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- Lindsey, Merry L. L., et al.
(author)
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Skin wound healing as a mirror to cardiac wound healing
- 2023
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In: Experimental Physiology. - : John Wiley & Sons. - 0958-0670 .- 1469-445X. ; 108:8, s. 1003-1010
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Journal article (peer-reviewed)abstract
- Wound healing is a general response of the body to injury. All organs share in commonthree response elements to wound healing: inflammation to prevent infection andstimulate the removal of dead cells, active anti-inflammatory signalling to turn off theinflammatory response, and a repair phase characterized by extracellular matrix scarformation. The extent of scar formed depends on the ability of endogenous cells thatpopulate each organ to regenerate. The skin has keratinocytes that have regenerativecapacity, and in general, wounds are fully re-epithelialized. Heart, in contrast, hascardiac myocytes that have little to no regenerative capacity, and necrotic myocytesare entirely replaced by scars. Despite differences in tissue regeneration, the skin andheart share many wound-healing properties that can be exploited to predict the cardiacresponse to pathology. We summarize in this review article our current understandingof how the response of the skin to a wounding event can inform us about the ability ofthe myocardium to respond to a myocardial infarction.
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