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- Mataix-Cols, David, et al.
(author)
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All-Cause and Cause-Specific Mortality Among Individuals With Hypochondriasis
- 2024
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In: JAMA psychiatry. - : American Medical Association (AMA). - 2168-6238 .- 2168-622X. ; 81:3, s. 284-291
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Journal article (peer-reviewed)abstract
- IMPORTANCE: Hypochondriasis, also known as health anxiety disorder, is a prevalent, yet underdiagnosed psychiatric disorder characterized by persistent preoccupation about having serious and progressive physical disorders. The risk of mortality among individuals with hypochondriasis is unknown.OBJECTIVE: To investigate all-cause and cause-specific mortality among a large cohort of individuals with hypochondriasis.DESIGN, SETTING, AND PARTICIPANTS: This Swedish nationwide matched-cohort study included 4129 individuals with a validated International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10) diagnosis of hypochondriasis assigned between January 1, 1997, and December 31, 2020, and 41 290 demographically matched individuals without hypochondriasis. Individuals with diagnoses of dysmorphophobia (body dysmorphic disorder) assigned during the same period were excluded from the cohort. Statistical analyses were conducted between May 5 and September 27, 2023. EXPOSURE: Validated ICD-10 diagnoses of hypochondriasis in the National Patient Register.MAIN OUTCOME AND MEASURES: All-cause and cause-specific mortality in the Cause of Death Register. Covariates included birth year, sex, county of residence, country of birth (Sweden vs abroad), latest recorded education, civil status, family income, and lifetime psychiatric comorbidities. Stratified Cox proportional hazards regression models were used to estimate the hazard ratios (HRs) and 95% CIs of all-cause and cause-specific mortality.RESULTS: Of the 4129 individuals with hypochondriasis (2342 women [56.7%]; median age at first diagnosis, 34.5 years [IQR, 26.3-46.1 years]) and 41 290 demographically matched individuals without hypochondriasis (23 420 women [56.7%]; median age at matching, 34.5 years [IQR, 26.4-46.2 years]) in the study, 268 individuals with hypochondriasis and 1761 individuals without hypochondriasis died during the study period, corresponding to crude mortality rates of 8.5 and 5.5 per 1000 person-years, respectively. In models adjusted for sociodemographic variables, an increased rate of all-cause mortality was observed among individuals with hypochondriasis compared with individuals without hypochondriasis (HR, 1.69; 95% CI, 1.47-1.93). An increased rate was observed for both natural (HR, 1.60; 95% CI, 1.38-1.85) and unnatural (HR, 2.43; 95% CI, 1.61-3.68) causes of death. Most deaths from unnatural causes were attributed to suicide (HR, 4.14; 95% CI, 2.44-7.03). The results were generally robust to additional adjustment for lifetime psychiatric disorders.CONCLUSIONS AND RELEVANCE: This cohort study suggests that individuals with hypochondriasis have an increased risk of death from both natural and unnatural causes, particularly suicide, compared with individuals from the general population without hypochondriasis. Improved detection and access to evidence-based care should be prioritized.
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| 3. |
- Säätelä, Simo, et al.
(author)
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Note from the editors
- 2018
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In: Nordic Wittgenstein Review. - Uppsala : University of Bergen Library. - 2194-6825 .- 2242-248X. ; 7:1, s. 5-8
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Journal article (other academic/artistic)abstract
- The debate surrounding Open Access publishing moved into a new and heated stage after the launching of the so called ”plan S” earlier this autumn.The plan is an initiative of cOAlition S, a consortium consisting of major national research agencies and funders from twelve European countries, coordinated bytheEuropean Research Council,and it requires that all scholarly publications resulting from research funded by members of the coalition must be openly available immediately upon publication without any embargo period, and be permanently accessible under an open license allowing for re-use for any purpose, subject to proper attribution of authorship. This means that the CC BY Attribution 4.0 license will be demanded for scholarly articles.
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