| 1. |
- Liu, Yehai, et al.
(författare)
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Prognostic significance of matrix metalloproteinase-20 overexpression in laryngeal squamous cell carcinoma
- 2011
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Ingår i: Acta Oto-Laryngologica. - : Informa UK Limited. - 0001-6489 .- 1651-2251. ; 131:7, s. 769-773
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Tidskriftsartikel (refereegranskat)abstract
- Conclusion: Matrix metalloproteinase (MMP)-20 is overexpressed in laryngeal squamous cell carcinoma (LSCC) compared with the adjacent normal laryngeal epithelium and MMP-20 plays a role in lymph node metastasis. Overexpression of MMP-20 may be used as a significant prognostic factor for lymph node metastasis. All the findings indicate that MMP-20 may play a role in the initiation and progression of LSCC. Objective: The MMPs are a gene family of zinc-dependent endopeptidases that have been implicated in tumor invasion and metastasis, and MMP-20 is a new member of the MMP family. The purpose of this study was to investigate whether MMP-20 is overexpressed in human LSCC and, if so, the significance of its overexpression in relation to clinical parameters. Methods: We analyzed 33 cases of LSCC with RT-PCR and 73 cases of LSCC with immunohistochemistry compared with normal laryngeal epithelium. Results: We found that MMP-20 is overexpresssed in LSCC compared with the adjacent normal laryngeal epithelium.
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| 2. |
- Ma, Chao, et al.
(författare)
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Applications of X-ray and Electron Crystallography in Structural Investigations of Zeolites
- 2021
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Ingår i: Gaodeng xuéxiào huàxué xuébào. - 0251-0790. ; 42:1, s. 188-200
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Tidskriftsartikel (refereegranskat)abstract
- Zeolites, a class of crystalline microporous materials with unique channels or cavities, have excellent performance in adsorption, separation, and catalysis. In order to correlate the structure-properly relationship, it is essential to determine the crystallographic structures of zeolite at the atomic level. In this review, a series of conventional and emerging techniques regarding X-ray crystallography and electron crystallography for characterizing the crystallographic structures of zeolites through real space and reciprocal space are introduced. Furthermore, 85 recently discovered novel zeolites are systemically summarized based on the structure determination approaches and their chemical compositions. Nine zeolites with different framework type codes(FTCs) are further highlighted due to their unique synthetic methodologies or structural features.
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| 3. |
- Geng, Longlong, et al.
(författare)
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Valence-mixed CuOx-nanoparticles anchored biomass-based carbon nanofiber for boosting toxic nitroarenes reduction : Synthesis, kinetics, and mechanisms
- 2022
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Ingår i: Journal of Environmental Chemical Engineering. - : Elsevier. - 2213-3437. ; 10:6
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Tidskriftsartikel (refereegranskat)abstract
- The rational modulation of metal catalysts with tailorable valence and redox properties is a promising strategy for further improving their catalytic performance. Herein, an environment-friendly grafting and thermal strategy was adopted to immobilize copper oxides nanoparticles on carbon nanofiber (CuOx/CF). Benefiting from the defect-rich surface and valence-mixed composition of the CuOx species, the optimized sample CuOx/CF-3 exhibits superb activity for the catalytic reduction of toxic nitrophenols. The complete conversion took only 1 min and an outstanding rate constant (k) of 112.7 × 10-3 s-1 was achieved under mild conditions (25 °C and 1 atm). Kinetic and recycle experiments demonstrated that the whole catalytic process obeys a pseudo-order kinetic, and the catalyst could maintain high conversion even after 13 successive recycles. These results demonstrate that CuOx/CF-3 is an alternative catalyst to noble metals, providing superb catalytic efficiency and stability in the reduction of toxic nitrophenols, and it can be expanded to develop other noble-metal-free catalysts for various applications.
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| 4. |
- Gu, Jian, et al.
(författare)
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TGF-beta-Induced CD4(+) Foxp3(+) T Cells Attenuate Acute Graft-versus-Host Disease by Suppressing Expansion and Killing of Effector CD8(+) Cells
- 2014
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Ingår i: Journal of Immunology. - : The American Association of Immunologists. - 0022-1767 .- 1550-6606. ; 193:7, s. 3388-3397
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Tidskriftsartikel (refereegranskat)abstract
- The use of TGF-beta-induced CD4(+) Foxp3(+) T cells (induced regulatory T cells [iTregs]) is an important prevention and treatment strategy in autoimmune diseases and other disorders. However, the potential use of iTregs as a treatment modality for acute graft-versus-host disease (aGVHD) has not been realized because they may be unstable and less suppressive in this disease. We restudied the ability of iTregs to prevent and treat aGVHD in two mouse models. Our results showed that, as long as an appropriate iTreg-generation protocol is used, these iTregs consistently displayed a potent ability to control aGVHD development and reduce mortality in the aGVHD animal models. iTreg infusion markedly suppressed the engraftment of donor CD8(+) cells and CD4(+) cells, the expression of granzyme A and B, the cytotoxic effect of donor CD8(+) cells, and the production of T cell cytokines in aGVHD. Therefore, we conclude that as long as the correct methods for generating iTregs are used, they can prevent and even treat aGVHD.
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| 5. |
- Lin, Shangrong, et al.
(författare)
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Underestimated Interannual Variability of Terrestrial Vegetation Production by Terrestrial Ecosystem Models
- 2023
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Ingår i: Global Biogeochemical Cycles. - 0886-6236. ; 37:4
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Tidskriftsartikel (refereegranskat)abstract
- Vegetation gross primary production (GPP) is the largest terrestrial carbon flux and plays an important role in regulating the carbon sink. Current terrestrial ecosystem models (TEMs) are indispensable tools for evaluating and predicting GPP. However, to which degree the TEMs can capture the interannual variability (IAV) of GPP remains unclear. With large data sets of remote sensing, in situ observations, and predictions of TEMs at a global scale, this study found that the current TEMs substantially underestimate the GPP IAV in comparison to observations at global flux towers. Our results also showed the larger underestimations of IAV in GPP at nonforest ecosystem types than forest types, especially in arid and semiarid grassland and shrubland. One cause of the underestimation is that the IAV in GPP predicted by models is strongly dependent on canopy structure, that is, leaf area index (LAI), and the models underestimate the changes of canopy physiology responding to climate change. On the other hand, the simulated interannual variations of LAI are much less than the observed. Our results highlight the importance of improving TEMs by precisely characterizing the contribution of canopy physiological changes on the IAV in GPP and of clarifying the reason for the underestimated IAV in LAI. With these efforts, it may be possible to accurately predict the IAV in GPP and the stability of the global carbon sink in the context of global climate change.
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| 6. |
- Wang, Lei, et al.
(författare)
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Exploring Bronsted acids confined in the 10-ring channels of the zeolite ferrierite
- 2018
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Ingår i: CrystEngComm. - : Royal Society of Chemistry (RSC). - 1466-8033. ; 20:6, s. 699-702
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Tidskriftsartikel (refereegranskat)abstract
- Locations of Bronsted acids confined in the 10-ring channels of ferrierite have been unravelled by refining structural models of as-made and probe-molecule-adsorbed samples against powder X-ray diffraction data, respectively. By analysing both refinement results, it is suggested that Bronsted acid sites can be tailored by controlling the distribution of inorganic ions.
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| 7. |
- Wang, Zheng, et al.
(författare)
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Trade-off effect of hydrogen-bonded dopant-free hole transport materials on performance of inverted perovskite solar cells
- 2024
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Ingår i: Nano Energy. - 2211-2855. ; 128
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Tidskriftsartikel (refereegranskat)abstract
- Benefiting from their ordered orientation and superior stability compared to traditional conjugated materials, hydrogen bonding (HB)-induced H-aggregates in organic small molecule hole-transport materials (HTMs) hold a big potential for high-performance inverted perovskite solar cells (IPSCs). However, H-aggregates can also lead to excessive face-aggregation by forming the gaps between aggregates, which is in turn unfavorable for charge mobility and thus for the overall device performance. Herein, we design and synthesize a new set of HB-containing triphenylamine-based small molecules to tailor the degree of H-aggregation, namely O1 (without HB), O2 (unilateral HB unit), and O3 (bilateral HB units). These HTMs make a clear trade-off effect on the charge mobility within the HTM and the interfacial properties of perovskite and HTM. Although the interfacial hole extraction process is promoted upon the HB-functionalized interface, the best performance of IPSCs is still achieved by O1 HTM, which is mainly influenced by the higher hole mobility without HB-induced H-aggregates. Nevertheless, the photo stability of as-fabricated devices is effectively improved upon the HB passivation effect on the interface of HTM (O2 or O3) and perovskite, as well as the better quality of atop perovskite layers with less grain boundary compared to the reference case (O1).
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| 8. |
- Yan, Nana, et al.
(författare)
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Probing locations of organic structure-directing agents (OSDAs) and host-guest interactions in CHA-type SAPO-34/44
- 2018
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Ingår i: Microporous and Mesoporous Materials. - : Elsevier BV. - 1387-1811 .- 1873-3093. ; 264, s. 55-59
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Tidskriftsartikel (refereegranskat)abstract
- In this work, we have synthesized four SAPO-34/44 (framework type code: CHA) samples by utilizing different organic structure-directing agent (OSDA) such as cyclohexylamine (CA), n-butylamine (BA), diisopropylamine (DIPA), and dipropylamine (DPA). An approach combining Rietveld refinement and simulated annealing has been successfully applied to determine the location of the individual OSDA and the host (inorganic framework)-guest (OSDA) interaction. The final Rietveld refinements show that 1) one cha cage can be occupied by either two OSDAs (CA and BA) in the up-and-down arrangement or one OSDA (DIPA and DPA) in the longitudinal configuration and 2) the classical hydrogen bond between CA/BA and the inorganic framework in SAPO-44-CA and SAPO-34-BA could be identified. The host-guest interactions among these four samples are also investigated by FT-IR, which are consistent with Rietveld refinement results. The approach employed here could be applicable for the host-guest investigation in other crystalline porous materials.
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