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Search: L773:1356 5524 OR L773:1473 6810

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  • Henriksson, C., et al. (author)
  • What effect does breastfeeding have on coeliac disease? : A systematic review update
  • 2013
  • In: Evidence-Based Medicine. - : BMJ. - 1356-5524 .- 1473-6810. ; 18:3, s. 98-103
  • Journal article (peer-reviewed)abstract
    • Objective: To update the evidence published in a previous systematic review and meta-analysis that compared the effect of breastfeeding on risk of coeliac disease (CD). Material and methods: A systematic review of observational studies published between 1966 and May 2004 on the subject was conducted in 2005. This update is a systematic review of observational studies published between June 2004 and April 2011. Pubmed, EMBASE and Cinahl were searched for published studies that examined the association between breastfeeding and CD. Results: After duplicates were removed 90 citations were screened. Four observational studies were included in the review. Two of three studies which had examined the duration of breastfeeding and CD reported significant associations between longer duration of breastfeeding and later onset of CD (OR ranged from 0.18 to 0.665). Breastfeeding during the introduction of gluten to the infant was reported to have a protective effect in two studies. Conclusions: Our findings support previous published findings that breastfeeding seems to offer a protection against the development of CD in predisposed infants. Breastfeeding at time of gluten introduction is the most significant variable in reducing the risk. Timing of gluten introduction may also be a factor in the development of CD.
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  • Anttila, Sten, et al. (author)
  • Challenge of communicating uncertainty in systematic reviews when applying GRADE ratings
  • 2018
  • In: Evidence-Based Medicine. - : BMJ. - 1356-5524 .- 2515-446X .- 2515-4478.
  • Journal article (peer-reviewed)abstract
    • One of the most widely used tools for assessing and communicating scienti c uncertainty is Grading of Recommendations Assessment, Development, and Evaluation (GRADE), a system for rating the quality of evidence and grading strength of recommendations in healthcare. More than 100 organisations around the world—WHO included1— are using GRADE or have endorsed it.In GRADE, a quantitative assessment of uncertainty is qualitatively communicated, so that a result obtained as a CI relative to a threshold is expressed as a nding in which assessors have low, moderate or high certainty, or certainty described with other such quali ers. What these correspond to in quantitative terms, and how decision-makers interpret them, is our issue here. We con ne our attention to GRADE’s decision rules for systematic reviews, and do not comment on the problem of multiple outcomes in guideline recommendations.
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