1. |
- Poyatos, R., et al.
(author)
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Global transpiration data from sap flow measurements: the SAPFLUXNET database
- 2021
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In: Earth System Science Data. - : Copernicus GmbH. - 1866-3508 .- 1866-3516. ; 13:6, s. 2607-2649
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Journal article (peer-reviewed)abstract
- Plant transpiration links physiological responses of vegetation to water supply and demand with hydrological, energy, and carbon budgets at the land-atmosphere interface. However, despite being the main land evaporative flux at the global scale, transpiration and its response to environmental drivers are currently not well constrained by observations. Here we introduce the first global compilation of whole-plant transpiration data from sap flow measurements (SAPFLUXNET, https://sapfluxnet.creaf.cat/, last access: 8 June 2021). We harmonized and quality-controlled individual datasets supplied by contributors worldwide in a semi-automatic data workflow implemented in the R programming language. Datasets include sub-daily time series of sap flow and hydrometeorological drivers for one or more growing seasons, as well as metadata on the stand characteristics, plant attributes, and technical details of the measurements. SAPFLUXNET contains 202 globally distributed datasets with sap flow time series for 2714 plants, mostly trees, of 174 species. SAPFLUXNET has a broad bioclimatic coverage, with woodland/shrubland and temperate forest biomes especially well represented (80 % of the datasets). The measurements cover a wide variety of stand structural characteristics and plant sizes. The datasets encompass the period between 1995 and 2018, with 50 % of the datasets being at least 3 years long. Accompanying radiation and vapour pressure deficit data are available for most of the datasets, while on-site soil water content is available for 56 % of the datasets. Many datasets contain data for species that make up 90 % or more of the total stand basal area, allowing the estimation of stand transpiration in diverse ecological settings. SAPFLUXNET adds to existing plant trait datasets, ecosystem flux networks, and remote sensing products to help increase our understanding of plant water use, plant responses to drought, and ecohydrological processes. SAPFLUXNET version 0.1.5 is freely available from the Zenodo repository (https://doi.org/10.5281/zenodo.3971689; Poyatos et al., 2020a). The "sapfluxnetr" R package - designed to access, visualize, and process SAPFLUXNET data - is available from CRAN.
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2. |
- Beck, S., et al.
(author)
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The Open Innovation in Science research field: a collaborative conceptualisation approach
- 2022
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In: Industry and Innovation. - : Informa UK Limited. - 1366-2716 .- 1469-8390. ; 29:2, s. 136-185
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Journal article (peer-reviewed)abstract
- Openness and collaboration in scientific research are attracting increasing attention from scholars and practitioners alike. However, a common understanding of these phenomena is hindered by disciplinary boundaries and disconnected research streams. We link dispersed knowledge on Open Innovation, Open Science, and related concepts such as Responsible Research and Innovation by proposing a unifying Open Innovation in Science (OIS) Research Framework. This framework captures the antecedents, contingencies, and consequences of open and collaborative practices along the entire process of generating and disseminating scientific insights and translating them into innovation. Moreover, it elucidates individual-, team-, organisation-, field-, and society-level factors shaping OIS practices. To conceptualise the framework, we employed a collaborative approach involving 47 scholars from multiple disciplines, highlighting both tensions and commonalities between existing approaches. The OIS Research Framework thus serves as a basis for future research, informs policy discussions, and provides guidance to scientists and practitioners.
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3. |
- Cherenko, M., et al.
(author)
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Venous thromboembolism in Cushing syndrome: results from an EuRRECa and Endo-ERN survey
- 2024
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In: Endocrine Connections. - 2049-3614. ; 13:6
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Journal article (peer-reviewed)abstract
- Background: Patients with Cushing syndrome (CS) are at increased risk of venous thromboembolism (VTE). Objective: The aim was to evaluate the current management of new cases of CS with a focus on VTE and thromboprophylaxis. Design and methods: A survey was conducted within those that report in the electronic reporting tool (e-REC) of the European Registries for Rare Endocrine Conditions (EuRRECa) and the involved main thematic groups (MTG’s) of the European Reference Networks for Rare Endocrine Disorders (Endo-ERN) on new patients with CS from January 2021 to July 2022. Results: Of 222 patients (mean age 44 years, 165 females), 141 patients had Cushing disease (64%), 69 adrenal CS (31%), and 12 patients with ectopic CS (5.4%). The mean follow-up period post-CS diagnosis was 15 months (range 3–30). Cortisol-lowering medications were initiated in 38% of patients. One hundred fifty-four patients (69%) received thromboprophylaxis (including patients on chronic anticoagulant treatment), of which low-molecular-weight heparins were used in 96% of cases. VTE was reported in six patients (2.7%), of which one was fatal: two long before CS diagnosis, two between diagnosis and surgery, and two postoperatively. Three patients were using thromboprophylaxis at time of the VTE diagnosis. The incidence rate of VTE in patients after Cushing syndrome diagnosis in our study cohort was 14.6 (95% CI 5.5; 38.6) per 1000 person-years. Conclusion: Thirty percent of patients with CS did not receive preoperative thromboprophylaxis during their active disease stage, and half of the VTE cases even occurred during this stage despite thromboprophylaxis. Prospective trials to establish the optimal thromboprophylaxis strategy in CS patients are highly needed. Significance statement The incidence rate of venous thromboembolism in our study cohort was 14.6 (95% CI 5.5; 38.6) per 1000 person-years. Notably, this survey showed that there is great heterogeneity regarding time of initiation and duration of thromboprophylaxis in expert centers throughout Europe.
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4. |
- Schvartz, D., et al.
(author)
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The Human Diabetes Proteome Project (HDPP) : The 2014 update
- 2015
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In: Translational Proteomics. - : Elsevier BV. - 2212-9626. ; 8-9, s. 1-7
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Journal article (peer-reviewed)abstract
- Diabetes is an increasing worldwide problem leading to major associated health issues and increased health care costs. In 2012, 9.3% of the American population was affected by diabetes, according to the American Diabetes Association, with 1.7 million of new cases since during the year (www.diabetes.org). Proteome initiatives can provide a deeper understanding of the biology of this disease and help develop more effective treatments. The collaborative effort of the Human Diabetes Proteome Project (HDPP) brings together a wide variety of complementary resources to increase the existing knowledge about both type 1 and type 2 diabetes and their related complications. The goals are to identify proteins and protein isoforms associated with the pathology and to characterize underlying disease-related pathways and mechanisms. Moreover, a considerable effort is being made on data integration and network biology. Sharing these data with the scientific community will be an important part of the consortium. Here we report on: the content of the HDPP session held at the 12th HUPO meeting in Yokohama; recent achievements of the consortium; discussions of several HDPP workshops; as well as future HDPP directions as discussed at the 13th HUPO congress in Madrid, with a special attention given to the lists of prioritized, diabetes-related proteins and the proteomic means to study them.
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6. |
- Pintado, P., et al.
(author)
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On the mechanical behavior of rubber springs for high speed rail vehicles
- 2018
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In: Journal of Vibration and Control. - : Sage Publications. - 1077-5463 .- 1741-2986. ; 24:20, s. 4676-4688
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Journal article (peer-reviewed)abstract
- There are many engineering design problems that call for rubber components as the best solution. Vulcanized rubber has found its way into all sorts of devices, from the universal automobile pneumatic tire to the ubiquitous compliant bushing. Some high-speed rail vehicle suspensions make use of rubber, not only in the air spring itself, but also in the auxiliary spring. The mechanical characteristics of this component influence vehicle dynamics and, therefore, accurate spring models with which to conduct dynamic analysis would make for powerful design tools. Nevertheless, the mechanical behavior of rubber defies simple modeling on account of stress relaxation, creep, set, viscosity, internal friction, and nonlinear stress-strain relations. Despite the advances in the micromechanical understanding of these phenomena, as well as in the macroscopic modeling of rubber spring behavior, there is ample room for refinement, and this is precisely the goal of this paper. The mechanical behavior of a particular rubber spring for high speed rail vehicles has been characterized. The results reveal the necessary components of the model, and suggest the appropriate procedure for parameter extraction. Our model proposal consists of three elements in parallel: a nonlinear elastic spring; a soft friction element; and a Maxwell viscous component. The characterization procedure takes into account both stress relaxation and nonlinear elasticity. The proposed model accurately reproduces experimental results and may then be used with confidence in any type of numerical simulation. Nevertheless, for this statement to be true, the problem of numerical softening potentially induced by soft friction models should be resolved. The paper will show that a trailing moving average filter, seamlessly tied to the model, wipes out the softening effect.
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7. |
- Priego, T, et al.
(author)
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TAS1R3 and UCN2 Transcript Levels in Blood Cells Are Associated With Sugary and Fatty Food Consumption in Children.
- 2015
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In: The Journal of clinical endocrinology and metabolism. - 1945-7197. ; 100:9, s. 3556-64
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Journal article (peer-reviewed)abstract
- New types of dietary exposure biomarkers are needed to implement effective strategies for obesity prevention in children. Of special interest are biomarkers of consumption of food rich in simple sugars and fat because their intake has been associated with obesity development. Peripheral blood cells (PBCs) represent a promising new tool for identifying novel, transcript-based biomarkers.
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