| 1. |
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| 2. |
- Franceschini, N., et al.
(author)
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GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes
- 2018
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In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 9:1
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Journal article (peer-reviewed)abstract
- Carotid artery intima media thickness (cIMT) and carotid plaque are measures of subclinical atherosclerosis associated with ischemic stroke and coronary heart disease (CHD). Here, we undertake meta-analyses of genome-wide association studies (GWAS) in 71,128 individuals for cIMT, and 48,434 individuals for carotid plaque traits. We identify eight novel susceptibility loci for cIMT, one independent association at the previously-identified PINX1 locus, and one novel locus for carotid plaque. Colocalization analysis with nearby vascular expression quantitative loci (cis-eQTLs) derived from arterial wall and metabolic tissues obtained from patients with CHD identifies candidate genes at two potentially additional loci, ADAMTS9 and LOXL4. LD score regression reveals significant genetic correlations between cIMT and plaque traits, and both cIMT and plaque with CHD, any stroke subtype and ischemic stroke. Our study provides insights into genes and tissue-specific regulatory mechanisms linking atherosclerosis both to its functional genomic origins and its clinical consequences in humans. © 2018, The Author(s).
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| 3. |
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| 4. |
- Voight, Benjamin F, et al.
(author)
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Plasma HDL cholesterol and risk of myocardial infarction : a mendelian randomisation study
- 2012
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In: The Lancet. - 0140-6736 .- 1474-547X. ; 380:9841, s. 572-580
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Journal article (peer-reviewed)abstract
- BACKGROUND: High plasma HDL cholesterol is associated with reduced risk of myocardial infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes are randomly assigned at meiosis, are independent of non-genetic confounding, and are unmodified by disease processes, mendelian randomisation can be used to test the hypothesis that the association of a plasma biomarker with disease is causal.METHODS: We performed two mendelian randomisation analyses. First, we used as an instrument a single nucleotide polymorphism (SNP) in the endothelial lipase gene (LIPG Asn396Ser) and tested this SNP in 20 studies (20,913 myocardial infarction cases, 95,407 controls). Second, we used as an instrument a genetic score consisting of 14 common SNPs that exclusively associate with HDL cholesterol and tested this score in up to 12,482 cases of myocardial infarction and 41,331 controls. As a positive control, we also tested a genetic score of 13 common SNPs exclusively associated with LDL cholesterol.FINDINGS: Carriers of the LIPG 396Ser allele (2·6% frequency) had higher HDL cholesterol (0·14 mmol/L higher, p=8×10(-13)) but similar levels of other lipid and non-lipid risk factors for myocardial infarction compared with non-carriers. This difference in HDL cholesterol is expected to decrease risk of myocardial infarction by 13% (odds ratio [OR] 0·87, 95% CI 0·84-0·91). However, we noted that the 396Ser allele was not associated with risk of myocardial infarction (OR 0·99, 95% CI 0·88-1·11, p=0·85). From observational epidemiology, an increase of 1 SD in HDL cholesterol was associated with reduced risk of myocardial infarction (OR 0·62, 95% CI 0·58-0·66). However, a 1 SD increase in HDL cholesterol due to genetic score was not associated with risk of myocardial infarction (OR 0·93, 95% CI 0·68-1·26, p=0·63). For LDL cholesterol, the estimate from observational epidemiology (a 1 SD increase in LDL cholesterol associated with OR 1·54, 95% CI 1·45-1·63) was concordant with that from genetic score (OR 2·13, 95% CI 1·69-2·69, p=2×10(-10)).INTERPRETATION: Some genetic mechanisms that raise plasma HDL cholesterol do not seem to lower risk of myocardial infarction. These data challenge the concept that raising of plasma HDL cholesterol will uniformly translate into reductions in risk of myocardial infarction.
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| 5. |
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- 2019
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Journal article (peer-reviewed)
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| 6. |
- Akkoyun, S., et al.
(author)
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AGATA - Advanced GAmma Tracking Array
- 2012
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In: Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. - : Elsevier BV. - 0168-9002 .- 0167-5087 .- 1872-9576. ; 668, s. 26-58
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Journal article (peer-reviewed)abstract
- The Advanced GAmma Tracking Array (AGATA) is a European project to develop and operate the next generation γ-ray spectrometer. AGATA is based on the technique of γ-ray energy tracking in electrically segmented high-purity germanium crystals. This technique requires the accurate determination of the energy, time and position of every interaction as a γ ray deposits its energy within the detector volume. Reconstruction of the full interaction path results in a detector with very high efficiency and excellent spectral response. The realisation of γ-ray tracking and AGATA is a result of many technical advances. These include the development of encapsulated highly segmented germanium detectors assembled in a triple cluster detector cryostat, an electronics system with fast digital sampling and a data acquisition system to process the data at a high rate. The full characterisation of the crystals was measured and compared with detector- response simulations. This enabled pulse-shape analysis algorithms, to extract energy, time and position, to be employed. In addition, tracking algorithms for event reconstruction were developed. The first phase of AGATA is now complete and operational in its first physics campaign. In the future AGATA will be moved between laboratories in Europe and operated in a series of campaigns to take advantage of the different beams and facilities available to maximise its science output. The paper reviews all the achievements made in the AGATA project including all the necessary infrastructure to operate and support the spectrometer. © 2011 Elsevier B.V. All rights reserved.
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| 7. |
- Andgren, Karin, et al.
(author)
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Excited states in the neutron-deficient nuclei Rn-197,Rn-199,Rn-201
- 2008
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In: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 77:5, s. 054303-1-054303-7
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Journal article (peer-reviewed)abstract
- Excited states of the extremely neutron-deficient radon isotopes with N = 111, 113, 115 have been studied for the first time in a series of in-beam experiments performed at the Accelerator Laboratory of the University of Jyvaskyla. The reactions used were: Sn-118(Kr-82, 3n)Rn-197, Sn-120(Kr-82, 3n)Rn-199, Sm-150(Cr-52, 3n)Rn-199, and Sn-122(Kr-82, 3n)Rn-201. The gamma rays emitted from excited states in the different isotopes were identified using the recoil-alpha-decay tagging technique. The estimated cross section for the production of Rn-197(m) was 7(3) nb, which is the lowest cross section reported so far for an in-beam study. The energies of the (17/2(+)) levels built on the isomeric (13/2(+)) states in Rn-197,Rn-199,Rn-201 indicate a transition from an anharmonic vibrational structure toward a rotational structure at low spins for these nuclei. However, the transition is not as sharp as predicted by theory.
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| 8. |
- Andgren, Karin, et al.
(author)
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gamma-ray spectroscopy of At-197
- 2008
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In: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 78:4, s. 044328-1-044328-8
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Journal article (peer-reviewed)abstract
- Excited states of the extremely neutron-deficient nucleus At-197 have been studied in an in-beam experiment using the fusion-evaporation reaction Sn-118(Kr-82,p2n)At-197. gamma rays belonging to At-197 feeding the I-pi=(9/2(-)) ground state, as well as gamma rays feeding the 311-keV I-pi=(13/2(+)) isomer, decaying via the emission of gamma rays, and the 52-keV I-pi=(1/2(+)) alpha-decaying isomer have been identified using the recoil-alpha-decay tagging technique. Total Routhian surface calculations predict a near-spherical shape for the (9/2(-)) ground state and oblate shapes with beta(2) around -0.2 for the (1/2(+)) and the (13/2(+)) states. These predictions agree with our experimental findings.
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| 9. |
- Andgren, Karin, et al.
(author)
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Low-spin collective behavior in the transitional nuclei Mo-86,Mo-88
- 2007
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In: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 76:1, s. 014307-
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Journal article (peer-reviewed)abstract
- Low-spin structures in Mo-86,Mo-88 were populated using the Ni-58(Ar-36, x alpha yp) heavy-ion fusion-evaporation reaction at a beam energy of 111 MeV. Charged particles and gamma rays were emitted in the reactions and detected by the DIAMANT CsI ball and the EXOGAM Ge array, respectively. In addition to the previously reported low-to-medium spin states in these nuclei, new low-spin structures were observed. Angular correlation and linear polarization measurements were performed in order to unambiguously determine the spins and parities of intensely populated states in Mo-88. Quasiparticle Random Phase Approximation (QRPA) calculations were performed for the first and second excited 2(+) states in Mo-86 and Mo-88. The results are in qualitative agreement with the experimental results, supporting a collective interpretation of the low-spin states for these transitional nuclei.
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| 10. |
- Ashrafi, S., et al.
(author)
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Monte-Carlo simulation of the charged particle detector used in the NORDBALL gamma-ray spectrometer
- 2001
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In: Nuclear Instruments and Methods in Physics Research Section A. - 0168-9002 .- 1872-9576. ; 458:3, s. 690-697
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Journal article (peer-reviewed)abstract
- The NORDBALL silicon detector array for detecting light charged particles emitted in fusion evaporation reactions was simulated with the Monte-Carlo method. The data from the reaction of 261 MeV Ni-58 ions with Cr-50 nuclei in a 4.8 mg/cm(2) thick target was used to adjust the simulation parameters. Relative population of residual nuclei in the reaction was determined, by comparing the intensities of gamma -rays.
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| 11. |
- Aybas, Deniz, et al.
(author)
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Search for Axionlike Dark Matter Using Solid-State Nuclear Magnetic Resonance
- 2021
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In: Physical Review Letters. - : American Physical Society (APS). - 0031-9007 .- 1079-7114. ; 126:14
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Journal article (peer-reviewed)abstract
- We report the results of an experimental search for ultralight axionlike dark matter in the mass range 162-166 neV. The detection scheme of our Cosmic Axion Spin Precession Experiment is based on a precision measurement of Pb-207 solid-state nuclear magnetic resonance in a polarized ferroelectric crystal. Axionlike dark matter can exert an oscillating torque on Pb-20(7) nuclear spins via the electric dipole moment coupling g(d) or via the gradient coupling g(aNN). We calibrate the detector and characterize the excitation spectrum and relaxation parameters of the nuclear spin ensemble with pulsed magnetic resonance measurements in a 4.4 T magnetic field. We sweep the magnetic field near this value and search for axionlike dark matter with Compton frequency within a 1 MHz band centered at 39.65 MHz. Our measurements place the upper bounds vertical bar g(d)vertical bar < 9.5 x 10(-4) GeV-2 and vertical bar g(aNN)vertical bar( )< 2.8 x 10(-1) GeV-1 (95% confidence level) in this frequency range. The constraint on g d corresponds to an upper bound of 1.0 x 10(-21) e cm on the amplitude of oscillations of the neutron electric dipole moment and 4.3 x 10(-6) on the amplitude of oscillations of CP-violating theta parameter of quantum chromodynamics. Our results demonstrate the feasibility of using solid-state nuclear magnetic resonance to search for axionlike dark matter in the neV mass range.
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| 12. |
- Bonanomi, N., et al.
(author)
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Role of fast ion pressure in the isotope effect in JET L-mode plasmas
- 2019
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In: Nuclear Fusion. - : Institute of Physics Publishing (IOPP). - 0029-5515 .- 1741-4326. ; 59:9
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Journal article (peer-reviewed)abstract
- This paper presents results of JET ITER-like wall L-mode experiments in hydrogen and deuterium (D) plasmas, dedicated to the study of the isotope dependence of ion heat transport by determination of the ion critical gradient and stiffness by varying the ion cyclotron resonance heating power deposition. When no strong role of fast ions in the plasma core is expected, the main difference between the two isotope plasmas is determined by the plasma edge and the core behavior is consistent with a gyro-Bohm scaling. When the heating power (and the fast ion pressure) is increased, in addition to the difference in the edge region, also the plasma core shows substantial changes. The stabilization of ion heat transport by fast ions, clearly visible in D plasmas, appears to be weaker in H plasmas, resulting in a higher ion heat flux in H with apparent anti-gyro-Bohm mass scaling. The difference is found to be caused by the different fast ion pressure between H and D plasmas, related to the heating power settings and to the different fast ion slowing down time, and is completely accounted for in non-linear gyrokinetic simulations. The application of the TGLF quasi-linear model to this set of data is also discussed.
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| 13. |
- Bäck, Torbjörn, et al.
(author)
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A TOF-PET system for educational purposes
- 2002
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In: Nuclear Instruments and Methods in Physics Research Section A. - : Elsevier. - 0168-9002 .- 1872-9576. ; 477, s. 82-82
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Journal article (peer-reviewed)abstract
- A TOF-PET system has been designed and constructed for educational purposes. The aim of this system is to demonstrate the possibilities of positron emission tomography in general and the time-of-flight method in particular to the students of various courses at the Royal Institute of Technology, Stockholm, Sweden. The set-up consists of 48 small BaF2 crystals coupled to fast photomultipliers placed in a ring geometry. The signals of the photomultipliers are fed into fast constant fraction discriminators (CFD). The outputs of these are directed to a specially designed logic VME unit. which combines the CFD signals of 6 neighbouring channels to one signal by adding a different delay to each channel. The logic circuitry produces a prompt pulse for each event that serves as the start pulse for the 8-channel fast TDC. The delayed pulses act as the stop pulses for the TDC. In a computer. the measured times are converted into information about which the photomultipliers fired with the difference in the time of flight. The set-up is described and the results are presented.
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| 14. |
- Bäck, Torbjörn, et al.
(author)
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An educational tool for demonstrating the TOF-PET technique
- 2001
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In: Nuclear Instruments and Methods in Physics Research Section A. - : AMERICAN PHYSICAL SOC. - 0168-9002 .- 1872-9576. ; 471:1-2, s. 200-204
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Journal article (peer-reviewed)abstract
- A detector system for positron emission tomography with time-of-flight capability has been built to serve as an educational tool for undergraduate students. The set-up consists of 48 BaF2 scintillator crystals, each coupled to a fast photo-multiplier tube, mounted in a circular geometry. The analogue detector pulses are handled by fast constant fraction discriminators. A dedicated unit reduces the 48 channels to eight channels via delay-fine encoding, and the signals are then fed to an eight channel fast time-to-digital converter. A VME processor sorts the events and sends them to a workstation where the coincident events are extracted. The time resolution of the detectors together with fast VME based electronics allows for time-of-flight measurements to improve on the signal-to-noise ratio in the, reconstructed images. The system can be used for different types of exercises for the students, varying from the fundamentals of scintillator detectors to advanced image reconstruction. The set-up is described and some results are presented. (C) 2001 Elsevier Science B.V. All rights reserved.
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| 15. |
- Bäck, Torbjörn, et al.
(author)
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First observation of gamma-rays from the proton emitter Au-171
- 2003
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In: European Physical Journal A. - : Springer Science and Business Media LLC. - 1434-6001 .- 1434-601X. ; 16:4, s. 489-494
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Journal article (peer-reviewed)abstract
- Gamma-rays from the alpha- and proton-unstable nuclide Au-171 have been observed for the first time. The gamma-rays were correlated with both a proton- and an alpha-particle decay branch, confirming that the nucleus decays by alpha and proton emission from a single (11/2(-)) state. The measurement confirms the previously determined half-lives for these particle decays but the present values are of higher precision. In addition, a longer half-life than determined in previous work was measured for the proton-unstable tentative ground state. The results are discussed in relation to structures in neighbouring nuclei and compared with a Strutinsky-type TRS calculation.
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| 16. |
- Bäck, Torbjörn, et al.
(author)
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Lifetime measurement of the first excited 2(+) state in (108)Te
- 2011
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In: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 84:4, s. 041306-
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Journal article (peer-reviewed)abstract
- The lifetime of the first excited 2(+) state in the neutron deficient nuclide (108)Te has been measured for the first time, using a combined recoil decay tagging and recoil distance Doppler shift technique. The deduced reduced transition probability is B(E2;0(g.s.)(+) -> 2(+)) = 0.39(-0.04)(+0.05)e(2)b(2). Compared to previous experimental data on neutron deficient tellurium isotopes, the new data point constitutes a large step (six neutrons) toward the N = 50 shell closure. In contrast to what has earlier been reported for the light tin isotopes, our result for tellurium does not show any enhanced transition probability with respect to the theoretical predictions and the tellurium systematics including the new data is successfully reproduced by state-of-the-art shell model calculations.
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| 17. |
- Bäck, Torbjörn, et al.
(author)
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Observation of superdeformed states in Mo-88
- 1999
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In: European Physical Journal A. - New York : SPRINGER VERLAG. - 1434-6001 .- 1434-601X. ; 6:4, s. 391-397
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Journal article (peer-reviewed)abstract
- High-spin states in Mo-88 were studied using the GAMMASPHERE germanium detector array in conjunction with the MICROBALL CsI(TI) charged-particle detector system. Three gamma-ray cascades with dynamic moments of inertia showing similar characteristics to superdeformed rotational bands observed in the neighbouring A = 80 region have been identified and assigned to the nucleus Mo-88. The quadrupole moment of the strongest band, deduced by the Residual Doppler Shift Method, corresponds to a quadrupole deformation of beta(2) approximate to 0.6. This confirms the superdeformed nature of this band. The experimental data are interpreted in the framework of total routhian surface calculations. All three hands are assigned to two-quasi-particle proton configurations at superdeformed shape.
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| 18. |
- Bäck, Torbjörn, et al.
(author)
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Spectroscopy of the neutron-deficient nuclide Pt-171
- 2003
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In: European Physical Journal A. - : Springer Science and Business Media LLC. - 1434-6001 .- 1434-601X. ; 17:1, s. 1-5
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Journal article (peer-reviewed)abstract
- A number of previously unobserved gamma-rays emitted from the neutron-deficient nuclide Pt-171 have been identified using the recoil decay tagging technique. The level scheme has been updated using information from gamma-gamma coincidences and angular distribution measurements. To further confirm the assignments of the gamma-rays to Pt-171, the events were correlated with the alpha-decay of the daughter nucleus Os-167.
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| 19. |
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| 20. |
- Bäck, Torbjörn, et al.
(author)
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Transition probabilities near Sn-100 and the stability of the N, Z=50 shell closure
- 2013
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In: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 87:3, s. 031306-
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Journal article (peer-reviewed)abstract
- Recent B(E2; 0(g.s.)(+) -> 2(1)(+)) measurements in light tin isotopes have revealed surprisingly large values relative to standard shell model predictions, generating an unexpected asymmetry in the B(E2) values with respect to the neutron midshell. This effect has triggered various speculations as to its origin, such as a possible weakening of the N, Z = 50 shell closure. Here we present new shell model calculations to investigate the origin of the observed asymmetric character of the B(E2) values in the tin isotopes. By including the effects of the neutron g(9/2) orbital below the N = 50 shell gap it is shown that Pauli blocking effects may play an important role near the N = 50 shell closure. A new set of single-particle energies and monopole interactions, fitted to the experimental data in the region, together with the isospin-dependent effective charge suggested by Bohr and Mottelson is shown to reproduce the experimental transition rate values in the Sn isotopic chain.
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| 21. |
- Cannas, Barbara, et al.
(author)
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Recurrence Plots for Dynamic Analysis of Type-I ELMs at JET With a Carbon Wall
- 2019
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In: IEEE Transactions on Plasma Science. - : Institute of Electrical and Electronics Engineers (IEEE). - 0093-3813 .- 1939-9375. ; 47:4, s. 1871-1877
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Journal article (peer-reviewed)abstract
- In this paper, the dynamic characteristics of type-I edge-localized modes (ELM) time series from the JET tokamak, the world's largest magnetic confinement plasma physics experiment, have been investigated through recurrence plots (RPs). The analysis has been focused on RPs of pedestal temperature, line averaged electron density, and outer divertor D-alpha time series during experiments with a carbon wall. The analysis of RPS shows the patterns similar to those characteristics of signals exhibiting type-2 intermittency, in particular, a characteristic kite-like shape; this gives useful hints to model the temperature signal as well as the D-alpha radiation time series, with simple nonlinear maps capturing the nearly periodic behavior of type-I ELMs.
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| 22. |
- Carvalho, D. D., et al.
(author)
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Deep neural networks for plasma tomography with applications to JET and COMPASS
- 2019
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In: Journal of Instrumentation. - : Institute of Physics Publishing (IOPP). - 1748-0221. ; 14
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Journal article (peer-reviewed)abstract
- Convolutional neural networks (CNNs) have found applications in many image processing tasks, such as feature extraction, image classification, and object recognition. It has also been shown that the inverse of CNNs, so-called deconvolutional neural networks, can be used for inverse problems such as plasma tomography. In essence, plasma tomography consists in reconstructing the 2D plasma profile on a poloidal cross-section of a fusion device, based on line-integrated measurements from multiple radiation detectors. Since the reconstruction process is computationally intensive, a deconvolutional neural network trained to produce the same results will yield a significant computational speedup, at the expense of a small error which can be assessed using different metrics. In this work, we discuss the design principles behind such networks, including the use of multiple layers, how they can be stacked, and how their dimensions can be tuned according to the number of detectors and the desired tomographic resolution for a given fusion device. We describe the application of such networks at JET and COMPASS, where at JET we use the bolometer system, and at COMPASS we use the soft X-ray diagnostic based on photodiode arrays.
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| 23. |
- Cederwall, Bo, et al.
(author)
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Evidence for a spin-aligned neutron-proton paired phase from the level structure of 92Pd
- 2011
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In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 469:7328, s. 68-71
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Journal article (peer-reviewed)abstract
- Shell structure and magic numbers in atomic nuclei were generally explained by pioneering work(1) that introduced a strong spin-orbit interaction to the nuclear shell model potential. However, knowledge of nuclear forces and the mechanisms governing the structure of nuclei, in particular far from stability, is still incomplete. In nuclei with equal neutron and proton numbers (N = Z), enhanced correlations arise between neutrons and protons (two distinct types of fermions) that occupy orbitals with the same quantum numbers. Such correlations have been predicted to favour an unusual type of nuclear superfluidity, termed isoscalar neutron-proton pairing(2-6), in addition to normal isovector pairing. Despite many experimental efforts, these predictions have not been confirmed. Here we report the experimental observation of excited states in the N = Z = 46 nucleus Pd-92. Gamma rays emitted following the Ni-58(Ar-36,2n)Pd-92 fusion-evaporation reaction were identified using a combination of state-of-the-art high-resolution c-ray, charged-particle and neutron detector systems. Our results reveal evidence for a spin-aligned, isoscalar neutron-proton coupling scheme, different from the previous prediction(2-6). We suggest that this coupling scheme replaces normal superfluidity (characterized by seniority coupling(7,8)) in the ground and low-lying excited states of the heaviest N = Z nuclei. Such strong, isoscalar neutron-proton correlations would have a considerable impact on the nuclear level structure and possibly influence the dynamics of rapid proton capture in stellar nucleosynthesis.
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| 24. |
- Cederwall, Bo, et al.
(author)
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Favoured superdeformed states in 89TC
- 1999
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In: European Physical Journal A. - New York : Springer-Verlag New York. - 1434-6001 .- 1434-601X. ; 6:3, s. 251-255
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Journal article (peer-reviewed)abstract
- A superdeformed band consisting of a cascade of ten gamma-ray transitions has been identified and assigned to the nucleus Tc-89, close to the proton dripline. The quadrupole moment of the band (Q(t) = 6.7(-2.3)(+3.0) eb, as measured by the Residual Doppler Shift Method) as well as a large dynamic moment of inertia point to a highly elongated shape. With a relative population of approximately 15% of the gamma-ray flux in the Tc-89 exit channel, thp band is among the most intense superdeformed bands observed to date.
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| 25. |
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