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1.	Bolin, S, et al. (author) QUIESCENT SOX9-POSITIVE CELLS BEHIND MYC DRIVEN MEDULLOBLASTOMA RECURRENCE 2020 In: NEURO-ONCOLOGY. - 1522-8517. ; 22, s. 400-400 Conference paper (other academic/artistic)
2.	Čančer, Matko, et al. (author) Humanized Stem Cell Models of Pediatric Medulloblastoma Reveal an Oct4/mTOR Axis that Promotes Malignancy 2019 In: Cell Stem Cell. - : CELL PRESS. - 1934-5909 .- 1875-9777. ; 25:6, s. 855-870 Journal article (peer-reviewed)abstract Medulloblastoma (MB), the most frequent malignant childhood brain tumor, can arise from cellular malfunctions during hindbrain development. Here we generate humanized models for Sonic Hedgehog (SHH)-subgroup MB via MYCN overexpression in primary human hindbrain-derived neuroepithelial stem (hbNES) cells or iPSC-derived NES cells, which display a range of aggressive phenotypes upon xenografting. iPSC-derived NES tumors develop quickly with leptomeningeal dissemination, whereas hbNES-derived cells exhibit delayed tumor formation with less dissemination. Methylation and expression profiling show that tumors from both origins recapitulate hallmarks of infant SHH MB and reveal that mTOR activation, as a result of increased Oct4, promotes aggressiveness of human SHH tumors. Targeting mTOR decreases cell viability and prolongs survival, showing the utility of these varied models for dissecting mechanisms mediating tumor aggression and demonstrating the value of humanized models for a better understanding of pediatric cancers.
3.	Roswall, P, et al. (author) MicroRNA-21 regulates Sox2 expression and tumor self-renewal in PDGF-driven glioma 2011 In: CANCER RESEARCH. - 0008-5472. ; 71 Conference paper (other academic/artistic)
4.	Zafar, I, et al. (author) Targeting brain tumours with radiolabelled chlorotoxin, a scorpion venom peptide 2023 In: NUCLEAR MEDICINE AND BIOLOGY. - 0969-8051. ; 126, s. S301-S301 Conference paper (other academic/artistic)

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Type of publication: conference paper (3); journal article (1)

Type of content: other academic/artistic (3); peer-reviewed (1)

Author/Editor: Swartling, FJ (4); Lu, L. (1); Lewis, J (1); Jernberg-Wiklund, H (1); Li, K. (1); Singh, U. (1); show more...; Essand, Magnus (1); Sundström, Anders (1); Westermark, B (1); Tran, T (1); Holmin, S. (1); Sundstrom, A (1); Sangfelt, O (1); Zhao, M. (1); Rosén, G (1); Chen, XQ (1); Varshney, M. (1); Falk, Anna (1); Richardson, S. (1); Bergström, Tobias, 1 ... (1); Weishaupt, Holger (1); Bergstrom, T (1); Bolin, S (1); Savov, V (1); Borgenvik, A (1); Garancher, A (1); Hutter, S (1); Rusert, J (1); Fotaki, G (1); Hill, RM (1); Dubuc, AM (1); Remke, M (1); Ramaswamy, V (1); Schuller, U (1); Weishaupt, H (1); Holmberg Olausson, K ... (1); Rosén, Gabriela (1); Hutter, Sonja (1); Garancher, Alexandra (1); Čančer, Matko (1); Wechsler-Reya, Rober ... (1); Rahmanto, AS (1); Mainwaring, O (1); Olausson, KH (1); Kalushkova, A (1); Cancer, M (1); Taylor, MD (1); Clifford, SC (1); Wechsler-Reya, RJ (1); Johansson, Fredrik K ... (1); show less...

University: Karolinska Institutet (4); Uppsala University (1)

Language: English (4)

Research subject (UKÄ/SCB): Natural sciences (1); Medical and Health Sciences (1)

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