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| 4. |
- Morales Salinas, Alberto, et al.
(author)
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Clinical Perspective on Antihypertensive Drug Treatment in Adults With Grade 1 Hypertension and Low-to-Moderate Cardiovascular Risk : An International Expert Consultation
- 2017
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In: Current problems in cardiology. - : Elsevier. - 0146-2806 .- 1535-6280. ; 42:7, s. 198-225
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Research review (peer-reviewed)abstract
- Hypertension is a leading risk factor for disease burden globally. An unresolved question is whether grade 1 hypertension (140-159/90-99 mm Hg) with low (cardiovascular mortality < 1% at 10 years) to moderate (cardiovascular mortality ≥ 1% and <5% at 10 years) absolute total cardiovascular risk (CVR) should be treated with antihypertensive agents. A virtual international consultation process was undertaken to summarize the opinions of select experts. After holistic analysis of all epidemiological, clinical, psychosocial, and public health elements, this consultation process reached the following consensus in hypertensive adults aged < 80 years: (1) The question of whether drug treatment in grade 1 should be preceded by a period of some weeks or months during which only lifestyle measures are recommended cannot be evidence based, but the consensus opinion is to have a period of lifestyle alone reserved only to patients with grade 1 "isolated" hypertension (grade 1 uncomplicated hypertension with low absolute total CVR, and without other major CVR factors and risk modifiers). (2) The initiation of antihypertensive drug therapy in grade 1 hypertension with moderate absolute total CVR should not be delayed. (3) Men ≥ 55 years and women ≥ 60 years with uncomplicated grade 1 hypertension should automatically be classified within the moderate absolute total CVR category, even in the absence of other major CVR factors and risk modifiers. (4) Statins should be considered along with blood-pressure lowering therapy, irrespective of cholesterol levels, in patients with grade 1 hypertensive with moderate CVR.
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| 7. |
- Ruilope, LM, et al.
(author)
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Design and Baseline Characteristics of the Finerenone in Reducing Cardiovascular Mortality and Morbidity in Diabetic Kidney Disease Trial
- 2019
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In: American journal of nephrology. - : S. Karger AG. - 1421-9670 .- 0250-8095. ; 50:5, s. 345-356
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Journal article (peer-reviewed)abstract
- <b><i>Background:</i></b> Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials. <b><i>Patients and</i></b> <b><i>Methods:</i></b> The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate ≥25 mL/min/1.73 m<sup>2</sup> and albuminuria (urinary albumin-to-creatinine ratio ≥30 to ≤5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level α = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure. <b><i>Conclusions:</i></b> FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen. Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049.
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| 11. |
- Ahlström, Hanna, et al.
(author)
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An Earth system law perspective on governing social-hydrological systems in the Anthropocene
- 2021
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In: Earth System Governance. - : Elsevier BV. - 2589-8116. ; 10
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Journal article (peer-reviewed)abstract
- The global hydrological cycle is characterized by complex interdependencies and self-regulating feedbacks that keep water in an ever-evolving state of flux at local, regional, and global levels. Increasingly, the scale of human impacts in the Anthropocene is altering the dynamics of this cycle, which presents additional challenges for water governance. Earth system law provides an important approach for addressing gaps in governance that arise from the mismatch between the global hydrological cycle and dispersed regulatory architecture across institutions and geographic regions. In this article, we articulate the potential for Earth system law to account for core hydrological problems that complicate water governance, including delay, redistribution, intertwinements, permanence, and scale. Through merging concepts from Earth system law with existing policy and legal principles, we frame an approach for addressing hydrological problems in the Anthropocene and strengthening institutional fit between established governance systems and the global hydrological cycle. We discuss how such an approach can be applied, and the challenges and implications for governing water as a cycle and complex social-hydrological system, both in research and practice.
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| 12. |
- Aminjafari, Saeid, 1988-, et al.
(author)
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Assessing the Effects of Regulation on Swedish Lake Water Levels with Satellite Altimetry
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Other publication (other academic/artistic)abstract
- Lakes are important sources of freshwater for human activities and provide critical ecosystem services. However, despite having approximately 100,000 lakes, Sweden has limited continuous gauged water level data. Although satellite radar altimetry has emerged as a popular alternative to measure water levels in inland water bodies, it is yet to be exploited to understand large-scale changes in inland water bodies in Sweden. Here, we quantify the changes in water levels of 144 lakes using satellite altimetry data and in-situ gauged measurements and examine the effects of flow regulation and hydroclimatic variability. Data from multiple altimetry missions, including ERS-2, ENVISAT, JASON-1,2,3, SARAL, and Sentinel-3A/B, are employed to estimate the variability and yearly and seasonal trends of water levels in two periods, 1995-2022 and 2013-2022. Our study finds that water levels significantly increased in 52% of the lakes during 1995-2022. The increasing trends primarily occurred in northern Sweden and are potentially attributed to earlier snowmelt. On the other hand, 43% of the lakes exhibited a significant decreasing trend, which was mostly concentrated in Southern Sweden. Dividing the set of lakes into regulated and unregulated groups shows how lake regulation in Sweden can partly explain the spatial patterns of water levels and their variability. This study highlights the need to continuously monitor lake water levels for adaptation strategies in the face of climate change and understand the downstream effects of water regulatory schemes.
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| 13. |
- Aminjafari, Saeid, 1988-, et al.
(author)
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Distinctive Patterns of Water Level Change in Swedish Lakes Driven by Climate and Human Regulation
- 2024
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In: Water resources research. - 0043-1397 .- 1944-7973. ; 60:3
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Journal article (peer-reviewed)abstract
- Despite having approximately 100,000 lakes, Sweden has limited continuous gauged lake water level data. Although satellite radar altimetry (RA) has emerged as a popular alternative to measure water levels in inland water bodies, it has not yet been used to understand the large-scale changes in Swedish lakes. Here, we quantify the changes in water levels in 144 lakes using RA data and in situ gauged measurements to examine the effects of flow regulation and hydroclimatic variability. We use data from several RA missions, including ERS-2, ENVISAT, JASON-1,2,3, SARAL, and Sentinel-3A/B. We found that during 1995–2022, around 52% of the lakes exhibited an increasing trend and 43% a decreasing trend. Most lakes exhibiting an increasing trend were in the north of Sweden, while most lakes showing a decreasing trend were in the south. Regarding the potential effects of regulation, we found that unregulated lakes had smaller trends in water level and dynamic storage than regulated ones. While the seasonal patterns of water levels in the lakes in the north are similar in regulated and unregulated lakes, in the south, they differ substantially. This study highlights the need to continuously monitor lake water levels for adaptation strategies in the face of climate change and understand the downstream effects of water regulatory schemes.
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| 14. |
- Aminjafari, Saeid, et al.
(author)
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Drivers and extent of surface water occurrence in the Selenga River Delta, Russia
- 2021
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In: Journal of Hydrology. - : Elsevier BV. - 2214-5818. ; 38
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Journal article (peer-reviewed)abstract
- Study region: Selenga River Delta (SRD), Russia.Study focus: How is water occurrence changing in the SRD, and what are the hydroclimatic drivers behind these changes? The presence of water on the surface in river deltas is governed by land use, geomorphology, and the flux of water to and from the Delta. We trained an accurate image classification of the Landsat satellite imagery during the last 33 years to quantify surface water occurrence and its changes in the SRD. After comparing our estimations with global-scale data sets, we determined the hydrological drivers of these changes.New hydrological insights for the region: We find mild decreases in water occurrence in 51% of the SRD's surface area from 1987-2002 to 2003-2020. Water occurrence in the most affected areas decreased by 20% and in the most water-gaining areas increased by 10%. We find a significant relationship between water occurrence and runoff (R-2 = 0.56) that does not exist between water occurrence and suspended sediment concentration (SSC), Lake Baikal's water level, and potential evapotranspiration. The time series of water occurrence follows the peaks in the runoff but not its long-term trend. However, the extremes in SSC do not influence surface water occurrence (R-2 < 0.1), although their long-term trends are similar. Contrary to expected, we find that the Delta has a relatively stable long-term water availability for the time being.
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| 15. |
- Aminjafari, Saeid, 1988-, et al.
(author)
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Evaluating D-InSAR Performance to Detect Small Water Level Fluctuations in Lakes
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Other publication (other academic/artistic)abstract
- It is essential to track lake water level fluctuations, however, the number of conventional gauging stations is declining worldwide due to impractical installation and maintenance procedures. Satellite altimetry is a substitute for traditional gauges. Nevertheless, altimetry sensors cannot identify small lakes owing to poor spatial coverage. Their application is limited to lakes falling exactly below the path of the altimeter. Differential Interferometric Synthetic Aperture Radar (D-InSAR) is commonly used to track land deformation and water surface changes, with the latter being comparatively limited and focused mainly on wetlands. We here explore the potential of D-InSAR to track water level changes in two Swedish lakes, focusing on the shoreline in search of potential double-bounce backscattering and analyzing pixel phase changes and coherence. We use Sentinel-1A and Sentinel-1B data from 2019, generate six-day interferograms, and exclude those when corresponding to in-situ water level changes exceeding one phase cycle. We find that D-InSAR is sensitive to minor water level changes, obtaining Lin's correlations of up to 0.63 and 0.89 (RMSE = 9 & 4 mm, respectively). These results evidence the potential of future L-band SAR missions with larger wavelengths, such as NISAR, to track water level changes in lakes and aid water tracking missions such as the SWOT.
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| 16. |
- Aminjafari, Saeid, 1988-
(author)
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Monitoring Water Availability in Northern Inland Waters from Space
- 2023
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Doctoral thesis (other academic/artistic)abstract
- River deltas and lakes support biodiversity and offer crucial ecosystem services such as freshwater provision, flood control, and fishing. However, climate change and human activities have affected deltas and lakes globally, altering the services they provide. Since delta and lake surface water occurrence and water levels respond to climate change and anthropogenic activities, we need to monitor their variations to understand the potential drivers for effective water management strategies. However, important deltas like the Selenga River Delta (SRD) in Russia lack a detailed analysis of water occurrence. Regarding lake water level, there has been a decline in the number of gauging stations globally, due to installation and maintenance costs. For example, Sweden has ~100,000 lakes which are sources of freshwater and hydro-power, but only 38 lakes have long and continuous in-situ records of water level.As satellite data are reliable alternatives for conventional methods to monitor deltas and lakes, I employed Earth Observations (EO) to quantify changes in surface water occurrence in the SRD and water levels in Swedish lakes and identify their main drivers. I also developed and explored a novel methodology for lake water level estimation based on Differential Interferometric Synthetic Aperture Radar (D-InSAR) by calculating the six-day phase differences in 30 Swedish lakes.To achieve these objectives, I trained and applied a Maximum Likelihood classification to Landsat images from 1987 to 2020 and quantified surface water occurrence and its changes in the SRD. I found that surface water occurrence in 51% of the delta experienced a decrease. As the Selenga River is the only river flowing into the SRD, the change in surface water occurrence in the SRD correlated with river discharge, but not with the river suspended sediment concentration, the lake water level in the outlet of the SRD, or evapotranspiration over the delta.In Sweden, I used satellite altimetry data from ERS-2, ENVISAT, JASON-1,2,3, SARAL, and Sentinel-3A/B to quantify water levels in 144 lakes from 1995-2022. I found that 52% of the lakes showed increasing trends (mostly in the north) and 43% decreasing trends (mostly in the south). Water level trends and variabilities did not correlate strongly with hydroclimatic changes (precipitation and temperature) but differed in regulated lakes compared to unregulated ones, both in the north and in the south of Sweden.The results of the D-InSAR method for water level estimation in two Swedish lakes (Hjälmaren and Solnen) showed that with water level changes smaller than a complete SAR phase, the phase changes correlate with in-situ water level changes with a minimum Root Mean Square Error of 0.43 cm in some pixels. In all 30 lakes, I accumulated the phase changes of each pixel throughout the whole number of interferograms to construct water levels. This method replicated the direction of water level changes shown by high Pearson’s correlations in at least one pixel in each lake.This thesis highlights the importance of EO for estimating surface water occurrence and lake water levels and brings focus to the future of EO through advanced space missions such as Surface Water and Ocean Topography (SWOT) and NASA-ISRO Synthetic Aperture Radar (NISAR). The findings underscore the need to continuously monitor lake water level and occurrence to adapt to climate change and understand the effects of water-regulatory schemes.
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| 17. |
- Aminjafari, Saeid, 1988-, et al.
(author)
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The Potential of D-InSAR for Water Level Estimation in Swedish Lakes
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Other publication (other academic/artistic)abstract
- Lakes are valuable water resources that support aquatic and terrestrial ecosystems and supply fresh water for the agricultural, industrial, and urban sectors worldwide. Although water levels should be tracked to monitor these services, conventional gauging is unfeasible in most lakes. This study explores the potential, advantages, and limitations of using Differential Interferometric Synthetic Aperture Radar (D-InSAR) to estimate small water level changes in lakes (i.e., less than the full cycle of the SAR signal) and overall long-term direction of change. We validated the method across the shores of 30 Swedish lakes with gauged observations during 2019. We used Sentinel-1A/B images with a six-day temporal separation to construct consecutive interferograms and accumulated the phase changes in pixels of high coherence to build time series of water levels. We find that the accumulated phase change replicates the magnitude of water levels in seven lakes in Southern Sweden, where water level changes seldom exceed a complete SAR phase (i.e., 1.8 cm in the vertical direction), evident from the Concordance Correlation Coefficients (0.30 < CCC < 0.55). Furthermore, D-InSAR can estimate the long-term direction of water level change (i.e., increase or decrease) in all 30 lakes. We elaborate on the possible explanation for this last finding. The novel methodology could be used to validate future altimetry missions such as SWOT in lakes worldwide and can be improved with upcoming SAR missions with longer wavelengths.
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| 18. |
- Aminjafari, Saeid, et al.
(author)
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Tracking Centimeter-Scale Water Level Changes in Swedish Lakes Using D-InSAR
- 2024
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In: Water resources research. - 0043-1397 .- 1944-7973. ; 60:2
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Journal article (peer-reviewed)abstract
- Lakes are valuable water resources that support aquatic and terrestrial ecosystems and supply fresh water for the agricultural, industrial, and urban sectors worldwide. Although water levels should be tracked to monitor these services, conventional gauging is unfeasible in most lakes. This study applies Differential Interferometric Synthetic Aperture Radar (D-InSAR) to estimate small water level changes, less than 2 cm, in Swedish lakes over 6-day intervals. We validated the method across the shores of 30 Swedish lakes with gauged observations in 2019. We used Sentinel-1A/B images with a 6-day temporal separation to construct consecutive interferograms and accumulated the phase changes in pixels of high coherence to build a time series of water levels. We find that the accumulated phase change obtained by D-InSAR replicates the magnitude of water levels in seven lakes in Southern Sweden, where water levels change slowly, less than 2 cm per 6-day period, as validated by in-situ gauges. In addition, this study demonstrates the application of D-InSAR to estimate the long-term direction of water level change (i.e., increase or decrease) in all 30 lakes. This work reveals the utility of high temporal resolution water level observations in support of other satellite water level instruments such as conventional altimeters and the recently launched Surface Water and Ocean Topography Mission.
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| 19. |
- Andersson, Erik, et al.
(author)
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A social-ecological analysis of ecosystem services in two different farming systems
- 2015
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In: Ambio. - : Springer Science and Business Media LLC. - 0044-7447 .- 1654-7209. ; 44, s. 102-112
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Journal article (peer-reviewed)abstract
- In this exploratory study we use existing in situ qualitative and quantitative data on biophysical and social indicators to compare two contrasting Swedish farming systems (low intensity and high intensity) with regard to ecosystem service supply and demand of a broad suite of services. We show that the value (demand) placed on a service is not necessarily connected to the quantity (supply) of the service, most clearly shown for the services recreation, biodiversity, esthetic experience, identity, and cultural heritage. To better capture this complexity we argue for the need to develop portfolios of indicators for different ecosystem services and to further investigate the different aspects of supply and demand. The study indicates that available data are often ill-suited to answer questions about local delivery of services. If ecosystem services are to be included in policy, planning, and management, census data need to be formatted and scaled appropriately.
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| 20. |
- Anjana, Ranjit Mohan, et al.
(author)
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Contrasting Associations Between Diabetes and Cardiovascular Mortality Rates in Low-, Middle-, and High-Income Countries: Cohort Study Data From 143,567 Individuals in 21 Countries in the PURE Study.
- 2020
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In: Diabetes care. - : American Diabetes Association. - 1935-5548 .- 0149-5992. ; 43:12, s. 3094-3101
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Journal article (peer-reviewed)abstract
- We aimed to compare cardiovascular (CV) events, all-cause mortality, and CV mortality rates among adults with and without diabetes in countries with differing levels of income.The Prospective Urban Rural Epidemiology (PURE) study enrolled 143,567 adults aged 35-70 years from 4 high-income countries (HIC), 12 middle-income countries (MIC), and 5 low-income countries (LIC). The mean follow-up was 9.0 ± 3.0 years.Among those with diabetes, CVD rates (LIC 10.3, MIC 9.2, HIC 8.3 per 1,000 person-years, P < 0.001), all-cause mortality (LIC 13.8, MIC 7.2, HIC 4.2 per 1,000 person-years, P < 0.001), and CV mortality (LIC 5.7, MIC 2.2, HIC 1.0 per 1,000 person-years, P < 0.001) were considerably higher in LIC compared with MIC and HIC. Within LIC, mortality was higher in those in the lowest tertile of wealth index (low 14.7%, middle 10.8%, and high 6.5%). In contrast to HIC and MIC, the increased CV mortality in those with diabetes in LIC remained unchanged even after adjustment for behavioral risk factors and treatments (hazard ratio [95% CI] 1.89 [1.58-2.27] to 1.78 [1.36-2.34]).CVD rates, all-cause mortality, and CV mortality were markedly higher among those with diabetes in LIC compared with MIC and HIC with mortality risk remaining unchanged even after adjustment for risk factors and treatments. There is an urgent need to improve access to care to those with diabetes in LIC to reduce the excess mortality rates, particularly among those in the poorer strata of society.
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| 21. |
- Arheimer, Berit, et al.
(author)
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The IAHS Science for Solutions decade, with Hydrology Engaging Local People IN a Global world (HELPING)
- 2024
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In: Hydrological Sciences Journal. - 0262-6667 .- 2150-3435.
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Journal article (peer-reviewed)abstract
- The new scientific decade (2023-2032) of the International Association of Hydrological Sciences (IAHS) aims at searching for sustainable solutions to undesired water conditions - may it be too little, too much or too polluted. Many of the current issues originate from global change, while solutions to problems must embrace local understanding and context. The decade will explore the current water crises by searching for actionable knowledge within three themes: global and local interactions, sustainable solutions and innovative cross-cutting methods. We capitalise on previous IAHS Scientific Decades shaping a trilogy; from Hydrological Predictions (PUB) to Change and Interdisciplinarity (Panta Rhei) to Solutions (HELPING). The vision is to solve fundamental water-related environmental and societal problems by engaging with other disciplines and local stakeholders. The decade endorses mutual learning and co-creation to progress towards UN sustainable development goals. Hence, HELPING is a vehicle for putting science in action, driven by scientists working on local hydrology in coordination with local, regional, and global processes.
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| 22. |
- Bataille, Christopher, et al.
(author)
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Net-zero deep decarbonization pathways in Latin America : Challenges and opportunities
- 2020
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In: Energy Strategy Reviews. - : Elsevier BV. - 2211-467X .- 2211-4688. ; 30
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Journal article (peer-reviewed)abstract
- This synthesis paper presents the objectives, approach and cross-cutting results of the Latin American Deep Decarbonization Pathways project (DDP-LAC). It synthesizes and compares detailed national and sectoral deep decarbonization pathways (DDPs) to 2050 compatible with the Paris Agreement objectives and domestic development priorities in Argentina, Colombia, Costa Rica, Ecuador, Mexico and Peru. The first five countries analysed in detail the energy system and agriculture, forestry and land use (AFOLU) at a high level, while Peru focussed on a detailed analysis of AFOLU given its predominance in its GHG emissions. While economy-wide results were produced, this paper focuses on the electricity, passenger transport, and AFOLU results because of their current emissions, potential to grow, and identification of successful strategies for decarbonization (e.g. switching to clean electricity and other net-zero emissions fuels across the economy; urban planning, mode shifting, and electrification in passenger transport; and intensive sustainable agriculture, assignment of land use rights and their enforcement and afforestation in AFOLU). It also highlights where significant emissions remain in 2050, notably in industry, AFOLU, freight, and oil and gas production, all areas for future research. It derives insights for the design of domestic policy packages and identifies priorities for international cooperation. This analysis provides critical information for Long-Term Strategies, Nationally Determined Contributions and Global Stocktaking in the context of the Paris Agreement.
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| 23. |
- Berghuijs, Wouter R., et al.
(author)
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Groundwater recharge is sensitive to changing long-term aridity
- 2024
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In: Nature Climate Change. - 1758-678X .- 1758-6798. ; 14, s. 357-363
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Journal article (peer-reviewed)abstract
- Sustainable groundwater use relies on adequate rates of groundwater recharge, which are expected to change with climate change. However, climate impacts on recharge remain uncertain due to a paucity of measurements of recharge trends globally. Here we leverage the relationship between climatic aridity and long-term recharge measurements at 5,237 locations globally to identify regions where recharge is most sensitive to changes in climatic aridity. Recharge is most sensitive to climate changes in regions where potential evapotranspiration slightly exceeds precipitation, meaning even modest aridification can substantially decrease groundwater recharge. Future climate-induced recharge changes are expected to be dominated by precipitation changes, whereby changes in groundwater recharge will be amplified relative to precipitation changes. Recharge is more sensitive to changes in aridity than global hydrological models suggest. Consequently, the effects of climatic changes on groundwater replenishment and their impacts on the sustainability of groundwater use by humans and ecosystems probably exceed previous predictions.
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| 24. |
- Bring, Arvid, et al.
(author)
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Implications of freshwater flux data from the CMIP5 multimodel output across a set of Northern Hemisphere drainage basins
- 2015
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In: EARTHS FUTURE. - 2328-4277. ; 3:6, s. 206-217
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Journal article (peer-reviewed)abstract
- The multimodel ensemble of the Coupled Model Intercomparison Project, Phase 5 (CMIP5) synthesizes the latest research in global climate modeling. The freshwater system on land, particularly runoff, has so far been of relatively low priority in global climate models, despite the societal and ecosystem importance of freshwater changes, and the science and policy needs for such model output on drainage basin scales. Here we investigate the implications of CMIP5 multimodel ensemble output data for the freshwater system across a set of drainage basins in the Northern Hemisphere. Results of individual models vary widely, with even ensemble mean results differing greatly from observations and implying unrealistic long-term systematic changes in water storage and level within entire basins. The CMIP5 projections of basin-scale freshwater fluxes differ considerably more from observations and among models for the warm temperate study basins than for the Arctic and cold temperate study basins. In general, the results call for concerted research efforts and model developments for improving the understanding and modeling of the freshwater system and its change drivers. Specifically, more attention to basin-scale water flux analyses should be a priority for climate model development, and an important focus for relevant model-based advice for adaptation to climate change.
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| 25. |
- Campbell, Bruce M., et al.
(author)
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Agriculture production as a major driver of the Earth system exceeding planetary boundaries
- 2017
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In: Ecology and Society. - 1708-3087. ; 22:4
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Journal article (peer-reviewed)abstract
- We explore the role of agriculture in destabilizing the Earth system at the planetary scale, through examining nine planetary boundaries, or safe limits: land-system change, freshwater use, biogeochemical flows, biosphere integrity, climate change, ocean acidification, stratospheric ozone depletion, atmospheric aerosol loading, and introduction of novel entities. Two planetary boundaries have been fully transgressed, i.e., are at high risk, biosphere integrity and biogeochemical flows, and agriculture has been the major driver of the transgression. Three are in a zone of uncertainty i.e., at increasing risk, with agriculture the major driver of two of those, land-system change and freshwater use, and a significant contributor to the third, climate change. Agriculture is also a significant or major contributor to change for many of those planetary boundaries still in the safe zone. To reduce the role of agriculture in transgressing planetary boundaries, many interventions will be needed, including those in broader food systems.
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