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- Cappi, C, et al.
(author)
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Association study between functional polymorphisms in the TNF-alpha gene and obsessive-compulsive disorder
- 2012
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In: Arquivos de neuro-psiquiatria. - : FapUNIFESP (SciELO). - 1678-4227 .- 0004-282X. ; 70:2, s. 87-90
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Journal article (peer-reviewed)abstract
- Obsessive-compulsive disorder (OCD) is a prevalent psychiatric disorder of unknown etiology. However, there is some evidence that the immune system may play an important role in its pathogenesis. In the present study, two polymorphisms (rs1800795 and rs361525) in the promoter region of the cytokine tumor necrosis factor-alpha (TNFA) gene were genotyped in 183 OCD patients and in 249 healthy controls. The statistical tests were performed using the PLINK® software. We found that the A allele of the TNFA rs361525 polymorphism was significantly associated with OCD subjects, according to the allelic χ² association test (p=0.007). The presence of genetic markers, such as inflammatory cytokines genes linked to OCD, may represent additional evidence supporting the role of the immune system in its pathogenesis.
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- Cordeiro, Q, et al.
(author)
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Investigation of possible association between Ser9Gly polymorphism of the D3 dopaminergic receptor gene and response to typical antipsychotics in patients with schizophrenia
- 2006
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In: Sao Paulo medical journal = Revista paulista de medicina. - : FapUNIFESP (SciELO). - 1516-3180. ; 124:3, s. 165-7
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Journal article (peer-reviewed)abstract
- Typical antipsychotics have a high affinity for dopamine receptors. It is therefore of interest to investigate such loci in pharmacogenetic studies on psychosis. We investigated the hypothesis that Ser9Gly polymorphism of the DRD3 gene may play a role in the differences in individual response to typical antipsychotics between schizophrenic patients. The sample was composed of 53 good responders and 59 poor ones. No significant differences between the good and poor responders were found in the allelic distribution (good responders: Ser9 61.32%, Gly9 38.67%; poor responders: Ser9 64.40%, Gly9 35.59%; odds ratio, OR = 0.88, 0.49 < OR < 1.56; chi2 = 0.23, 1 degree of freedom, df, p = 0.63) and genotype distribution (good responders: Ser9/Ser9 37.73%, Ser9/Gly9 47.16%, Gly9/Gly9 15.09%; poor responders: Ser9/Ser9 42.37%, Ser9/Gly9 44.06%, Gly9/Gly9 13.55%; chi2 = 0.25, 2 df, p = 0.88). Nor was there any association with homozygosity (good responders: homozygous: 52.82%, heterozygous: 47.16%; poor responders: homozygous: 55.92%, heterozygous: 44.06%; odds ratio, OR = 0.88, 0.39 < OR < 1.99; chi2 = 0.11, 1 df, p = 0.74). The results did not support the hypothesis that Ser9Gly polymorphism of the DRD3 gene influences the response to typical antipsychotics in our sample of schizophrenics.
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- Lucchetti, G, et al.
(author)
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Exploring the acceptance of religious assistance among patients of a psychiatric hospital
- 2013
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In: The International journal of social psychiatry. - : SAGE Publications. - 1741-2854 .- 0020-7640. ; 59:4, s. 311-317
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Journal article (peer-reviewed)abstract
- Spiritual issues are rarely addressed by psychiatric institutions in daily routine practice. Aims: To report the prevalence of, and factors associated with, inpatients’ acceptance of religious assistance in a psychiatric hospital. Methods: All patients evaluated by the religious assistance service in a psychiatric hospital were included. Patients admitted were asked about their need for religious assistance and were assessed on several religious aspects. Additional information was collected from patients’ hospital charts. A comparison between those who accepted the religious assistance and those who did not was performed. Results: Most of the 213 patients evaluated requested religious assistance (85.0%), including those that reported having no religion (79.1%). Patients with a diagnosis of schizophrenia ( p = .010) and lower intrinsic religiousness ( p = .002) tended to request less religious assistance. More than 80% of patients requested assistance based on religious traditions other than their own. Conclusion: Most psychiatric inpatients were willing to participate in religious assistance sessions, even those without formal religious affiliations. Patients with lower intrinsic religiosity and schizophrenia tended to request less assistance. We believe the findings of this study can serve to foster discussion on whether psychiatric hospitals should provide a structured religious care service.
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