| 1. |
- Balduzzi, A., et al.
(author)
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Laparoscopic versus open extended radical left pancreatectomy for pancreatic ductal adenocarcinoma: an international propensity-score matched study
- 2021
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In: Surgical Endoscopy. - : SPRINGER. - 0930-2794 .- 1432-2218. ; 35:12, s. 6949-6959
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Journal article (peer-reviewed)abstract
- Background A radical left pancreatectomy in patients with pancreatic ductal adenocarcinoma (PDAC) may require extended, multivisceral resections. The role of a laparoscopic approach in extended radical left pancreatectomy (ERLP) is unclear since comparative studies are lacking. The aim of this study was to compare outcomes after laparoscopic vs open ERLP in patients with PDAC. Methods An international multicenter propensity-score matched study including patients who underwent either laparoscopic or open ERLP (L-ERLP; O-ERLP) for PDAC was performed (2007-2015). The ISGPS definition for extended resection was used. Primary outcomes were overall survival, margin negative rate (R0), and lymph node retrieval. Results Between 2007 and 2015, 320 patients underwent ERLP in 34 centers from 12 countries (65 L-ERLP vs. 255 O-ERLP). After propensity-score matching, 44 L-ERLP could be matched to 44 O-ERLP. In the matched cohort, the conversion rate in L-ERLP group was 35%. The L-ERLP R0 resection rate (matched cohort) was comparable to O-ERLP (67% vs 48%; P = 0.063) but the lymph node yield was lower for L-ERLP than O-ERLP (median 11 vs 19, P = 0.023). L-ERLP was associated with less delayed gastric emptying (0% vs 16%, P = 0.006) and shorter hospital stay (median 9 vs 13 days, P = 0.005), as compared to O-ERLP. Outcomes were comparable for additional organ resections, vascular resections (besides splenic vessels), Clavien-Dindo grade >= III complications, or 90-day mortality (2% vs 2%, P = 0.973). The median overall survival was comparable between both groups (19 vs 20 months, P = 0.571). Conversion did not worsen outcomes in L-ERLP. Conclusion The laparoscopic approach may be used safely in selected patients requiring ERLP for PDAC, since morbidity, mortality, and overall survival seem comparable, as compared to O-ERLP. L-ERLP is associated with a high conversion rate and reduced lymph node yield but also with less delayed gastric emptying and a shorter hospital stay, as compared to O-ERLP.
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| 2. |
- Nayak, S., et al.
(author)
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Magnetic compensation, field-dependent magnetization reversal, and complex magnetic ordering in Co2TiO4
- 2015
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In: Physical Review B. Condensed Matter and Materials Physics. - 1098-0121 .- 1550-235X. ; 92:21
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Journal article (peer-reviewed)abstract
- The complex nature of magnetic ordering in the spinel Co2TiO4 is investigated by analyzing the temperature and magnetic field dependence of its magnetization (M), specific heat (C-p), and ac magnetic susceptibilities chi' and chi ''. X-ray diffraction of the sample synthesized by the solid-state reaction route confirmed the spinel structure whereas x-ray photoelectron spectroscopy shows its electronic structure to be Co2TiO4 = [Co2+][Co3+ Ti3+]O-4. From analysis of the temperature dependence of the dc paramagnetic susceptibility, the magnetic moments mu(A) = 3.87 mu(B) and mu(B) = 5.19 mu B on the A and B sites are determined with mu(B) in turn yielding mu(Ti3+) = 1.73 mu(B) and mu(Co3+) = 4.89 mu(B). Analysis of the dc and ac susceptibilities combined with the weak anomalies observed in the C-p vs T data shows the existence of a quasi-long-range ferrimagnetic state below T-N similar to 47.8K and a compensation temperature T-comp similar to 32 K, the latter characterized by sign reversal of magnetization with its magnitude depending on the applied magnetic field and the cooling protocol. Analysis of the temperature dependence of M (field cooled) and M (zero field cooled) data and the hysteresis loop parameters is interpreted in terms of large spin clusters. These results in Co2TiO4, significantly different from those reported recently in isostructural Co2SnO4 = [Co2+][Co2+ Sn4+]O-4, warrant further investigations of its magnetic structure using neutron diffraction.
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