| 1. |
- Bäckman, Sven, et al.
(author)
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Bakhtinian Dialogue in Early Modernist Poetry in English
- 2003
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In: Rytm och dialog: studier framlagda vid åttonde nordiska metrikkonferensen, Umeå 4-7 oktober 2001 ; Skrifter utgivna av Centrum för metriska studier. - 9187988119 ; 14
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Conference paper (other academic/artistic)
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| 2. |
- Bicak, Mesude, et al.
(author)
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Genetic signature of prostate cancer mouse models resistant to optimized hK2 targeted α-particle therapy
- 2020
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In: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 1091-6490. ; 117:26, s. 15172-15181
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Journal article (peer-reviewed)abstract
- Hu11B6 is a monoclonal antibody that internalizes in cells expressing androgen receptor (AR)-regulated prostate-specific enzyme human kallikrein-related peptidase 2 (hK2; KLK2). In multiple rodent models, Actinium-225-labeled hu11B6-IgG1 ([225Ac]hu11B6-IgG1) has shown promising treatment efficacy. In the present study, we investigated options to enhance and optimize [225Ac]hu11B6 treatment. First, we evaluated the possibility of exploiting IgG3, the IgG subclass with superior activation of complement and ability to mediate FC-γ-receptor binding, for immunotherapeutically enhanced hK2 targeted α-radioimmunotherapy. Second, we compared the therapeutic efficacy of a single high activity vs. fractionated activity. Finally, we used RNA sequencing to analyze the genomic signatures of prostate cancer that progressed after targeted α-therapy. [225Ac]hu11B6-IgG3 was a functionally enhanced alternative to [225Ac]hu11B6-IgG1 but offered no improvement of therapeutic efficacy. Progression-free survival was slightly increased with a single high activity compared to fractionated activity. Tumor-free animals succumbing after treatment revealed no evidence of treatment-associated toxicity. In addition to up-regulation of canonical aggressive prostate cancer genes, such as MMP7, ETV1, NTS, and SCHLAP1, we also noted a significant decrease in both KLK3 (prostate-specific antigen ) and FOLH1 (prostate-specific membrane antigen) but not in AR and KLK2, demonstrating efficacy of sequential [225Ac]hu11B6 in a mouse model.
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| 3. |
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| 4. |
- Bruce, Gösta, et al.
(author)
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Hur rytmen stiger och faller – om rytmiska mönster i talet.
- 2003
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In: Rytm och dialog: studier framlagda vid åttonde nordiska metrikkonferensen, Umeå 4-7 oktober 2001 ; Skrifter utgivna av Centrum för metriska studier. - 9187988119 ; 14, s. 49-60
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Conference paper (other academic/artistic)
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| 5. |
- Cuzick, Jack, et al.
(author)
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Prevention and early detection of prostate cancer.
- 2014
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In: The Lancet Oncology. - 1470-2045 .- 1474-5488. ; 15:11, s. e484-92
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Journal article (peer-reviewed)abstract
- Prostate cancer is a common malignancy in men and the worldwide burden of this disease is rising. Lifestyle modifications such as smoking cessation, exercise, and weight control offer opportunities to reduce the risk of developing prostate cancer. Early detection of prostate cancer by prostate-specific antigen (PSA) screening is controversial, but changes in the PSA threshold, frequency of screening, and the use of other biomarkers have the potential to minimise the overdiagnosis associated with PSA screening. Several new biomarkers for individuals with raised PSA concentrations or those diagnosed with prostate cancer are likely to identify individuals who can be spared aggressive treatment. Several pharmacological agents such as 5α-reductase inhibitors and aspirin could prevent development of prostate cancer. In this Review, we discuss the present evidence and research questions regarding prevention, early detection of prostate cancer, and management of men either at high risk of prostate cancer or diagnosed with low-grade prostate cancer.
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| 6. |
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| 7. |
- Elmståhl, Sölve, et al.
(author)
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Autonomic cardiovascular responses to tilting in patients with alzheimer's disease and in healthy elderly women
- 1992
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In: Age and Ageing. - : Oxford University Press (OUP). - 0002-0729 .- 1468-2834. ; 21:4, s. 301-307
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Journal article (peer-reviewed)abstract
- The cardiovascular responses to tilting and breathing were studied in 24 patients with late-onset Alzheimer's disease (AD) and 54 healthy control women aged between 75 and 96 years in order to study the parasympathetic and sympathetic heart-rate control. The cardiovascular response to tilting and breathing showed no age-associated decrease in the healthy control women. During rest, the AD patients had lower mean systolic and diastolic blood pressure but the same heart rate as the control patients. After tilting, the AD patients had a greater increase in heart rate, and the mean systolic blood pressure fell to 126 mmHg compared with 160 mmHg in the control women (p<0.001). After the initial acceleration, the following deceleration of the heart rate, an expression of parasympathetic nervous activity, was lower in the AD patients (p <0.001). The deep-breathing test showed no significant difference between the two groups, but the changes of acceleration and brake indices could indicate a dysfunction of the autonomic nervous system since the AD patients were not recumbent.
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| 8. |
- Evans Axelsson, Susan, et al.
(author)
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Targeting free prostate-specific antigen for in vivo imaging of prostate cancer using a monoclonal antibody specific for unique epitopes accessible on free prostate-specific antigen alone
- 2012
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In: Cancer Biotherapy and Radiopharmaceuticals. - : Mary Ann Liebert Inc. - 1084-9785 .- 1557-8852. ; 27:4, s. 243-251
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Journal article (peer-reviewed)abstract
- This study investigated the feasibility of targeting the free, unbound forms of prostate-specific antigen (fPSA) for in vivo imaging of prostate adenocarcinomas (PCa), as PSA is produced and secreted at abundance during every clinical stage and grade of PCa, including castration-resistant disease. We injected 125I-labeled monoclonal antibody PSA30 (specific for an epitope uniquely accessible on fPSA alone) intravenously in male nude mice carrying subcutaneous xenografts of LNCaP tumors (n=36). Mice were sacrificed over a time course from 4 hours to 13 days after injecting 125I-labeled PSA30. Tissue uptake of 125I-PSA30 at 48 and 168 hours after intravenous injection was compared with two clinically used positron emission tomography radiopharmaceuticals, 18F-fluoro-deoxy-glucose (18F-FDG) or 18F-choline, in cryosections using Digital AutoRadiography (DAR) and also compared with immunohistochemical staining of PSA and histopathology. On DAR, the areas with high 125I-PSA30 uptake corresponded mainly to morphologically intact and PSA-producing LNCaP cells, but did not associate with the areas of high uptake of either 18F-FDG or 18F-choline. Biodistribution of 125I-PSA30 measured in dissected organs ex vivo during 4 to 312 hours after intravenous injection demonstrated maximum selective tumor uptake 24–48 hours after antibody injection. Our data showed selective uptake in vivo of a monoclonal antibody highly specific for fPSA in LNCaP cells. Hence, in vivo imaging of fPSA may be feasible with putative usefulness in disseminated PCa.
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| 9. |
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Fiske, jordbruk och klimat i Östersjöregionen under förmodern tid. : Projektet Förmoderna kustmiljöer. Rapport 3.
- 2012. - 1
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Editorial collection (peer-reviewed)abstract
- Projektet Förmoderna kustmiljöer handlar om samspelet mellan kustmiljöernas förändring och människors liv från yngre järnålder till tidigt 1800-tal. Projektet ställer naturprocesser mot samhälleliga förändringar i ett försök att förstå samspelet mellan människa och miljö. Det har lagts upp som en samverkan mellan forskare från historia, arkeologi och geografi, och det har hvudsakligen varit inriktat på jämförande studier mellan Södertörns kustområden och Estland, särskilt Ösel. Denna rapport är den tredje och sista. Den ger bland annat en sammanfattning av de övergripande projektresultaten.
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| 10. |
- Fällmar, David, et al.
(author)
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Arterial spin labeling-based Z-maps have high specificity and positive predictive value for neurodegenerative dementia compared to FDG-PET.
- 2017
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In: European Radiology. - : Springer Science and Business Media LLC. - 0938-7994 .- 1432-1084. ; 27:10, s. 4237-4246
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Journal article (peer-reviewed)abstract
- OBJECTIVE: Cerebral perfusion analysis based on arterial spin labeling (ASL) MRI has been proposed as an alternative to FDG-PET in patients with neurodegenerative disease. Z-maps show normal distribution values relating an image to a database of controls. They are routinely used for FDG-PET to demonstrate disease-specific patterns of hypometabolism at the individual level. This study aimed to compare the performance of Z-maps based on ASL to FDG-PET.METHODS: Data were combined from two separate sites, each cohort consisting of patients with Alzheimer's disease (n = 18 + 7), frontotemporal dementia (n = 12 + 8) and controls (n = 9 + 29). Subjects underwent pseudocontinuous ASL and FDG-PET. Z-maps were created for each subject and modality. Four experienced physicians visually assessed the 166 Z-maps in random order, blinded to modality and diagnosis.RESULTS: Discrimination of patients versus controls using ASL-based Z-maps yielded high specificity (84%) and positive predictive value (80%), but significantly lower sensitivity compared to FDG-PET-based Z-maps (53% vs. 96%, p < 0.001). Among true-positive cases, correct diagnoses were made in 76% (ASL) and 84% (FDG-PET) (p = 0.168).CONCLUSION: ASL-based Z-maps can be used for visual assessment of neurodegenerative dementia with high specificity and positive predictive value, but with inferior sensitivity compared to FDG-PET.KEY POINTS: • ASL-based Z-maps yielded high specificity and positive predictive value in neurodegenerative dementia. • ASL-based Z-maps had significantly lower sensitivity compared to FDG-PET-based Z-maps. • FDG-PET might be reserved for ASL-negative cases where clinical suspicion persists. • Findings were similar at two study sites.
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| 11. |
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| 12. |
- Haller, Sven, et al.
(author)
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Amyloid Load, Hippocampal Volume Loss, and Diffusion Tensor Imaging Changes in Early Phases of Brain Aging
- 2019
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In: Frontiers in Neuroscience. - : FRONTIERS MEDIA SA. - 1662-4548 .- 1662-453X. ; 13
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Journal article (peer-reviewed)abstract
- Background and Purpose Amyloid imaging, gray matter (GM) morphometry and diffusion tensor imaging (DTI) have all been used as predictive biomarkers in dementia. Our objective was to define the imaging profile of healthy elderly controls as a function of their cognitive trajectories and explore whether amyloid burden and white matter (WM) microstructure changes are associated with subtle decrement of neuropsychological performances in old age. Materials and Methods We performed a 4.5-year longitudinal study in 133 elderly individuals who underwent cognitive testing at inclusion and follow-up, amyloid PET, MRI including DTI sequences at inclusion, and APOE epsilon 4 genotyping. All cases were assessed using a continuous cognitive score (CCS) taking into account the global evolution of neuropsychological performances. Data processing included region of interest analysis of amyloid PET analysis, GM densities and tract-based spatial statistics (TBSS)-DTI. Regression models were built to explore the association between the CCS and imaging parameters controlling for significant demographic and clinical covariates. Results Amyloid uptake was not related to the cognitive outcome. In contrast, GM densities in bilateral hippocampus were associated with worst CCS at follow-up. In addition, radial and axial diffusivities in left hippocampus were negatively associated with CCS. Amyloid load was associated with decreased VBM and increased radial and axial diffusivity in the same area. These associations persisted when adjusting for gender and APOE4 genotype. Importantly, they were absent in amygdala and neocortical areas studied. Conclusion The progressive decrement of neuropsychological performances in normal aging is associated with volume loss and WM microstructure changes in hippocampus long before the emergence of clinically overt symptoms. Higher amyloid load in hippocampus is compatible with cognitive preservation in cases with better preservation of GM densities and WM microstructure in this area.
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| 13. |
- Haller, Sven, et al.
(author)
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PET amyloid in normal aging : direct comparison of visual and automatic processing methods
- 2020
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In: Scientific Reports. - : NATURE RESEARCH. - 2045-2322. ; 10
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Journal article (peer-reviewed)abstract
- Assessment of amyloid deposits is a critical step for the identification of Alzheimer disease (AD) signature in asymptomatic elders. Whether the different amyloid processing methods impacts on the quality of clinico-radiological correlations is still unclear. We directly compared in 155 elderly controls with extensive neuropsychological testing at baseline and 4.5 years follow-up three approaches: (i) operator-dependent standard visual reading, (ii) operator-independent automatic SUVR with four different reference regions, and (iii) novel operator and region of reference-independent automatic A beta-index. The coefficient of variance was used to examine inter-individual variability for each processing method. Using visually-established amyloid positivity as the gold standard, the area under the receiver operating characteristic curve (ROC) was computed. Linear regression models were used to assess the association between changes in continuous cognitive score and amyloid uptake values. In SUVR analyses, the coefficient of variance varied from 1.718 to 1.762 according to the area of reference and was of - 3.045 for the A beta-index method. Compared to the visual rating, A beta-index method showed the largest area under the ROC curve [0.9568 (95% CI 0.9252, 0.98833)]. The best cut-off score was of - 0.3359 with sensitivity and specificity values of 0.97 and 0.83, respectively. Only the A beta-index was related to more severe decrement of cognitive performances [regression coefficient: 9.103 (95% CI 1.148, 17.058)]. The A beta-index is considered as preferred option in asymptomatic elders, since it is operator-independent, avoids the selection of reference area, is closer to established visual scoring and correlates with the evolution of cognitive performances.
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| 14. |
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| 15. |
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| 16. |
- Kusterer, Hanna Li, 1976-, et al.
(author)
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Krokiga vägar till etablering – upplevda hinder för arbetsmarknadsetablering av migranter under coronapandemin
- 2021
-
Conference paper (peer-reviewed)abstract
- Arbetsmarknadsetablering av migranter i Sverige innefattar både möjligheter till arbetskraft för arbetsgivare och meningsfull sysselsättning och försörjning för den enskilde. Denna är dock kantad av hinder i arbetsmarknadsintegration och förmåga att ta tillvara på kompetens som utvecklats utanför Sverige. Hindren är särskilt uttalade för personer som saknar gymnasieutbildning eller formell yrkesutbildning. Arbetskraftsdeltagandet är lägre för utlandsfödda än för svenskfödda, och kvinnliga flyktingar och asylinvandrare med lågutbildningsnivå står utanför arbetsmarknaden i mycket stor utsträckning. Därtill satsas mindre resurser på arbetsmarknadsintegration för kvinnor än för män, och det är även en lägre andel kvinnor med låg utbildning som väljer att delta i Arbetsförmedlingens etableringsinsatser. Föreliggande studie ingår i ett delprojekt inom Integration Gävleborg 2.0, ett forsknings- och utvecklingsprojekt som drivs av Länsstyrelsen Gävleborg. Gävleborg har tagit emot ett stort antal nyanlända och regionen har generellt låg utbildningsnivå och hög arbetslöshet i jämförelse med riksgenomsnittet. Dessa aspekter gör arbetsmarknadsetablering särskilt svår för migranter med begränsad skolgång. Det har också blivit tydligt hur coronapandemin ytterligare begränsat möjligheterna till arbetsmarknadsetablering och integration.
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| 17. |
- Kusterer, Hanna Li, 1976-, et al.
(author)
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Tre år senare : Migranter berättar om sina vägar mot arbetsmarknadsetablering
- 2024
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Reports (other academic/artistic)abstract
- För många migranter från utomeuropeiska länder tar det lång tid att etablera sig i Sverige. Det gäller i synnerhet personer med låg utbildning, och särskilt kvinnor som saknar erfarenhet av lönearbete i hemlandet. Denna rapport handlar om migranter i Gävleborgs län, som fått asyl i Sverige, avslutat etableringsperioden och stod utanför den reguljära arbetsmarknaden år 2020. Under 2020 genomfördes intervjuer med 23 personer i tre kommuner som gick på SFI. Knappt tre år senare (2023) kontaktade vi deltagarna igen för att ta reda på om de kommit närmare arbetsmarknadsetablering och hur de såg på sin livssituation och framtid. Vi fick kontakt med 13 personer varav 8 medverkade i en ny intervju. För att öka förståelsen för migranternas perspektiv har vi dessutom intervjuat 10 personer från andra kommuner med liknande bakgrund och livssituation som de ursprungliga deltagarna. Resultaten visar att nästan alla respondenter hade kommit närmare arbetsmarknaden och såg ljusare på tillvaron än under 2020. Samtliga hade kommit ut på arbetsplatser genom praktik och anställningar, och många hade gått eller gick på yrkesutbildningar. Att behärska svenska språket upplevdes centralt. Det betraktades som nyckeln till att kunna få ett arbete, samtidigt som arbetet sågs som det bästa sättet att utveckla språket. Det förefaller vara ganska stora skillnader mellan vilket stöd migranter i olika kommuner får. Migranterna uttryckte också stora variationer avseende behov av stöd, vilka hinder de mötte, och i vilken utsträckning de kunde styra sin tillvaro och bestämma en väg framåt. Alla var motiverade till att arbeta och skapa en bättre framtid för sig och sina barn, men det var tydligt att myndigheterna behöver anpassa sina insatser till varje persons individuella förutsättningar för att kunna realisera detta.
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| 18. |
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| 19. |
- Kåreholt, Ingemar, 1960-, et al.
(author)
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Of premature demise - a follow-up study of young men exposed to violence in Sweden
- 2018
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In: International Journal of Behavioral Medicine. - : Springer. - 1070-5503 .- 1532-7558. ; 25:Suppl. 1, s. S75-S75
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Journal article (peer-reviewed)abstract
- Introduction & Purpose: The discourse of violence has largely focused on female victims of male violence, and partly ignored male victims. More men than women die of homicide and are exposed to non-fatal violence. Being physically assaulted is a traumatic experience with serious and long-lasting consequences. It is primarily young men aged 16-24 who suffer from violence. It can be difficult for these men to be in the role of victims, and this can be reinforced by norms that say masculinity stands for power and strength while the role of crime victims is rather an expression of weakness. The purpose of the study are to analyze mortality patterns among men aged 18-24 who have been exposed to violence leading to hospital care.Methods: Register data including all men in Sweden 18-24 years that received at least one night of hospital care after injury from another person in 1992-2005. For each hospitalized man, nine age-matched men were randomly selected from the population each year. Data is available from the year before hospitalization/inclusion and 10 years after (or to 2006 when follow-up ends).Results: Analyses are based on Cox regressions, controlled for age, days of inpatient care from violence, days of hospital care for other reasons, degree of urbanization, country of birth, presence of preschool children, gainfully employed/ not, financial assistance/not, education, and income. Compared to men from the population, exposed men had >3 times higher risk (HR=3.34) for all-cause mortality, >4 times higher risk (HR=4.16) to die from suicide, and about 20 times higher risk (HR=19.63) to die from violence. The difference between exposed and non-exposed men in all-cause mortality, decrease significantly over the 10-year follow-up from HR 4.48 to 2.66, in mortality from violence from HR 45.23 to 2.06. Regarding mortality from violence, the difference between exposed and non-exposed men was not significant after 10 years. The risk difference to die from suicide remained stable over the follow-up period.Conclusions: Paying attention to the long-term consequences from violence, there are also opportunities to change the situation and allow for alternative development for men who have been abused. This is especially important when it comes to the risk for suicide.
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| 20. |
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Leva vid Östersjöns kust : en antologi om naturförutsättningar och resursutnyttjande på båda sidor av Östersjön ca 800-1800 : rapport 2 / från projektet Förmoderna kustmiljöer, naturresurser, klimat, och samhälle vid östersjökusten före 1800 - ett miljöhistoriskt projekt
- 2008. - 1
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Editorial collection (other academic/artistic)abstract
- Projektet "Förmoderna kustmiljöer" handlar om samspelet mellan kustmiljöernas förändring och människornas liv huvudsakligen under de senaste 1500 åren. Projektet ställer naturprocesser mot samhälleliga förändringar i ett försök att förstå samspelet mellan människa och miljö. Kustens resurser bildar en fond mot vilken vi försöker förstå människornas verksamheter, strategier och tänkande. Naturens utmaning möter människors kamp och anpassning, och i den processen skapas landskap och miljöer. Förändringarna är ofta smygande, nästan omärkligt gradvisa, men ibland också kortsiktiga, tillfälliga och dramatiska. Projektet strävar efter att belysa utvecklingen ur båda dessa tidsperspektiv, i ett försök att se historiens riktning, upptäcka brytpunkter och eventuella "systemskiften".
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| 21. |
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| 22. |
- Lileikyte, Gabriele, et al.
(author)
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Serum proteome profiles in patients treated with targeted temperature management after out-of-hospital cardiac arrest
- 2023
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In: Intensive Care Medicine Experimental. - 2197-425X. ; 11:1
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Journal article (peer-reviewed)abstract
- BACKGROUND: Definition of temporal serum proteome profiles after out-of-hospital cardiac arrest may identify biological processes associated with severe hypoxia-ischaemia and reperfusion. It may further explore intervention effects for new mechanistic insights, identify candidate prognostic protein biomarkers and potential therapeutic targets. This pilot study aimed to investigate serum proteome profiles from unconscious patients admitted to hospital after out-of-hospital cardiac arrest according to temperature treatment and neurological outcome.METHODS: Serum samples at 24, 48, and 72 h after cardiac arrest at three centres included in the Target Temperature Management after out-of-hospital cardiac arrest trial underwent data-independent acquisition mass spectrometry analysis (DIA-MS) to find changes in serum protein concentrations associated with neurological outcome at 6-month follow-up and targeted temperature management (TTM) at 33 °C as compared to 36 °C. Neurological outcome was defined according to Cerebral Performance Category (CPC) scale as "good" (CPC 1-2, good cerebral performance or moderate disability) or "poor" (CPC 3-5, severe disability, unresponsive wakefulness syndrome, or death).RESULTS: Of 78 included patients [mean age 66 ± 12 years, 62 (80.0%) male], 37 (47.4%) were randomised to TTM at 36 °C. Six-month outcome was poor in 47 (60.3%) patients. The DIA-MS analysis identified and quantified 403 unique human proteins. Differential protein abundance testing comparing poor to good outcome showed 19 elevated proteins in patients with poor outcome (log 2-fold change (FC) range 0.28-1.17) and 16 reduced proteins (log 2(FC) between - 0.22 and - 0.68), involved in inflammatory/immune responses and apoptotic signalling pathways for poor outcome and proteolysis for good outcome. Analysis according to level of TTM showed a significant protein abundance difference for six proteins [five elevated proteins in TTM 36 °C (log 2(FC) between 0.33 and 0.88), one reduced protein (log 2(FC) - 0.6)] mainly involved in inflammatory/immune responses only at 48 h after cardiac arrest. CONCLUSIONS: Serum proteome profiling revealed an increase in inflammatory/immune responses and apoptosis in patients with poor outcome. In patients with good outcome, an increase in proteolysis was observed, whereas TTM-level only had a modest effect on the proteome profiles. Further validation of the differentially abundant proteins in response to neurological outcome is necessary to validate novel biomarker candidates that may predict prognosis after cardiac arrest.
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| 23. |
- Lilja, John, et al.
(author)
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Counselling och forskning
- 2010. - 1
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In: Counselling. - Stockholm : Gothia. - 9789172056688 ; , s. 155-175
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Book chapter (other academic/artistic)
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| 24. |
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| 25. |
- Lilja, Sven, 1947-
(author)
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Appendix - Projektbeskrivning : förmoderna kustmiljöer. Naturresurser, klimat och samhälle vid östersjökusten före 1800 - ett miljöhistoriskt projekt
- 2006
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In: Människan anpassaren - människan överskridaren. - Huddinge : Södertörns högskola. - 9789189315617 - 9189315618 ; , s. 231-241
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Book chapter (other academic/artistic)abstract
- Projektet Förmoderna kustmiljöer. Natur, klimat och samhälle vid Östersjökusten före ca 1800 är en komparativ miljöhistorisk studie av lokalt resursutnyttjande och miljöpåverkan under förmodern tid (järnålder till tidigt 1800-tal). Projektets övergripande tema ”människoskapade miljöförändringarkontra naturprocesser” undersöks genom intensivstudier av några lokalakustsamhällens elasticitet och överlevnadsförmåga. Såväl långsiktiga somkortsiktiga förändringar studeras. Hur anpassade sig sådana samhällen tilllångsamma naturprocesser, och vilka strategier valdes för att hantera kortarehistoriska fluktuationer och förändringsförlopp? Vilka konsekvenser fick devalda anpassningsstrategierna för närmiljön? Projektet syftar till ett disciplinöverskridande samarbete mellan arkeologi, historia och geografi. Delprojekten behandlar kompletterande perspektiv, där yttre naturförhållanden(landhöjning, klimatförändringar och växlingar i den marinbiologiska faunanetc.), samt yttre samhällsförhållanden (närhet till stat och marknad) ställsmot lokalsamhällets inre anpassnings- och förändringsstrategier. Undersökningen är komparativ, med undersökningsområden i lokala kust- och skärgårdsmiljöer vid Östersjön. I första hand kommer Stockholms södra skärgård och Estlands kust, med Saaremaa (Ösel) och Hiumaa (Dagö), att studeras, men även områden i Finland och västra Ryssland.
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