonon mixed-symmetry quadrupole excitations are a well-known feature of near-spherical, vibrational nuclei. Their interpretation as a fundamental building block of vibrational structures is supported by the identification of multiphonon states resulting from a coupling of fully-symmetric and mixed-symmetric quadrupole phonons. In addition, the observation of strong M1 transitions between low-lying 3(-) and 4(+) states has been interpreted as an evidence for one-phonon mixed-symmetry excitations of octupole and hexadecapole character. Purpose: The aim of the present study is to identify collective one-and two-phonon excitations in the heaviest stable N = 52 isotone Ru-96 based on a measurement of absolute M1, E1, and E2 transition strengths. Methods: Inelastic proton-scattering experiments have been performed at the Wright Nuclear Structure Laboratory (WNSL), Yale University, and the Institute for Nuclear Physics (IKP), University of Cologne. From the acquired proton-gamma and gamma gamma coincidence data we deduced spins of excited states, gamma-decay branching ratios, and multipole mixing ratios, as well as lifetimes of excited states via the Doppler-shift attenuation method (DSAM). Results: Based on the new experimental data on absolute transition strengths, we identified the 2(+) and 3(+) members of the two-phonon mixed-symmetry quintuplet (2(1,ms)(+) circle times 2(1,s)(+)). Furthermore, we observed strong M1 transitions between low-lying 3(-) and 4(+) states suggesting one-phonon symmetric andmixed-symmetric octupole and hexadecapole components in their wave functions, respectively. The experimental results are compared to sdg-IBM-2 and shell-model calculations. Conclusions: Both the sdg-IBM-2 and the shell-model calculations are able to describe key features of mixed-symmetry excitations of Ru-96. Moreover, they support the one-phonon mixed-symmetry hexadecapole assignment of the experimental 4(2)(+) state.
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| 17. |
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| 18. |
- Corcoran, Martin M., et al.
(author)
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Production of individualized V gene databases reveals high levels of immunoglobulin genetic diversity
- 2016
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In: nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 7
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Journal article (peer-reviewed)abstract
- Comprehensive knowledge of immunoglobulin genetics is required to advance our understanding of B cell biology. Validated immunoglobulin variable (V) gene databases are close to completion only for human and mouse. We present a novel computational approach, IgDiscover, that identifies germline V genes from expressed repertoires to a specificity of 100%. IgDiscover uses a cluster identification process to produce candidate sequences that, once filtered, results in individualized germline V gene databases. IgDiscover was tested in multiple species, validated by genomic cloning and cross library comparisons and produces comprehensive gene databases even where limited genomic sequence is available. IgDiscover analysis of the allelic content of the Indian and Chinese-origin rhesus macaques reveals high levels of immunoglobulin gene diversity in this species. Further, we describe a novel human IGHV3-21 allele and confirm significant gene differences between Balb/c and C57BL6 mouse strains, demonstrating the power of IgDiscover as a germline V gene discovery tool.
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| 19. |
- Dusek, U., et al.
(author)
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Water uptake by biomass burning aerosol at sub- and supersaturated conditions: closure studies and implications for the role of organics
- 2011
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In: Atmospheric Chemistry and Physics. - : Copernicus GmbH. - 1680-7324. ; 11, s. 9519-9532
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Journal article (peer-reviewed)abstract
- We investigate the CCN activity of freshly emitted biomass burning particles and their hygroscopic growth at a relative humidity (RH) of 85%. The particles were produced in the Mainz combustion laboratory by controlled burning of various wood types. The water uptake at sub- and supersaturations is parameterized by the hygroscopicity parameter, κ (c.f. Petters and Kreidenweis, 2007). For the wood burns, κ is low, generally around 0.06. The main emphasis of this study is a comparison of κ derived from measurements at sub- and supersaturated conditions (κG and κCCN), in order to see whether the water uptake at 85% RH can predict the CCN properties of the biomass burning particles. Differences in κGand κCCN can arise through solution non-idealities, the presence of slightly soluble or surface active compounds, or non-spherical particle shape. We find that κG and κCCN agree within experimental uncertainties (of around 30%) for particle sizes of 100 and 150 nm; only for 50 nm particles is κCCN larger than κG by a factor of 2. The magnitude of this difference and its dependence on particle size is consistent with the presence of surface active organic compounds. These compounds mainly facilitate the CCN activation of small particles, which form the most concentrated solution droplets at the point of activation. The 50 nm particles, however, are only activated at supersaturations higher than 1% and are therefore of minor importance as CCN in ambient clouds. By comparison with the actual chemical composition of the biomass burning particles, we estimate that the hygroscopicity of the water-soluble organic carbon (WSOC) fraction can be represented by a κWSOC value of approximately 0.2. The effective hygroscopicity of a typical wood burning particle can therefore be represented by a linear mixture of an inorganic component with κ ≅ 0.6, a WSOC component with κ ≅ 0.2, and an insoluble component with κ = 0.
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| 20. |
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| 21. |
- Hennig, A., et al.
(author)
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Mixed-symmetry octupole and hexadecapole excitations in N=52 isotones
- 2015
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In: EPJ Web of Conferences. - : EDP Sciences. - 2101-6275 .- 2100-014X. - 9782759817948 ; 93
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Conference paper (peer-reviewed)abstract
- In addition to the well-established quadrupole mixed-symmetry states, octupole and hexadecapole excitations with mixed-symmetry character have been recently proposed for the N = 52 isotones 92Zr and 94Mo. We performed two inelastic proton-scattering experiments to study this kind of excitations in the heaviest stable N = 52 isotone 96Ru. From the combined experimental data of both experiments absolute transition strengths were extracted.
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| 22. |
- Hennig, A., et al.
(author)
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Mixed-symmetry octupole and hexadecapole excitations in the N=52 isotones
- 2014
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In: Physical Review C - Nuclear Physics. - 2469-9985 .- 2469-9993. ; 90:5, s. Art. no. 051302-
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Journal article (peer-reviewed)abstract
- Background: Excitations with mixed proton-neutron symmetry have been previously observed in the N=52 isotones. Besides the well-established quadrupole mixed-symmetry states (MSS), octupole and hexadecapole MSS have been recently proposed for the nuclei Zr92 and Mo94. Purpose: The heaviest stable N=52 isotone Ru96 was investigated to study the evolution of octupole and hexadecapole MSS with increasing proton number. Methods: Two inelastic proton-scattering experiments on Ru96 were performed to extract branching ratios, multipole mixing ratios, and level lifetimes. From the combined data, absolute transition strengths were calculated. Results: Strong M1 transitions between the lowest-lying 3- and 4+ states were observed, providing evidence for a one-phonon mixed-symmetry character of the 32(-) and 42+ states. Conclusions: sdg-IBM-2 calculations were performed for Ru96. The results are in excellent agreement with the experimental data, pointing out a one-phonon hexadecapole mixed-symmetry character of the 42+ state. The 31-||M1||32(-) matrix element is found to scale with the 2s+||M1||2ms+ matrix element.
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| 23. |
- Hennig, A., et al.
(author)
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Study of mixed-symmetry excitations in Ru-96 via inelastic proton-scattering
- 2015
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In: Journal of Physics: Conference Series. - : IOP Publishing. - 1742-6588 .- 1742-6596. ; 580:1
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Conference paper (peer-reviewed)abstract
- Mixed-symmetry states of octupole (L = 3) and hexadecapole (L = 4) character have been recently proposed in the N = 52 isotones Zr-92 and Mo-94, based on strong M1 transitions to the lowest-lying 3(-) and 4(+) states, respectively. In order to investigate similar excitations in the heaviest stable N = 52 isotone Ru-96, two inelastic proton-scattering experiments have been performed at the Wright Nuclear Structure Laboratory (WNSL), Yale University, USA and the Institute for Nuclear Physics, University of Cologne, Germany. From the combined data of both experiments, absolute E-1, M-1, and E2 transition strengths were extracted, allowing for the identification of candidates for MS octupole and hexadecapole states. The structure of the low-lying 4(+) states is investigated by means of sdg-IBM-2 calculations.
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| 24. |
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| 25. |
- Lopez, Victor A., et al.
(author)
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A Bacterial Effector Mimics a Host HSP90 Client to Undermine Immunity
- 2019
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In: Cell. - : Elsevier BV. - 0092-8674. ; 179:1, s. 21-218
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Journal article (peer-reviewed)abstract
- The molecular chaperone HSP90 facilitates the folding of several client proteins, including innate immune receptors and protein kinases. HSP90 is an essential component of plant and animal immunity, yet pathogenic strategies that directly target the chaperone have not been described. Here, we identify the HopBF1 family of bacterial effectors as eukaryotic-specific HSP90 protein kinases. HopBF1 adopts a minimal protein kinase fold that is recognized by HSP90 as a host client. As a result, HopBF1 phosphorylates HSP90 to completely inhibit the chaperone's ATPase activity. We demonstrate that phosphorylation of HSP90 prevents activation of immune receptors that trigger the hypersensitive response in plants. Consequently, HopBF1-dependent phosphorylation of HSP90 is sufficient to induce severe disease symptoms in plants infected with the bacterial pathogen, Pseudomonas syringae. Collectively, our results uncover a family of bacterial effector kinases with toxin-like properties and reveal a previously unrecognized betrayal mechanism by which bacterial pathogens modulate host immunity.
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