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- Ademuyiwa, Adesoji O., et al.
(author)
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Determinants of morbidity and mortality following emergency abdominal surgery in children in low-income and middle-income countries
- 2016
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In: BMJ Global Health. - : BMJ Publishing Group Ltd. - 2059-7908. ; 1:4
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Journal article (peer-reviewed)abstract
- Background: Child health is a key priority on the global health agenda, yet the provision of essential and emergency surgery in children is patchy in resource-poor regions. This study was aimed to determine the mortality risk for emergency abdominal paediatric surgery in low-income countries globally.Methods: Multicentre, international, prospective, cohort study. Self-selected surgical units performing emergency abdominal surgery submitted prespecified data for consecutive children aged <16 years during a 2-week period between July and December 2014. The United Nation's Human Development Index (HDI) was used to stratify countries. The main outcome measure was 30-day postoperative mortality, analysed by multilevel logistic regression.Results: This study included 1409 patients from 253 centres in 43 countries; 282 children were under 2 years of age. Among them, 265 (18.8%) were from low-HDI, 450 (31.9%) from middle-HDI and 694 (49.3%) from high-HDI countries. The most common operations performed were appendectomy, small bowel resection, pyloromyotomy and correction of intussusception. After adjustment for patient and hospital risk factors, child mortality at 30 days was significantly higher in low-HDI (adjusted OR 7.14 (95% CI 2.52 to 20.23), p<0.001) and middle-HDI (4.42 (1.44 to 13.56), p=0.009) countries compared with high-HDI countries, translating to 40 excess deaths per 1000 procedures performed.Conclusions: Adjusted mortality in children following emergency abdominal surgery may be as high as 7 times greater in low-HDI and middle-HDI countries compared with high-HDI countries. Effective provision of emergency essential surgery should be a key priority for global child health agendas.
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- 2019
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Journal article (peer-reviewed)
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- Haghighi, Mona, et al.
(author)
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A Comparison of Rule-based Analysis with Regression Methods in Understanding the Risk Factors for Study Withdrawal in a Pediatric Study
- 2016
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In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 6
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Journal article (peer-reviewed)abstract
- Regression models are extensively used in many epidemiological studies to understand the linkage between specific outcomes of interest and their risk factors. However, regression models in general examine the average effects of the risk factors and ignore subgroups with different risk profiles. As a result, interventions are often geared towards the average member of the population, without consideration of the special health needs of different subgroups within the population. This paper demonstrates the value of using rule-based analysis methods that can identify subgroups with heterogeneous risk profiles in a population without imposing assumptions on the subgroups or method. The rules define the risk pattern of subsets of individuals by not only considering the interactions between the risk factors but also their ranges. We compared the rule-based analysis results with the results from a logistic regression model in The Environmental Determinants of Diabetes in the Young (TEDDY) study. Both methods detected a similar suite of risk factors, but the rule-based analysis was superior at detecting multiple interactions between the risk factors that characterize the subgroups. A further investigation of the particular characteristics of each subgroup may detect the special health needs of the subgroup and lead to tailored interventions.
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| 11. |
- Aad, G., et al.
(author)
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- 2014
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In: The European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6052. ; 74:8
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Journal article (peer-reviewed)
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| 12. |
- Aad, G., et al.
(author)
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- 2014
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In: The European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6052. ; 74:6
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Journal article (peer-reviewed)
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| 13. |
- Aad, G., et al.
(author)
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- 2014
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Journal article (peer-reviewed)
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| 14. |
- Aad, G., et al.
(author)
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- 2014
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Journal article (peer-reviewed)
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| 15. |
- Aad, G., et al.
(author)
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- 2014
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In: Journal of High Energy Physics. - 1029-8479 .- 1126-6708. ; :8
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Journal article (peer-reviewed)
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| 16. |
- Aad, G., et al.
(author)
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- 2014
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In: Journal of High Energy Physics. - 1029-8479 .- 1126-6708. ; :6
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Journal article (peer-reviewed)
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| 17. |
- Aad, G., et al.
(author)
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- 2014
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In: Journal of High Energy Physics. - 1029-8479 .- 1126-6708. ; :9
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Journal article (peer-reviewed)
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| 18. |
- Aad, G., et al.
(author)
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- 2015
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In: Journal of High Energy Physics. - : Springer-Verlag New York. - 1029-8479 .- 1126-6708. ; :9
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Journal article (peer-reviewed)
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| 19. |
- Aad, G., et al.
(author)
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- 2013
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Journal article (peer-reviewed)
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| 20. |
- Aad, G., et al.
(author)
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- 2014
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In: Physical Review D (Particles, Fields, Gravitation and Cosmology). - 1550-2368 .- 1550-7998. ; 90:5
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Journal article (peer-reviewed)
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| 21. |
- Aad, G., et al.
(author)
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- 2013
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Journal article (peer-reviewed)
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| 22. |
- Aad, G., et al.
(author)
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- 2015
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In: Journal of High Energy Physics. - : Springer-Verlag New York. - 1029-8479 .- 1126-6708. ; :6
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Journal article (peer-reviewed)
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| 23. |
- Aad, G., et al.
(author)
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- 2015
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In: Physical Review D (Particles, Fields, Gravitation and Cosmology). - 1550-2368 .- 1550-7998. ; 91:3
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Journal article (peer-reviewed)
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| 24. |
- Aad, G., et al.
(author)
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- 2014
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In: Journal of High Energy Physics. - 1029-8479 .- 1126-6708. ; :5, s. 1-52
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Journal article (peer-reviewed)
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| 25. |
- Abbafati, Cristiana, et al.
(author)
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- 2020
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Journal article (peer-reviewed)
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