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- Agca, R., et al.
(author)
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EULAR recommendations for cardiovascular disease risk management in patients with rheumatoid arthritis and other forms of inflammatory joint disorders: 2015/2016 update
- 2017
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In: Ann Rheum Dis. - : BMJ. - 0003-4967 .- 1468-2060. ; 76:1, s. 17-28
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Journal article (peer-reviewed)abstract
- Patients with rheumatoid arthritis (RA) and other inflammatory joint disorders (IJD) have increased cardiovascular disease (CVD) risk compared with the general population. In 2009, the European League Against Rheumatism (EULAR) taskforce recommended screening, identification of CVD risk factors and CVD risk management largely based on expert opinion. In view of substantial new evidence, an update was conducted with the aim of producing CVD risk management recommendations for patients with IJD that now incorporates an increasing evidence base. A multidisciplinary steering committee (representing 13 European countries) comprised 26 members including patient representatives, rheumatologists, cardiologists, internists, epidemiologists, a health professional and fellows. Systematic literature searches were performed and evidence was categorised according to standard guidelines. The evidence was discussed and summarised by the experts in the course of a consensus finding and voting process. Three overarching principles were defined. First, there is a higher risk for CVD in patients with RA, and this may also apply to ankylosing spondylitis and psoriatic arthritis. Second, the rheumatologist is responsible for CVD risk management in patients with IJD. Third, the use of non-steroidal anti-inflammatory drugs and corticosteroids should be in accordance with treatment-specific recommendations from EULAR and Assessment of Spondyloarthritis International Society. Ten recommendations were defined, of which one is new and six were changed compared with the 2009 recommendations. Each designated an appropriate evidence support level. The present update extends on the evidence that CVD risk in the whole spectrum of IJD is increased. This underscores the need for CVD risk management in these patients. These recommendations are defined to provide assistance in CVD risk management in IJD, based on expert opinion and scientific evidence.
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- Lindström, H, et al.
(author)
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Electron transport properties in dye-sensitized nanoporous-nanocrystalline TiO2 films
- 1996
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In: JOURNAL OF PHYSICAL CHEMISTRY. - : AMER CHEMICAL SOC. ; 100:8, s. 3084-3088
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Journal article (other academic/artistic)abstract
- Spectral response measurements have been performed on dye-sensitized nanoporous-nanocrystalline TiO2 photoelectrodes. The effects of film thickness, electron scavengers in the electrolyte, and surface treatment of the nanocrystalline film were studied by
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- Lindström, H, et al.
(author)
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Li+ ion insertion in TiO2 (anatase) .1. Chronoamperometry on CVD films and nanoporous films
- 1997
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In: JOURNAL OF PHYSICAL CHEMISTRY B. - : AMER CHEMICAL SOC. - 1089-5647. ; 101:39, s. 7710-7716
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Journal article (other academic/artistic)abstract
- Electrochemical insertion of lithium in nanoporous and CVD samples of TiO2 (anatase) was studied by chronoamperometry. The currents following cathodic and anodic potential steps were monitored as a function of film thickness, temperature, and electrolyte
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- Lindström, H, et al.
(author)
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Li+ ion insertion in TiO2 (anatase) .2. Voltammetry on nanoporous films
- 1997
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In: JOURNAL OF PHYSICAL CHEMISTRY B. - : AMER CHEMICAL SOC. - 1089-5647. ; 101:39, s. 7717-7722
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Journal article (other academic/artistic)abstract
- Electrochemical properties of Li+ ion insertion in nanoporous TiO2 (anatase) electrodes were studied by voltammetry. Linear and cyclic potential scans were recorded as a function of electrolyte concentration, film thickness, and temperature. The currents
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- Lindström, H, et al.
(author)
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Redox properties of nanoporous TiO2 (anatase) surface modified with phosphotungstic acid
- 1998
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In: THIN SOLID FILMS. - : ELSEVIER SCIENCE SA. - 0040-6090. ; 323:1-2, s. 141-145
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Journal article (other academic/artistic)abstract
- Nanostructured anatase TiO2 electrodes surface modified with inorganic metal oxide clusters, i.e., phosphotungstic acid (PWA), was studied by XPS and spectroelectrochemistry. The surface modifiers were electroactive and could be addressed reversibly by ch
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- Persson, Petter, et al.
(author)
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N1s x-ray Absorption Study of the Bonding Interaction of Bi-Isonicotinic Acid on Rutile TiO2 (110)
- 2000
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In: Journal of Chemical Physics. - : AIP Publishing. - 0021-9606 .- 1089-7690. ; 112:9, s. 3945-3948
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Journal article (peer-reviewed)abstract
- N1s x-ray absorption spectra of bi-isonicotinic acid (2,28-bipyridine–4,48-dicarboxylic acid! on rutile TiO2(110) have been studied experimentally and quantum chemically. Differences between multilayer and monolayer spectra are explained by the adsorbate bonding to the substrate. A connection to the electronic coupling in dye-sensitized electrochemical devices is made.
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- Rensmo, H, et al.
(author)
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XPS studies of Ru-polypyridine complexes for solar cell applications
- 1999
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In: JOURNAL OF CHEMICAL PHYSICS. - 0021-9606. ; 111:6, s. 2744-2750
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Journal article (peer-reviewed)abstract
- A series of Ru-polypyridine dyes has been studied with electron spectroscopy using AlK alpha and synchrotron radiation. Both pure complexes and complexes adsorbed on nanostructured TiO2 (anatase) surfaces have been examined and special emphasis was g
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- Södergren, S, et al.
(author)
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Lithium intercalation in nanoporous anatase TiO2 studied with XPS
- 1997
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In: JOURNAL OF PHYSICAL CHEMISTRY B. - : AMER CHEMICAL SOC. - 1089-5647. ; 101:16, s. 3087-3090
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Journal article (other academic/artistic)abstract
- Intercalation of lithium ions in nanoporous anatase TiO2 was studied with XPS using a novel electrochemical preparation technique. The electrolyte was 0.5 M LiClO4 in acetonitrile (not water-free). The electrochemical insertion of lithium ions creates red
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16. |
- Berglund, S, et al.
(author)
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Atherothrombotic events in rheumatoid arthritis are predicted by homocysteine : a six-year follow-up study
- 2009
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In: Clinical and Experimental Rheumatology. - 0392-856X .- 1593-098X. ; 27:5, s. 822-825
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Journal article (peer-reviewed)abstract
- OBJECTIVE: The aim of this study was to investigate whether homocysteine is linked to atherothrombotic (AT) events in patients with rheumatoid arthritis (RA). METHODS: Analysis of homocysteine (Hcy) levels was carried out in 235 consecutive RA patients. They were followed-up for 6.5 years or until death, with analysis of AT risk factors and the type and length of DMARD and corticosteroid treatment. The disease history before inclusion was collected. Six categories of AT events were defined. In addition, the diagnosis of the patients at follow-up was co-analyzed with the nationwide population-based Swedish Inpatient Register and Death Register to certify all events. RESULTS: The Hcy level was found to be higher in males (p<0.05) and increased with age (p<0.001). Patients with folic acid supplementation had significantly lower levels, while those on corticosteroids had higher levels. High Hcy levels predicted AT events (n=48) during a 6.5-year follow-up adjusted for age and male sex in a logistic regression analysis. CONCLUSION: In this study, RA patients on folic acid had lower Hcy levels. High Hcy levels (in addition to age, sex and diabetes) predicted AT event prospectively.
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- Laranjeiro, F., et al.
(author)
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Comparative assessment of the acute toxicity of commercial bio-based polymer leachates on marine plankton
- 2024
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In: Science of the Total Environment. - : Elsevier. - 0048-9697 .- 1879-1026. ; 946
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Journal article (peer-reviewed)abstract
- Conventional plastics have become a major environmental concern due to their persistence and accumulation in marine ecosystems. The development of potential degradable polymers (PBP), such as polyhydroxyalkanoates (PHAs) and polylactic acid (PLA), has gained attention as an alternative to mitigate plastic pollution, since they have the potential to biodegrade under certain conditions, and their production is increasing as replacement of conventional polyolefins. This study aimed to assess and compare the toxicity of leachates of pre-compounding PBP (PLA and the PHA, polyhydroxybutyrate-covalerate (PHBv)) and polypropylene (PP) on five marine planktonic species. A battery of standard bioassays using bacteria, microalgae, sea urchin embryos, mussel embryos and copepod nauplii was conducted to assess the toxicity of leachates from those polymers. Additionally, the presence of chemical additives in the leachates was also verified through GC-MS and LC-HRMS analysis. Results showed that PHBv leachates exhibited higher toxicity compared to other polymers, with the microalgae Rhodomonas salina, being the most sensitive species to the tested leachates. On the other hand, PP and PLA generally displayed minimal to no toxicity in the studied species. Estimated species sensitivity distribution curves (SSD) show that PHBv leachates can be 10 times more hazardous to marine plankton than PP or PLA leachates, as demonstrated by the calculated Hazardous Concentration for 5 % of species (HC5). Qualitative chemical analysis supports the toxicological results, with 80 % of compounds being identified in PHBv leachates of which 2,4,6-trichlorophenol is worth mentioning due to the deleterious effects to aquatic biota described in literature. These findings underscore the fact that whereas environmental persistence can be targeted using PBP, the issue of chemical safety remains unsolved by some alternatives, such as PHBv. Gaining a comprehensive understanding of the toxicity profiles of PBP materials through a priori toxicological risk assessment is vital for their responsible application as alternatives to conventional plastics.
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25. |
- Liu, Yen Po, et al.
(author)
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Low temperature scanning tunneling microscopy and spectroscopy on laterally grown InxGa1-xAs nanowire devices
- 2020
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In: Applied Physics Letters. - : AIP Publishing. - 0003-6951 .- 1077-3118. ; 117:16
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Journal article (peer-reviewed)abstract
- Laterally grown InxGa1-xAs nanowires (NWs) are promising candidates for radio frequency and quantum computing applications, which, however, can require atomic scale surface and interface control. This is challenging to obtain, not least due to ambient air exposure between fabrication steps, which induces surface oxidation. The geometric and electronic surface structures of InxGa1-xAs NWs and contacts, which were grown directly in a planar configuration, exposed to air, and then subsequently cleaned using atomic hydrogen, are studied using low-temperature scanning tunneling microscopy and spectroscopy (STM/S). Atomically flat facets witha root mean square roughness of 0.12 nm and the InGaAs (001) 4 × 2 surface reconstruction areobserved on the top facet of the NWs and the contacts. STS shows a surface bandgap variation of 30 meV from the middle to the end of the NWs, which is attributed to a compositional variation of the In/Ga element concentration. The well-defined facets and small bandgap variations found after area selective growth and atomic hydrogen cleaning are a good starting point for achieving high-quality interfaces during further processing.
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