| 1. |
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| 2. |
- Kwiecinski, Jakub, 1985, et al.
(author)
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Staphylokinase controls Staphylococcus aureus biofilm formation and detachment through host plasminogen activation.
- 2016
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In: The Journal of infectious diseases. - : Oxford University Press (OUP). - 0022-1899 .- 1537-6613. ; 213:1, s. 139-148
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Journal article (peer-reviewed)abstract
- Staphylococcus aureus biofilms, a leading cause of persistent infections, are highly resistant to immune defenses and antimicrobial therapies. In this study, we investigated the contribution of fibrin and staphylokinase to biofilm formation. Both in clinical S. aureus isolates and in laboratory strains, high staphylokinase-producing strains formed less biofilm than strains that lacked staphylokinase, suggesting that staphylokinase prevents biofilm formation. Additionally, staphylokinase induced detachment of mature biofilms. This effect depended on plasminogen activation by staphylokinase. Host-derived fibrin, the main substrate cleaved by staphylokinase-activated plasminogen, was a major component of biofilm matrix and dissolution of this fibrin scaffold greatly increased susceptibility of biofilms to antibiotics and neutrophil phagocytosis. Staphylokinase also attenuated biofilm-associated catheter infections in mouse models. In conclusion, our results reveal a novel role for staphylokinase-induced plasminogen activation that prevents S. aureus biofilm formation and induces detachment of existing biofilms through proteolytic cleavage of biofilm matrix components.
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| 3. |
- Szweda, P., et al.
(author)
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Chitosan-protein scaffolds loaded with lysostaphin as potential antistaphylococcal wound dressing materials
- 2014
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In: Journal of Applied Microbiology. - : Oxford University Press (OUP). - 1364-5072. ; 117:3, s. 634-642
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Journal article (peer-reviewed)abstract
- Aims: The development of technology for preparing chitosan-protein scaffolds loaded with lysostaphin, which potentially could be used as dressing for wound treatment and soft tissue infections caused by Staphylococcus aureus. Methods and Results: The unique technology of chitosan solubilization using gaseous CO2 instead of organic or inorganic acids was used for the incorporation of lysostaphin, the enzyme that exhibits bactericidal activity against staphylococci, within the structure of chitosan-protein sponges. The developed chitosan-protein scaffolds loaded with lysostaphin revealed high antistaphylococcal activity, which has been confirmed with a large (n = 143) collection of clinical (skin and wound infections) and animal (bovine mastitis) isolates of these bacteria, including MRSA. No change of bactericidal activity of the lyophilized materials has been observed during half-year storage at 4 degrees C. Conclusions: The developed materials are potential candidates for preparing biologically active, antistaphylococcal wound dressing materials. Significance and Impact of the Study: Staphylococci belong to the most popular and most burdensome aetiological factors of wound and soft tissues infections. The developed chitosan-protein scaffolds loaded with lysostaphin could be a possible solution to problems associated with treatment of these infections.
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| 4. |
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| 5. |
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| 6. |
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| 7. |
- Andersen, JR, et al.
(author)
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Small-x phenomenology - summary and status 2002
- 2004
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In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 35:1, s. 67-98
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Research review (peer-reviewed)abstract
- A second workshop on small-x physics, within the Small-x Collaboration, was held in Lund in June 2002 with the aim of over-viewing recent theoretical progress in this area and summarizing the experimental status.
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| 8. |
- Badelek, B, et al.
(author)
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The photon collider at TESLA
- 2004
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In: International Journal of Modern Physics A. - 0217-751X. ; 19:30, s. 5097-5186
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Research review (peer-reviewed)abstract
- High energy photon colliders (gammagamma,gammae) are based on e(-)e(-) linear colliders where high energy photons are produced using Compton scattering of laser light on high energy electrons just before the interaction point. This paper is a part of the Technical Design Report of the linear collider TESLA.(1) Physics program, possible parameters and some technical aspects of the photon collider at TESLA are discussed.
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| 9. |
- Kwiecinski, J, et al.
(author)
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Integral equation for spin dependent unintegrated parton distributions incorporating double In-2(1/x) effects at low x
- 2003
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In: Physical Review D (Particles and Fields). - 0556-2821. ; 67:3: 034014
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Journal article (peer-reviewed)abstract
- In this paper we derive an integral equation for the evolution of unintegrated (longitudinally) polarized quark and gluon parton distributions. The conventional Catani-Ciafaloni-Fiorani-Marchesini (CCFM) framework is modified at small x in order to incorporate the QCD expectations concerning the double ln(2)(1/x) resummation at low x for the integrated distributions. Complete Altarelli-Parisi splitting functions are included that makes the formalism compatible with the leading order Altarelli-Parisi evolution at large and moderately small values of x. The obtained modified polarized CCFM equation is shown to be partially diagonalized by the Fourier-Bessel transformation. Results of the numerical solution for this modifed polarized CCFM equation for the nonsinglet quark distributions are presented.
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| 10. |
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| 11. |
- Kwiecinski, J., et al.
(author)
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Two-photon cross-sections from the saturation model
- 2002
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In: Acta Physica Polonica B. - : Jagellonian University, Cracow. - 0587-4254 .- 1509-5770. ; B33:6, s. 1559-
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Journal article (peer-reviewed)abstract
- A saturation model for the total \gamma \gamma and \gamma* \gamma* cross-sections and for the real photon structure function F2\gamma (x,Q2) is described. The model is based on a QCD dipole picture of high energy scattering. The two-dipole cross-section is assumed to satisfy the saturation property with the saturation radius taken from the GBW analysis of the \gamma*p interaction at HERA. The model is combined with the QPM and non-pomeron reggeon contributions and it gives a very good description of the data on the \gamma \gamma total cross-section, on the photon structure function F2\gamma (x,Q2) at low x and on the \gamma* \gamma* cross-section. Production of heavy quarks in \gamma \gamma collisions is also studied.
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| 12. |
- Tîmneanu, Niccusor, et al.
(author)
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Saturation model for 2-gamma physics
- 2002
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In: Acta Physica Polonica B. - : Jagellonian University, Cracow. - 0587-4254 .- 1509-5770. ; B33:10, s. 3045-3050
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Journal article (peer-reviewed)abstract
- We introduce a saturation model for photon-photon interactions, based on a QCD dipole picture of high energy scattering. The two-dipole cross-section is assumed to satisfy the saturation property. This pomeron-like contribution is supplemented with QPM and non-pomeron reggeon contributions. The model gives a very good description of the data on the \gamma \gamma total cross-section, on the photon structure function F2\gamma (x,Q2) at low x and on the \gamma * \gamma * cross section.
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| 13. |
- Timneanu, Niccusor, et al.
(author)
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Saturation model for two-photon interactions at high energies
- 2002
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In: European Physical Journal C. - : Springer-Verlag, Berlin, Heidelberg. - 1434-6044 .- 1434-6052. ; 23:3, s. 513-526
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Journal article (peer-reviewed)abstract
- We formulate and analyse a saturation model for the total γγ and γ∗γ∗ cross-sections and for the real photon structure function Fγ2(x,Q2) . The model is based on a picture in which the γ∗γ∗ total cross-section for arbitrary photon virtualities is driven by the interaction of colour dipoles into which the virtual photons fluctuate. The cross-section describing this interaction is assumed to satisfy the saturation property with the saturation radius taken from the Golec-Biernat and Wüsthoff analysis of the γ∗p interaction at HERA. The model is supplemented by the QPM and non-pomeron reggeon contributions. The model gives a very good description of the data on the γγ total cross-section, on the photon structure function Fγ2(x,Q2) at lowx and on the γ∗γ∗ cross-section extracted from LEP double tagged events. The production of heavy flavours in γγ collisions is also studied. Predictions of the model for the very high energy range which will be probed at future linear colliders are given.
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| 14. |
- Badelek, B, et al.
(author)
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A model of F-2(gamma) at arbitrary Q(2) and the total photon-photon cross-sections at high energies
- 2001
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In: NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT. - : ELSEVIER SCIENCE BV. - 0168-9002. ; 472:1-2, s. 222-228
-
Journal article (peer-reviewed)abstract
- A model of the real photon structure function F-2(gamma) which can be used in the low Q(2), low x region is formulated. It includes both the VMD and the QCD components, the latter based on arbitrary parton distributions in the photon and suitably extrapol
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| 15. |
- Kwiecinski, J, et al.
(author)
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Azimuthal decorrelation of forward and backward jets at the Tevatron
- 2001
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In: PHYSICS LETTERS B. - : ELSEVIER SCIENCE BV. - 0370-2693. ; 514:3-4, s. 355-360
-
Journal article (peer-reviewed)abstract
- We analyse the azimuthal decorrelation of 'Mueller-Navelet' dijets produced in the p (p) over bar collisions at Tevatron energies using a BFKL framework which incorporates dominant subleading effects. We show that these effects significantly reduce the de
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| 16. |
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| 17. |
- Badelek, B, et al.
(author)
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Spin dependent structure function g(1) at low x and low Q(2) - art. no. 014009
- 2000
-
In: PHYSICAL REVIEW D. - : AMERICAN PHYSICAL SOC. - 0556-2821. ; 6101:1, s. 4009-
-
Journal article (peer-reviewed)abstract
- A theoretical description of the spin dependent structure function g(1)(x, Q(2)) in the region of low values of x and Q(2) is presented. It contains the vector meson dominance contribution and the QCD improved parton model suitably extended to the low Q(2
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| 18. |
- Badelek, B, et al.
(author)
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F-2(gamma) at low Q(2) and sigma(gamma gamma) at high energies
- 1999
-
In: ACTA PHYSICA POLONICA B. - : ACTA PHYSICA POLONICA B, JAGELLONIAN UNIV, INST PHYSICS. - 0587-4254. ; 30:6, s. 1807-1815
-
Journal article (other academic/artistic)abstract
- The parametrisation of the photon structure function in the low Q(2) region is formulated. It includes the VMD contribution and the QCD improved parton model component suitably extrapolated to the low Q(2) region. The parametrisation describes reasonably
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| 19. |
- Badelek, B, et al.
(author)
-
Spin dependent structure function g(1) at small x and small Q(2)
- 1999
-
In: JOURNAL OF PHYSICS G-NUCLEAR AND PARTICLE PHYSICS. - : IOP PUBLISHING LTD. - 0954-3899. ; 25:7, s. 1533-1535
-
Journal article (other academic/artistic)abstract
- The QCD improved parton model description of the spin dependent structure function g(1)(x, Q(2)) based on the unintegrated spin dependent parton distributions is extended to the low Q(2) region. Theoretical predictions are compared with the recent SMC dat
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| 20. |
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| 21. |
- Badelek, B, et al.
(author)
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A model for F-L and R=F-L/F-T at low x and low Q(2)
- 1997
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In: ZEITSCHRIFT FUR PHYSIK C-PARTICLES AND FIELDS. - : SPRINGER VERLAG. - 0170-9739. ; 74:2, s. 297-305
-
Journal article (other academic/artistic)abstract
- A model for the longitudinal structure function F-L at low x and low Q(2) is presented, which includes the kinematical constraint F-L similar to Q(4) as Q(2) --> 0. It is based on the photon-gluon fusion mechanism suitably extrapolated to the region of lo
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| 22. |
- Badelek, B, et al.
(author)
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The low-Q(2), low-x region in electroproduction
- 1996
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In: REVIEWS OF MODERN PHYSICS. - : AMER INST PHYSICS. ; 68:2, s. 445-471
-
Review (other academic/artistic)abstract
- The authors summarize existing experimental and theoretical knowledge of the structure function F-2 in the region of low Q(2) and low x. Constraints on the behavior of structure functions in the limit of Q(2)=0 are listed. Phenomenological low-Q(2) parame
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