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- Acharya, B. S., et al.
(author)
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Introducing the CTA concept
- 2013
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In: Astroparticle physics. - : Elsevier BV. - 0927-6505 .- 1873-2852. ; 43, s. 3-18
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Journal article (other academic/artistic)abstract
- The Cherenkov Telescope Array (CTA) is a new observatory for very high-energy (VHE) gamma rays. CTA has ambitions science goals, for which it is necessary to achieve full-sky coverage, to improve the sensitivity by about an order of magnitude, to span about four decades of energy, from a few tens of GeV to above 100 TeV with enhanced angular and energy resolutions over existing VHE gamma-ray observatories. An international collaboration has formed with more than 1000 members from 27 countries in Europe, Asia, Africa and North and South America. In 2010 the CTA Consortium completed a Design Study and started a three-year Preparatory Phase which leads to production readiness of CTA in 2014. In this paper we introduce the science goals and the concept of CTA, and provide an overview of the project. (C) 2013 Elsevier B.V. All rights reserved.
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- Abdalla, H., et al.
(author)
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HESS J1741-302 : a hidden accelerator in the Galactic plane
- 2018
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In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 612
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Journal article (peer-reviewed)abstract
- The H.E.S.S. Collaboration has discovered a new very high energy (VHE, E > 0.1 TeV) gamma-ray source, HESS J1741-302, located in the Galactic plane. Despite several attempts to constrain its nature, no plausible counterpart has been found so far at X-ray and MeV/GeV gamma-ray energies, and the source remains unidentified. An analysis of 145-h of observations of HESS J1741-302 at VHEs has revealed a steady and relatively weak TeV source (similar to 1% of the Crab Nebula flux), with a spectral index of Gamma = 2.3 +/- 0.2(stat) +/- 0.2(sys), extending to energies up to 10 TeV without any clear signature of a cut-off. In a hadronic scenario, such a spectrum implies an object with particle acceleration up to energies of several hundred TeV. Contrary to most H.E.S.S. unidentified sources, the angular size of HESS J1741-302 is compatible with the H.E.S.S. point spread function at VHEs, with an extension constrained to be below 0.068 degrees at a 99% confidence level. The gamma-ray emission detected by H.E.S.S. can be explained both within a hadronic scenario, due to collisions of protons with energies of hundreds of TeV with dense molecular clouds, and in a leptonic scenario, as a relic pulsar wind nebula, possibly powered by the middle-aged (20 kyr) pulsar PSR B1737-30. A binary scenario, related to the compact radio source 1LC 358.266+0.038 found to be spatially coincident with the best fit position of HESS J1741-302, is also envisaged.
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| 7. |
- Ochi, Y, et al.
(author)
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Clonal evolution and clinical implications of genetic abnormalities in blastic transformation of chronic myeloid leukaemia
- 2021
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In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 12:1, s. 2833-
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Journal article (peer-reviewed)abstract
- Blast crisis (BC) predicts dismal outcomes in patients with chronic myeloid leukaemia (CML). Although additional genetic alterations play a central role in BC, the landscape and prognostic impact of these alterations remain elusive. Here, we comprehensively investigate genetic abnormalities in 136 BC and 148 chronic phase (CP) samples obtained from 216 CML patients using exome and targeted sequencing. One or more genetic abnormalities are found in 126 (92.6%) out of the 136 BC patients, including the RUNX1-ETS2 fusion and NBEAL2 mutations. The number of genetic alterations increase during the transition from CP to BC, which is markedly suppressed by tyrosine kinase inhibitors (TKIs). The lineage of the BC and prior use of TKIs correlate with distinct molecular profiles. Notably, genetic alterations, rather than clinical variables, contribute to a better prediction of BC prognosis. In conclusion, genetic abnormalities can help predict clinical outcomes and can guide clinical decisions in CML.
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- Rojas-Macias, Miguel A., 1979, et al.
(author)
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Towards a standardized bioinformatics infrastructure for N- and O-glycomics
- 2019
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In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10
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Journal article (peer-reviewed)abstract
- The mass spectrometry (MS)-based analysis of free polysaccharides and glycans released from proteins, lipids and proteoglycans increasingly relies on databases and software. Here, we review progress in the bioinformatics analysis of protein-released N- and O-linked glycans (N-and O-glycomics) and propose an e-infrastructure to overcome current deficits in data and experimental transparency. This workflow enables the standardized submission of MS-based glycomics information into the public repository UniCarb-DR. It implements the MIRAGE (Minimum Requirement for A Glycomics Experiment) reporting guidelines, storage of unprocessed MS data in the GlycoPOST repository and glycan structure registration using the GlyTouCan registry, thereby supporting the development and extension of a glycan structure knowledgebase.
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- Yamada, K., et al.
(author)
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Long-term outcome of targeted therapy for low back pain in elderly degenerative lumbar scoliosis
- 2021
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In: European Spine Journal. - : Springer Science and Business Media LLC. - 0940-6719 .- 1432-0932. ; 30, s. 2020-2032
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Journal article (peer-reviewed)abstract
- Purpose Treatment of low back pain (LBP) associated with elderly degenerative lumbar scoliosis (DLS) remains controversial. We have developed percutaneous intervertebral-vacuum polymethylmethacrylate injection (PIPI) targeting to the intervertebral vacuum as a minimally invasive surgery. The present study compared the long-term clinical outcomes of PIPI to that of nonoperative treatment. Methods Patients with de novo DLS, aged >= 65 years, who had LBP with visual analog scale (VAS) of >= 50 for >= 6 months with intervertebral vacuum on computed tomography and bone marrow edema (BME) on magnetic resonance imaging were included. The clinical outcomes were evaluated using VAS and the Oswestry Disability Index (ODI) at baseline, 1, 6, 12, 24 months, and at the final follow-up. The course of BME was also evaluated. Results One hundred and one patients underwent PIPI and 61 received nonoperative treatment. The mean follow-up duration after PIPI and nonoperative treatment was 63.7 +/- 32.4 and 43.9 +/- 20.9 months, respectively. VAS and ODI after PIPI were significantly improved compared to post-nonoperative treatment. BME decreased substantially in the PIPI group and it was significantly correlated with VAS and ODI improvement. Following PIPI, LBP recurred in 28 patients (35%). LBP recurrence was identified at the same level of PIPI in 10 patients, at the adjacent level of PIPI in 11 patients, and at the non-adjacent level of PIPI in seven patients. Eighteen patients underwent additional PIPIs, and both VAS and ODI were significantly improved after additional PIPIs. Conclusion Bone marrow lesions of the endplate are strongly associated with the presence of LBP. PIPI can be considered as an effective, safe and repeatable treatment for LBP in elderly DLS patients.
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| 15. |
- Adachi, N., et al.
(author)
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Epitaxial Bi3Fe5O12(001) films grown by pulsed laser deposition and reactive ion beam sputtering techniques
- 2000
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In: Journal of Applied Physics. - : AIP Publishing. - 0021-8979 .- 1089-7550. ; 88:5, s. 2734-2739
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Journal article (peer-reviewed)abstract
- We report on processing and comparative characterization of epitaxial Bi3Fe5O12 (BIG) films grown onto Gd-3(ScGa)(5)O-12[GSGG,(001)] single crystal using pulsed laser deposition (PLD) and reactive ion beam sputtering (RIBS) techniques. A very high deposition rate of about 0.8 mu m/h has been achieved in the PLD process. Comprehensive x-ray diffraction analyses reveal epitaxial quality both of the films: they are single phase, exclusively (001) oriented, the full width at half maximum of the rocking curve of (004) Bragg reflection is 0.06 deg for PLD and 0.05 deg for RIBS film, strongly in-plane textured with cube-on-cube film-to-substrate epitaxial relationship. Saturation magnetization 4 pi M-s and Faraday rotation at 635 nm were found to be 1400 Gs and -7.8 deg/mu m in PLD-BIG, and 1200 Gs and -6.9 deg/mu m in RIBS-BIG. Ferromagnetic resonance (FMR) measurements performed at 9.25 GHz yielded the gyromagnetic ratio gamma=1.797x10(7) l/s Oe, 1.826x10(7) l/s Oe; the constants of uniaxial magnetic anisotropy were K-u(*)=-8.66x10(4) erg/cm(3), -8.60x10(4) erg/cm(3); the cubic magnetic anisotropy K-1=-2.7x10(3) erg/cm(3),-3.8x10(3) erg/cm(3); and the FMR linewidth Delta H=25 and 34 Oe for PLD and RIBS films correspondingly. High Faraday rotation, low microwave loss, and low coercive field less than or equal to 40 Oe of BIG/GSGG(001) films promise their use in integrated magneto-optic applications.
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| 16. |
- Adachi, N., et al.
(author)
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Magnetic properties of single crystal film Bi3Fe5O12 prepared onto Sm3(Sc, Ga)5O12(111)
- 2002
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In: Journal of Magnetism and Magnetic Materials. - 0304-8853 .- 1873-4766. ; 242:Part 2, s. 775-777
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Journal article (peer-reviewed)abstract
- Magnetic properties of single crystal Bi3Fe5O12 has been investigated in the temperature range between 2 and 670K. The Sm3(Sc,Ga)5O12 wafer has been used for substrates. Due to the small contribution of the substrate's magnetization, the film's magnetization can be clearly estimated to be 2040G (0K) and the Curie temperature has been estimated to be around 650K.
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- Jalali-Roudsar, Amir A., et al.
(author)
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Microwave and magneto-optic properties of pulsed laser deposited bismuth iron garnet films
- 2001
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In: IEEE transactions on magnetics. - : Institute of Electrical and Electronics Engineers (IEEE). - 0018-9464 .- 1941-0069. ; 37:4, s. 2454-2456
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Journal article (peer-reviewed)abstract
- We report on processing and comparative characterization of epitaxial Bi3Fe5O12 (BIG) films grown by pulsed laser ablation of a precursor oxide target onto (NdGd)(3)(ScGa)(5)O-12 [NGSGG(111)] and Gd-3 (ScGa)(5)O-12 (GSGG(001)] single crystals. Comprehensive X-ray diffraction analyses reveal the epitaxial quality of the BIG films: they are single phase, exclusively (111) and (001) oriented with less than 0.4 degrees and 0.06 degrees of the full width at half maximum of the rocking curve of main texture Bragg reflection [(111) for NGSGG and (001) for GSGG substrate, respectively]. The films are strongly in-plane textured with cube-on-cube film-to-substrate epitaxial relationship. VSM and ferromagnetic resonance measurements revealed in-plane magnetization in BIG/GSGG(001) film, while the BIG/NGSGG(111) film was found to have perpendicular magnetization. For BIG(001) and (111) films the saturation magnetization 4 piM(s) was found to be 1400 and 1200 Gs; the Faraday rotation at 635 nm was -7.8 and -6.7 deg/mum; the constant of uniaxial magnetic anisotropy was K-u* = -8.70 X 10(4) and +1.16 x 10(4) erg/cm(3); the constant of cubic magnetic anisotropy K-1 = -3.6 x 10(3) and -7.14 x 10(3) erg/cm(3). High Faraday rotation and low coercive field (less than or equal to 40 Oe) of BIG/GSGG(001) films show promise for their use in integrated magneto-optic applications.
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- Qi, QB, et al.
(author)
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Dietary Intake, FTO Genetic Variants, and Adiposity: A Combined Analysis of Over 16,000 Children and Adolescents
- 2015
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In: Diabetes. - : American Diabetes Association. - 1939-327X .- 0012-1797. ; 64:7, s. 2467-2476
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Journal article (peer-reviewed)abstract
- The FTO gene harbors variation with the strongest effect on adiposity and obesity risk. Previous data support a role for FTO variation in influencing food intake. We conducted a combined analysis of 16,094 boys and girls aged 1–18 years from 14 studies to examine the following: 1) the association between the FTO rs9939609 variant (or a proxy) and total energy and macronutrient intake; and 2) the interaction between the FTO variant and dietary intake, and the effect on BMI. We found that the BMI-increasing allele (minor allele) of the FTO variant was associated with increased total energy intake (effect per allele = 14.3 kcal/day [95% CI 5.9, 22.7 kcal/day], P = 6.5 × 10−4), but not with protein, carbohydrate, or fat intake. We also found that protein intake modified the association between the FTO variant and BMI (interactive effect per allele = 0.08 SD [0.03, 0.12 SD], P for interaction = 7.2 × 10−4): the association between FTO genotype and BMI was much stronger in individuals with high protein intake (effect per allele = 0.10 SD [0.07, 0.13 SD], P = 8.2 × 10−10) than in those with low intake (effect per allele = 0.04 SD [0.01, 0.07 SD], P = 0.02). Our results suggest that the FTO variant that confers a predisposition to higher BMI is associated with higher total energy intake, and that lower dietary protein intake attenuates the association between FTO genotype and adiposity in children and adolescents.
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| 25. |
- Xu, Su-Yang, et al.
(author)
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Lifshitz transition and Van Hove singularity in a three-dimensional topological Dirac semimetal
- 2015
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In: Physical Review B (Condensed Matter and Materials Physics). - 1098-0121. ; 92:7
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Journal article (peer-reviewed)abstract
- A three-dimensional (3D) Dirac semimetal is a novel state of quantum matter which has recently attracted much attention as an apparent 3D version of graphene. In this paper, we report results on the electronic structure of the 3D Dirac semimetal Na3Bi at a surface that reveals its nontrivial ground state. Our studies reveal that the two 3D Dirac cones go through a topological change in the constant energy contour as a function of the binding energy, featuring a Lifshitz point, which is missing in a strict 3D analog of graphene. Our results identify an example of a band saddle-point singularity in 3D Dirac materials. This is in contrast to its two-dimensional analogs such as graphene and the Dirac surface states of a topological insulator. The observation of multiple Dirac nodes in Na3Bi connecting via a Lifshitz point along its crystalline rotational axis away from the Kramers point serves as a decisive signature for the symmetry-protected nature of the Dirac semimetal's topological bulk ground state.
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