| 1. |
- Evangelou, Evangelos, et al.
(author)
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Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.
- 2018
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 50:10, s. 1412-1425
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Journal article (peer-reviewed)abstract
- High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.
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| 2. |
- Grover, Francis, et al.
(author)
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Intermittent coupling between grip force and load force during oscillations of a hand-held object
- 2018
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In: Experimental Brain Research. - : Springer Berlin/Heidelberg. - 0014-4819 .- 1432-1106. ; 236:10, s. 2531-2544
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Journal article (peer-reviewed)abstract
- Tightly coordinated grip force adaptations in response to changing load forces have been reported as continuous, stable, and proportional to the load force changes. Considering the existence of inherent sensorimotor feedback delays, current accounts of grip force–load force coupling invoke explicit predictive mechanisms in the form of internal models for feedforward control to account for anticipatory grip force modulations. However, recent findings suggest that the stability and regularity of grip force–load force coupling is less persistent than previously thought. Thus, the objective of the current study was to comprehensively quantify the time-varying characteristics of grip force–load force coupling. Investigations into the coupling’s dynamics during continuous 30 s bouts of load force oscillation revealed intermittent phases of coordination, as well as phases that varied in stability, rather than a persistent and continuously stable pattern of coordination. These findings have important implications for accounts of grip force–load force coupling and of anticipation in motor control, more broadly.
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| 3. |
- Lamb, Maurice, et al.
(author)
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A Hierarchical Behavioral Dynamic Approach for Naturally Adaptive Human-Agent Pick-and-Place Interactions
- 2019
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In: Complexity. - : John Wiley & Sons. - 1076-2787 .- 1099-0526.
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Journal article (peer-reviewed)abstract
- Interactive or collaborative pick-and-place tasks occur during all kinds of daily activities, for example, when two or more individuals pass plates, glasses, and utensils back and forth between each other when setting a dinner table or loading a dishwasher together. In the near future, participation in these collaborative pick-and-place tasks could also include robotic assistants. However, for human-machine and human-robot interactions, interactive pick-and-place tasks present a unique set of challenges. A key challenge is that high-level task-representational algorithms and preplanned action or motor programs quickly become intractable, even for simple interaction scenarios. Here we address this challenge by introducing a bioinspired behavioral dynamic model of free-flowing cooperative pick-and-place behaviors based on low-dimensional dynamical movement primitives and nonlinear action selection functions. Further, we demonstrate that this model can be successfully implemented as an artificial agent control architecture to produce effective and robust human-like behavior during human-agent interactions. Participants were unable to explicitly detect whether they were working with an artificial (model controlled) agent or another human-coactor, further illustrating the potential effectiveness of the proposed modeling approach for developing systems of robust real/embodied human-robot interaction more generally.
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| 4. |
- Lamb, Maurice, et al.
(author)
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Behavioral Dynamics and Action Selection in a Joint Action Pick-and-Place Task
- 2017
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In: Proceedings of the 39th Annual Meeting of the Cognitive Science Society (CogSci). - : Cognitive Science Society. - 9780991196760 ; , s. 2506-2511
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Conference paper (peer-reviewed)abstract
- Many common tasks require or are made more efficient by coordinating with others. In this paper we investigate the coordination dynamics of a joint action pick-and-place task in order to identify the behavioral dynamics that underlie the emergence of human coordination. More precisely, we introduce a task dynamics approach for modeling multi-agent interaction in a continuous pick-and-place task where two agents must decide to work together or alone to move an object from one location to another. Our aims in the current paper are to identify and model (1) the relevant affordance dynamics that underlie the selection of the different action modes required by the task and (2) the trajectory dynamics of each actor’s hand movements when moving to grasp, relocate, or pass the object. We demonstrate that the emergence of successful coordination can be characterized in terms of behavioral dynamics models which may have applications for artificial agent design.
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| 5. |
- Nieuwenhuijsen, Mark, et al.
(author)
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The Superblock model : A review of an innovative urban model for sustainability, liveability, health and well-being
- 2024
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In: Environmental Research. - : Elsevier. - 0013-9351 .- 1096-0953. ; 251
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Research review (peer-reviewed)abstract
- IntroductionCurrent urban and transport planning practices have significant negative health, environmental, social and economic impacts in most cities. New urban development models and policies are needed to reduce these negative impacts. The Superblock model is one such innovative urban model that can significantly reduce these negative impacts through reshaping public spaces into more diverse uses such as increase in green space, infrastructure supporting social contacts and physical activity, and through prioritization of active mobility and public transport, thereby reducing air pollution, noise and urban heat island effects. This paper reviews key aspects of the Superblock model, its implementation and initial evaluations in Barcelona and the potential international uptake of the model in Europe and globally, focusing on environmental, climate, lifestyle, liveability and health aspects.MethodsWe used a narrative meta-review approach and PubMed and Google scholar databases were searched using specific terms.ResultsThe implementation of the Super block model in Barcelona is slow, but with initial improvement in, for example, environmental, lifestyle, liveability and health indicators, although not so consistently. When applied on a large scale, the implementation of the Superblock model is not only likely to result in better environmental conditions, health and wellbeing, but can also contribute to the fight against the climate crisis. There is a need for further expansion of the program and further evaluation of its impacts and answers to related concerns, such as environmental equity and gentrification, traffic and related environmental exposure displacement. The implementation of the Superblock model gained a growing international reputation and variations of it are being planned or implemented in cities worldwide. Initial modelling exercises showed that it could be implemented in large parts of many cities.ConclusionThe Superblock model is an innovative urban model that addresses environmental, climate, liveability and health concerns in cities. Adapted versions of the Barcelona Superblock model are being implemented in cities around Europe and further implementation, monitoring and evaluation are encouraged. The Superblock model can be considered an important public health intervention that will reduce mortality and morbidity and generate cost savings for health and other sectors.
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| 6. |
- Ntalla, Ioanna, et al.
(author)
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Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction
- 2020
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In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 11:1
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Journal article (peer-reviewed)abstract
- The electrocardiographic PR interval reflects atrioventricular conduction, and is associated with conduction abnormalities, pacemaker implantation, atrial fibrillation (AF), and cardiovascular mortality. Here we report a multi-ancestry (N=293,051) genome-wide association meta-analysis for the PR interval, discovering 202 loci of which 141 have not previously been reported. Variants at identified loci increase the percentage of heritability explained, from 33.5% to 62.6%. We observe enrichment for cardiac muscle developmental/contractile and cytoskeletal genes, highlighting key regulation processes for atrioventricular conduction. Additionally, 8 loci not previously reported harbor genes underlying inherited arrhythmic syndromes and/or cardiomyopathies suggesting a role for these genes in cardiovascular pathology in the general population. We show that polygenic predisposition to PR interval duration is an endophenotype for cardiovascular disease, including distal conduction disease, AF, and atrioventricular pre-excitation. These findings advance our understanding of the polygenic basis of cardiac conduction, and the genetic relationship between PR interval duration and cardiovascular disease. On the electrocardiogram, the PR interval reflects conduction from the atria to ventricles and also serves as risk indicator of cardiovascular morbidity and mortality. Here, the authors perform genome-wide meta-analyses for PR interval in multiple ancestries and identify 141 previously unreported genetic loci.
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| 7. |
- Roselli, Carolina, et al.
(author)
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Multi-ethnic genome-wide association study for atrial fibrillation
- 2018
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 50:9, s. 1225-1233
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Journal article (peer-reviewed)abstract
- Atrial fibrillation (AF) affects more than 33 million individuals worldwide(1) and has a complex heritability(2). We conducted the largest meta-analysis of genome-wide association studies (GWAS) for AF to date, consisting of more than half a million individuals, including 65,446 with AF. In total, we identified 97 loci significantly associated with AF, including 67 that were novel in a combined-ancestry analysis, and 3 that were novel in a European-specific analysis. We sought to identify AF-associated genes at the GWAS loci by performing RNA-sequencing and expression quantitative trait locus analyses in 101 left atrial samples, the most relevant tissue for AF. We also performed transcriptome-wide analyses that identified 57 AF-associated genes, 42 of which overlap with GWAS loci. The identified loci implicate genes enriched within cardiac developmental, electrophysiological, contractile and structural pathways. These results extend our understanding of the biological pathways underlying AF and may facilitate the development of therapeutics for AF.
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