| 1. |
|
|
| 2. |
- Glasbey, JC, et al.
(author)
-
- 2021
-
swepub:Mat__t
|
|
| 3. |
- Tabiri, S, et al.
(author)
-
- 2021
-
swepub:Mat__t
|
|
| 4. |
- Bravo, L, et al.
(author)
-
- 2021
-
swepub:Mat__t
|
|
| 5. |
|
|
| 6. |
|
|
| 7. |
|
|
| 8. |
- Walker, Anthony P, et al.
(author)
-
Horizon 2020 EuPRAXIA design study
- 2017
-
In: Journal of Physics: Conference Series. - : IOP Publishing. - 1742-6588 .- 1742-6596. ; 874:1
-
Journal article (peer-reviewed)abstract
- The Horizon 2020 Project EuPRAXIA ("European Plasma Research Accelerator with eXcellence In Applications") is preparing a conceptual design report of a highly compact and cost-effective European facility with multi-GeV electron beams using plasma as the acceleration medium. The accelerator facility will be based on a laser and/or a beam driven plasma acceleration approach and will be used for photon science, high-energy physics (HEP) detector tests, and other applications such as compact X-ray sources for medical imaging or material processing. EuPRAXIA started in November 2015 and will deliver the design report in October 2019. EuPRAXIA aims to be included on the ESFRI roadmap in 2020.
|
|
| 9. |
- Nechaeva, T., et al.
(author)
-
Hosing of a Long Relativistic Particle Bunch in Plasma
- 2024
-
In: Physical Review Letters. - : American Physical Society. - 0031-9007 .- 1079-7114. ; 132:7
-
Journal article (peer-reviewed)abstract
- Experimental results show that hosing of a long particle bunch in plasma can be induced by wakefields driven by a short, misaligned preceding bunch. Hosing develops in the plane of misalignment, selfmodulation in the perpendicular plane, at frequencies close to the plasma electron frequency, and are reproducible. Development of hosing depends on misalignment direction, its growth on misalignment extent and on proton bunch charge. Results have the main characteristics of a theoretical model, are relevant to other plasma -based accelerators and represent the first characterization of hosing.
|
|
| 10. |
- Verra, L., et al.
(author)
-
Controlled Growth of the Self-Modulation of a Relativistic Proton Bunch in Plasma
- 2022
-
In: Physical Review Accelerators and Beams. - : American Physical Society. - 2469-9888. ; 25:7
-
Journal article (peer-reviewed)abstract
- A long, narrow, relativistic charged particle bunch propagating in plasma is subject to the self -modulation (SM) instability. We show that SM of a proton bunch can be seeded by the wakefields driven by a preceding electron bunch. SM timing reproducibility and control are at the level of a small fraction of the modulation period. With this seeding method, we independently control the amplitude of the seed wakefields with the charge of the electron bunch and the growth rate of SM with the charge of the proton bunch. Seeding leads to larger growth of the wakefields than in the instability case.
|
|
| 11. |
- Verra, L., et al.
(author)
-
Development of the self-modulation instability of a relativistic proton bunch in plasma
- 2023
-
In: Physics of Plasmas. - : American Institute of Physics (AIP). - 1070-664X .- 1089-7674. ; 30:8
-
Journal article (peer-reviewed)abstract
- Self-modulation is a beam-plasma instability that is useful to drive large-amplitude wakefields with bunches much longer than the plasma skin depth. We present experimental results showing that, when increasing the ratio between the initial transverse size of the bunch and the plasma skin depth, the instability occurs later along the bunch, or not at all, over a fixed plasma length because the amplitude of the initial wakefields decreases. We show cases for which self-modulation does not develop, and we introduce a simple model discussing the conditions for which it would not occur after any plasma length. Changing bunch size and plasma electron density also changes the growth rate of the instability. We discuss the impact of these results on the design of a particle accelerator based on the self-modulation instability seeded by a relativistic ionization front, such as the future upgrade of the Advanced WAKefield Experiment.
|
|
| 12. |
- Martel, I., et al.
(author)
-
An innovative Superconducting Recoil Separator for HIE-ISOLDE
- 2023
-
In: Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms. - : ELSEVIER. - 0168-583X .- 1872-9584. ; 541, s. 176-179
-
Journal article (peer-reviewed)abstract
- The ISOLDE Scientific Infrastructure at CERN offers a unique range of post-accelerated radioactive beams. The scientific program can be improved with the “Isolde Superconducting Recoil Separator” (ISRS), an innovative spectrometer able to deliver unprecedented (A, Z) resolution. In this paper we present an overview of the physics and ongoing technical developments.
|
|
| 13. |
- Habs, D., et al.
(author)
-
The REX-ISOLDE project
- 2000
-
In: Hyperfine Interactions. - 0304-3843 .- 1572-9540. ; 129:1-4, s. 43-66
-
Journal article (peer-reviewed)abstract
- The Radioactive Beam Experiment REX-ISOLDE [1-3] is a pilot experiment at ISOLDE (CERN) testing the new concept of post acceleration of radioactive ion beams by using charge breeding of the ions in a high charge state ion source and the efficient acceleration of the highly charged ions in a short LINAC using modern ion accelerator structures. In order to prepare the ions for the experiments singly charged radioactive ions from the on-line mass separator ISOLDE will be cooled and bunched in a Penning trap, charge bred in an electron beam ion source (EBIS) and finally accelerated in the LINAC. The LINAC consists of a radiofrequency quadrupole (RFQ) accelerator, which accelerates the ions up to 0.3 MeV/u, an interdigital H-type (IH) structure with a final energy between 1.1 and 1.2 MeV/u and three seven gap resonators, which allow the variation of the final energy. With an energy of the radioactive beams between 0.8 MeV/u and 2.2 MeV/u a wide range of experiments in the field of nuclear spectroscopy, astrophysics and solid state physics will be addressed by REX-ISOLDE.
|
|
| 14. |
- Pontarollo, G., et al.
(author)
-
Commensal bacteria weaken the intestinal barrier by suppressing epithelial neuropilin-1 and Hedgehog signaling
- 2023
-
In: Nature Metabolism. - 2522-5812. ; 5:7, s. 1174-87
-
Journal article (peer-reviewed)abstract
- The gut microbiota influences intestinal barrier integrity through mechanisms that are incompletely understood. Here we show that the commensal microbiota weakens the intestinal barrier by suppressing epithelial neuropilin-1 (NRP1) and Hedgehog (Hh) signaling. Microbial colonization of germ-free mice dampens signaling of the intestinal Hh pathway through epithelial Toll-like receptor (TLR)-2, resulting in decreased epithelial NRP1 protein levels. Following activation via TLR2/TLR6, epithelial NRP1, a positive-feedback regulator of Hh signaling, is lysosomally degraded. Conversely, elevated epithelial NRP1 levels in germ-free mice are associated with a strengthened gut barrier. Functionally, intestinal epithelial cell-specific Nrp1 deficiency (Nrp1(& UDelta;IEC)) results in decreased Hh pathway activity and a weakened gut barrier. In addition, Nrp1(& UDelta;IEC) mice have a reduced density of capillary networks in their small intestinal villus structures. Collectively, our results reveal a role for the commensal microbiota and epithelial NRP1 signaling in the regulation of intestinal barrier function through postnatal control of Hh signaling. A molecular mechanism is revealed through which commensal bacteria modulate intestinal epithelial barrier function.
|
|
| 15. |
|
|
| 16. |
- Brown, Richard J. P., et al.
(author)
-
Liver-expressed Cd302 and Cr1l limit hepatitis C virus cross-species transmission to mice
- 2020
-
In: Science Advances. - : American Association for the Advancement of Science. - 2375-2548. ; 6:45
-
Journal article (peer-reviewed)abstract
- Hepatitis C virus (HCV) has no animal reservoir, infecting only humans. To investigate species barrier determinants limiting infection of rodents, murine liver complementary DNA library screening was performed, identifying transmembrane proteins Cd302 and Cr1l as potent restrictors of HCV propagation. Combined ectopic expression in human hepatoma cells impeded HCV uptake and cooperatively mediated transcriptional dysregulation of a noncanonical program of immunity genes. Murine hepatocyte expression of both factors was constitutive and not interferon inducible, while differences in liver expression and the ability to restrict HCV were observed between the murine orthologs and their human counterparts. Genetic ablation of endogenous Cd302 expression in human HCV entry factor transgenic mice increased hepatocyte permissiveness for an adapted HCV strain and dysregulated expression of metabolic process and host defense genes. These findings highlight human-mouse differences in liver-intrinsic antiviral immunity and facilitate the development of next-generation murine models for preclinical testing of HCV vaccine candidates.
|
|
| 17. |
- Coffineau, L., et al.
(author)
-
INSIGHT_E-A Think Tank Informing the European Commission
- 2017
-
In: Europe's Energy Transition - Insights for Policy Making. - : Elsevier. - 9780128098066 - 9780128099032 ; , s. 11-20
-
Book chapter (peer-reviewed)abstract
- INSIGHT_E is a think tank that offers unbiased energy policy advice and insights to the European Commission. The consortium forming INSIGHT_E combines a multidisciplinary group of 12 different partners based in nine different European countries. In order to provide energy policy advice and insights, it has developed tools and instruments to assess the impact of the energy transition in all its dimensions, including its drivers. Its three main types of publications include Rapid Response Energy Briefs, Hot Energy Topics, and Policy Reports. Its fourth key output is an Observatory, which provides access to all of INSIGHT_E's publications, tools, and instruments, including webinars, information corners, and statistical indicators on the energy transition of the European Union.
|
|
| 18. |
- Dabrowski, A. E., et al.
(author)
-
Measuring the bunch frequency multiplication at CTF3
- 2010
-
Conference paper (peer-reviewed)abstract
- The CTF3 facility is being built and commissioned by an international collaboration in order to test the feasibility of the proposed CLIC drive beam generation scheme. Central to this scheme is the use of RF deflectors to inject bunches into a Delay Loop and a Combiner Ring, in order to transform the initial bunch spacing of 1.5 GHz from the linac to a final bunch spacing of 12 GHz. The optimization procedure relies on several steps. The active length of each ring is carefully adjusted to within a few millimeters accuracy using a two‐period undulator. The transverse optics of the machine must be set-up in a way so as to ensure the beam isochronicity. Diagnostics based on optical streak cameras and RF power measurements have been designed to measure the longitudinal behaviour of the beam during the combination. This paper presents their performance and highlights recent measurements.
|
|
| 19. |
- Dabrowski, A. E., et al.
(author)
-
Measuring the bunch frequency multiplication at the 3rd CLIC Test Facility
- 2012
-
In: Journal of Instrumentation. - 1748-0221. ; 7, s. P01005-
-
Journal article (peer-reviewed)abstract
- The CLIC Test Facility 3 (CTF3) is being built and commissioned by an international collaboration to test the feasibility of the proposed Compact Linear Collider (CLIC) drive beam generation scheme. Central to this scheme is the use of RF deflectors to inject bunches into a delay loop and a combiner ring, in order to transform the initial bunch frequency of 1.5 GHz from the linac to a final bunch frequency of 12 GHz. To do so, the machine's transverse optics must be tuned to ensure beam isochronicity and each ring's length can finally be adjusted with wiggler magnets to a sub millimeter path length accuracy. Diagnostics based on optical streak camera and RF power measurements, in particular frequency bands, have been designed to measure the longitudinal behaviour of the beam during the combination. This paper presents the diagnostics and recent commissioning measurements.
|
|
| 20. |
- Loh, Z-H, et al.
(author)
-
Observation of the fastest chemical processes in the radiolysis of water
- 2020
-
In: Science. - : AMER ASSOC ADVANCEMENT SCIENCE. - 0036-8075 .- 1095-9203. ; 367:6474, s. 179-182
-
Journal article (peer-reviewed)abstract
- Elementary processes associated with ionization of liquid water provide a framework for understanding radiation-matter interactions in chemistry and biology. Although numerous studies have been conducted on the dynamics of the hydrated electron, its partner arising from ionization of liquid water, H2O+, remains elusive. We used tunable femtosecond soft x-ray pulses from an x-ray free electron laser to reveal the dynamics of the valence hole created by strong-field ionization and to track the primary proton transfer reaction giving rise to the formation of OH. The isolated resonance associated with the valence hole (H2O+/OH) enabled straightforward detection. Molecular dynamics simulations revealed that the x-ray spectra are sensitive to structural dynamics at the ionization site. We found signatures of hydrated-electron dynamics in the x-ray spectrum.
|
|
| 21. |
|
|
| 22. |
- Welsch, Manuel, et al.
(author)
-
Adding value with CLEWS - Modelling the energy system and its interdependencies for Mauritius
- 2014
-
In: Applied Energy. - : Elsevier BV. - 0306-2619 .- 1872-9118. ; 113, s. 1434-1445
-
Journal article (peer-reviewed)abstract
- Climate, Energy, Water and Land-use Systems (CLEWS) are closely integrated. Yet, most related decision and policy making occurs in disparate institutional entities, informed by relatively disconnected assessments of the individual resource systems. This paper presents the added value of an integrated analytical assessment approach. In doing so, it explicitly values various interdependencies and interactions between CLEWS primarily from an energy sector perspective. The island state of Mauritius was identified as a useful case study given its diverse climate, its increasing water stresses, and its policy focus on reshaping agricultural land-use and reducing fossil fuel imports. Several scenarios to 2030 were defined and analysed to demonstrate the tensions around the CLEWS nexus. Results from an assessment of the energy system with no modelled interlinkages to land-use, energy and water systems are first presented. Then, these are compared to those from an integrated CLEWS assessment. This serves to highlight important dynamics that would have been overlooked without such a systems approach. As an example, the added value of this approach is clearly demonstrated when rainfall reductions are taken into account, and where future land-use changes might occur.
|
|
