| 1. |
- Jelic, V., et al.
(author)
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Initial LOFAR observations of epoch of reionization windows II. Diffuse polarized emission in the ELAIS-N1 field
- 2014
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In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 568, s. A101-
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Journal article (peer-reviewed)abstract
- Aims. This study aims to characterise the polarized foreground emission in the ELAIS-N1 field and to address its possible implications or extracting of the cosmological 21 cm signal from the LOw-Frequency ARray - Epoch of Reionization (LOFAR-EoR) data Methods. We used the high band antennas of LOFAR to image this region and RM-synthesis to unravel structures of polarized emission at high Galactic latitudes. Results. The brightness temperature of the detected Galactic emission is on average similar to 4 K in polarized intensity and covers the range from -10 to +13 rad m(-2) in Faraday depth, The total polarized intensity and polarization angle show a wide range of morphological features. We have also used the Westerbork Synthesis Radio Telescope (WSRT) at 350 MHz to image the same region. The LOFAR and WSRT images show a similar complex morphology at comparable brightness levels, but their spatial correlation is very low. The fractional polarization at 150 MHz, expressed as a percentage of the total intensity, amounts to approximate to 1.5%. There is no indication of diffuse emission in total intensity in the interferometric data. in line with results at higher frequencies Conclusions. The wide frequency range. high angular resolution, and high sensitivity make LOFAR an exquisite instrument for studying Galactic polarized emission at a resolution of similar to 1-2 rad m(-2) in Faraday depth. The different polarized patterns observed at 150 MHz and 350 MHz are consistent with different source distributions along the line of sight wring in a variety of Faraday thin regions of emission. The presence of polarized foregrounds is a serious complication for epoch of reionization experiments. To avoid the leakage of polarized emission into total intensity, which can depend on frequency, we need to calibrate the instrumental polarization across the field of view to a small fraction of 1%.
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| 2. |
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| 3. |
- Titarenko, Yu E., et al.
(author)
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Measurement and simulation of the cross sections for nuclide production in Fe-56 and Cr-nat targets irradiated with 0.04- to 2.6-GeV protons
- 2011
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In: Physics of Atomic Nuclei. - 1063-7788 .- 1562-692X. ; 74:4, s. 523-536
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Journal article (peer-reviewed)abstract
- The cross sections for nuclide production in thin Fe-56 and Cr-nat targets irradiated by 0.04-2.6-GeV protons are measured by direct gamma spectrometry using two gamma spectrometers with the resolutions of 1.8 and 1.7 keV for the Co-60 1332-keV gamma line. As a result, 649 yields of radioactive residual product nuclei have been obtained. The Al-27(p, x)Na-22 reaction has been used as a monitor reaction. The experimental data are compared with the MCNPX (BERTINI, ISABEL), CEM03.02, INCL4.2, INCL4.5, PHITS, and CASCADE07 calculations.
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| 4. |
- Titarenko, Yu E., et al.
(author)
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Measurement and simulation of the cross sections for nuclide production in Nb-93 and Ni-nat targets irradiated with 0.04- to 2.6-GeV protons
- 2011
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In: Physics of Atomic Nuclei. - 1063-7788 .- 1562-692X. ; 74:4, s. 537-550
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Journal article (peer-reviewed)abstract
- The cross sections for nuclide production in thin Nb-93 and Ni-nat targets irradiated by 0.04- to 2.6-GeV protons have been measured by direct gamma spectrometry using two gamma spectrometers with the resolutions of 1.8 and 1.7 keV in the Co-60 1332-keV gamma line. As a result, 1112 yields of radioactive residual nuclei have been obtained. The Al-27(p, x)Na-22 reaction has been used as a monitor reaction. The experimental data have been compared with the MCNPX (BERTINI, ISABEL), CEM03.02, INCL4.2, INCL4.5, PHITS, and CASCADE07 calculations.
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| 5. |
- Titarenko, Yu E., et al.
(author)
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Measurement and simulation of the cross sections for nuclide production in W-nat and Ta-181 targets irradiated with 0.04- to 2.6-GeV protons
- 2011
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In: Physics of Atomic Nuclei. - 1063-7788 .- 1562-692X. ; 74:4, s. 551-572
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Journal article (peer-reviewed)abstract
- The cross sections for nuclide production in thin (nat)Wand Ta-181 targets irradiated by 0.04-2.6-GeV protons have been measured by direct gamma spectrometry using two gamma spectrometers with the resolutions of 1.8 and 1.7 keV in the Co-60 1332-keV gamma line. As a result, 1895 yields of radioactive residual product nuclei have been obtained. The Al-27(p, x)Na-22 reaction has been used as a monitor reaction. The experimental data have been compared with the MCNPX (BERTINI, ISABEL), CEM03.02, INCL4.2, INCL4.5, PHITS, and CASCADE07 calculations.
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| 6. |
- Titarenko, Yu E., et al.
(author)
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Measurement and simulation of the cross sections for the production of Gd-148 in thin W-nat and Ta-181 targets irradiated with 0.4- to 2.6-GeV protons
- 2011
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In: Physics of Atomic Nuclei. - 1063-7788 .- 1562-692X. ; 74:4, s. 573-579
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Journal article (peer-reviewed)abstract
- The cross sections for the production of Gd-148 in W-nat and Ta-181 targets irradiated by 0.4-, 0.6-, 0.8-, 1.2-, 1.6-, and 2.6-GeV protons at the ITEP accelerator complex have been measured by direct alpha spectrometry without chemical separation. The experimental data have been compared with the data obtained at other laboratories and with the theoretical simulations of the yields on the basis of the BERTINI, ISABEL, CEM03.02, INCL4.2, INCL4.5, CASCADE07, and PHITS codes.
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| 7. |
- Titarenko, Yu. E., et al.
(author)
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Verification of high-energy transport codes on the basis of activation data
- 2011
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In: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 84:6, s. 064612-
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Journal article (peer-reviewed)abstract
- Nuclide production cross sections measured at the Institute for Theoretical and Experimental Physics (ITEP) for the targets of (nat)Cr, (56)Fe, (nat)Ni, (93)Nb, (181)Ta, (nat)W, (nat)Pb, and (209)Bi irradiated by protons with energies from 40 to 2600 MeV were used to estimate the predictive accuracy of several popular high-energy transport codes. A general agreement of the ITEP data with the data obtained by other groups, including the numerous GSI data measured by the inverse kinematics method was found. Simulations of the measured data were performed with the MCNPX (BERTINI and ISABEL options), CEM03.02, INCL4.2 + ABLA, INCL4.5 + ABLA07, PHITS, and CASCADE.07 codes. Deviation factors between the calculated and experimental cross sections have been estimated for each target and for the whole energy range covered by our measurements. Two-dimensional diagrams of deviation factor values were produced for estimating the predictive power of every code for intermediate, not measured masses of nuclei targets and bombarding energies of protons. Further improvements of all tested here codes are recommended. In addition, new measurements at ITEP of nuclide yields from the (208)Pb target irradiated by 500-MeV protons are presented. A good agreement between these new data and the GSI measurements obtained by the inverse kinematics method was found.
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| 9. |
- Mathijssen, S. G. J., et al.
(author)
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Scanning Kelvin probe microscopy on organic field-effect transistors during gate bias stress
- 2007
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In: Applied Physics Letters. - : American Institute of Physics (AIP). - 0003-6951 .- 1077-3118. ; 90:19
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Journal article (peer-reviewed)abstract
- The reliability of organic field-effect transistors is studied using both transport and scanning Kelvin probe microscopy measurements. A direct correlation between the current and potential of a p-type transistor is demonstrated. During gate bias stress, a decrease in current is observed, that is correlated with the increased curvature of the potential profile. After gate bias stress, the potential changes consistently in all operating regimes: the potential profile gets more convex, in accordance with the simultaneously observed shift in threshold voltage. The changes of the potential are attributed to positive immobile charges, which contribute to the potential, but not to the current. (C) 2007 American Institute of Physics.
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| 11. |
- Danquah, Ina, et al.
(author)
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Subgroups of adult-onset diabetes : a data-driven cluster analysis in a Ghanaian population
- 2023
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In: Scientific Reports. - : Nature Publishing Group. - 2045-2322. ; 13:1
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Journal article (peer-reviewed)abstract
- Adult-onset diabetes mellitus (here: aDM) is not a uniform disease entity. In European populations, five diabetes subgroups have been identified by cluster analysis using simple clinical variables; these may elucidate diabetes aetiology and disease prognosis. We aimed at reproducing these subgroups among Ghanaians with aDM, and establishing their importance for diabetic complications in different health system contexts. We used data of 541 Ghanaians with aDM (age: 25–70 years; male sex: 44%) from the multi-center, cross-sectional Research on Obesity and Diabetes among African Migrants (RODAM) Study. Adult-onset DM was defined as fasting plasma glucose (FPG) ≥ 7.0 mmol/L, documented use of glucose-lowering medication or self-reported diabetes, and age of onset ≥ 18 years. We derived subgroups by cluster analysis using (i) a previously published set of variables: age at diabetes onset, HbA1c, body mass index, HOMA-beta, HOMA-IR, positivity of glutamic acid decarboxylase autoantibodies (GAD65Ab), and (ii) Ghana-specific variables: age at onset, waist circumference, FPG, and fasting insulin. For each subgroup, we calculated the clinical, treatment-related and morphometric characteristics, and the proportions of objectively measured and self-reported diabetic complications. We reproduced the five subgroups: cluster 1 (obesity-related, 73%) and cluster 5 (insulin-resistant, 5%) with no dominant diabetic complication patterns; cluster 2 (age-related, 10%) characterized by the highest proportions of coronary artery disease (CAD, 18%) and stroke (13%); cluster 3 (autoimmune-related, 5%) showing the highest proportions of kidney dysfunction (40%) and peripheral artery disease (PAD, 14%); and cluster 4 (insulin-deficient, 7%) characterized by the highest proportion of retinopathy (14%). The second approach yielded four subgroups: obesity- and age-related (68%) characterized by the highest proportion of CAD (9%); body fat-related and insulin-resistant (18%) showing the highest proportions of PAD (6%) and stroke (5%); malnutrition-related (8%) exhibiting the lowest mean waist circumference and the highest proportion of retinopathy (20%); and ketosis-prone (6%) with the highest proportion of kidney dysfunction (30%) and urinary ketones (6%). With the same set of clinical variables, the previously published aDM subgroups can largely be reproduced by cluster analysis in this Ghanaian population. This method may generate in-depth understanding of the aetiology and prognosis of aDM, particularly when choosing variables that are clinically relevant for the target population.
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| 12. |
- Darolti, Iulia, et al.
(author)
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Extreme heterogeneity in sex chromosome differentiation and dosage compensation in livebearers
- 2019
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In: Proceedings of the National Academy of Sciences of the United States of America. - : NATL ACAD SCIENCES. - 0027-8424 .- 1091-6490. ; 116:38, s. 19031-19036
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Journal article (peer-reviewed)abstract
- Once recombination is halted between the X and Y chromosomes, sex chromosomes begin to differentiate and transition to heteromorphism. While there is a remarkable variation across clades in the degree of sex chromosome divergence, far less is known about the variation in sex chromosome differentiation within clades. Here, we combined whole-genome and transcriptome sequencing data to characterize the structure and conservation of sex chromosome systems across Poeciliidae, the livebearing Glade that includes guppies. We found that the Poecilia reticulata XY system is much older than previously thought, being shared not only with its sister species, Poecilia wingei, but also with Poecilia picta, which diverged roughly 20 million years ago. Despite the shared ancestry, we uncovered an extreme heterogeneity across these species in the proportion of the sex chromosome with suppressed recombination, and the degree of Y chromosome decay. The sex chromosomes in P. reticulata and P. wingei are largely homomorphic, with recombination in the former persisting over a substantial fraction. However, the sex chromosomes in P. picta are completely nonrecombining and strikingly heteromorphic. Remarkably, the profound degradation of the ancestral Y chromosome in P. picta is counterbalanced by the evolution of functional chromosome-wide dosage compensation in this species, which has not been previously observed in teleost fish. Our results offer important insight into the initial stages of sex chromosome evolution and dosage compensation.
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| 14. |
- Mank, A, et al.
(author)
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A longitudinal study on quality of life along the spectrum of Alzheimer's disease
- 2022
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In: Alzheimer's research & therapy. - : Springer Science and Business Media LLC. - 1758-9193. ; 14:1, s. 132-
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Journal article (peer-reviewed)abstract
- BackgroundQuality of life (QoL) is an important outcome from the perspective of patients and their caregivers, in both dementia and pre-dementia stages. Yet, little is known about the long-term changes in QoL over time. We aimed to compare the trajectories of QoL between amyloid-positive and amyloid-negative SCD or MCI patients and to evaluate QoL trajectories along the Alzheimer’s disease (AD) continuum of cognitively normal to dementia.MethodsWe included longitudinal data of 447 subjective cognitive decline (SCD), 276 mild cognitive impairment (MCI), and 417 AD dementia patients from the Amsterdam Dementia Cohort. We compared QoL trajectories (EQ-5D and visual analog scale (VAS)) between (1) amyloid-positive and amyloid-negative SCD or MCI patients and (2) amyloid-positive SCD, MCI, and dementia patients with linear mixed-effect models. The models were adjusted for age, sex, Charlson Comorbidity Index (CCI), education, and EQ-5D scale (3 or 5 level).ResultsIn SCD, amyloid-positive participants had a higher VAS at baseline but showed a steeper decline over time in EQ-5D and VAS than amyloid-negative participants. Also, in MCI, amyloid-positive patients had higher QoL at baseline but subsequently showed a steeper decline in QoL over time compared to amyloid-negative patients. When we compared amyloid-positive patients along the Alzheimer continuum, we found no difference between SCD, MCI, or dementia in baseline QoL, but QoL decreased at a faster rate in the dementia stage compared with the of SCD and MCI stages.ConclusionsQoL decreased at a faster rate over time in amyloid-positive SCD or MCI patients than amyloid-negative patients. QoL decreases over time along the entire AD continuum of SCD, MCI and dementia, with the strongest decrease in dementia patients. Knowledge of QoL trajectories is essential for the future evaluation of treatments in AD.
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| 16. |
- Rolland, J., et al.
(author)
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Conceptual and empirical bridges between micro- and macroevolution
- 2023
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In: Nature Ecology and Evolution. - 2397-334X. ; 7, s. 1181-1193
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Journal article (peer-reviewed)abstract
- This Perspective discusses four questions of evolutionary biology that bridge macro and microevolution perspectives and proposes future research avenues to link evolutionary mechanisms and processes. Explaining broad molecular, phenotypic and species biodiversity patterns necessitates a unifying framework spanning multiple evolutionary scales. Here we argue that although substantial effort has been made to reconcile microevolution and macroevolution, much work remains to identify the links between biological processes at play. We highlight four major questions of evolutionary biology whose solutions require conceptual bridges between micro and macroevolution. We review potential avenues for future research to establish how mechanisms at one scale (drift, mutation, migration, selection) translate to processes at the other scale (speciation, extinction, biogeographic dispersal) and vice versa. We propose ways in which current comparative methods to infer molecular evolution, phenotypic evolution and species diversification could be improved to specifically address these questions. We conclude that researchers are in a better position than ever before to build a synthesis to understand how microevolutionary dynamics unfold over millions of years.
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