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1.	Huang, J, et al. (author) Genome-wide association study for circulating tissue plasminogen activator levels and functional follow-up implicates endothelial STXBP5 and STX2 2014 In: Arteriosclerosis, thrombosis, and vascular biology. - 1524-4636. ; 34:5, s. 1093-1101 Journal article (peer-reviewed)
2.	Sabater-Lleal, M, et al. (author) Genome-Wide Association Transethnic Meta-Analyses Identifies Novel Associations Regulating Coagulation Factor VIII and von Willebrand Factor Plasma Levels 2019 In: Circulation. - 1524-4539. ; 139:5, s. 620-635 Journal article (peer-reviewed)
3.	Bennett, JA, et al. (author) The choline transporter Slc44a2 controls platelet activation and thrombosis by regulating mitochondrial function 2020 In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 11:1, s. 3479- Journal article (peer-reviewed)abstract Genetic factors contribute to the risk of thrombotic diseases. Recent genome wide association studies have identified genetic loci including SLC44A2 which may regulate thrombosis. Here we show that Slc44a2 controls platelet activation and thrombosis by regulating mitochondrial energetics. We find that Slc44a2 null mice (Slc44a2(KO)) have increased bleeding times and delayed thrombosis compared to wild-type (Slc44a2(WT)) controls. Platelets from Slc44a2(KO) mice have impaired activation in response to thrombin. We discover that Slc44a2 mediates choline transport into mitochondria, where choline metabolism leads to an increase in mitochondrial oxygen consumption and ATP production. Platelets lacking Slc44a2 contain less ATP at rest, release less ATP when activated, and have an activation defect that can be rescued by exogenous ADP. Taken together, our data suggest that mitochondria require choline for maximum function, demonstrate the importance of mitochondrial metabolism to platelet activation, and reveal a mechanism by which Slc44a2 influences thrombosis.
4.	Blankenberg, S, et al. (author) Diagnostic value of multimarker testing including myeloperoxidase in patients with acute coronary syndrome results from a multicentre biomarker study 2006 In: CIRCULATION. - 0009-7322. ; 114:18, s. 422-422 Conference paper (other academic/artistic)
5.	de Vries, PS, et al. (author) A genetic association study of circulating coagulation factor VIII and von Willebrand factor levels 2024 In: Blood. - 1528-0020. ; 143:18, s. 1845-1855 Journal article (peer-reviewed)
6.	Reventun, P, et al. (author) CD36 regulates factor VIII secretion from liver endothelial cells 2024 In: Blood advances. - 2473-9537. ; 8:1, s. 143-149 Journal article (peer-reviewed)
7.	Reynolds, MA, et al. (author) A cardiac marker panel for the diagnosis of acute myocardial infarction. 2004 In: CLINICAL CHEMISTRY. - 0009-9147. ; 50:6, s. A22-A22 Conference paper (other academic/artistic)

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Result 1-7 of 7

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Type of publication: journal article (5); conference paper (2)

Type of content: peer-reviewed (5); other academic/artistic (2)

Author/Editor: Lowenstein, CJ (7); Sabater-Lleal, M. (5); Smith, NL (5); de Vries, PS (4); Huffman, JE (4); Trompet, S (3); show more...; Yanek, LR (3); Jukema, JW (3); Psaty, BM (3); Stott, DJ (3); Fornage, M (3); Campbell, H (3); Johnson, AD (3); Wilson, JF (3); Morrison, AC (3); Hayward, C. (3); Polašek, O. (3); Rudan, I. (3); Chen, MH (3); Morange, PE (3); Tregouet, DA (3); Kleber, ME (3); Becker, DM (2); Hofman, A (2); Rotter, JI (2); Uitterlinden, AG (2); Ikram, MA (2); Caidahl, K (2); Martínez-Perez, A (2); Delgado, GE (2); Dehghan, A (2); Boerwinkle, E (2); Marz, W. (2); Rosendaal, FR (2); Strachan, DP (2); Souto, JC (2); Soria, JM (2); van der Harst, P (2); Kolcic, I. (2); Joshi, PK (2); Cushman, M (2); McKnight, B (2); de Maat, MPM (2); Tofler, GH (2); Franco, OH (2); Reiner, AP (2); O'Donnell, CJ (2); Mastrangelo, MA (2); Bartz, TM (2); Guo, X (2); show less...

University: Karolinska Institutet (7); Lund University (1)

Language: English (7)

Research subject (UKÄ/SCB): Medical and Health Sciences (1)

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