| 1. |
- Bravo, L, et al.
(author)
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- 2021
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| 2. |
- Tabiri, S, et al.
(author)
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- 2021
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- Thomas, HS, et al.
(author)
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- 2019
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| 14. |
- Webber, K. B., et al.
(author)
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Chemical Analysis of the Brightest Star of the Cetus II Ultrafaint Dwarf Galaxy Candidate
- 2023
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In: Astrophysical Journal. - 0004-637X .- 1538-4357. ; 959:2
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Journal article (peer-reviewed)abstract
- We present a detailed chemical abundance analysis of the brightest star in the ultrafaint dwarf (UFD) galaxy candidate Cetus II from high-resolution Magellan/MIKE spectra. For this star, DES J011740.53-173053, abundances or upper limits of 18 elements from carbon to europium are derived. Its chemical abundances generally follow those of other UFD galaxy stars, with a slight enhancement of the alpha-elements (Mg, Si, and Ca) and low neutron-capture element (Sr, Ba, and Eu) abundances supporting the classification of Cetus II as a likely UFD. The star exhibits lower Sc, Ti, and V abundances than Milky Way (MW) halo stars with similar metallicity. This signature is consistent with yields from a supernova originating from a star with a mass of similar to 11.2 M-circle dot. In addition, the star has a potassium abundance of [K/Fe] = 0.81, which is somewhat higher than the K abundances of MW halo stars with similar metallicity, a signature that is also present in a number of UFD galaxies. A comparison including globular clusters and stellar stream stars suggests that high K is a specific characteristic of some UFD galaxy stars and can thus be used to help classify objects as UFD galaxies.
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| 15. |
- Cinar, C., et al.
(author)
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Determinants of Severe Nocturnal Hypoxemia in Adults with Chronic Thromboembolic Pulmonary Hypertension and Sleep-Related Breathing Disorders
- 2023
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In: Journal of Clinical Medicine. - 2077-0383. ; 12:14
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Journal article (peer-reviewed)abstract
- Objectives: We aimed to investigate the occurrence of sleep-related breathing disorders (SRBDs) in patients with chronic thromboembolic pulmonary hypertension (CTEPH) and addressed the effect of pulmonary hemodynamics and SRBD indices on the severity of nocturnal hypoxemia (NH). Methods: An overnight polysomnography (PSG) was conducted in patients with CTEPH, who were eligible for pulmonary endarterectomy. Pulmonary hemodynamics (mean pulmonary arterial pressure (mPAP), pulmonary arterial wedge pressure (PAWP), pulmonary vascular resistance (PVR) measured with right heart catheterization (RHC)), PSG variables (apnea-hypopnea index (AHI)), lung function and carbon monoxide diffusion capacity (DLCO) values, as well as demographics and comorbidities were entered into a logistic regression model to address the determinants of severe NH (nocturnal oxyhemoglobin saturation (SpO(2)) < 90% under >20% of total sleep time (TST)). SRBDs were defined as obstructive sleep apnea (OSA; as an AHI & GE; 15 events/h), central sleep apnea with Cheyne-Stokes respiration (CSA-CSR; CSR pattern & GE; 50% of TST), obesity hypoventilation syndrome (OHS), and isolated sleep-related hypoxemia (ISRH; SpO(2) < 88% under >5 min without OSA, CSA, or OHS). Results: In all, 50 consecutive patients (34 men and 16 women; mean age 54.0 (SD 15.1) years) were included. The average mPAP was 43.8 (SD 16.8) mmHg. SRBD was observed in 40 (80%) patients, of whom 27 had OSA, 2 CSA-CSR, and 11 ISRH. None had OHS. Severe NH was observed in 31 (62%) patients. Among the variables tested, age (odds ratio (OR) 1.08, 95% confidence interval [CI] 1.01-1.15; p = 0.031), mPAP (OR 1.11 [95% CI 1.02-1.12; p = 0.012]), and AHI (OR 1.17 [95% CI 1.02-1.35; p = 0.031]) were independent determinants of severe NH. Conclusions: Severe NH is highly prevalent in patients with CTEPH. Early screening for SRBDs and intervention with nocturnal supplemental oxygen and/or positive airway pressure as well as pulmonary endarterectomy may reduce adverse outcomes in patients with CTEPH.
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| 16. |
- Einspieler, C, et al.
(author)
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Cerebral Palsy: Early Markers of Clinical Phenotype and Functional Outcome
- 2019
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In: Journal of clinical medicine. - : MDPI AG. - 2077-0383. ; 8:10
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Journal article (peer-reviewed)abstract
- The Prechtl General Movement Assessment (GMA) has become a cornerstone assessment in early identification of cerebral palsy (CP), particularly during the fidgety movement period at 3–5 months of age. Additionally, assessment of motor repertoire, such as antigravity movements and postural patterns, which form the Motor Optimality Score (MOS), may provide insight into an infant’s later motor function. This study aimed to identify early specific markers for ambulation, gross motor function (using the Gross Motor Function Classification System, GMFCS), topography (unilateral, bilateral), and type (spastic, dyskinetic, ataxic, and hypotonic) of CP in a large worldwide cohort of 468 infants. We found that 95% of children with CP did not have fidgety movements, with 100% having non-optimal MOS. GMFCS level was strongly correlated to MOS. An MOS > 14 was most likely associated with GMFCS outcomes I or II, whereas GMFCS outcomes IV or V were hardly ever associated with an MOS > 8. A number of different movement patterns were associated with more severe functional impairment (GMFCS III–V), including atypical arching and persistent cramped-synchronized movements. Asymmetrical segmental movements were strongly associated with unilateral CP. Circular arm movements were associated with dyskinetic CP. This study demonstrated that use of the MOS contributes to understanding later CP prognosis, including early markers for type and severity.
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| 17. |
- Kängsepp, P., et al.
(author)
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First full-scale combined MBBR, coagulation, flocculation, discfilter plant with phosphorus removal in France
- 2020
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In: Water Practice and Technology. - : IWA Publishing. - 1751-231X. ; 15:1, s. 19-27
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Journal article (peer-reviewed)abstract
- The suspended solids (SS) concentrations in effluent from moving bed biofilm reactors (MBBRs) used for secondary biological treatment can be up to 500 mg/L. Microscreens (Drumfilters or Discfilters) can be used as alternatives to traditional clarification or dissolved air flotation to remove SS and total phosphorus (TP). This study shows how a small-scale municipal WWTP for 5,700 population equivalent (PE) can be upgraded to 12,000 PE by combining MBBR with coagulation-flocculation tanks and a Discfilter with a total footprint of 160 m2. This long-term investigation demonstrated that even though influent turbidity (range 146-431 NTU) and flow (25-125 m3/h) varied considerably, very low effluent turbidities (below 10 NTU) could be achieved continuously. Furthermore, this compact treatment system can provide average reductions of ammonium (NH4-N) from 19 to 0.04 mg/L, COD from 290 to 10 mg/L, and TP from 4.5 to 0.3 mg/L. The results show that effluent requirements can be reached by combining MBBR, coagulation-flocculation and disc filtration at full scale, without a primary clarifier upstream of MBBR.
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| 19. |
- Niklasson, Mia, et al.
(author)
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Membrane-Depolarizing Channel Blockers Induce Selective Glioma Cell Death by Impairing Nutrient Transport and Unfolded Protein/Amino Acid Responses
- 2017
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In: Cancer Research. - : AMER ASSOC CANCER RESEARCH. - 0008-5472 .- 1538-7445. ; 77:7, s. 1741-1752
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Journal article (peer-reviewed)abstract
- Glioma-initiating cells (GIC) are considered the underlying cause of recurrences of aggressive glioblastomas, replenishing the tumor population and undermining the efficacy of conventional chemotherapy. Here we report the discovery that inhibiting T-type voltage-gated Ca2+ and KCa channels can effectively induce selective cell death of GIC and increase host survival in an orthotopic mouse model of human glioma. At present, the precise cellular pathways affected by the drugs affecting these channels are unknown. However, using cell-based assays and integrated proteomics, phosphoproteomics, and transcriptomics analyses, we identified the downstreamsignaling events these drugs affect. Changes in plasma membrane depolarization and elevated intracellular Na+, which compromised Na+-dependent nutrient transport, were documented. Deficits in nutrient deficit acted in turn to trigger the unfolded protein response and the amino acid response, leading ultimately to nutrient starvation and GIC cell death. Our results suggest new therapeutic targets to attack aggressive gliomas.
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| 20. |
- Ruhland, Kerstin, et al.
(author)
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A Review of Eye Gaze in Virtual Agents, Social Robotics and HCI : Behaviour Generation, User Interaction and Perception
- 2015
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In: Computer graphics forum (Print). - : Wiley-Blackwell. - 0167-7055 .- 1467-8659. ; 34:6, s. 299-326
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Research review (peer-reviewed)abstract
- A person's emotions and state of mind are apparent in their face and eyes. As a Latin proverb states: ‘The face is the portrait of the mind; the eyes, its informers’. This presents a significant challenge for Computer Graphics researchers who generate artificial entities that aim to replicate the movement and appearance of the human eye, which is so important in human–human interactions. This review article provides an overview of the efforts made on tackling this demanding task. As with many topics in computer graphics, a cross-disciplinary approach is required to fully understand the workings of the eye in the transmission of information to the user. We begin with a discussion of the movement of the eyeballs, eyelids and the head from a physiological perspective and how these movements can be modelled, rendered and animated in computer graphics applications. Furthermore, we present recent research from psychology and sociology that seeks to understand higher level behaviours, such as attention and eye gaze, during the expression of emotion or during conversation. We discuss how these findings are synthesized in computer graphics and can be utilized in the domains of Human–Robot Interaction and Human–Computer Interaction for allowing humans to interact with virtual agents and other artificial entities. We conclude with a summary of guidelines for animating the eye and head from the perspective of a character animator.
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| 21. |
- Ruhland, Kerstin, et al.
(author)
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Look me in the Eyes : A Survey of Eye and Gaze Animation for Virtual Agents and Artificial Systems
- 2014
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Conference paper (peer-reviewed)abstract
- A person's emotions and state of mind are apparent in their face and eyes. As a Latin proverb states: ''The face is the portrait of the mind; the eyes, its informers.''. This presents a huge challenge for computer graphics researchers in the generation of artificial entities that aim to replicate the movement and appearance of the human eye, which is so important in human-human interactions. This State of the Art Report provides an overview of the efforts made on tackling this challenging task. As with many topics in Computer Graphics, a cross-disciplinary approach is required to fully understand the workings of the eye in the transmission of information to the user. We discuss the movement of the eyeballs, eyelids, and the head from a physiological perspective and how these movements can be modelled, rendered and animated in computer graphics applications. Further, we present recent research from psychology and sociology that seeks to understand higher level behaviours, such as attention and eye-gaze, during the expression of emotion or during conversation, and how they are synthesised in Computer Graphics and Robotics.
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