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1.	Ortiz Catalan, Max Jair, 1982, et al. (author) Patterned Stimulation of Peripheral Nerves Produces Natural Sensations With Regards to Location but Not Quality 2019 In: IEEE Transactions on Medical Robotics and Bionics. - 2576-3202. ; 1:3, s. 199-203 Journal article (peer-reviewed)abstract Sensory feedback is crucial for dexterous manipulation and sense of ownership. Electrical stimulation of severed afferent fibers due to an amputation elicits referred sensations in the missing limb. However, these sensations are commonly reported with a concurrent “electric” or “tingling” character (paresthesia). In this paper, we examined the effect of modulating different pulse parameters on the quality of perceived sensations. Three subjects with above-elbow amputation were implanted with cuff electrodes and stimulated with a train of pulses modulated in either amplitude, width, or frequency (“patterned stimulation”). Pulses were shaped using a slower carrier wave or via quasi-random generation. Subjects were asked to evaluate the natural quality of the resulting sensations using a numeric rating scale. We found that the location of the percepts was distally referred and somatotopically congruent, but their quality remained largely perceived as artificial despite employing patterned modulation. Sensations perceived as arising from the missing limb are intuitive and natural with respect to their location and, therefore, useful for functional restoration. However, our results indicate that sensory transformation from paresthesia to natural qualia seems to require more than patterned stimulation.
2.	Rezaei Aghdam, Sina, 1989, et al. (author) Reducing Motion Artifacts in Microwave-Based Hemorrhagic Stroke Detection 2019 In: 13th European Conference on Antennas and Propagation, EuCAP 2019. Conference paper (peer-reviewed)abstract The use of microwave technology for brain stroke detection opens up the opportunity for developing low-cost transportable devices which can be employed for rapid and prehospital detection of bleeding in patients with traumatic brain injury. Since the detection relies on changes in the scattering parameters of the tissues during pathological conditions, the movements in head or the antennas can deteriorate the detection accuracy. As a countermeasure to this problem, we introduce a technique for reducing the sensitivity of the detection system to motion artifacts. Via analyzing the scattering from an anatomically accurate model of human brain, we evidence that the channels between different pairs of antennas exhibit significantly different levels of sensitivity to the movement. Using this as a ground truth, we develop a generalized singular value decomposition (GSVD)-based approach for assigning appropriate weights to the channels between different antennas such that the probability of correct bleeding detection is maximized.
3.	Rowa, Per, et al. (author) Automated Malaria Parasite Detection 1977 Reports (other academic/artistic)abstract A system for malaria parasite detection in thin blood-smears is presented. Sample slides prepared with standard methods are accepted. A low-cost TV-camera mounted on an ordinary microscope with a computer controlled stage is used as a picture sensor. Frames, digitized in windows of 64 x 64 pixels are fed into a special purpose picture processor at normal frame rate (25 frames/sec). In the picture processor measurements are made on the images at high speed. The classification problem is split into different levels each having different characteristics such as different sampling density. Four classes, three of which are different types of malaria parasites, are recognized. As a whole the classification is best labelled as a sequential pattern recognition procedure.In its preliminary version the system has been run at a speed comparable to that of a human operator, that is l 500 cells per minute. A test on 80 000 cells gave 25 false negatives out of 283 parasites (9%) and 41 false positives (0.05%).
4.	Tomasic, Ivan, et al. (author) Comparison of publicly available beat detection algorithms performances on the ECGs obtained by a patch ECG device 2019 In: 2019 42nd International Convention on Information and Communication Technology, Electronics and Microelectronics, MIPRO 2019 - Proceedings. - : Institute of Electrical and Electronics Engineers Inc.. - 9789532330984 ; , s. 275-278 Conference paper (peer-reviewed)abstract Eight ECG beat detection algorithms, from the PhysioNet's WFDB and Cardiovascular Signal toolboxes, were tested on twenty measurements, obtained by the Savvy patch ECG device, for their accuracy in beat detection. On each subject, one measurement is obtained while sitting and one while running. Each measurement lasted from thirty seconds to one minute. The measurements obtained while running were more challenging for all the algorithms, as most of them almost perfectly detected all the beats on the measurements obtained in sitting position. However, when applied on the measurements obtained while running, all the algorithms have performed with decreased accuracy. Considering overall percentage of the faulty detected peaks, the four best algorithms were jqrs, from the Cardiovascular Signal Toolbox, and ecgpuwave, gqrs, and wqrs, from the WFDB Toolbox, with percentages of faulty detected beats 1.7, 2.3, 2.9, and 3, respectively.
5.	Zanoli, Massimiliano, 1989 (author) Ultra wideband microwave hyperthermia for brain cancer treatment 2022 Doctoral thesis (other academic/artistic)abstract Despite numerous clinical trials demonstrating that microwave hyperthermia is a powerful adjuvant modality in the treatment of cancers, there have been few instances where this method has been applied to brain tumors. The reason is a combination of anatomical and physiological factors in this site that require an extra degree of accuracy and precision in the thermal dose delivery. Current clinical applicators are not able to provide such control, partly because they are designed to operate at a single fixed frequency. In terms of treatment planning, the use of a single frequency is limiting as the size of the focal spot cannot be modified to accommodate the specific tumor volume and location. The introduction of ultra wide-band (UWB) systems opens up an opportunity to overcome these limitations, as they convey the possibility of adapting the focal spot and obtaining different power deposition patterns to reduce the heating of healthy tissues. In this thesis, we explore whether the current SAR-based treatment planning methods can be meaningfully translated to the UWB setting and propose new solutions for deep UWB microwave hyperthermia. We analyze the most commonly used cost functions for treatment planning optimization and discuss their suitability for use with UWB systems. Then, we propose a novel SAR-based cost function (HCQ) for UWB optimization that exhibits a high correlation with the resulting tumor temperature. To solve for the HCQ, we describe a novel, time-reversal-based, iterative scheme for a rapid and efficient optimization of UWB treatment plans. Next, we investigate the design possibilities of UWB brain applicators and introduce a fast E-field approximation scheme to quickly explore a large number of array configurations. The method determines the best antenna arrangement around the head with respect to the multiple objectives and requirements of clinical hyperthermia. Together, the proposed solutions manage to achieve the level of tumor coverage and hot-spot suppression that is necessary for a successful treatment. Finally, we investigate the benefit of integrating hyperthermia delivered by an optimized UWB applicator into the radiation therapy plan for a pediatric medulloblastoma patient. The results suggest that UWB microwave hyperthermia for brain cancer treatment is feasible and motivate efforts for further development of UWB applicators and systems.
6.	Zeng, Xuezhi, 1980, et al. (author) Investigation of an ultra wideband noise sensor for health monitoring 2020 In: Sensors. - : MDPI AG. - 1424-8220. ; 20:4 Journal article (peer-reviewed)abstract Quick on-scene assessment and early intervention is the key to reduce the mortality of stroke and trauma patients, and it is highly desirable to develop ambulance-based diagnostic and monitoring devices in order to provide additional support to the medical personnel. We developed a compact and low cost ultra wideband noise sensor for medical diagnostics and vital sign monitoring in pre-hospital settings. In this work, we demonstrated the functionality of the sensor for respiration and heartbeat monitoring. In the test, metronome was used to manipulate the breathing pattern and the heartbeat rate reference was obtained with a commercial electrocardiogram (ECG) device. With seventeen tests performed for respiration rate detection, sixteen of them were successfully detected. The results also show that it is possible to detect the heartbeat rate accurately with the developed sensor.
7.	Khodadad, Davood, 1985-, et al. (author) Optimized breath detection algorithm in electrical impedance tomography 2018 In: Physiological Measurement. - : IOP Publishing. - 0967-3334 .- 1361-6579. ; 39:9 Journal article (peer-reviewed)abstract Objective: This paper defines a method for optimizing the breath delineation algorithms used in electrical impedance tomography (EIT). In lung EIT the identification of the breath phases is central for generating tidal impedance variation images, subsequent data analysis and clinical evaluation. The optimisation of these algorithms is particularly important in neonatal care since the existing breath detectors developed for adults may give insufficient reliability in neonates due to their very irregular breathing pattern.Approach: Our approach is generic in the sense that it relies on the definition of a gold standard and the associated definition of detector sensitivity and specificity, an optimisation criterion and a set of detector parameters to be investigated. The gold standard has been defined by 11 clinicians with previous experience with EIT and the performance of our approach is described and validated using a neonatal EIT dataset acquired within the EU-funded CRADL project.Main results: Three different algorithms are proposed that improve the breath detector performance by adding conditions on (1) maximum tidal breath rate obtained from zero-crossings of the EIT breathing signal, (2) minimum tidal impedance amplitude and (3) minimum tidal breath rate obtained from time-frequency analysis. As a baseline a zero-crossing algorithm has been used with some default parameters based on the Swisstom EIT device.Significance: Based on the gold standard, the most crucial parameters of the proposed algorithms are optimised by using a simple exhaustive search and a weighted metric defined in connection with the receiver operating characterics. This provides a practical way to achieve any desirable trade-off between the sensitivity and the specificity of the detectors.
8.	Grishenkov, Dmitry, 1983-, et al. (author) In search of the optimal ultrasound heart perfusion imaging platform 2015 In: Journal of ultrasound in medicine. - : Wiley. - 0278-4297 .- 1550-9613. ; 34:9, s. 1599-1605 Journal article (peer-reviewed)abstract ObjectiveQuantification of the myocardial perfusion by contrast echocardiography (CEC) remains a challenge. Existing imaging phantoms used to evaluate the performance of ultrasound scanners do not comply with perfusion basics in the myocardium, where perfusion and motion are inherently coupled.MethodsTo contribute towards an improvement, we developed a CEC perfusion imaging platform based on isolated rat heart coupled to the ultrasound scanner. Perfusion was assessed using three different types of contrast agent: dextran-based Promiten®, phospholipid-shelled SonoVue®, and polymer-shelled MB-pH5-RT. The myocardial video-intensity was monitored over time from contrast administration to peak and two characteristic constants were calculated using exponential fit (A representing capillary volume and b representing inflow velocity).ResultsAcquired experimental evidence demonstrates that the application of all three types of contrast agent allow ultrasonic estimation of myocardial perfusion in the isolated rat heart. Video-intensity maps show that an increase in contrast concentration increases the late plateau values, A, mimicking increased capillary volume. Estimated values of the flow, proportional to Axb, increase when the pressure of the perfusate column increases from 80 to 110 cm of water. This finding is in agreement with the true values of the coronary flow increase measured by the flowmeter attached to the aortic cannula.ConclusionsThe described CEC perfusion imaging platform holds promise for standardized evaluation and optimization of ultrasound contrast perfusion imaging where real time inflow curves at low acoustic power semi-quantitatively reflect coronary flow.
9.	Kothapalli, Veera Venkata Satya Naray, 1985-, et al. (author) Unique pumping-out fracturing mechanism of a polymer-shelled contrast agent : An acoustic characterization and optical visualization 2014 In: IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control. - 0885-3010 .- 1525-8955. ; 62:3, s. 451-462 Journal article (peer-reviewed)abstract This work describes the fracturing mechanism of air-filled microbubbles (MBs) encapsulated by a cross-linked poly(vinyl alcohol) (PVA) shell. The radial oscillation and fracturing events following the ultrasound exposure were visualized with an ultrahigh-speed camera, and backscattered timedomain signals were acquired with the acoustic setup specific for harmonic detection. No evidence of gas emerging from defects in the shell with the arrival of the first insonation burst was found. In optical recordings, more than one shell defect was noted, and the gas core was drained without any sign of air extrusion when several consecutive bursts of 1 MPa amplitude were applied. In acoustic tests, the backscattered peak-to-peak voltage gradually reached its maximum and exponentially decreased when the PVA-based MB suspension was exposed to approximately 20 consecutive bursts arriving at pulse repetition frequencies of 100 and 500 Hz. Taking into account that the PVA shell is porous and possibly contains large air pockets between the cross-linked PVA chains, the aforementioned acoustic behavior might be attributed to pumping gas from these pockets in combination with gas release from the core through shell defects. We refer to this fracturing mechanism as pumping-out behavior, and this behavior could have potential use for the local delivery of therapeutic gases, such as nitric oxide.
10.	Boyraz Baykas, Pinar, 1981, et al. (author) Design of a Low-cost Tactile Robotic Sleeve for Autonomous Endoscopes and Catheters 2020 In: Measurement and Control. - : SAGE Publications. - 0020-2940. ; 53:3-4, s. 613-626 Journal article (peer-reviewed)abstract Recent developments in medical robotics have been significant, supporting the minimally invasive operation requirements, such as smaller devices and more feedback available to surgeons. Nevertheless, the tactile feedback from a catheter or endoscopic type robotic device has been restricted mostly on the tip of the device and was not aimed to support the autonomous movement of the medical device during operation. In this work, we design a robotic sheath/sleeve with a novel and more comprehensive approach, which can function for whole-body or segment-based feedback control as well as diagnostic purposes. The robotic sleeve has several types of piezo-resistive pressure and extension sensors, which are embedded at several latitudes and depths of the silicone substrate. The sleeve takes the human skin as a biological model for its structure. It has a better tactile sensation of the inner tissues in the torturous narrow channels such as cardiovascular or endo-luminal tracts in human body thus can be used to diagnose abnormalities. In addition to this capability, using the stretch sensors distributed alongside its body, the robotic sheath/sleeve can perceive the ego-motion of the robotic backbone of the catheter and can act as a position feedback device. Because of the silicone substrate, the sleeve contributes toward safety of the medical device passively by providing a compliant interface. As an active safety measure, the robotic sheath can sense blood-clots or sudden turns inside a channel and by modifying the local trajectory, and can prevent embolisms or tissue rupture. In the future, advanced manufacturing techniques will increase the capabilities of the tactile robotic sleeve.
11.	Böhler, Christian, et al. (author) Multilayer Arrays for Neurotechnology Applications (MANTA): Chronically Stable Thin-Film Intracortical Implants 2023 In: Advanced Science. - : John Wiley & Sons. - 2198-3844. ; 10:14 Journal article (peer-reviewed)abstract Flexible implantable neurointerfaces show great promise in addressing one of the major challenges of implantable neurotechnology, namely the loss of signal connected to unfavorable probe tissue interaction. The authors here show how multilayer polyimide probes allow high-density intracortical recordings to be combined with a reliable long-term stable tissue interface, thereby progressing toward chronic stability of implantable neurotechnology. The probes could record 10–60 single units over 5 months with a consistent peak-to-peak voltage at dimensions that ensure robust handling and insulation longevity. Probes that remain in intimate contact with the signaling tissue over months to years are a game changer for neuroscience and, importantly, open up for broader clinical translation of systems relying on neurotechnology to interface the human brain.
12.	Cubo, Rubén, et al. (author) Electric field modeling and spatial control in Deep Brain Stimulation 2015 In: Proc. 54th Conference on Decision and Control. - Piscataway, NJ : IEEE. - 9781479978847 - 9781479978861 ; , s. 3846-3851 Conference paper (peer-reviewed)abstract Deep Brain Stimulation (DBS) is an established treatment, in e.g. Parkinson's Disease, whose underlying biological mechanisms are unknown. In DBS, electrical stimulation is delivered through electrodes surgically implanted into certain regions of the brain of the patient. Mathematical models aiming at a better understanding of DBS and optimization of its therapeutical effect through the simulation of the electrical field propagating in the brain tissue have been developed in the past decade. The contribution of the present study is twofold: First, an analytical approximation of the electric field produced by an emitting contact is suggested and compared to the numerical solution given by a Finite Element Method (FEM) solver. Second, the optimal stimulation settings are evaluated by fitting the field distribution to a target one to control the spread of the stimulation. Optimization results are compared to those of a geometric approach, maximizing the intersection between the target and the activated volume in the brain tissue and reducing the stimulated area beyond said target. Both methods exhibit similar performance with respect to the optimal stimuli, with the electric field control approach being faster and more versatile.
13.	Davidsson, Johan, 1967, et al. (author) A Model for Research on Penetrating Traumatic Brain Injuries 2019 In: Neuromethods. - New York, NY : Springer New York. - 1940-6045 .- 0893-2336. ; 149, s. 47-59 Book chapter (other academic/artistic)abstract The animal model presented here produces high-speed penetrating traumatic brain injuries (pen-TBI) to simulate a form of neurotrauma that is severe and is the prevailing TBI in warzones and in areas with high incidence of violence. Commonly, these neurotraumas involve laceration of brain tissue, accompanying hemorrhage, edema, and inflammation. This also occurs in the pen-TBI model designed for rats that is presented here. During trauma, a probe, constructed in one single unit in aluminum and guided by a probe holder, is propelled by a lead bullet and penetrates at high speed into the brain parenchyma of the anesthetized animal. The animal’s head is held in position in a purposely built stereotactic frame. This frame can be adjusted in position relative the tip of the probe so that the tip of the probe is positioned on the exposed dura, using three orthogonally arranged horizontal slides. This procedure will facilitate high similarity in probe penetration location. By adjusting the air pressure in the air-driven accelerator used to accelerate the lead bullet, a large range of probe velocities can be achieved; 110 m/s probe velocity is commonly used. Several probe tip shapes are available for use in the pen-TBI model; pointy, blunt, and flat. The distance the probe penetrates the brain can be controlled. A typical distance is 5.5 mm, and this distance has been found to be almost independent of probe velocity and probe tip shape. After the probe has penetrated the animal, the pen-TBI device facilitates removal of the probe without causing additional brain damage. To do so, the animal is removed using the horizontal slider on the device that moves the animal’s head away from the probe in the direction of probe travel. The pen-TBI device is easy to operate and requires limited pre-trauma and post-trauma surgery. The device induces a small cavity, primary injury in a greater volume of the brain than the cavity and secondary injuries in an even greater volume that is several times that of the primary injury volume. The model appears to produce identical injuries in terms of appearance and dimensions in-between animals of same sex and body mass. The device also produces substantial but short-lived intracranial brain pressure changes, some 8-bar overpressure in the contralateral ventricle has been recorded, with high repeatability.
14.	Fredén Jansson, Karl-Johan, 1988, et al. (author) Robustness and lifetime of the bone conduction implant - a pilot study 2019 In: Medical Devices: Evidence and Research. - 1179-1470. ; 12, s. 89-100 Journal article (peer-reviewed)abstract Objectives: The objective of this study was to develop methods for evaluating the mechanical robustness and estimating the lifetime of the novel bone conduction implant (BCI) that is used in a clinical study. The methods are intended to be applicable to any similar device. Materials and methods: The robustness was evaluated using tests originally developed for cochlear implants comprising a random vibration test, a shock test, a pendulum test, and an impact test. Furthermore, magnetically induced torque and demagnetization during magnetic resonance imaging at 1.5 T were investigated using a dipole electromagnet. To estimate the lifetime of the implant, a long-term age-accelerated test was performed. Results: Out of all the tests, the pendulum and the impact tests had the largest effect on the electro-acoustic performance of the BCI implant, even if the change in performance was within acceptable limits (< 20%). In comparison with baseline data, the lower and higher resonance peaks shifted down in frequency by 13% and 18%, respectively, and with a loss in magnitude of 1.1 and 2.0 dB, respectively, in these tests. Conclusion: A complete series of tests were developed, and the BCI passed all the tests; its lifetime was estimated to be at least 26 years for patients who are using the implant for 12 hours on a daily basis.
15.	Håkansson, Bo, 1953, et al. (author) VEMP using a new low-frequency bone conduction transducer 2018 In: Medical Devices: Evidence and Research. - 1179-1470. ; 11, s. 301-312 Journal article (peer-reviewed)abstract Objective: A new prototype bone conduction (BC) transducer B250, with an emphasized low-frequency response, is evaluated in vestibular evoked myogenic potential (VEMP) investigations. The aim was to compare cervical (cVEMP) and ocular (oVEMP) responses using tone bursts at 250 and 500 Hz with BC stimulation using the B250 and the conventional B81 transducer and by using air conduction (AC) stimulation. Methods: Three normal subjects were investigated in a pilot study. BC stimulation was applied to the mastoids in cVEMP, and both mastoid and forehead in oVEMP investigations. Results: BC stimulation was found to reach VEMP thresholds at considerably lower hearing levels than in AC stimulation (30-40 dB lower oVEMP threshold at 250 Hz). Three or more cVEMP and oVEMP responses at consecutive 5 dB increasing mastoid stimulation levels were only obtained in all subjects using the B250 transducer at 250 Hz. Similar BC thresholds were obtained for both ipsilateral and contralateral mastoid stimulation. Forehead stimulation, if needed, may require a more powerful vibration output. Conclusion: Viable VEMP responses can be obtained at a considerably lower hearing level with BC stimulation than by AC stimulation. The cVEMP and oVEMP responses were similar when measured on one side and with the B250 attached to both ipsilateral and contralateral mastoids.
16.	Lindau, Björn, 1961, et al. (author) Virtual fixturing: Inspection of a non-rigid detail resting on 3-points to estimate free state and over-constrained shapes 2020 In: ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE). ; 2B-2020 Conference paper (peer-reviewed)abstract When the geometry of a non-rigid part or pre-assembly is measured fully clamped (over-constrained) in a measurement fixture, the spring-back information and influence from gravity forces are usually lost in the collected data. From the 3D-measurement data, it is hard to understand built in tensions, and the detail's tendency to bend, twist and warp after release from the measurement fixture. These effects are however important to consider when analyzing each part´s contribution to geometrical deviations after assembly. In this paper a method is presented, describing how free state shape and over-constrained shape of a measured detail can be virtually estimated starting from acquired data when the part or the preassembly is resting on only 3-points. The objective is to minimize the information loss, to spare measurement resources and to allow for a wider use of the collected data, describing the geometry. Part stiffnesses, part to part contacts and gravity effects are considered in the proposed method. The method is based on 3D-scanning techniques to acquire the shape of the measured object. Necessary compensations for part stiffnesses and gravity effects are based upon Finite Element Analysis (FEA) and the Method of Influence Coefficients (MIC). The presented method is applied to an industrial case to demonstrate its potential. The results show that estimated over-constrained shapes show good resemblance with measurements acquired when part is over-constrained in its measurement fixture.
17.	Persson, Ann-Charlotte, 1970, et al. (author) A novel method for objective in-situ measurement of audibility in bone conduction hearing devices - a pilot study using a skin drive BCD 2023 In: International Journal of Audiology. - : Informa UK Limited. - 1499-2027 .- 1708-8186. ; 62:4, s. 357-361 Journal article (peer-reviewed)abstract Objective Objective measurement of audibility (verification) using bone conduction devices (BCDs) has long remained an elusive problem for BCDs. For air conduction hearing aids there are well-defined and often used objective methods, and the aim of this study is to develop an objective method for BCDs. Design In a novel setup for audibility measurements of bone-anchored hearing aid (BAHA) attached via a soft band, we used a skin microphone (SM) on the forehead measuring in-situ sound field thresholds, maximum power output (MPO) and international speech test signal (ISTS) responses. Study sample Five normal-hearing persons. Result Using the electrical output of SM it was possible to objectively measure the audibility of a skin drive BCD, presented as an eSPL-o-gram showing thresholds, MPO and ISTS response. Normalised eSPL-o-gram was verified against corresponding FL-o-grams (corresponding force levels from skull simulator and artificial mastoid (AM)). Conclusion The proposed method with the SM can be used for objective measurements of the audibility of any BCDs based on thresholds, MPO and speech response allowing for direct comparisons of hearing and BCD output on the same graph using an eSPL-o-gram. After normalisation to hearing thresholds, the audibility can be assessed without the need for complicated calibration procedures.
18.	Rems, Lea, et al. (author) Cell electrofusion using nanosecond electric pulses 2013 In: Scientific Reports. - : Macmillan Publishers Ltd.. - 2045-2322. ; 3 Journal article (peer-reviewed)abstract Electrofusion is an efficient method for fusing cells using short-duration high-voltage electric pulses. However, electrofusion yields are very low when fusion partner cells differ considerably in their size, since the extent of electroporation (consequently membrane fusogenic state) with conventionally used microsecond pulses depends proportionally on the cell radius. We here propose a new and innovative approach to fuse cells with shorter, nanosecond (ns) pulses. Using numerical calculations we demonstrate that ns pulses can induce selective electroporation of the contact areas between cells (i.e. the target areas), regardless of the cell size. We then confirm experimentally on B16-F1 and CHO cell lines that electrofusion of cells with either equal or different size by using ns pulses is indeed feasible. Based on our results we expect that ns pulses can improve fusion yields in electrofusion of cells with different size, such as myeloma cells and B lymphocytes in hybridoma technology.
19.	Fredén Jansson, Karl-Johan, 1988 (author) The Balanced Electromagnetic Separation Transducer for Bone Conduction Audiometry and Hearing Rehabilitation 2017 Doctoral thesis (other academic/artistic)abstract Hearing via air conduction (AC) and bone conduction (BC) are attributed to bethe natural ways of conducting sound to the cochlea. With AC hearing, air pressurevariations are transmitted to the cochlea via the ear canal, whereas with BChearing, sound vibrations are transmitted through the skull bone to the cochlea.Patients with a hearing loss in the cochlea or auditory nerve are commonly rehabilitatedwith conventional AC hearing aids in the ear canal, but also using cochlearimplants. If the pathway for AC sound to reach the cochlea is obstructed, patientscan often benet from bone conduction devices (BCDs). In order to determinethe type and degree of hearing loss, the BC hearing thresholds are measured usinga bone conduction vibrator, and then analyzed together with the AC hearingthresholds for the diagnosis and to suggest an appropriate rehabilitation alternative.The motor unit in conventional BCDs and bone vibrators are known togenerate high amount of distortion at low frequencies where the Balanced ElectromagneticSeparation Transducer (BEST) principle may oer a new era in BChearing rehabilitation and audiometry.This thesis combines two BC hearing related topics, where the rst topic is anevaluation of a new audiometric bone vibrator, Radioear B81, which is assumedto oer more accurate BC hearing threshold measurements. The second topic isrelated to a new type of active transcutaneous BCD, called the Bone ConductionImplant (BCI), which leaves the skin intact by using a wireless solution thatdoes not require a permanent skin penetration. Even though the applications aredierent, both devices use the BEST principle as motor unit in their design.The audiometric bone vibrator Radioear B81 was found to have an improvedperformance at low frequencies where it can produce higher output levels with lessharmonic distortion than the conventional Radioear B71. In a clinical study of therst six patients, the BCI was found as ecient as already commercially availableBCDs, and with the advantage of not needing a skin penetration. In a technicalevaluation of the BCI, it was shown to be a mechanically robust design and totolerate magnetic resonance imaging at 1.5 Tesla.
20.	Khodadad, Davood, 1985-, et al. (author) The Value of Phase Angle in Electrical Impedance Tomography Breath Detection 2018 In: 2018 Progress in Electromagnetics Research Symposium (PIERS-Toyama). - : Electromagnetics Academy. - 9784885523168 - 9781538654552 ; , s. 1040-1043 Conference paper (peer-reviewed)abstract The objective of this paper is to report our investigation demonstrating that the phase angle information of complex impedance could be a simple indicator of a breath cycle in chest Electrical Impedance Tomography (EIT). The study used clinical neonatal EIT data. The results show that measurement of the phase angle from complex EIT data can be used as a complementary information for improving the conventional breath detection algorithms.
21.	Eeg-Olofsson, Måns, 1967, et al. (author) Transmission of bone conducted sound – Correlation between hearing perception and cochlear vibration 2013 In: Hearing Research. - : Elsevier. - 0378-5955 .- 1878-5891. ; 306, s. 11-20 Journal article (peer-reviewed)abstract The vibration velocity of the lateral semicircular canal and the cochlear promontory was measured on 16 subjects with a unilateral middle ear common cavity, using a laser Doppler vibrometer, when the stimulation was by bone conduction (BC). Four stimulation positions were used: three ipsilateral positions and one contralateral position. Masked BC pure tone thresholds were measured with the stimulation at the same four positions. Valid vibration data were obtained at frequencies between 0.3 and 5.0 kHz. Large intersubject variation of the results was found with both methods. The difference in cochlear velocity with BC stimulation at the four positions varied as a function of frequency while the tone thresholds showed a tendency of lower thresholds with stimulation at positions close to the cochlea. The correlation between the vibration velocities of the two measuring sites of the otic capsule was high. Also, relative median data showed similar trends for both vibration and threshold measurements. However, due to the high variability for both vibration and perceptual data, low correlation between the two methods was found at the individual level. The results from this study indicated that human hearing perception from BC sound can be estimated from the measure of cochlear vibrations of the otic capsule. It also showed that vibration measurements of the cochlea in cadaver heads are similar to that measured in live humans.
22.	Iacobaeus, Christian, et al. (author) A novel portal imaging device for advanced radiation therapy 2001 In: Nuclear Science, IEEE Transactions on. - Nuclear Science, IEEE Transactions on : Institute of Electrical and Electronics Engineers (IEEE). - 0018-9499 .- 1558-1578. ; 48:4, Part 2, s. 1496-1502 Journal article (peer-reviewed)
23.	Rohlén, Robin, et al. (author) Estimating the neural spike train from an unfused tetanic signal of low-threshold motor units using convolutive blind source separation 2023 In: Biomedical engineering online. - : BioMed Central (BMC). - 1475-925X. ; 22 Journal article (peer-reviewed)abstract Background: Individual motor units have been imaged using ultrafast ultrasound based on separating ultrasound images into motor unit twitches (unfused tetanus) evoked by the motoneuronal spike train. Currently, the spike train is estimated from the unfused tetanic signal using a Haar wavelet method (HWM). Although this ultrasound technique has great potential to provide comprehensive access to the neural drive to muscles for a large population of motor units simultaneously, the method has a limited identification rate of the active motor units. The estimation of spikes partly explains the limitation. Since the HWM may be sensitive to noise and unfused tetanic signals often are noisy, we must consider alternative methods with at least similar performance and robust against noise, among other factors.Results: This study aimed to estimate spike trains from simulated and experimental unfused tetani using a convolutive blind source separation (CBSS) algorithm and compare it against HWM. We evaluated the parameters of CBSS using simulations and compared the performance of CBSS against the HWM using simulated and experimental unfused tetanic signals from voluntary contractions of humans and evoked contraction of rats. We found that CBSS had a higher performance than HWM with respect to the simulated firings than HWM (97.5 ± 2.7 vs 96.9 ± 3.3, p < 0.001). In addition, we found that the estimated spike trains from CBSS and HWM highly agreed with the experimental spike trains (98.0% and 96.4%).Conclusions: This result implies that CBSS can be used to estimate the spike train of an unfused tetanic signal and can be used directly within the current ultrasound-based motor unit identification pipeline. Extending this approach to decomposing ultrasound images into spike trains directly is promising. However, it remains to be investigated in future studies where spatial information is inevitable as a discriminating factor.
24.	Sepehri, Sobhan, 1986, et al. (author) Volume-amplified magnetic bioassay integrated with microfluidic sample handling and high-Tc SQUID magnetic readout 2018 In: APL Bioengineering. - : AIP Publishing. - 2473-2877. ; 2:1 Journal article (peer-reviewed)abstract A bioassay based on a high-Tc superconducting quantum interference device (SQUID) reading out functionalized magnetic nanoparticles (fMNPs) in a prototype microfluidic platform is presented. The target molecule recognition is based on volume amplification using padlock-probe-ligation followed by rolling circle amplification (RCA). The MNPs are functionalized with single-stranded oligonucleotides, which give a specific binding of the MNPs to the large RCA coil product, resulting in a large change in the amplitude of the imaginary part of the ac magnetic susceptibility. The RCA products from amplification of synthetic Vibrio cholera target DNA were investigated using our SQUID ac susceptibility system in microfluidic channel with an equivalent sample volume of 3 μl. From extrapolation of the linear dependence of the SQUID signal versus concentration of the RCA coils, it is found that the projected limit of detection for our system is about 1.0 e5 RCA coils (0.2e−18 mol), which is equivalent to 66 fM in the 3 μl sample volume. This ultra-high magnetic sensitivity and integration with microfluidic sample handling are critical steps towards magnetic bioassays for rapid detection of DNA and RNA targets at the point of care.
25.	Taghavi, Hamidreza, 1981 (author) The Bone Conduction Implant (BCI) - Preclinical Studies, Technical Design and a Clinical Evaluation 2014 Doctoral thesis (other academic/artistic)abstract The Bone Conduction Implant (BCI) system has been developed as an alternative to the percutaneous bone anchored hearing aid (BAHA) with the advantage that the skin is kept intact. The transducer is permanently implanted and attached to the skull via a flat surface contact to the temporal bone. By applying amplitude modulation, the sound signal is transmitted to the implanted transducer through the intact skin via an efficient wireless inductive link. The external audio processor includes digital and analog signal processing units, and an Application Specific Integrated Circuit driving the inductive link. Its retention is provided by permanent magnets.Preclinical investigations of the BCI system have been performed on a skull simulator, a dry skull, cadaver heads and in an animal model study. In an extensive technical evaluation using a skull simulator, it was found that the power output from the BCI system was very robust for skin flap thicknesses from 2 to 8 mm with variability of less than 1.5 dB. Moreover, the peak of the maximum power output was 107 dB relative to 1 μN at transducer resonance frequency and at 5 mm skin flap thickness. This means that the highest output forces were produced in the "normal" skin thickness range, which in fact was one important design goal. The BCI system drains approximately 7.5 mA of battery current at 1 kHz and at 65 dB input sound pressure level, which corresponds to a battery lifetime of 5-7 days under normal use. It was found that significantly higher gain setting can be used without feedback problems for the BCI as compared to the BAHA. In an animal model (sheep), it was found that the implant-to-bone attachment became firmer over time and that the vibration transmission was stable over this period of eight months.Finally, in a clinical study, the results of the first patient were reported at one month follow up. The surgical procedure for installing the implant was found to be easy and safe, and the BCI gave a significant improvement in hearing over the unaided condition. The functional power output of the BCI was similar to most powerful ear level BAHA devices on headband at lower frequencies and superior at higher frequencies. In summary, it was found that the new BCI system can be an attractive alternative to the present percutaneous BAHA system.

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