| 1. |
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| 2. |
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- 2019
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Journal article (peer-reviewed)
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| 3. |
- Klionsky, Daniel J., et al.
(author)
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Guidelines for the use and interpretation of assays for monitoring autophagy
- 2012
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In: Autophagy. - : Informa UK Limited. - 1554-8635 .- 1554-8627. ; 8:4, s. 445-544
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Research review (peer-reviewed)abstract
- In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process vs. those that measure flux through the autophagy pathway (i.e., the complete process); thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from stimuli that result in increased autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field.
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| 4. |
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| 5. |
- Wang, Kui, et al.
(author)
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Efficient electro-demulsification of O/W emulsions and simultaneous oil removal enabled by a multiscale porous biocarbon electrode
- 2024
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In: Chemical Engineering Journal. - : Elsevier BV. - 1385-8947 .- 1873-3212. ; 481
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Journal article (peer-reviewed)abstract
- Emulsion wastewater contain substantial amounts of oil and various additives, which pose threats to the environment and human health. Demulsification is a crucial pretreatment stage for wastewater. This study aims to identify a novel electro-demulsification method with high oil removal efficiency and low energy consumption. Modified carbonized birch wood with a unique isotropic multiscale pore structure is used as a self-standing electrode to treat a toluene oil-in-water (O/W) emulsion. The electrode must have a highly porous structure to facilitate efficient water diffusion and oil adsorption. It must also have high electronic conductivity to expedite polarized molecular electrophoresis to realize penetration into the pores and, subsequently, demulsification. Guided by an applied electric field force, polarized O/W droplets are drawn toward the electrode, revealing electrical characteristics distinct from those of polarized organic molecules. This electric field force augments the capture and adhesion of droplets by the electric double layer at the electrode interface. Consequently, adsorbed droplets in close proximity to the electrode rupture due to the combined influence of the electric field force and the electrostatic effects stemming from the electrode's multiscale porous structure. This synergistic action enables demulsification to occur efficiently at low energy consumption levels. This study has revealed that electro-demulsification can effectively treat toluene emulsions stabilized by various surfactants and microemulsion containing toluene. Therefore, this electro-demulsification technology can be further developed for various types of water pollution.
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| 6. |
- Chen, Hongjian, et al.
(author)
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Resilient Synchronization of Networked Lagrangian Systems in Adversarial Environments
- 2023
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In: 2023 62nd IEEE Conference on Decision and Control, CDC 2023. - : Institute of Electrical and Electronics Engineers (IEEE). ; , s. 7539-7545
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Conference paper (peer-reviewed)abstract
- This paper considers the resilient synchronization problems of multiple Euler-Lagrange (EL) systems, where the communication network is affected by the external attacks or internal non-participant agents. The considered adversarial environments can cover several types of cyber-attacks, such as misbehaving agents and false data injection attacks. The remaining normal agents aim to reach a common decision despite the influence of faulty agents. To this end, a 'safe kernel' based secure control scheme is proposed for the networked Lagrangian systems. According to the scheme, each healthy agent generates a convex hull based on the states of its neighbors and updates its reference state toward this kernel only in each sampling instant to reduce the computational burden. The 'average sampling interval' is used to define the number of sampling instants for faster convergence. With an assumption on the number of misbehaving agents, the proposed scheme guarantees consensus of Euler-Lagrange systems even in adversarial environments. Mathematical proofs and a numerical example are presented to verify the resilience and validity of the proposed scheme.
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| 7. |
- Cong, Lin, et al.
(author)
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Use of Cardiovascular Drugs for Primary and Secondary Prevention of Cardiovascular Disease Among Rural-Dwelling Older Chinese Adults
- 2020
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In: Frontiers in Pharmacology. - : Frontiers Media SA. - 1663-9812. ; 11
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Journal article (peer-reviewed)abstract
- Cardiovascular risk factors and related disorders are common among older adults, and use of various classes of cardiovascular (CV) drugs could reduce the risk of cardiovascular disease (CVD). However, data are sparse with regard to the use of CV drugs among rural-dwelling older adults in China. Therefore, this population-based study aimed to describe use of CV drugs among older adults living in the rural communities in China, while taking into account the use of CV drugs for primary and secondary prevention of CVDs. This study included 5,246 participants (age >= 65 years; 57.17% women; 40.68% illiteracy) in the baseline examination of the MIND-China study. In March-September 2018, data on health-related factors, CVDs (ischemic heart disease, atrial fibrillation, heart failure, and stroke), and CV drug use were collected via face-to-face survey, clinical examination, and laboratory tests. We classified CV drugs according to the Anatomical Therapeutic Chemical classification system for western medications and specific cardiovascular effects for the products of traditional Chinese medicine (TCM). We conducted descriptive analysis. The overall prevalence of major cardiovascular risk factors ranged from 14.30% in diabetes and 23.81% in dyslipidemia to 66.70% in hypertension, and CVDs affected 35.07% of all participants (36.28% in women vs. 33.47% in men, p = 0.035). In the total sample, calcium channel blockers (C08) were most commonly used (10.39%), followed by TCM products (7.64%), hypoglycemic agents (A10, 4.73%), renin-angiotensin system (RAS)-acting agents (C09, 4.61%), and lipid-lowering agents (C10, 4.17%). The proportions of CV drugs for primary prevention (i.e., use of CV drugs among people without CVD) were 3.14% for antithrombotic agents (mainly aspirin), 1.38% for lipid-lowering agents, and 3.11% for RAS-acting agents; the corresponding figures for secondary prevention (i.e., use of CV drugs among people with CVD) were 13.97%, 9.35%, and 7.39%. In conclusion, despite highly prevalent cardiovascular risk factors and CVDs, a fairly low proportion of the rural-dwelling older adults take CV medications for primary and secondary prevention. Notably, TCM products are among the most commonly used CV drugs. These results call for additional efforts to promote implementation of the evidence-based recommendations for prevention of CVDs in the primary care settings.
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| 8. |
- Deng, Zhongwei, et al.
(author)
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Battery health evaluation using a short random segment of constant current charging
- 2022
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In: iScience. - : Elsevier BV. - 2589-0042. ; 25:5
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Journal article (peer-reviewed)abstract
- Accurately evaluating the health status of lithium-ion batteries (LIBs) is significant to enhance the safety, efficiency, and economy of LIBs deployment. However, the complex degradation processes inside the battery make it a thorny challenge. Data-driven methods are widely used to resolve the problem without exploring the complex aging mechanisms; however, random and incomplete charging-discharging processes in actual applications make the existing methods fail to work. Here, we develop three data-driven methods to estimate battery state of health (SOH) using a short random charging segment (RCS). Four types of commercial LIBs (75 cells), cycled under different temperatures and discharging rates, are employed to validate the methods. Trained on a nominal cycling condition, our models can achieve high-precision SOH estimation under other different conditions. We prove that an RCS with a 10mV voltage window can obtain an average error of less than 5%, and the error plunges as the voltage window increases.
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| 9. |
- Guo, Xiaolei, et al.
(author)
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The cutting performance of Al2O3 and Si3N4 ceramic cutting tools in the milling plywood
- 2018
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In: Advances in Applied Ceramics. - : Taylor & Francis. - 1743-6753 .- 1743-6761. ; 117:1, s. 16-22
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Journal article (peer-reviewed)abstract
- This research focuses on the cutting performance of Al2O3 and Si3N4 ceramic cutting tools in upmillingplywood, the results of which are as follows. First, whether the tool material is Al2O3 orSi3N4 ceramic, the cutting forces at low-speed cutting were less than those at high-speedcutting, and the machining quality at low-speed cutting was greater than that at high-speedcutting. Then, whether at low- or high-speed cutting, the cutting forces of Al2O3 cutting toolswere higher than those of Si3N4 cutting tools, and the machining quality of plywood milledby Al2O3 ceramic cutting tools was poorer than that milled by Si3N4 ceramic cutting tools.Finally, Si3N4 ceramic cutting tools were more suitable to machine the wooden productionswith much glue content than Al2O3 ceramic cutting tools for the better machined quality.
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| 10. |
- Li, Rongrong, et al.
(author)
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Non-standard test method for glue line shear strength
- 2017
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In: Wood research. - : Statny Drevarsky Vyskumny Ustav. - 1336-4561. ; 62:5, s. 825-830
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Journal article (peer-reviewed)abstract
- The relevant standards for glueline shear strength testing were summarized and analyzed in this paper. Depending on these existing test standards, the resulting stress in glueline is not pure shear stress, but a combination of shear and normal stresses. In order to overcome this deficiency, a symmetrical structure was proposed for making samples. Some comparative testing was accomplished by using these symmetrical samples, the results showed that the normal stress could be avoided during testing. These results were also confirmed by finite element method (FEM), the simulation results showed that the shear stress in glueline was uniform
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| 11. |
- Li, Rongrong, et al.
(author)
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Prediction of cutting force during gypsum fiber composite milling process using response surface methodology
- 2017
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In: Wood and Fiber Science. - : Society of Wood Science and Technology. - 0735-6161. ; 49:4, s. 453-460
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Journal article (peer-reviewed)abstract
- Gypsum fiber composite (GFC) is a kind of building material widely used in interior decoration. Milling is the most commonly used machining process for GFC. Cutting force as an important cutting characteristic parameter has significant influence on the quality of machined surface, power consumption, and tools wear. The tangential force (Fx) and normal force (Fy) were measured and analyzed to find out the effects of milling parameters on these cutting forces. Milling parameters considered were spindle speed, feed rate, and depth of cut. The response surface methodology (RSM) was selected to develop mathematical models and optimize milling parameters. The results showed that with the increase of feed rate and depth of cut, the Fx and Fy increased. But the cutting forces decreased with the increase of spindle speed. The optimization results indicated that high spindle speed, low feed rate, and small depth of cut are preferable for milling of GFC to obtain the best result.
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| 12. |
- Li, Xiaolei, et al.
(author)
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Resilience for Communication Faults in Reactive Power Sharing of Microgrids
- 2021
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In: IEEE Transactions on Smart Grid. - : Institute of Electrical and Electronics Engineers (IEEE). - 1949-3053 .- 1949-3061. ; 12:4, s. 2788-2799
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Journal article (peer-reviewed)abstract
- In this paper, we consider the distributed reactive power sharing control problem for an autonomous inverter-based microgrid with resilience for communication faults, which may be caused by partial communication link failures or some channel manipulation attacks. Under the standard decoupling approximation for bus angle differences, the reactive power flow of each inverter can be controlled by manipulating the voltage amplitudes of itself and its neighbour inverters. By designing an adaptive resilient cooperative control scheme, accurate reactive power sharing can be guaranteed even in the presence of communication faults. Some simulation results are presented to verify the superiority of the proposed control approach compared with the existing methods.
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| 13. |
- Luo, Xiaoyuan, et al.
(author)
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Event-Based Attack Detection and Mitigation for DC Microgrids via Adaptive LQR Approach
- 2024
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In: IEEE Transactions on Smart Grid. - : Institute of Electrical and Electronics Engineers (IEEE). - 1949-3053 .- 1949-3061. ; 15:4, s. 4196-4206
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Journal article (peer-reviewed)abstract
- Data manipulation attacks have become one of the main threats to cyber-physical direct current (DC) microgrids, but how to ensure voltage and current restoration under cyber attacks has not been well explored. In this paper, the event-based attack detection and mitigation problem for DC microgrids is considered. Specifically, an attack detection mechanism is designed to detect whether an attack has occurred. Then the proposed resilient secondary control strategy is only activated when the detection mechanism generates an attack event. For unknown types of attacks that aim at tampering with the information transmitted in the communication network, an adaptive linear quadratic regulator (LQR) based control strategy is designed to mitigate the effects such that the voltage and current restoration is achieved. Finally, the effectiveness of the proposed strategy is verified through simulationthis.
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| 14. |
- Ren, Yifei, et al.
(author)
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Prevalence, Incidence, and Progression of Cognitive Impairment, No Dementia Among Rural-Dwelling Chinese Older Adults
- 2022
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In: Journal of Alzheimer's Disease. - 1387-2877 .- 1875-8908. ; 85:4, s. 1583-1592
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Journal article (peer-reviewed)abstract
- Background: Few studies have examined occurrence and progression of cognitive impairment, no dementia (CIND) in rural China.Objective: To determine the prevalence and incidence of CIND in rural-dwelling Chinese older adults, and to examine risk and protective factors associated with progression to CIND and dementia.Methods: This population-based study included 2,781 dementia-free participants (age≥65 years) who were examined at baseline (2014) and followed in 2018. Demographic, epidemiological, clinical, and neuropsychological data were collected following a structured questionnaire. We defined CIND according to subjective cognitive complaints and the age- and education-specific Mini-Mental State Examination (MMSE) score. Data were analyzed with the multinomial logistic regression models.Results: The overall prevalence of CIND was 10.54% and the incidence was 28.26 per 1,000 person-years. CIND at baseline was associated with the multi-adjusted odds ratio (OR) of 2.06 (95% confidence interval = 1.23–3.47) for incident dementia. Multinomial logistic regression analysis suggested that compared with no CIND, the multi-adjusted OR of incident CIND was 2.21 (1.51–3.23) for women and 0.62 (0.38–0.99) for high social support, whereas the multi-adjusted OR of incident dementia was 1.14 (1.09–1.18) for older age, 0.29 (0.16–0.53) for high education, and 2.91 (1.47–5.74) for having a stroke history.Conclusion: CIND affects over one-tenth of older adults living in rural communities of western Shandong province. People with CIND are twice as likely to progress to dementia as people without CIND. Female sex, low education, stroke history, and low social support are associated with an increased risk of progression from normal cognition to CIND or dementia.
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| 15. |
- Shang, Ke, et al.
(author)
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Multi-Objective Optimal Dispatching for Heterogeneous Multienergy Ship Microgrid
- 2023
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In: 2023 62nd IEEE Conference on Decision and Control, CDC 2023. - : Institute of Electrical and Electronics Engineers (IEEE). ; , s. 6576-6581
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Conference paper (peer-reviewed)abstract
- With the growth of energy and transportation demand, the integrated energy dispatching of ship power grid has become the focus of researchers. The optimization technique is used to reduce the total energy consumption and pollutant emissions of ships, optimizing the ship power generation planning. The purpose is to achieve environmental protection and energy saving while ensuring the continuous and reliable power supply of ships. However, heterogeneous ship microgrid poses new challenges to integrated energy dispatch. This paper proposes an integrated energy scheduling scheme that integrates photovoltaic, wind power, diesel engine, gas turbine, and battery for a heterogeneous multienergy ship microgrid. Under the system constraints, a multi-objective optimal scheduling model including operating costs and pollutant emissions is established, then the gravity search algorithm is applied to solve such an issue. The simulation results show that the scheme can effectively reduce the cost of energy consumption and pollutant emissions of ships, improving the economy, reliability and energy conservation, which verify the advantages of the proposed scheme.
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| 16. |
- Tang, Fei, et al.
(author)
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Study of the smoke toxicity characteristics in an inclined tunnel
- 2024
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In: Fire Safety Journal. - 0379-7112. ; 142
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Journal article (peer-reviewed)abstract
- Fire smoke is one of the most important factors causing casualties, but also has the potential to bring some harm to the surrounding environment. In this work, the longitudinal temperature profile and the pollutant toxicity of a ceiling jet induced by a wall-attached fire with different tunnel slopes, were numerically and experimentally investigated by using a 1:8 reduced-scale inclined tunnel. The results show that for a given heat release rate (HRR), the flame extension is longer and the temperature decay is slower in ceiling jets induced by a wall-attached fire than for similar free-burning fires, because the air entrainment is restricted by the tunnel side walls. Further, the uphill pollutant toxicity was found to be higher with greater HRR and lower tunnel slope. Finally, a correlation between the non-dimensional longitudinal smoke temperature and CO concentration could be established for the inclined tunnel fire.
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| 17. |
- Tu, Li, et al.
(author)
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A wide-range operating synaptic device based on organic ferroelectricity with low energy consumption
- 2018
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In: RSC Advances. - : Royal Society of Chemistry. - 2046-2069. ; 8:47, s. 26549-26553
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Journal article (peer-reviewed)abstract
- In thiswork, a wide-range operating synaptic device based on organic ferroelectricity has been demonstrated. The device possesses a simple two-terminal structure by using a ferroelectric phase-separated polymer blend as the active layer and gold/indium tin oxide (ITO) as the top/bottom electrodes, and exhibits a distinctive history-dependent resistive switching behavior at room temperature. And the device with low energy consumption (similar to 50 fJ mu m(-2) per synaptic event) can provide a reliable synaptic function of potentiation, depression and the complex memory behavior simulation of differential responses to diverse stimulations. In addition, using simulations, the accuracy of 32 x 32 pixel image recognition is improved from 76.21% to 85.06% in the classical model Cifar-10 with 1024 levels of the device, which is an important step towards the higher performance goal in image recognition based on memristive neuromorphic networks.
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| 18. |
- Wang, Jiange, et al.
(author)
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Distributed MPC for Vehicle Platoon Control with String Stability
- 2023
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In: Proceedings - 2023 China Automation Congress, CAC 2023. - : Institute of Electrical and Electronics Engineers (IEEE). ; , s. 8018-8023
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Conference paper (peer-reviewed)abstract
- In this paper, a distributed model predictive control (DMPC) approach is proposed for the undirected networked vehicle platoon under state constraints. Unlike the existing results, Lyapunov and string stability of the closed-loop systems are simultaneously guaranteed for the undirected vehicle network. Specifically, the designed terminal constraints ensure the iterative feasibility of the DMPC algorithm. Then, the control design problem is formulated as a distributed optimization problem by using the state information of itself and its neighbors. The closed-loop stability of the system is established by using the cost functions as a Lyapunov function. In addition, two state constraints are designed to ensure the string stability under the constant distance strategy. Finally, the effectiveness of the proposed DMPC controller is verified by simulation results.
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| 19. |
- Zhang, Zhiqiang, et al.
(author)
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Demo Abstract: Frequent Pattern-based Trajectory Completion
- 2018
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In: Proceedings of the 16th ACM Conference on Embedded Networked Sensor Systems. - New York, NY, USA : ACM. ; , s. 311-312
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Conference paper (other academic/artistic)abstract
- GPS sensors have been widely used to track people's everyday life trajectories, generating massive trajectory datasets. The trajectory data typically contains sparse GPS points, and completing trajectories is often necessary. State-of-the-art methods [3, 4] essentially complete the entire route by using a single metric, e.g., either the shortest distance or the fastest driving/walking time. Unfortunately, using a single metric may not always work in real life due to the diversity of mobility patterns. In this demo abstract, we propose a frequent pattern (FP)-based trajectory completion approach, and demonstrate a system prototype to showcase the advantages of our approach over four previous works, in terms of accuracy and running time.
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| 20. |
- Zhou, Mengtao, et al.
(author)
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The efficiency of continuous regional intra-arterial infusion in the treatment of infected pancreatic necrosis
- 2013
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In: Pancreatology. - : Elsevier BV. - 1424-3903. ; 13:3, s. 212-215
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Journal article (peer-reviewed)abstract
- Objective: Our aim was to investigate the efficiency of continuous regional intra-arterial infusion (CRAI) with antisecretory agents and antibiotics in the treatment of infected pancreatic necrosis. Materials and methods: CRAI was used as a new clinical technique to treat acute pancreatitis patients during a 4-year period at the First Affiliated Hospital, Wenzhou Medical College, China. In this retrospective study, thirty-four patients with proven infected pancreatic necrosis were included. Twelve patients were treated with CRAL and were matched according to age, sex, APACHE II scores, Ranson scores and remote organ dysfunction, with 22 patients with IPN treated surgically. The clinical outcome following surgery and CRAI were compared. Results: No difference was found between the two groups when comparing age, gender, APACHE II scores, Ranson scores and remote organ dysfunction (p > 0.05). The patients treated with CRAI had a lower incidence of complications (33.3% vs 72.7%), duration of hospitalization (27.1 +/- 4.7 days vs 43.0 +/- 12.0 days) and cost of hospitalization (4.09 +/- 1.64 thousand RMB vs 8.77 +/- 3.74 thousand RMB) as compared to patients treated with surgery (p < 0.05). The survival rate was significantly higher in the CRAI group as compared to the surgical group (91.7% vs 63.6%; p < 0.01). However, the two groups had similar rates of concomitant operative treatment and incidence of remote organ dysfunction (p > 0.05). Conclusions: CRAI or CRAI in combination with abscess drainage seemingly improve the clinical outcome in patients with infected pancreatic necrosis. Further confirmative prospective randomized multicenter studies are warranted prior to broad introduction of the CRAI concept. Copyright (C) 2013, IAP and EPC. Published by Elsevier India, a division of Reed Elsevier India Pvt. Ltd. All rights reserved.
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| 21. |
- Zhu, Zhaolong, et al.
(author)
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Energy Efficiency Optimization for Machining of Wood Plastic Composite
- 2022
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In: Machines. - : MDPI. - 2075-1702. ; 10:2
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Journal article (peer-reviewed)abstract
- Enhancing energy efficiency is the key to realizing green manufacturing. One major area of interest in this regard is the improvement of energy efficiency of machine tools during the production of building materials. This project focuses on energy efficiency during the spiral milling of wood plastic composites. To this end, a response surface method was adopted to develop a model and establish the relationship between energy efficiency and milling conditions. Analysis of variance based on individual factors as well as two-factor interactions was performed to gauge their effects on energy efficiency. It was found that milling depth was positively correlated to power efficiency, while spiral angle and feed per tooth displayed non-monotonic behavior. An attempt was made to predict milling conditions that will yield the greatest material removal rate and power efficiency. For wood plastic composites subjected to up-milling, it was determined that a feed per tooth of 0.1 mm, milling depth of 1.5 mm, and spiral angle of 70° were ideal. Considering the potential improvements in energy efficiency and surface quality that these process parameters will bring, it is strongly recommended for use in the industrial machining of wood plastic composites.
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| 22. |
- Zhu, Zhalong, et al.
(author)
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Machinability of Different Wood-Plastic Composites during Peripheral Milling
- 2022
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In: Materials. - : MDPI. - 1996-1944. ; 15:4
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Journal article (peer-reviewed)abstract
- The aim of this study was to improve the machinability of wood-plastic composites by exploring the effects of different wood-plastic composites on machinability. In particular, the effects of milling with cemented carbide cutters were assessed by investigating cutting forces, cutting temperature, surface quality, chip formation, and tool wear. The cutting parameters determined to yield an optimal surface quality were rake angle 2°, cutting speed 9.0 m/s, feed per tooth 0.3 mm, and cutting depth 1.5 mm. In these optimized milling conditions, the wood-plastic composite with polypropylene exhibited the highest cutting forces, cutting temperature, and tool wear, followed by polyethylene and polyvinyl chloride wood-plastic composites. Two wear patterns were determined during wood-plastic composite machining, namely chipping and flaking. Due to the different material composition, semi-discontinuous ribbon chips and continuous ribbon chips were generated from the machining process of wood-plastic composites with polypropylene and polyethylene, respectively. The wood-plastic composite with polyvinyl chloride, on the other hand, formed needle-like chips. These results contribute to a theoretical and practical basis for improved wood-plastic composite machining in industrial settings.
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