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1.	Corbin, Laura J., et al. (author) Formalising recall by genotype as an efficient approach to detailed phenotyping and causal inference 2018 In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 9:1 Journal article (peer-reviewed)abstract Detailed phenotyping is required to deepen our understanding of the biological mechanisms behind genetic associations. In addition, the impact of potentially modifiable risk factors on disease requires analytical frameworks that allow causal inference. Here, we discuss the characteristics of Recall-by-Genotype (RbG) as a study design aimed at addressing both these needs. We describe two broad scenarios for the application of RbG: studies using single variants and those using multiple variants. We consider the efficacy and practicality of the RbG approach, provide a catalogue of UK-based resources for such studies and present an online RbG study planner.

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Type of publication: journal article (1)

Type of content: peer-reviewed (1)

Author/Editor: van Heel, David A (1); Tan, Vanessa Y (1); Franks, Paul W. (1); McCarthy, Mark I (1); Scott, Robert A (1); Palmer, Colin N. A. (1); show more...; Karpe, Fredrik (1); Wain, Louise V (1); Evans, David M (1); Smith, George Davey (1); Tobin, Martin D (1); O'Rahilly, Stephen (1); Pearson, Ewan R (1); Timpson, Nicholas J. (1); Lindgren, Cecilia M. (1); Owen, Michael J. (1); Hughes, David A. (1); Corbin, Laura J (1); Paul, Dirk S. (1); Wade, Kaitlin H. (1); Danesh, John (1); Tansey, Katherine E. (1); Butcher, Frances (1); Dudbridge, Frank (1); Howson, Joanna M. (1); Jallow, Momodou W. (1); John, Catherine (1); Kingston, Nathalie (1); O'Donavan, Michael (1); Whittaker, John (1); Frayling, Tim (1); show less...

University: Umeå University (1); Lund University (1)

Language: English (1)

Research subject (UKÄ/SCB): Medical and Health Sciences (1)

Year: 2018 (1)

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