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| 11. |
- Koch, Max, et al.
(author)
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Rethinking state-civil society relations
- 2022
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In: Degrowth & Strategy : How to bring about social-ecological transformation - How to bring about social-ecological transformation. - 9781906948603 ; , s. 170-181
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Book chapter (peer-reviewed)
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| 12. |
- Amare, Azmeraw, et al.
(author)
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Association of Polygenic Score and the involvement of Cholinergic and Glutamatergic Pathways with Lithium Treatment Response in Patients with Bipolar Disorder.
- 2023
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In: Research square. - : Research Square Platform LLC.
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Journal article (peer-reviewed)abstract
- Lithium is regarded as the first-line treatment for bipolar disorder (BD), a severe and disabling mental disorder that affects about 1% of the population worldwide. Nevertheless, lithium is not consistently effective, with only 30% of patients showing a favorable response to treatment. To provide personalized treatment options for bipolar patients, it is essential to identify prediction biomarkers such as polygenic scores. In this study, we developed a polygenic score for lithium treatment response (Li+PGS) in patients with BD. To gain further insights into lithium's possible molecular mechanism of action, we performed a genome-wide gene-based analysis. Using polygenic score modeling, via methods incorporating Bayesian regression and continuous shrinkage priors, Li+PGS was developed in the International Consortium of Lithium Genetics cohort (ConLi+Gen: N=2,367) and replicated in the combined PsyCourse (N=89) and BipoLife (N=102) studies. The associations of Li+PGS and lithium treatment response - defined in a continuous ALDA scale and a categorical outcome (good response vs. poor response) were tested using regression models, each adjusted for the covariates: age, sex, and the first four genetic principal components. Statistical significance was determined at P<����������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������.
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| 13. |
- Amare, Azmeraw T, et al.
(author)
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Association of polygenic score and the involvement of cholinergic and glutamatergic pathways with lithium treatment response in patients with bipolar disorder.
- 2023
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In: Molecular psychiatry. - 1476-5578. ; 28, s. 5251-5261
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Journal article (peer-reviewed)abstract
- Lithium is regarded as the first-line treatment for bipolar disorder (BD), a severe and disabling mental healthdisorder that affects about 1% of the population worldwide. Nevertheless, lithium is not consistently effective, with only 30% of patients showing a favorable response to treatment. To provide personalized treatment options for bipolar patients, it is essential to identify prediction biomarkers such as polygenic scores. In this study, we developed a polygenic score for lithium treatment response (Li+PGS) in patients with BD. To gain further insights into lithium's possible molecular mechanism of action, we performed a genome-wide gene-based analysis. Using polygenic score modeling, via methods incorporating Bayesian regression and continuous shrinkage priors, Li+PGS was developed in the International Consortium of Lithium Genetics cohort (ConLi+Gen: N=2367) and replicated in the combined PsyCourse (N=89) and BipoLife (N=102) studies. The associations of Li+PGS and lithium treatment response - defined in a continuous ALDA scale and a categorical outcome (good response vs. poor response) were tested using regression models, each adjusted for the covariates: age, sex, and the first four genetic principal components. Statistical significance was determined at P<0.05. Li+PGS was positively associated with lithium treatment response in the ConLi+Gen cohort, in both the categorical (P=9.8×10-12, R2=1.9%) and continuous (P=6.4×10-9, R2=2.6%) outcomes. Compared to bipolar patients in the 1st decile of the risk distribution, individuals in the 10th decile had 3.47-fold (95%CI: 2.22-5.47) higher odds of responding favorably to lithium. The results were replicated in the independent cohorts for the categorical treatment outcome (P=3.9×10-4, R2=0.9%), but not for the continuous outcome (P=0.13). Gene-based analyses revealed 36 candidate genes that are enriched in biological pathways controlled by glutamate and acetylcholine. Li+PGS may be useful in the development of pharmacogenomic testing strategies by enabling a classification of bipolar patients according to their response to treatment.
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| 14. |
- Angelin, Anna, et al.
(author)
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Patterns of Institutional Change in Minimum Income Protection in Sweden and Germany
- 2014
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In: Journal of International and Comparative Social Policy. - : Cambridge University Press (CUP). - 2169-9763 .- 2169-978X. ; 30:2, s. 165-179
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Journal article (peer-reviewed)abstract
- Germany is generally regarded as a case of qualitative “change” in minimum income protection (MIP) schemes, while Sweden is perceived as one of institutional “inertia”.This paper seeks to qualify this view by embedding developments in MIP in wider policy and governance trends. Empirically, it is based on document analysis and qualitative expert interviews in the two countries. Theoretically, the paper applies recent institutional approaches that address patterns of change in more complex ways. In Sweden, an exclusive focus on formal continuity regarding social assistance would disguise its change in function from temporary security system of last resort into one that permanently provides income protection when neighboring policy fields,unemployment and sickness insurance, are downsized. Conversely, in Germany a merger of social assistance and unemployment assistance took place. Yet an exclusive focus on the Hartz reforms would downplay the degree of continuity that nevertheless exists in the unemployment insurance.
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| 15. |
- Angelin, Anna, et al.
(author)
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The national arena for combating poverty - national report: Sweden
- 2013
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Reports (other academic/artistic)abstract
- Reducing poverty and social exclusion is one of the main challenges for ensuring social cohesion in Europe. The research project COPE – Combating Poverty in Europe: Re-organising Active Inclusion through Participatory and Integrated Modes of Multilevel Governance’ – analyses trends in poverty and social exclusion in Europe, and examines the dynamics of minimum income protection policies that potentially help alleviate the risk of poverty in Europe. A particular focus is on the situation of single parents, long-term unemployed and the working poor, who face particular risks of poverty and social exclusion. To what extent have minimum income policies functioned as last resort social security for these three groups, and in what sense can ‘active inclusion’ policies credited with protecting them from poverty and social exclusion?The present report is part of COPE’s effort to uncover the dynamics of national level policy reforms in the area ‘active inclusion’, namely reforms affecting national policies that specify the adequacy of minimum income benefits, the provision of employment services, as well as the organisation of access to social services in Sweden. It focuses particularly on the three groups; single parents, long-term unemployed persons, as well as the working poor.
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- Brandstedt, Eric, et al.
(author)
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The Concept of Sustainable Welfare
- 2016
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In: Sustainability and the Political Economy of Welfare. - 9781138925281 - 9781315683850 ; 42, s. 15-28
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Book chapter (other academic/artistic)
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| 19. |
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| 20. |
- Buch-Hansen, Hubert, et al.
(author)
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An Economics of Deep Transformations
- 2023
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In: Real-world Economics Review. - 1755-9472. ; :106, s. 42-46
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Journal article (peer-reviewed)abstract
- A wide range of literatures have identified the capitalist organisation of societies, and the capitalist growth imperative central to this organisation, as the root cause of the catastrophic climate and biodiversity crises. Highlighting the need to break with this imperative, a growing community of scholars generally viewed as anti- and postcapitalist, there is no consensus on how precisely to conceptualise degrowth. In recent works we have proposed a conceptualisation according to which it is a process involving deep transformations on four interconnected planes of social being. These are (a) material transactions with nature, (b) social interactions between people, (c) social structure, and (d) the inner being of individuals. In our forthcoming book (Buch-Hansen et al. 2024), we theorise what such transformations entail in and how they can emanate from the sites of civil society, the state and business. In the present contribution we add to this perspective by briefly contemplating what sort of economics could play a positive role for deep transformations to unfold. We start out from the currently dominant perspective in economics, neoclassical economics, arguing that it constitutes an economics of deep degradation inasmuch as it produces harm on each plane of being. We then outline a vision of an economics of deep transformations a philosophically informed and genuinely interdisciplinary and holistic economics that could support change on all four planes.
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| 21. |
- Buch-Hansen, Hubert, et al.
(author)
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Deep Transformations : A Theory of Degrowth
- 2024
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Book (peer-reviewed)abstract
- As a research field, social movement and political project, degrowth is a multi-faceted phenomenon. It brings together a range of practices including alternative forms of living and initiatives of various kinds in civil society, business and the state. Yet no comprehensive theory of degrowth transformations has so far been developed. Deep transformations fills this gap. It develops a theory of degrowth transformations drawing on insights from multiple fields of knowledge, such as political economy, sociology and philosophy. The book offers a holistic perspective that brings into focus transformation processes on various scales and points to various mechanisms that can facilitate degrowth. These include ecosocial policies, transformative initiatives in business and civil society and alternative modes of being in and relating to the world.
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| 22. |
- Buch-Hansen, Hubert, et al.
(author)
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Degrowth through Income and Wealth Caps?
- 2019
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In: Ecological Economics. - 0921-8009. ; :160, s. 264-271
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Journal article (peer-reviewed)abstract
- In the degrowth literature, maximum caps on wealth and/or income are frequently mentioned among the policy instruments that could support transitions towards ecologically and socially sustainable societies. Yet an in-depth discussion of concrete policy proposals has yet to be initiated. To facilitate such a discussion, the present paper reviews several proposals for placing caps on wealth and/or income. Some of these proposals consider environmental limits, others focus exclusively on social inequality. The paper moreover raises various critical issues concerning the introduction of maximum caps on wealth and income in a degrowth context, discussing the role of the state, the impact on economic growth and the risk of emigration of high-skilled employees and capital flight. We conclude that while, in an ecologically constrained world, there is an argument for imposing limits on wealth and income above a certain level, it is crucial not to dictate such policies as mere top-down measures but to develop and deliberate them in democratic forums.
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| 23. |
- Buch-Hansen, Hubert, et al.
(author)
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Maximum limits on incomes and wealth
- 2018
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Conference paper (peer-reviewed)abstract
- Since Herman Daly’s original writings, growth-critical scholarship has frequently referred to the policy tools of minimum income schemes and maximum limits on incomes and wealth to tackle social inequality in a degrowth transition. However, while there is a broad discussion of minimum income schemes within the degrowth research community and beyond, not much has been produced on maximum limits on income and wealth – neither in relation to a conceptual/theoretical approach to understand and motivate such limits, nor in terms of concrete policy proposals at national or transnational levels. This paper sets out to contribute to fill this gap in research by proposing a theoretical approach towards defining maximum income levels based on a human needs approach (Koch/Buch-Hansen/Fritz 2017). We first seek to define the lowest amount of resources needed for any individual to participate meaningfully in society. Second, we attempt to define an upper limit for income and wealth in terms of an ‘affluence line’ (Concialdi 2017), the amount of resources above which any extra resource appropriated by some individuals would prevent other members from minimally participating in society. Third, we review the existing economic and social science literature on maximum incomes in relation to indicators of how such an upper limit may be operationalized at national and European levels. Here, we will particularly consider theories of incremental institutional change, which open up for the possibility that maximum income levels may be set differently and different policy tools may be applied in different countries (Buch-Hansen 2014).
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| 24. |
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| 25. |
- Buchs, Milena, et al.
(author)
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Challenges for the degrowth transition: the debate about wellbeing
- 2019
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In: Futures. - : Elsevier BV. - 0016-3287. ; 105, s. 155-165
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Journal article (peer-reviewed)abstract
- Degrowth scholars and activists have convincingly argued that degrowth in developed nations will need to be part of a global effort to tackle climate change, and to preserve the conditions for future generations’ basic needs satisfaction. However, the barriers to building a broader degrowth movement appear to be very entrenched at present. To improve the political feasibility of degrowth it is important to better understand these structural obstacles and develop arguments and strategies to address them. To contribute to the degrowth debate we focus in this paper on current generations in the rich countries and their concerns about possible short- to medium term wellbeing outcomes of degrowth. In particular, we highlight the ‘growth lock-in’ of current societies and how a transition away from this model might therefore affect wellbeing. We also argue that taking the basic human needs framework as a new ‘measuring rod’ for wellbeing outcomes is suitable for a degrowth context, but likely to clash with current expectations of ever improving health and wellbeing outcomes. We propose that deliberative forums on future needs satisfaction can help establish a ‘dialogue’ between current and future generations which could support cultural shifts on wellbeing thinking which will be much needed for advancing the cause for degrowth.
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