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Search: WFRF:(Jing YK)

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  • Jing, YK, et al. (author)
  • SARS-CoV-2 infection causes immunodeficiency in recovered patients by downregulating CD19 expression in B cells via enhancing B-cell metabolism
  • 2021
  • In: Signal transduction and targeted therapy. - : Springer Science and Business Media LLC. - 2059-3635. ; 6:1, s. 345-
  • Journal article (peer-reviewed)abstract
    • The SARS-CoV-2 infection causes severe immune disruption. However, it is unclear if disrupted immune regulation still exists and pertains in recovered COVID-19 patients. In our study, we have characterized the immune phenotype of B cells from 15 recovered COVID-19 patients, and found that healthy controls and recovered patients had similar B-cell populations before and after BCR stimulation, but the frequencies of PBC in patients were significantly increased when compared to healthy controls before stimulation. However, the percentage of unswitched memory B cells was decreased in recovered patients but not changed in healthy controls upon BCR stimulation. Interestingly, we found that CD19 expression was significantly reduced in almost all the B-cell subsets in recovered patients. Moreover, the BCR signaling and early B-cell response were disrupted upon BCR stimulation. Mechanistically, we found that the reduced CD19 expression was caused by the dysregulation of cell metabolism. In conclusion, we found that SARS-CoV-2 infection causes immunodeficiency in recovered patients by downregulating CD19 expression in B cells via enhancing B-cell metabolism, which may provide a new intervention target to cure COVID-19.
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  • Result 1-5 of 5
Type of publication
journal article (5)
Type of content
peer-reviewed (4)
other academic/artistic (1)
Author/Editor
Liu, CH (5)
Jing, YK (5)
Yang, L. (4)
Li, N (4)
Gong, Q. (4)
Jiang, PP (4)
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Kang, DQ (4)
Liu, J. (3)
Chang, J (3)
Westerberg, LS (3)
Miller, H. (3)
Chen, QY (3)
Chen, Y. (2)
Luo, X. (2)
Wang, CY (2)
Westerberg, L (2)
Kubo, M (2)
Luo, L. (2)
Chen, AW (2)
Park, CS (2)
Jellusova, J (2)
Hu, Y. (1)
Wang, Y. (1)
Mei, H. (1)
Zheng, B. (1)
Xiao, W (1)
Dai, X. (1)
Lin, SY (1)
Zhou, P (1)
Gu, H. (1)
Lu, ZX (1)
Herrada, AA (1)
Xu, ZP (1)
Lee, PPW (1)
Sui, ZW (1)
Dong, LL (1)
Zhu, YZ (1)
Li, ZZ (1)
Zhou, XR (1)
Chen, QL (1)
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University
Karolinska Institutet (5)
Language
English (5)

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