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- Munch, Marie W., et al.
(author)
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Effect of 12 mg vs 6 mg of Dexamethasone on the Number of Days Alive Without Life Support in Adults With COVID-19 and Severe Hypoxemia The COVID STEROID 2 Randomized Trial
- 2021
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In: Journal of the American Medical Association (JAMA). - : AMER MEDICAL ASSOC. - 0098-7484 .- 1538-3598. ; 326:18, s. 1807-1817
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Journal article (peer-reviewed)abstract
- Question What is the effect of 12 mg vs 6 mg of dexamethasone on the number of days alive without life support at 28 days in patients with COVID-19 and severe hypoxemia? Findings In this randomized trial that included 1000 patients with COVID-19 and severe hypoxemia, treatment with 12 mg/d of dexamethasone resulted in 22.0 days alive without life support at 28 days compared with 20.5 days in those receiving 6 mg/d of dexamethasone. This difference was not statistically significant. Meaning Compared with 6 mg of dexamethasone, 12 mg of dexamethasone did not statistically significantly reduce the number of days alive without life support at 28 days. This multicenter randomized clinical trial compares the effects of 12 mg/d vs 6 mg/d of dexamethasone in patients with COVID-19 and severe hypoxemia. IMPORTANCE A daily dose with 6 mg of dexamethasone is recommended for up to 10 days in patients with severe and critical COVID-19, but a higher dose may benefit those with more severe disease. OBJECTIVE To assess the effects of 12 mg/d vs 6 mg/d of dexamethasone in patients with COVID-19 and severe hypoxemia. DESIGN, SETTING, AND PARTICIPANTS A multicenter, randomized clinical trial was conducted between August 2020 and May 2021 at 26 hospitals in Europe and India and included 1000 adults with confirmed COVID-19 requiring at least 10 L/min of oxygen or mechanical ventilation. End of 90-day follow-up was on August 19, 2021. INTERVENTIONS Patients were randomized 1:1 to 12 mg/d of intravenous dexamethasone (n = 503) or 6 mg/d of intravenous dexamethasone (n = 497) for up to 10 days. MAIN OUTCOMES AND MEASURES The primary outcome was the number of days alive without life support (invasive mechanical ventilation, circulatory support, or kidney replacement therapy) at 28 days and was adjusted for stratification variables. Of the 8 prespecified secondary outcomes, 5 are included in this analysis (the number of days alive without life support at 90 days, the number of days alive out of the hospital at 90 days, mortality at 28 days and at 90 days, and >= 1 serious adverse reactions at 28 days). RESULTS Of the 1000 randomized patients, 982 were included (median age, 65 [IQR, 55-73] years; 305 [31%] women) and primary outcome data were available for 971 (491 in the 12 mg of dexamethasone group and 480 in the 6 mg of dexamethasone group). The median number of days alive without life support was 22.0 days (IQR, 6.0-28.0 days) in the 12 mg of dexamethasone group and 20.5 days (IQR, 4.0-28.0 days) in the 6 mg of dexamethasone group (adjusted mean difference, 1.3 days [95% CI, 0-2.6 days]; P = .07). Mortality at 28 days was 27.1% in the 12 mg of dexamethasone group vs 32.3% in the 6 mg of dexamethasone group (adjusted relative risk, 0.86 [99% CI, 0.68-1.08]). Mortality at 90 days was 32.0% in the 12 mg of dexamethasone group vs 37.7% in the 6 mg of dexamethasone group (adjusted relative risk, 0.87 [99% CI, 0.70-1.07]). Serious adverse reactions, including septic shock and invasive fungal infections, occurred in 11.3% in the 12 mg of dexamethasone group vs 13.4% in the 6 mg of dexamethasone group (adjusted relative risk, 0.83 [99% CI, 0.54-1.29]). CONCLUSIONS AND RELEVANCE Among patients with COVID-19 and severe hypoxemia, 12 mg/d of dexamethasone compared with 6 mg/d of dexamethasone did not result in statistically significantly more days alive without life support at 28 days. However, the trial may have been underpowered to identify a significant difference.
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- Meenakshi, S, et al.
(author)
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High-pressure studies on YNi2B2C at room temperature
- 1998
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In: PHYSICAL REVIEW B-CONDENSED MATTER. - : AMERICAN PHYSICAL SOC. - 0163-1829. ; 58:6, s. 3377-3380
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Journal article (other academic/artistic)abstract
- The electronic and lattice structure, and equation of state behavior of YNi2B2C has been investigated by electrical resistivity, thermoelectric power, and angle-dispersive x-ray-diffraction measurements. The electrical resistance under pressure has also b
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- Kumar, Anil P., et al.
(author)
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Composition driven structural transition in La2-xSrxCuRuO6 (0 <= x <= 1) double perovskites
- 2017
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In: Journal of Alloys and Compounds. - : Elsevier BV. - 0925-8388 .- 1873-4669. ; 693, s. 1096-1101
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Journal article (peer-reviewed)abstract
- We report results of detailed structural investigations on the system La2-xSrxCuRuO6 (0 <= x <= 1) as a function of composition using neutron powder diffraction. Our results reveal that this series of compounds exhibit an interesting structural transition manifested through Sr doping; with Ru in single valency, in end members, and mixed valency otherwise. The end members La2CuRuO6 and LaSrCuRuO6 crystallize in monoclinic structures with space group P2(1)/n. However, the compositions with intermediate Sr doping (x = 0.2 and 0.8) crystallize in triclinic structure with space group P-1, albeit with minute distortions. The detailed structural studies by neutron powder diffraction at room temperature and at 10 K, for compositions, x = 0.2, 0.8 and 1 are presented. While magnetic measurements are indicative of ferro and antiferromagnetic like transitions for x = 0 and x > 0 respectively, neutron diffraction patterns collected at 10 K and 30 K across the characteristic transition temperature suggested by the magnetic data, do not show any extra peaks or extra intensity at lower temperature as compared to the high temperature, thus, establishing the absence of any long-range magnetic ordering in these samples.
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| 13. |
- Kumar, P. Anil, et al.
(author)
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Ferrimagnetism, antiferromagnetism, and magnetic frustration in La2-xSrxCuRuO6 (0 <= x <= 1)
- 2012
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In: Physical Review B. Condensed Matter and Materials Physics. - : APS. - 1098-0121 .- 1550-235X. ; 86:9, s. 094421-
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Journal article (peer-reviewed)abstract
- We studied structural and magnetic properties of a series of insulating double perovskite compounds, La2-xSrxCuRuO6 (0 <= x <= 1), representing doping via A-site substitution. The end members La2CuRuO6 and LaSrCuRuO6 form in monoclinic structure while the intermediate Sr doped compounds stabilize in triclinic structure. The Cu and Ru ions sit on alternate B sites of the perovskite lattice with similar to 15% antisite defects in the undoped sample while the Sr-doped samples show a tendency to higher ordering at B sites. The undoped (x = 0) compound shows a ferrimagnetic-like behavior at low temperatures. In surprising contrast to the usual expectation of an enhancement of ferromagnetic interaction on doping, an antiferromagnetic-like ground state is realized for all doped samples (x > 0). Heat capacity measurements indicate the absence of any long-range magnetic order in any of these compounds. The magnetic relaxation and memory effects observed in all compounds suggest glassy dynamical properties associated with magnetic disorder and frustration. We show that the observed magnetic properties are dominated by the competition between the nearest-neighbor Ru-O-Cu 180 degrees superexchange interaction and the next-nearest-neighbor Ru-O-O-Ru 90 degrees superexchange interaction as well as by the formation of antisite defects with interchanged Cu and Ru positions. Our calculated exchange interaction parameters from first principles calculations for x = 0 and x = 1 support this interpretation.
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- Kumari, Anshu, et al.
(author)
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Solar Radio Spectro-polarimeter (50-500 MHz). I. Design, Development, and Characterization of a Cross-polarized, Log-periodic Dipole Antenna
- 2023
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In: Astrophysical Journal. - 1538-4357 .- 0004-637X. ; 958:2
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Journal article (peer-reviewed)abstract
- The Zeeman effect has been routinely used to image and quantify the solar photospheric magnetic field (B). Such a direct measuring technique is not yet available for the corona (Lin et al. 2004). Since almost all transient nonthermal radio emissions from the corona are either partially or fully circularly polarized, observing their polarization signatures over broad frequency ranges would be of help to estimate B as a function of heliocentric height. This article aims to describe the design and development of a Cross-polarized Log-Periodic Dipole Antenna (CLPDA), an integral part of a radio spectro-polarimeter, which works in the 50-500 MHz frequency-range and to explain the tests that were carried out to characterize it. The above frequency range corresponds to a heliocentric height range ≈1.03 < r < 2.5 R ⊙ (R ⊙ = photospheric radius), wherein the numerous coronal nonthermal transients associated with space-weather effects are observed to originate. The CLPDA is used to determine the strength and sense of polarization of the received radio signal. The uncertainty involved in the determination depends on the polarization-isolation (PI) between the two orthogonal components of a CLPDA. Some of the recent advancements made in the antenna design concepts at high frequencies (∼GHz) were adopted to reduce the PI at low frequencies (∼MHz). Throughout the above frequency range, the CLPDA has a gain, return loss, and PI of ≈6.6 dBi, ≲−10 dB, and ≲−27 dB, respectively. The average PI of the CLPDA varies from −30 to −24 dB over an azimuthal angle range 0° to ±45° within which the observations are performed regularly.
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| 15. |
- Walters, Anthony, et al.
(author)
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The Hydrogen Intensity Real-time Analysis eXperiment: Overview and Status Update
- 2024
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In: 18th European Conference on Antennas and Propagation, EuCAP 2024.
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Conference paper (peer-reviewed)abstract
- The Hydrogen Intensity Real-time Analysis eXperiment (HIRAX) will be a large interferometric array of drift-scan radio telescopes designed to map the large-scale spatial fluctuations of neutral hydrogen in the Universe, in order to better understand the nature of dark energy. It will operate between 400-800 MHz, and is currently under construction in the Karoo desert of South Africa. It will also be a powerful tool for studying astronomical transients and the evolution of galaxies. Here we present an overview of the project, its anticipated deployment timelines, and highlight some of the characterisation and calibration efforts that are currently underway, or planned for the future.
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