SwePub - search: WFRF:(Johansson Gustav)

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1.	Andersson, Sarah, et al. (author) Malmbanan Diaries 2010 Reports (other academic/artistic)abstract This booklet is a report for a case study visit during four day field trip, a group of nine PhD students and their supervisors – all part of the National Research School for Architecture and Planning in the Urban Landscape, APULA – set out to explore what may be considered the outback of Western Europe’s conurbations, the transnational region of Kiruna -Narvik.Both “remote” and “resourceful”, “threatened” and “thriving” (equally relative notions), this region seemed to offer possibilities to reflect upon many of the current tendencies influencing contemporary planning practice and research.
2.	Johansson, Gustav, et al. (author) Picosecond level error detection using PCA in the hardware timing systems for the EISCAT_3D LAAR 2010 In: Radio Science Bulletin. - 1024-4530. ; :333, s. 45-50 Journal article (peer-reviewed)abstract While developing the timing system for the receiver arrays for the EISCAT_3D system, several approaches to detect and adjust for timing errors within the array have been explored. The demand on the timing error between all elements in the array is to have a standard deviation of less than 120 ps, thus requiring high quality error detection systems to guarantee radar operation. This paper investigates the qualities of a secondary error detection system based on statistical analysis of captured data. The measurements are assembled with a Signal-to-Noise Ratio (SNR) of -30 dB implying that the elements in a 2112 element array need to be grouped into sub-arrays of 48 elements each. The captured data is then evaluated by Principal Component Analysis (PCA) and averaged over 20,000 measurements, or about half a second. Timing errors between sub-arrays of down to ~120 ps and a percentage of faulty sub-arrays of up to 20% are detectable. As a secondary error detection system PCA is cheap to implement since the only need of the analysis is a small amount of computer time. It also provides a valuable detection system for hardware errors in the primary timing system that can otherwise be hard to find.
3.	Johansson, Gustav, et al. (author) Projekt: ESiS EP 2009 Other publication (pop. science, debate, etc.)abstract Sammanfattningsvis är forskningsmålet att optimera kretskortsproduktion för små och medelstora serier. Huvudsakligen handlar det om att undersöka och modellera det termiska systemet mellan kretskort och lödugn. Modellen kommer sedan att användas för att ge bättre konfigurationsparametrar för produktionslinjen. En bra modell kommer inte bara att öka lödningskvalitén och minska antalet kasserade kretskort men kan också även användas för att hitta avvikelser redan i kretskortsdesignen.
4.	Johansson, Gustav, et al. (author) Simulation of post-ADC digital beamforming for large aperture array radars 2010 In: Radio Science. - 0048-6604 .- 1944-799X. ; 45:RS3001 Journal article (peer-reviewed)abstract This paper presents simulations and methods developed to investigate the feasibility of using a Fractional-Sample-Delay (FSD) system in the planned EISCAT_3D incoherent scatter radar. Key requirements include a frequency-independent beam direction over a 30 MHz band centered around 220 MHz, with correct reconstruction of pulse lengths down to 200 ns. The clock jitter from sample to sample must be extremely low for the integer sample delays. The FSD must also be able to delay the 30 MHz wide signal band by 1/1024th of a sample without introducing phase shifts, and it must operate entirely in baseband. An extensive simulation system based on mathematical models has been developed, with inclusion of performance-degrading aspects such as noise, timing error, and bandwidth. Finite Impulse Response (FIR) filters in the baseband of a band-pass-sampled signal have been used to apply true time delay beamforming. It has been confirmed that such use is both possible and well behaved. The target beam-pointing accuracy of 0.06° is achievable using optimized FIR filters with lengths of 36 taps and an 18 bit coefficient resolution. Even though the minimum fractional delay step necessary for beamforming is ∼13.1 ps, the maximum sampling timing error allowed in the array is found to be σ ≤ 120 ps if the errors are close to statistically independent.
5.	Johansson, Jonny, et al. (author) EISCAT_3D : EISCAT 3D Radar Receiver/Antenna Subsystem Report 2009 Reports (other academic/artistic)
6.	Johansson, Jonny, et al. (author) Project: EISCAT 3D 2007 Other publication (pop. science, debate, etc.)
7.	Abbas, Ghulam, et al. (author) Quasi Three-Dimensional Tetragonal SiC Polymorphs as Efficient Anodes for Sodium-Ion Batteries 2023 In: ACS Applied Energy Materials. - : American Chemical Society (ACS). - 2574-0962. ; 6:17, s. 8976-8988 Journal article (peer-reviewed)abstract In the present work, we investigate, for the first time, quasi 3D porous tetragonal silicon–carbon polymorphs t(SiC)12 and t(SiC)20 on the basis of first-principles density functional theory calculations. The structural design of these q3-t(SiC)12 and q3-t(SiC)20 polymorphs follows an intuitive rational approach based on armchair nanotubes of a tetragonal SiC monolayer where C–C and Si–Si bonds are arranged in a paired configuration for retaining a 1:1 ratio of the two elements. Our calculations uncover that q3-t(SiC)12 and q3-t(SiC)20 polymorphs are thermally, dynamically, and mechanically stable with this lattice framework. The results demonstrate that the smaller polymorph q3-t(SiC)12 shows a small band gap (∼0.59 eV), while the larger polymorph of q3-t(SiC)20 displays a Dirac nodal line semimetal. Moreover, the 1D channels are favorable for accommodating Na ions with excellent (>300 mAh g–1) reversible theoretical capacities. Thus confirming potential suitability of the two porous polymorphs with an appropriate average voltage and vanishingly small volume change (<6%) as anodes for Na-ion batteries.
8.	Abbasi, R., et al. (author) Calibration and characterization of the IceCube photomultiplier tube 2010 In: Nuclear Instruments and Methods in Physics Research Section A. - : Elsevier BV. - 0168-9002 .- 1872-9576. ; 618:1-3, s. 139-152 Journal article (peer-reviewed)abstract Over 5000 PMTs are being deployed at the South Pole to compose the IceCube neutrino observatory. Many are placed deep in the ice to detect Cherenkov light emitted by the products of high-energy neutrino interactions, and others are frozen into tanks on the surface to detect particles from atmospheric cosmic ray showers. IceCube is using the 10-in. diameter R7081-02 made by Hamamatsu Photonics. This paper describes the laboratory characterization and calibration of these PMTs before deployment. PMTs were illuminated with pulses ranging from single photons to saturation level. Parameterizations are given for the single photoelectron charge spectrum and the saturation behavior. Time resolution, late pulses and afterpulses are characterized. Because the PMTs are relatively large, the cathode sensitivity uniformity was measured. The absolute photon detection efficiency was calibrated using Rayleigh-scattered photons from a nitrogen laser. Measured characteristics are discussed in the context of their relevance to IceCube event reconstruction and simulation efforts. (C) 2010 Elsevier B.V. All rights reserved.
9.	Abbasi, R, et al. (author) Determination of the atmospheric neutrino flux and searches for new physics with AMANDA-II 2009 In: Physical Review D. - 1550-7998 .- 1550-2368. ; 79, s. 102005- Journal article (peer-reviewed)abstract The AMANDA-II detector, operating since 2000 in the deep ice at the geographic South Pole, has accumulated a large sample of atmospheric muon neutrinos in the 100 GeV to 10 TeV energy range. The zenith angle and energy distribution of these events can be used to search for various phenomenological signatures of quantum gravity in the neutrino sector, such as violation of Lorentz invariance or quantum decoherence. Analyzing a set of 5511 candidate neutrino events collected during 1387 days of livetime from 2000 to 2006, we find no evidence for such effects and set upper limits on violation of Lorentz invariance and quantum decoherence parameters using a maximum likelihood method. Given the absence of evidence for new flavor-changing physics, we use the same methodology to determine the conventional atmospheric muon neutrino flux above 100 GeV.
10.	Abbasi, R, et al. (author) FIRST NEUTRINO POINT-SOURCE RESULTS FROM THE 22 STRING ICECUBE DETECTOR 2009 In: Astrophysical Journal Letters. - 2041-8205. ; 701, s. L47-L51 Journal article (peer-reviewed)abstract We present new results of searches for neutrino point sources in the northern sky, using data recorded in 2007-2008 with 22 strings of the IceCube detector (approximately one-fourth of the planned total) and 275.7 days of live time. The final sample of 5114 neutrino candidate events agrees well with the expected background of atmospheric muon neutrinos and a small component of atmospheric muons. No evidence of a point source is found, with the most significant excess of events in the sky at 2.2 sigma after accounting for all trials. The average upper limit over the northern sky for point sources of muon-neutrinos with E-2 spectrum is E-2 Phi(v mu) < 1.4 x 10(-11) TeV cm(-2) s(-1), in the energy range from 3 TeV to 3 PeV, improving the previous best average upper limit by the AMANDA-II detector by a factor of 2.
11.	Abbasi, R., et al. (author) First search for extremely high energy cosmogenic neutrinos with the IceCube Neutrino Observatory 2010 In: Physical review. D, Particles, fields, gravitation, and cosmology. - 1550-7998. ; 82:7, s. 072003- Journal article (peer-reviewed)abstract We report on the results of the search for extremely-high energy neutrinos with energies above 10(7) GeV obtained with the partially (similar to 30%) constructed IceCube in 2007. From the absence of signal events in the sample of 242.1 days of effective live time, we derive a 90% C.L. model independent differential upper limit based on the number of signal events per energy decade at E-2 phi(ve+v mu+v tau) similar or equal to 1.4 x 10(-6) GeV cm(-2) sec(-1) sr(-1) for neutrinos in the energy range from 3 x 10(7) to 3 x 10(9) GeV.
12.	Abbasi, R., et al. (author) Limits on a muon flux from Kaluza-Klein dark matter annihilations in the Sun from the IceCube 22-string detector 2010 In: Physical Review D. - 1550-7998 .- 1550-2368. ; 81:5, s. 057101- Journal article (peer-reviewed)abstract A search for muon neutrinos from Kaluza-Klein dark matter annihilations in the Sun has been performed with the 22-string configuration of the IceCube neutrino detector using data collected in 104.3 days of live time in 2007. No excess over the expected atmospheric background has been observed. Upper limits have been obtained on the annihilation rate of captured lightest Kaluza-Klein particle (LKP) WIMPs in the Sun and converted to limits on the LKP-proton cross sections for LKP masses in the range 250-3000 GeV. These results are the most stringent limits to date on LKP annihilation in the Sun.
13.	Abbasi, R, et al. (author) Limits on a Muon Flux from Neutralino Annihilations in the Sun with the IceCube 22-String Detector 2009 In: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 102:20, s. 201302- Journal article (peer-reviewed)abstract A search for muon neutrinos from neutralino annihilations in the Sun has been performed with the IceCube 22-string neutrino detector using data collected in 104.3 days of live time in 2007. No excess over the expected atmospheric background has been observed. Upper limits have been obtained on the annihilation rate of captured neutralinos in the Sun and converted to limits on the weakly interacting massive particle (WIMP) proton cross sections for WIMP masses in the range 250-5000 GeV. These results are the most stringent limits to date on neutralino annihilation in the Sun.
14.	Abbasi, R., et al. (author) Measurement of sound speed vs. depth in South Pole ice for neutrino astronomy 2010 In: Astroparticle physics. - : Elsevier BV. - 0927-6505 .- 1873-2852. ; 33:5-6, s. 277-286 Journal article (peer-reviewed)abstract We have measured the speed of both pressure waves and shear waves as a function of depth between 80 and 500 m depth in South Pole ice with better than 1% precision. The measurements were made using the South Pole Acoustic Test Setup (SPATS), an array of transmitters and sensors deployed in the ice at the South Pole in order to measure the acoustic properties relevant to acoustic detection of astrophysical neutrinos. The transmitters and sensors use piezoceramics operating at similar to 5-25 kHz. Between 200 m and 500 m depth, the measured profile is consistent with zero variation of the sound speed with depth, resulting in zero refraction, for both pressure and shear waves. We also performed a complementary study featuring an explosive signal propagating vertically from 50 to 2250 m depth, from which we determined a value for the pressure wave speed consistent with that determined for shallower depths, higher frequencies, and horizontal propagation with the SPATS sensors. The sound speed profile presented here can be used to achieve good acoustic source position and emission time reconstruction in general, and neutrino direction and energy reconstruction in particular. The reconstructed quantities could also help separate neutrino signals from background. (C) 2010 Elsevier B.V. All rights reserved.
15.	Abbasi, R., et al. (author) Measurement of the anisotropy of cosmic-ray arrival directions with icecube 2010 In: The Astrophysical Journal Letters. - 2041-8205. ; 718, s. L194-L198 Journal article (peer-reviewed)abstract We report the first observation of an anisotropy in the arrival direction of cosmic rays with energies in the multi-TeV region in the Southern sky using data from the IceCube detector. Between 2007 June and 2008 March, the partially deployed IceCube detector was operated in a configuration with 1320 digital optical sensors distributed over 22 strings at depths between 1450 and 2450 m inside the Antarctic ice. IceCube is a neutrino detector, but the data are dominated by a large background of cosmic-ray muons. Therefore, the background data are suitable for high-statistics studies of cosmic rays in the southern sky. The data include 4.3 billion muons produced by downward-going cosmic-ray interactions in the atmosphere; these events were reconstructed with a median angular resolution of 3 degrees and a median energy of similar to 20 TeV. Their arrival direction distribution exhibits an anisotropy in right ascension with a first-harmonic amplitude of (6.4 +/- 0.2 stat. +/- 0.8 syst.) x 10(-4).
16.	Abbasi, R., et al. (author) Search for a Lorentz-violating sidereal signal with atmospheric neutrinos in IceCube 2010 In: Physical Review D - Particles, Fields, Gravitation and Cosmology. - 1550-7998. ; 82, s. 112003- Journal article (peer-reviewed)abstract A search for sidereal modulation in the flux of atmospheric muon neutrinos in IceCube was performed. Such a signal could be an indication of Lorentz-violating physics. Neutrino oscillation models, derivable from extensions to the standard model, allow for neutrino oscillations that depend on the neutrino's direction of propagation. No such direction-dependent variation was found. A discrete Fourier transform method was used to constrain the Lorentz and CPT-violating coefficients in one of these models. Because of the unique high energy reach of IceCube, it was possible to improve constraints on certain Lorentz-violating oscillations by 3 orders of magnitude with respect to limits set by other experiments.
17.	Abbasi, R., et al. (author) Search for muon neutrinos from gamma-ray bursts with the IceCube neutrino telescope 2010 In: Astrophysical Journal. - 0004-637X .- 1538-4357. ; 710:1, s. 346-359 Journal article (peer-reviewed)abstract We present the results of searches for high-energy muon neutrinos from 41 gamma-ray bursts (GRBs) in the northern sky with the IceCube detector in its 22 string configuration active in 2007/2008. The searches cover both the prompt and a possible precursor emission as well as a model-independent, wide time window of -1 hr to + 3 hr around each GRB. In contrast to previous searches with a large GRB population, we do not utilize a standard Waxman-Bahcall GRB flux for the prompt emission but calculate individual neutrino spectra for all 41 GRBs from the burst parameters measured by satellites. For all of the three time windows, the best estimate for the number of signal events is zero. Therefore, we place 90% CL upper limits on the fluence from the prompt phase of 3.7 x 10(-3) erg cm(-2) (72 TeV-6.5 PeV) and on the fluence from the precursor phase of 2.3 x 10(-3) erg cm(-2) (2.2-55 TeV), where the quoted energy ranges contain 90% of the expected signal events in the detector. The 90% CL upper limit for the wide time window is 2.7 x 10(-3) erg cm(-2) (3 TeV-2.8 PeV) assuming an E-2 flux.
18.	Abbasi, R., et al. (author) Search for relativistic magnetic monopoles with the AMANDA-II neutrino telescope 2010 In: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 69:3-4, s. 361-378 Journal article (peer-reviewed)abstract We present the search for Cherenkov signatures from relativistic magnetic monopoles in data taken with the AMANDA-II detector, a neutrino telescope deployed in the Antarctic ice cap at the Geographic South Pole. The non-observation of a monopole signal in data collected during the year 2000 improves present experimental limits on the flux of relativistic magnetic monopoles: Our flux limit varies between 3.8x10(-17) cm(-2) s(-1) sr(-1) (for monopoles moving at the vacuum speed of light) and 8.8x10(-16) cm(-2) s(-1) sr(-1) (for monopoles moving at a speed beta=v/c=0.76, just above the Cherenkov threshold in ice). These limits apply to monopoles that are energetic enough to penetrate the Earth and enter the detector from below the horizon. The limit obtained for monopoles reaching the detector from above the horizon is less stringent by roughly an order of magnitude, due to the much larger background from down-going atmospheric muons. This looser limit is however valid for a larger class of magnetic monopoles, since the monopoles are not required to pass through the Earth.
19.	Abbasi, R., et al. (author) The energy spectrum of atmospheric neutrinos between 2 and 200 TeV with the AMANDA-II detector 2010 In: Astroparticle physics. - : Elsevier BV. - 0927-6505 .- 1873-2852. ; 34:1, s. 48-58 Journal article (peer-reviewed)abstract The muon and anti-muon neutrino energy spectrum is determined from 2000-2003 AMANDA telescope data using regularised unfolding. This is the first measurement of atmospheric neutrinos in the energy range 2-200 TeV. The result is compared to different atmospheric neutrino models and it is compatible with the atmospheric neutrinos from pion and kaon decays. No significant contribution from charm had-ron decays or extraterrestrial neutrinos is detected. The capabilities to improve the measurement of the neutrino spectrum with the successor experiment IceCube are discussed.
20.	Aldaeus, Fredrik, et al. (author) Dielectrophoresis of Living Cells - New Concepts and Challenges 2005 Conference paper (pop. science, debate, etc.)
21.	Andersson, Jakob, 1974-, et al. (author) Geomapping Landscapes of Writing (GLoW) : Large-Scale Spatial Analysis of the Cuneiform Corpus (c. 3400 BCE to 100 CE) 2021 Conference paper (other academic/artistic)abstract The cuneiform record ranks among the largest preserved bodies of historical documentation from the ancient world (Streck 2010). Conveyed on omnipresent and extremely durable types of material, cuneiform texts are preserved in immense, extending over all of the Middle East and a historical period of more than three millennia of early human history. Drawing on recent advances in digital humanities and geospatial data mapping, GLoW aims to survey, analyse, and investigate broader, macrohistorical patterns in the formation and preservation of this unique historical record. As a first quantifiable, comprehensive study of the cuneiform corpus, GLoW will provide a benchmark example of the application of digital and spatial computing tools to the study of writing in early human history. This poster offers an introduction to key research foci and the project research programme, including an introduction to data infrastructure, dissemination, and key collaborators.
22.	Andersson, Rebecca, et al. (author) Differential role of cytosolic Hsp70s in longevity assurance and protein quality control 2021 In: PLoS Genetics. - : Public Library of Science (PLoS). - 1553-7404 .- 1553-7390. ; 17:1 Journal article (peer-reviewed)abstract 70 kDa heat shock proteins (Hsp70) are essential chaperones of the protein quality control network; vital for cellular fitness and longevity. The four cytosolic Hsp70's in yeast, Ssa1-4, are thought to be functionally redundant but the absence of Ssa1 and Ssa2 causes a severe reduction in cellular reproduction and accelerates replicative aging. In our efforts to identify which Hsp70 activities are most important for longevity assurance, we systematically investigated the capacity of Ssa4 to carry out the different activities performed by Ssa1/2 by overproducing Ssa4 in cells lacking these Hsp70 chaperones. We found that Ssa4, when overproduced in cells lacking Ssa1/2, rescued growth, mitigated aggregate formation, restored spatial deposition of aggregates into protein inclusions, and promoted protein degradation. In contrast, Ssa4 overproduction in the Hsp70 deficient cells failed to restore the recruitment of the disaggregase Hsp104 to misfolded/aggregated proteins, to fully restore clearance of protein aggregates, and to bring back the formation of the nucleolus-associated aggregation compartment. Exchanging the nucleotide-binding domain of Ssa4 with that of Ssa1 suppressed this 'defect' of Ssa4. Interestingly, Ssa4 overproduction extended the short lifespan of ssa1 Delta ssa2 Delta mutant cells to a lifespan comparable to, or even longer than, wild type cells, demonstrating that Hsp104-dependent aggregate clearance is not a prerequisite for longevity assurance in yeast. Author summary All organisms have proteins that network together to stabilize and protect the cell throughout its lifetime. One of these types of proteins are the Hsp70s (heat shock protein 70). Hsp70 proteins take part in folding other proteins to their functional form, untangling proteins from aggregates, organize aggregates inside the cell and ensure that damaged proteins are destroyed. In this study, we investigated three closely related Hsp70 proteins in yeast; Ssa1, 2 and 4, in an effort to describe the functional difference of Ssa4 compared to Ssa1 and 2 and to answer the question: What types of cellular stress protection are necessary to reach a normal lifespan? We show that Ssa4 can perform many of the same tasks as Ssa1 and 2, but Ssa4 doesn't interact in the same manner as Ssa1 and 2 with other types of proteins. This leads to a delay in removing protein aggregates created after heat stress. Ssa4 also cannot ensure that misfolded proteins aggregate correctly inside the nucleus of the cell. However, this turns out not to be necessary for yeast cells to achieve a full lifespan, which shows us that as long as cells can prevent aggregates from forming in the first place, they can reach a full lifespan.
23.	Arvidsson, Gustav, et al. (author) Multimodal Single-Cell Sequencing of B Cells in Primary Sjögren's Syndrome 2024 In: Arthritis & Rheumatology. - 2326-5191 .- 2326-5205. ; 76:2, s. 255-267 Journal article (peer-reviewed)abstract Objective. B cells are important in the pathogenesis of primary Sjögren's syndrome (pSS). Patients positive for Sjögren's syndrome antigen A/Sjögren syndrome antigen B (SSA/SSB) autoantibodies are more prone to systemic disease manifestations and adverse outcomes. We aimed to determine the role of B cell composition, gene expression, and B cell receptor usage in pSS subgroups stratified for SSA/SSB antibodies.Methods. Over 230,000 B cells were isolated from peripheral blood of patients with pSS (n = 6 SSA−, n = 8 SSA+ single positive and n = 10 SSA/SSB+ double positive) and four healthy controls and processed for single-cell RNA sequencing (scRNA-seq) and single-cell variable, diversity, and joining (VDJ) gene sequencing (scVDJ-seq).Results. We show that SSA/SSB+ patients present the highest and lowest proportion of naïve and memory B cells, respectively, and the highest up-regulation of interferon-induced genes across all B cell subtypes. Differential usage of IGHV showed that IGHV1-69 and IGHV4-30-4 were more often used in all pSS subgroups compared with controls. Memory B cells from SSA/SSB+ patients displayed a higher proportion of cells with unmutated VDJ transcripts compared with other pSS patient groups and controls, indicating altered somatic hypermutation processes. Comparison with previous studies revealed heterogeneous clonotype pools, with little overlap in CDR3 sequences. Joint analysis using scRNA-seq and scVDJ-seq data allowed unsupervised stratification of patients with pSS and identified novel parameters that correlated to disease manifestations and antibody status.Conclusion. We describe heterogeneity and molecular characteristics in B cells from patients with pSS, providing clues to intrinsic differences in B cells that affect the phenotype and outcome and allowing stratification of patients with pSS at improved resolution.
24.	Bagni, T., et al. (author) Modeling Results of the Quench Behavior of a Nb-Ti Canted-Cosine-Theta Corrector Magnet for LHC 2024 In: IEEE transactions on applied superconductivity (Print). - : IEEE. - 1051-8223 .- 1558-2515. ; 34:5 Journal article (peer-reviewed)abstract A newly designed superconducting magnet of the Canted-Cosine-Theta (CCT) type was developed as a result of a collaboration between Swedish universities (Uppsala and Linneaus) and Swedish industries. This magnet was designed to function as a replacement of the present LHC orbit corrector magnets, which are approaching their end of life due to the radiation load. As a result, the new CCT magnet was developed to be more radiation tolerant and to constitute a one-to-one replacement to the currently installed version, which is a 1 m long 70 mm double aperture dipole magnet. The final magnet, which is currently under construction, will be tested at FREIA laboratory at Uppsala University and generate a magnetic field of 3.3 T and an integrated field of 2.8 Tm at about 85 A. To examine the magnet quench behavior and to identify a suitable quench protection system, the 3D electro-magnetic and thermal behavior of the coil was modeled using the RAT-Raccoon software. Based on the simulation results, a Metrosil varistor was selected to protect the magnet during the test. In this article, we report the results of the numerical analysis. The magnet model is equipped with a spot heater to initialize the quench and the temperature and voltages are monitored during the avalanche effect. The simulated current decay and the hot-spot temperature are analyzed with a focus on the impact of quench-back on the magnet protection.
25.	Baldanzi, Gabriel, et al. (author) Accelerometer-based physical activity is associated with the gut microbiota in 8416 individuals in SCAPIS. 2024 In: EBioMedicine. - : Elsevier. - 2352-3964. ; 100 Journal article (peer-reviewed)abstract BACKGROUND: Previous population-based studies investigating the relationship between physical activity and the gut microbiota have relied on self-reported activity, prone to reporting bias. Here, we investigated the associations of accelerometer-based sedentary (SED), moderate-intensity (MPA), and vigorous-intensity (VPA) physical activity with the gut microbiota using cross-sectional data from the Swedish CArdioPulmonary bioImage Study.METHODS: In 8416 participants aged 50-65, time in SED, MPA, and VPA were estimated with hip-worn accelerometer. Gut microbiota was profiled using shotgun metagenomics of faecal samples. We applied multivariable regression models, adjusting for sociodemographic, lifestyle, and technical covariates, and accounted for multiple testing.FINDINGS: Overall, associations between time in SED and microbiota species abundance were in opposite direction to those for MPA or VPA. For example, MPA was associated with lower, while SED with higher abundance of Escherichia coli. MPA and VPA were associated with higher abundance of the butyrate-producers Faecalibacterium prausnitzii and Roseburia spp. We observed discrepancies between specific VPA and MPA associations, such as a positive association between MPA and Prevotella copri, while no association was detected for VPA. Additionally, SED, MPA and VPA were associated with the functional potential of the microbiome. For instance, MPA was associated with higher capacity for acetate synthesis and SED with lower carbohydrate degradation capacity.INTERPRETATION: Our findings suggest that sedentary and physical activity are associated with a similar set of gut microbiota species but in opposite directions. Furthermore, the intensity of physical activity may have specific effects on certain gut microbiota species.FUNDING: European Research Council, Swedish Heart-Lung Foundation, Swedish Research Council, Knut and Alice Wallenberg Foundation.

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