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Enumeration	Reference	Cover	Find
1.	2019 Journal article (peer-reviewed)
2.	Gong, Zheng, et al. (author) A targetable fluorescent probe for detecting mitochondrial viscosity in live cells by using fluorescence lifetime imaging 2024 In: New Journal of Chemistry. - : ROYAL SOC CHEMISTRY. - 1144-0546 .- 1369-9261. Journal article (peer-reviewed)abstract Intracellular viscosity plays an important role in regulating cellular morphology and physiology and is closely related to a host of diseases. Especially, the changes in mitochondrial viscosity will cause some common diseases such as hyperlipidemia, Alzheimer's disease and cancer. In this work, we report the design of a red-emissive molecular rotor for the detection of mitochondrial viscosity in live cells. The probe showed fascinating performance, such as specific targeting to mitochondria, high sensitivity to viscosity, and rapid fluorescence response, especially the dual response mode of fluorescence intensity and fluorescence lifetime. By using this probe, we realized monitoring of the mitochondrial viscosity variations in live cells under different physiological processes. Our study offers an opportunity to discover potential tools for mitochondria-related physiology and pathology investigation. A D-pi-A typed fluorescence lifetime probe for sensitively detecting viscosity has been designed and synthesized. BSOH has been successfully applied to real-time monitoring mitochondrial viscosity in live cells by fluorescence lifetime imaging.

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Type of publication: journal article (2)

Type of content: peer-reviewed (2)

Author/Editor: Kelly, Daniel (1); Bengtsson-Palme, Joh ... (1); Nilsson, Henrik (1); Kelly, Ryan (1); Li, Ying (1); Moore, Matthew D. (1); show more...; Liu, Fang (1); Zhang, Yao (1); Jin, Yi (1); Raza, Ali (1); Rafiq, Muhammad (1); Zhang, Kai (1); Khatlani, T (1); Kahan, Thomas (1); Uvdal, Kajsa (1); Sörelius, Karl, 1981 ... (1); Batra, Jyotsna (1); Roobol, Monique J (1); Wei, Bing (1); Backman, Lars (1); Yan, Hong (1); Schmidt, Axel (1); Lorkowski, Stefan (1); Thrift, Amanda G. (1); Zhang, Wei (1); Hammerschmidt, Sven (1); Patil, Chandrashekha ... (1); Wang, Jun (1); Pollesello, Piero (1); Conesa, Ana (1); El-Esawi, Mohamed A. (1); Zhang, Weijia (1); Li, Jian (1); Marinello, Francesco (1); Frilander, Mikko J. (1); Wei, Pan (1); Badie, Christophe (1); Zhao, Jing (1); Li, You (1); Bansal, Abhisheka (1); Rahman, Proton (1); Parchi, Piero (1); Polz, Martin (1); Ijzerman, Adriaan P. (1); Subhash, Santhilal, ... (1); Quinn, Terence J. (1); Uversky, Vladimir N. (1); Gemmill, Alison (1); Zhang, Yi (1); Meule, Adrian (1); show less...

University: University of Gothenburg (1); Uppsala University (1); Halmstad University (1); Stockholm University (1); Linköping University (1); Lund University (1); show more...; Chalmers University of Technology (1); Karolinska Institutet (1); show less...

Language: English (2)

Research subject (UKÄ/SCB): Medical and Health Sciences (2); Natural sciences (1)

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