SwePub
Sök i SwePub databas

  Extended search

Träfflista för sökning "WFRF:(Hov Johannes Roksund) "

Search: WFRF:(Hov Johannes Roksund)

  • Result 1-2 of 2
Sort/group result
   
EnumerationReferenceCoverFind
1.
  • Carstens, Adam, 1975- (author)
  • Chronic inflammatory bowel diseases : studies of microbiota and its influence
  • 2021
  • Doctoral thesis (other academic/artistic)abstract
    • Introduction: Inflammatory bowel diseases are becoming increasingly common. The underlying mechanisms are not entirely known but the gut microbiota seem to be involved in the pathogenesis. Aim: The aim of this thesis was to characterise gut microbiota related to diagnosis, disease course and response to biological treatment, taking aspects of the source of biological material into account. Materials and methods: Patients and healthy individuals from several different cohorts in Sweden and Europe were invited. Faecal samples and mucosal biopsies were analysed using different sequencing platforms to investigate the gut microbiota. In Study I the faecal microbiota was correlated to different inflammatory bowel diseases. In Study II we compared the microbiota in faeces to the microbiota in mucosal biopsies. In StudyIII we related the faecal microbiota to the outcome of biological treatment. In Study IV we investigated the diagnostic and prognostic properties of the GAmapTM Dysbiosis Test.Results: The faecal microbiota in collagenous colitis resembles the faecalmicrobiota in inflammatory bowel disease. The faecal microbiota differs from the mucosal microbiota. Faecal microbiota at initiation of biological treatment among patients with Crohn’s disease differ between responders and non-responders. The GAmapTM Dysbiosis Test discriminates patients with inflammatory bowel disease from healthy individuals.Conclusion: Collagenous colitis may share microbial underpinnings with other inflammatory bowel diseases. Conclusions about mucosal interactions with the gut microbiota should be made with caution when usingfaecal samples to characterise the microbiota. In Crohn’s disease, the faecal microbiota may be included in a model to predict the outcome of biological treatment. The GAmap Dysbiosis Test does not seem to be superior to other current diagnostic tools in clinical decision-making. 
  •  
2.
  • Liu, Jimmy Z, et al. (author)
  • Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis.
  • 2013
  • In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 45:6, s. 670-5
  • Journal article (peer-reviewed)abstract
    • Primary sclerosing cholangitis (PSC) is a severe liver disease of unknown etiology leading to fibrotic destruction of the bile ducts and ultimately to the need for liver transplantation. We compared 3,789 PSC cases of European ancestry to 25,079 population controls across 130,422 SNPs genotyped using the Immunochip. We identified 12 genome-wide significant associations outside the human leukocyte antigen (HLA) complex, 9 of which were new, increasing the number of known PSC risk loci to 16. Despite comorbidity with inflammatory bowel disease (IBD) in 72% of the cases, 6 of the 12 loci showed significantly stronger association with PSC than with IBD, suggesting overlapping yet distinct genetic architectures for these two diseases. We incorporated association statistics from 7 diseases clinically occurring with PSC in the analysis and found suggestive evidence for 33 additional pleiotropic PSC risk loci. Together with network analyses, these findings add to the genetic risk map of PSC and expand on the relationship between PSC and other immune-mediated diseases.
  •  
Skapa referenser, mejla, bekava och länka
  • Result 1-2 of 2
Type of publication
journal article (1)
doctoral thesis (1)
Type of content
other academic/artistic (1)
peer-reviewed (1)
Author/Editor
Marschall, Hanns-Ulr ... (1)
Andreassen, Ole A (1)
Karlsen, Tom H (1)
Bergquist, Annika (1)
Boberg, Kirsten Muri (1)
Padyukov, Leonid (1)
show more...
Albrecht, Mario (1)
Färkkilä, Martti (1)
Herms, Stefan (1)
Nöthen, Markus M (1)
Vermeire, Severine (1)
Invernizzi, Pietro (1)
Rich, Stephen S (1)
Wijmenga, Cisca (1)
Rioux, John D. (1)
Schreiber, Stefan (1)
Hveem, Kristian (1)
Floreani, Annarosa (1)
Saarela, Janna (1)
Franke, Andre (1)
Winkelmann, Juliane (1)
Björnsson, Einar, 19 ... (1)
Schork, Andrew J (1)
Weismüller, Tobias J ... (1)
Milkiewicz, Piotr (1)
Schramm, Christoph (1)
Lazaridis, Konstanti ... (1)
Chapman, Roger W (1)
Silverberg, Mark S. (1)
Carstens, Adam, 1975 ... (1)
Halfvarson, Jonas, p ... (1)
Engstrand, Lars, pro ... (1)
Hov, Johannes Espoli ... (1)
Doncheva, Nadezhda T ... (1)
Ellinghaus, David (1)
Thompson, Wesley K. (1)
Dale, Anders M. (1)
Cleynen, Isabelle (1)
Annese, Vito (1)
Brand, Stephan (1)
Duerr, Richard H. (1)
Weersma, Rinse K. (1)
Melum, Espen (1)
Ellinghaus, Eva (1)
Folseraas, Trine (1)
Juran, Brian D. (1)
Mayr, Gabriele (1)
Ponsioen, Cyriel Y. (1)
Sans, Miquel (1)
Vatn, Morten H. (1)
show less...
University
University of Gothenburg (1)
Örebro University (1)
Karolinska Institutet (1)
Language
English (2)
Research subject (UKÄ/SCB)
Medical and Health Sciences (2)

Year

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view