1. |
- Ruilope, LM, et al.
(author)
-
Design and Baseline Characteristics of the Finerenone in Reducing Cardiovascular Mortality and Morbidity in Diabetic Kidney Disease Trial
- 2019
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In: American journal of nephrology. - : S. Karger AG. - 1421-9670 .- 0250-8095. ; 50:5, s. 345-356
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Journal article (peer-reviewed)abstract
- <b><i>Background:</i></b> Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials. <b><i>Patients and</i></b> <b><i>Methods:</i></b> The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate ≥25 mL/min/1.73 m<sup>2</sup> and albuminuria (urinary albumin-to-creatinine ratio ≥30 to ≤5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level α = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure. <b><i>Conclusions:</i></b> FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen. Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049.
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2. |
- Grieser, M., et al.
(author)
-
Storage ring at HIE-ISOLDE
- 2012
-
In: European Physical Journal: Special Topics. - : Springer Science and Business Media LLC. - 1951-6401 .- 1951-6355. ; 207:1, s. 1-117
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Journal article (peer-reviewed)abstract
- We propose to install a storage ring at an ISOL-type radioactive beam facility for the first time. Specifically, we intend to setup the heavy-ion, low-energy ring TSR at the HIE-ISOLDE facility in CERN, Geneva. Such a facility will provide a capability for experiments with stored secondary beams that is unique in the world. The envisaged physics programme is rich and varied, spanning from investigations of nuclear ground-state properties and reaction studies of astrophysical relevance, to investigations with highly-charged ions and pure isomeric beams. The TSR might also be employed for removal of isobaric contaminants from stored ion beams and for systematic studies within the neutrino beam programme. In addition to experiments performed using beams recirculating within the ring, cooled beams can also be extracted and exploited by external spectrometers for high-precision measurements. The existing TSR, which is presently in operation at the Max-Planck Institute for Nuclear Physics in Heidelberg, is well-suited and can be employed for this purpose. The physics cases as well as technical details of the existing ring facility and of the beam and infrastructure requirements at HIE-ISOLDE are discussed in the present technical design report.
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3. |
- Gottardo, A., et al.
(author)
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New Isomers in the Neutron-Rich Region Beyond 208Pb
- 2014
-
In: EPJ Web of Conferences. - : EDP Sciences. - 2100-014X. - 9782759811755 - 9782759811762 ; 66, s. 02043-02043
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Conference paper (peer-reviewed)abstract
- The region of neutron-rich nuclei beyond 208Pb has been very difficult to explore due to its high mass and exoticity. However, recent experimental improvements allowed one to perform a quite extended isomer decay spectroscopy of these nuclei.
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4. |
- Gottardo, A., et al.
(author)
-
Isomeric Decay Spectroscopy of the 217Bi Isotope
- 2014
-
In: Physical Review C (Nuclear Physics). - 0556-2813. ; 90:3
-
Journal article (peer-reviewed)abstract
- The structure of the neutron-rich bismuth isotope 217Bi has been studied for the first time. The fragmentation of a primary 238U beam at the FRS-RISING setup at GSI was exploited to perform γ-decay spectroscopy, since μs isomeric states were expected in this nucleus. Gamma rays following the decay of a t1/2=3 μs isomer were observed, allowing one to establish the low-lying structure of 217Bi. The level energies and the reduced electric quadrupole transition probability B(E2) from the isomeric state are compared to large-scale shell-model calculations.
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5. |
- Gottardo, A., et al.
(author)
-
New spectroscopic information on 211,213Tl : A changing structure beyond the N=126 shell closure
- 2019
-
In: Physical Review C. - 2469-9985. ; 99:5
-
Journal article (peer-reviewed)abstract
- The neutron-rich isotopes 211,213Tl, beyond the N=126 shell closure, have been studied for the first time in isomer γ-ray decay, exploiting the fragmentation of a primary uranium beam at the Fragment Separator-Rare Isotopes Investigation at GSI setup. The observed isomeric states in 211,213Tl show a deviation from the seniority-like scheme of 209Tl. The possible interpretation of the data is discussed on the basis of energy-level systematics and shell-model calculations.
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6. |
- Doornenbal, P., et al.
(author)
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RISING: Gamma‐ray Spectroscopy with Radioactive Beams at GSI
- 2007
-
In: AIP Conference Proceedings. - : AIP. - 0094-243X. - 9780735413283 ; 891, s. 99-107
-
Conference paper (peer-reviewed)abstract
- The Rare Isotope Spectroscopic INvestigation at GSI (RISING) project is a major pan‐European collaboration. Its physics aims are the studies of exotic nuclear matter with abnormal proton‐to‐neutron ratios compared with naturally occurring isotopes. RISING combines the FRagment Separator (FRS) which allows relativistic energies and projectile fragmentation reactions with EUROBALL Ge Cluster detectors for γ spectroscopic research. The RISING setup can be used in two different configurations. Either the nuclei of interest are investigated after being stopped or the heavy ions hit a secondary target at relativistic energies and the thereby occurring excitations are studied. For the latter case, MINIBALL Ge detectors and the HECTOR array are used in addition. Example achievements of the Fast Beam setup are presented and compared to various shell model calculations, while for the Stopped Beam setup initial results are shown.
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7. |
- Morales, A.I., et al.
(author)
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β-decay Studies of Neutron-rich Tl, Pb, and Bi Isotopes
- 2014
-
In: Physical Review C (Nuclear Physics). - 0556-2813. ; 89:1
-
Journal article (peer-reviewed)abstract
- The fragmentation of relativistic uranium projectiles has been exploited at the Gesellschaft für Schwerionenforschung laboratory to investigate the β decay of neutron-rich nuclei just beyond 208Pb. This paper reports on β-delayed γ decays of 211–213Tl, 215Pb, and 215–219Bi de-exciting states in the daughters 211–213Pb, 215Bi, and 215–219Po. The resulting partial level schemes, proposed with the help of systematics and shell-model calculations, are presented. The role of allowed Gamow-Teller and first-forbidden β transitions in this mass region is discussed.
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8. |
- Schlegel, C, et al.
(author)
-
K-isomers in very neutron-rich nuclei around mass 180
- 2000
-
In: Physica Scripta. Topical Issues. - 0281-1847. ; T88, s. 72-76
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Journal article (peer-reviewed)abstract
- gamma-spectroscopy methods have been used to search for microsecond isomers among the fragmentation products of a 1 GeV/nucleon Pb-208 beam. In particular the population of the known K-pi = 35/2(-) isomer in W-179 has been investigated and several new isomeric decays have been found for neutron rich nuclei in the A approximate to 180-200 mass region. The ground state band of the neutron rich N = 116 system of W-190 has been identified for the first time and we discuss its structure in comparison to neighboring systems.
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9. |
- Gottardo, A., et al.
(author)
-
Isomers in Neutron-rich Lead Isotopes Populated via the Fragmentation of 238U at 1 GeV A
- 2011
-
In: Journal of Physics: Conference Series. - : IOP Publishing. - 1742-6596 .- 1742-6588. ; 312
-
Journal article (peer-reviewed)abstract
- Neutron-rich nuclei beyond N = 126 in the lead region were populated by fragmenting a 238U beam at 1 GeV A on a Be target and then separated by the Fragment Separator (FRS) at GSI. Their isomeric decays were observed, enabling study of the shell structure of neutron-rich nuclei around the Z=82 shell closure. Some preliminary results are reported in this paper.
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10. |
- Kostyleva, D., et al.
(author)
-
Towards the Limits of Existence of Nuclear Structure: Observation and First Spectroscopy of the Isotope K-31 by Measuring Its Three-Proton Decay
- 2019
-
In: Physical Review Letters. - 1079-7114 .- 0031-9007. ; 123:9
-
Journal article (peer-reviewed)abstract
- The most remote isotope from the proton dripline (by 4 atomic mass units) has been observed: K-31. It is unbound with respect to three-proton (3p) emission, and its decays have been detected in flight by measuring the trajectories of all decay products using microstrip detectors. The 3p emission processes have been studied by the means of angular correlations of S-28 + 3p and the respective decay vertices. The energies of the previously unknown ground and excited states of K-31 have been determined. This provides its 3p separation energy value S-3p of -4.6(2) MeV. Upper half-life limits of 10 ps of the observed K-31 states have been derived from distributions of the measured decay vertices.
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11. |
- Mukha, I. G., et al.
(author)
-
Deep excursion beyond the proton dripline. I. Argon and chlorine isotope chains
- 2018
-
In: Physical Review C. - 2469-9993 .- 2469-9985. ; 98:6
-
Journal article (peer-reviewed)abstract
- The proton-unbound argon and chlorine isotopes have been studied by measuring trajectories of their decay-in-flight products by using a tracking technique with microstrip detectors. The proton (1p) and two-proton (2p) emission processes have been detected in the measured angular correlations "heavy-fragment"+p and "heavy-fragment"+p+p, respectively. The ground states of the previously unknown isotopes Cl30 and Cl28 have been observed for the first time, providing the 1p-separation energies Sp of -0.48(2) and -1.60(8), MeV, respectively. The relevant systematics of 1p- and 2p-separation energies have been studied theoretically in the core+p and core+p+p cluster models. The first-time observed excited states of Ar31 allow one to infer the 2p-separation energy S2p of 6(34) keV for its ground state. The first-time observed state in Ar29 with S2p=-5.50(18) MeV can be identified as either a ground state or an excited state according to different systematics.
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12. |
- Mukha, I., et al.
(author)
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Observation and Spectroscopy of New Proton-Unbound Isotopes Ar-30 and Cl-29: An Interplay of Prompt Two-Proton and Sequential Decay
- 2015
-
In: Physical Review Letters. - 1079-7114 .- 0031-9007. ; 115:20, s. 7-
-
Journal article (peer-reviewed)abstract
- Previously unknown isotopes Ar-30 and Cl-29 have been identified by measurement of the trajectories of their in-flight decay products S-28 + p + p and S-28 + p, respectively. The analysis of angular correlations of the fragments provided information on decay energies and the structure of the parent states. The ground states of Ar-30 and Cl-29 were found at 2.25(-0.10)(+0.15) and 1.8 +/- 0.1 MeV above the two-and one-proton thresholds, respectively. The lowest states in Ar-30 and Cl-29 point to a violation of isobaric symmetry in the structure of these unbound nuclei. The two-proton decay has been identified in a transition region between simultaneous two-proton and sequential proton emissions from the Ar-30 ground state, which is characterized by an interplay of three-body and two-body decay mechanisms. The first hint of a fine structure of the two-proton decay of Ar-30*(2(+)) has been obtained by detecting two decay branches into the ground and first-excited states of the S-28 fragment.
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13. |
- Neyens, G., et al.
(author)
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g-Factor Measurements on Relativistic Isomeric Beams Produced by Fragmentation and U-fission: The g-RISING Project at GSI
- 2007
-
In: Acta Physica Polonica. Series B: Elementary Particle Physics, Nuclear Physics, Statistical Physics, Theory of Relativity, Field Theory. - 0587-4254. ; 38:4, s. 1237-1247
-
Journal article (peer-reviewed)abstract
- Within the RISING (Rare ISotope INvestigations @ GSI) Collaboration at GSI, g factor measurements have been performed on isomeric states in neutron-rich isotopes approaching Sn-132 and in the neutron deficient Pb-region (the g-RISING campaign). We present the experimental technique and some typical aspects related to such studies on relativistic beams selected with the FRS fragment separator. First results are presented for the (19/2(+)) 4.5 mu s isomeric state in Sn-127, which has been produced by means of fission of a relativistic U-238 beam on the one hand, and by the fragmentation of a relativistic Xe-136 beam on the other hand. Spin-alignment has been observed in both reactions. It was the first time that spin-alignment has been established in a relativistic fission reaction.
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14. |
- Valiente-Dobón, J.J., et al.
(author)
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Manifestation of the Berry phase in the atomic nucleus 213Pb
- 2021
-
In: Physics Letters B. - : Elsevier BV. - 0370-2693. ; 816
-
Journal article (peer-reviewed)abstract
- The neutron-rich 213Pb isotope was produced in the fragmentation of a primary 1 GeV A 238U beam, separated in FRS in mass and atomic number, and then implanted for isomer decay γ-ray spectroscopy with the RISING setup at GSI. A newly observed isomer and its measured decay properties indicate that states in 213Pb are characterized by the seniority quantum number that counts the nucleons not in pairs coupled to angular momentum J=0. The conservation of seniority is a consequence of a geometric phase associated with particle-hole conjugation, which becomes observable in semi-magic nuclei where nucleons half-fill the valence shell. The γ-ray spectroscopic observables in 213Pb are thus found to be driven by two mechanisms, particle-hole conjugation and seniority conservation, which are intertwined through a Berry phase.
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15. |
- Zago, L., et al.
(author)
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High-spin states in 212Po above the α-decaying (18+) isomer
- 2022
-
In: Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 834
-
Journal article (peer-reviewed)abstract
- The nucleus 212Po has been produced through the fragmentation of a 238U primary beam at 1 GeV/nucleon at GSI, separated with the FRagment Separator, FRS, and studied via isomer γ-decay spectroscopy with the RISING setup. Two delayed previously unknown γ rays have been observed. One has been attributed to the E3 decay of a 21− isomeric state feeding the α-emitting 45-s (18+) high-spin isomer. The other γ-ray line has been assigned to the decay of a higher-lying 23+ metastable state. These are the first observations of high-spin states above the 212Po (18+) isomer, by virtue of the selectivity obtained via ion-by-ion identification of 238U fragmentation products. Comparison with shell-model calculations points to shortfalls in the nuclear interactions involving high-j proton and neutron orbitals, to which the region around Z∼100 is sensitive.
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16. |
- Caamano, M, et al.
(author)
-
Isomers in neutron-rich A approximate to 190 nuclides from Pb-208 fragmentation
- 2005
-
In: European Physical Journal A. Hadrons and Nuclei. - : Springer Science and Business Media LLC. - 1434-6001. ; 23:2, s. 201-215
-
Journal article (peer-reviewed)abstract
- Relativistic projectile fragmentation of Pb-208 has been used to produce isomers in neutron-rich, A approximate to 190 nuclides. A forward-focusing spectrometer provided ion-by-ion mass and charge identification. The detection of gamma-rays emitted by stopped ions has led to the assignment of isomers in Ta-188, W-190, Re-192, Re-193, Os-195, Ir-197, Ir-198, Pt-200, Pt-201, Pt-202 and Au-203, with half-lives ranging from approximately 10 ns to 1 ms. Tentative isomer information has been found also for Er-174, Er-175, Hf-185, Re-191, Re-194 and Ir-199. In most cases, time-correlated, singles gamma-ray events provided the first spectroscopic data on excited states for each nuclide. In Pt-200 and Pt-201. the assignments are supported by gamma-gamma coincidences. Isomeric ratios provide additional information, such as half-life and transition energy constraints in particular cases. The level structures of the platinum isotopes are discussed, and comparisons are made with isomer systematics.
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17. |
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18. |
- Regan, P. H., et al.
(author)
-
First Results from the Stopped RISING Campaign at GSI: The Mapping of Isomeric Decays in Highly Exotic Nuclei
- 2007
-
In: AIP Conference Proceedings. - : AIP. - 0094-243X. - 9780735413283 ; 899, s. 19-22
-
Conference paper (peer-reviewed)abstract
- The first results from the Stopped Beam RISING experimental campaign performed at the GSI laboratory in Darmstadt, Germany, are presented. RISING (Rare ISotope INvestigations at GSI) constitutes a major new experimental program in European nuclear structure physics research aimed at using relativistic‐energy, projectile‐fragmentation reactions to study nuclei with exotic proton‐to‐neutron ratios. This paper introduces the physics aims of the Stopped RISING collaboration and presents some technical details and initial results from experiments using the RISING array to study decays from metastable nuclear states in both proton and neutron‐rich nuclei.
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19. |
- Rudolph, Dirk, et al.
(author)
-
Exciting Isomers from the First Stopped-beam RISING Campaign
- 2007
-
In: The European Physical Journal. Special Topics. - : Springer Science and Business Media LLC. - 1951-6355 .- 1951-6401. ; 150, s. 173-176
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Journal article (peer-reviewed)abstract
- First results are reported from a major new initiative of experiments, which focus on nuclear structure studies at extreme isospin values by means of isomer spectroscopy. The experiments represent the first part of the so-called stopped-beam campaign within the Rare ISotope INvestigations at GSI (RISING) project. Time-correlated gamma decays from individually identified nuclear species have been measured, allowing the clean identification of isomeric decays in a wide range of exotic nuclei both at the proton drip-line and in heavy, neutron-rich systems. An overview of the experimental technique will be given, together with the performance of the new germanium detector array and future research plans for the collaboration.
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20. |
- Steer, S. J., et al.
(author)
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Isomeric Decay Studies In Neutron-Rich N Approximate To 126 Nuclei
- 2009
-
In: International Journal Of Modern Physics E-Nuclear Physics. - 0218-3013. ; 18:4, s. 1002-1007
-
Conference paper (peer-reviewed)abstract
- Heavy neutron-rich nuclei were populated via relativistic energy fragmentation of a E/A= 1 GeV Pb-208 beam. The nuclei of interest were selected and identified by a fragment separator and then implanted in a passive plastic stopper. Delayed. rays following internal isomeric decays were detected by the RISING array. Experimental information was obtained on a number of nuclei with Z=73-80 (Ta-Hg), providing new information both on the prolate-oblate transitional region as well as on the N=126 closed shell nuclei.
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21. |
- Wadsworth, R., et al.
(author)
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THE NORTHWEST FRONTIER : SPECTROSCOPY OF N similar to Z NUCLEI BELOW MASS 100
- 2009
-
In: Acta Physica Polonica B. - 0587-4254 .- 1509-5770. ; 40:3, s. 611-620
-
Journal article (peer-reviewed)abstract
- The spectroscopy and structure of excited states of N similar to Z nuclei in the mass 70-100 region has been investigated using two techniques. In the A similar to 70-80 region fusion evaporation reactions coupled with the recoil-beta-tagging method have been employed at Jyvaskyla to study low-lying states in odd-odd N = Z nuclei. Results from these and other data for known odd-odd nuclei above mass 60 will be discussed. In the heavier mass 90 region a fragmentation experiment has been performed using the RIS-ING/FRS setup at GSI. This experiment was primarily aimed at searching for spin gap isomers in nuclei around A similar to 96. The objectives of the latter experiment will be discussed.
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22. |
- Aleksandrov, D., et al.
(author)
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Invariant mass spectrum and alpha-n correlation function studied in the fragmentation of He-6 on a carbon target
- 1998
-
In: Nuclear Physics A. - 0375-9474. ; 633:2, s. 234-246
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Journal article (peer-reviewed)abstract
- Momentum distributions and invariant mass spectra from the breakup of He-6 ions with an energy of 240 MeV/u interacting with a carbon target have been studied. The data were used to extract information about the reaction mechanism which is influenced by the structure of He-6. It is found that the dominant reaction mechanism is a two-step process: knock out of one neutron followed by the decay of the He-5 resonance. The shape of the (alpha+n) two-body invariant mass spectrum is interpreted as mainly reflecting the 5He ground state which is a J(pi) = 3/2(-) resonance. However, no evidence for correlations between cu particles and neutrons is observed in the momentum widths of the distributions. It is demonstrated that a combined analysis of the two-body invariant mass spectrum and an appropriate correlation function may be used to determine the properties of the intermediate resonance. (C) 1998 Elsevier Science B.V.
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23. |
- Chulkov, L. V., et al.
(author)
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Large spin alignment of the unbound He-5 fragment after fragmentation of 240 MeV/nucleon He-6
- 1997
-
In: Physical Review Letters. - 1079-7114 .- 0031-9007. ; 79:2, s. 201-204
-
Journal article (peer-reviewed)abstract
- Peripheral fragmentation of a 240 MeV/nucleon beam of the halo nucleus He-6 incident on carbon target has been studied in a kinematically complete experiment. It is found that one-neutron stripping to the unbound nucleus He-5 is the dominant fragmentation mechanism and that it leads to a spin alignment of He-5 in a plane perpendicular to the He-5 momentum vector. This is expected to be a common feature for all neutron halo nuclei.
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24. |
- Garnsworthy, A. B., et al.
(author)
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Isomeric States in the Light Tc Isotopes
- 2007
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In: Acta Physica Polonica. Series B: Elementary Particle Physics, Nuclear Physics, Statistical Physics, Theory of Relativity, Field Theory. - 0587-4254. ; 38:4, s. 1265-1269
-
Journal article (peer-reviewed)abstract
- Preliminary results from the first experiment of the Stopped Beam RISING campaign are presented. The relativistic projectile fragmentation of a 750 MeV/u beam of Ag-107 populated isomeric states in very neutron deficient nuclei at the proton dripline around mass 80-90. Nuclei were unambiguously identified using the FRagment Separator (FRS) and its ancillary detectors located at GSI. The ions produced were slowed down from relativistic energies by means of an Al degrader and implanted in the centre of the high-efficiency Stopped RISING array. This allowed the identification of new excited states in the N = Z = 43 nucleus, Tc-86, populated following the de-excitation of a microsecond isomer. Preliminary results of this analysis, as well as previously unobserved isomeric states in Tc-87,Tc-88. are reported.
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25. |
- Garnsworthy, A B, et al.
(author)
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Neutron-proton pairing competition in N = Z nuclei: Metastable state decays in the proton dripline nuclei Nb-82(41) and Tc-86(43)
- 2008
-
In: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 660:4, s. 326-330
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Journal article (peer-reviewed)abstract
- The low-lying structures of the self-conjugate (N = Z) nuclei Nb-82(41)41 and Tc-86(43)43 have been investigated using isomeric-decay spectroscopy following the projectile fragmentation of a Ag-107 beam. These represent the heaviest odd-odd N = Z nuclei in which internal decays have been identified to date. The resulting level schemes shed light on the shape evolution along the N = Z line between the doubly-magic systems Ni-56(28) and Sn-100(50) and support a preference for T = 1 states in T-z = 0 odd-odd nuclei at low excitation energies associated with a T = 1 neutron-proton pairing gap. Comparison with Projected Shell Model calculations suggests that the decay in Nb-82 may be interpreted as an isospin-changing K isomer.
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