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1.	Parnetti, L, et al. (author) Cerebrospinal fluid levels of biomarkers and activity of acetylcholinesterase (AChE) and butyrylcholinesterase in AD patients before and after treatment with different AChE inhibitors 2002 In: Neurological Sciences. - : Springer Science and Business Media LLC. - 1590-1874 .- 1590-3478. ; 23, s. 95-96 Journal article (peer-reviewed)abstract In order to evaluate the biochemical effects of long-term treatment with inhibitors of acetylcholinesterase (AChE) in patients with Alzheimer's disease (AD), we measured the activities of AChE and butyry1cholinesterase (BuChe) and the concentrations of beta-amyloid (1-42), tau and phosphorylated tau proteins in the cerebrospinal fluid (CSF). A total of 91 patients suffering from probable AD of mild to moderate degree were treated for 6 months with donepezil (n=59), galantamine (n=15), rivastigmine (n=10), or placebo (n=7). AChE activity in CSF was significantly increased after treatment with donepezil and galantamine; the opposite was observed in the rivastigmine-treated group. Untreated patients did not show any AChE activity variation. BuChE did not show any change in any of the groups studied. Mean values of beta-amyloid(1-42), total tau and phosphorylated tau also did not vary significantly. We conclude that AChE inhibitors induce different effects on CSF AChE activity, while other CSF biomarkers are not significantly affected by treatment.
2.	Quaglino, E, et al. (author) A better immune reaction to Erbb-2 tumors is elicited in mice by DNA vaccines encoding rat/human chimeric proteins 2010 In: Cancer research. - 1538-7445. ; 70:7, s. 2604-2612 Journal article (peer-reviewed)
3.	Saez-Valero, J, et al. (author) Glycosylation of acetylcholinesterase and butyrylcholinesterase changes as a function of the duration of Alzheimer's disease 2003 In: Journal of neuroscience research. - : Wiley. - 0360-4012. ; 72:4, s. 520-526 Journal article (peer-reviewed)
4.	Zoccoli, G, et al. (author) Scoprism: a new algorithm for automatic sleep scoring in mice 2014 In: JOURNAL OF SLEEP RESEARCH. - 0962-1105. ; 23, s. 77-77 Conference paper (other academic/artistic)

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Type of publication: journal article (3); conference paper (1)

Type of content: peer-reviewed (3); other academic/artistic (1)

Author/Editor: Blennow, K (2); Parnetti, L (2); Andreasen, N (2); Amici, S (2); Gallai, V (2); Gabrielli, A. (1); show more...; Minthon, Lennart (1); Cavallo, F. (1); Masucci, G (1); Kimura, M. (1); Sjogren, M (1); Lanari, A. (1); Forni, G (1); Davidsson, P (1); Vanderstichele, H (1); Vanmechelen, E (1); Lanzardo, S (1); Iezzi, M (1); Quaglino, E (1); Bastianini, S (1); Berteotti, C (1); Lo Martire, V (1); Silvani, A (1); Zoccoli, G (1); Alexandre, C (1); Romani, C (1); Del Vecchio, F (1); Saez-Valero, J. (1); Amici, R (1); Pottel, H (1); Antognelli, C (1); Mastini, C (1); Amici, A (1); Marchini, C (1); De Giovanni, C (1); Montani, M (1); Lollini, PL (1); Fodero, LR (1); Small, DH (1); Gazea, M (1); Scammell, TE (1); show less...

University: Karolinska Institutet (4); Lund University (1)

Language: English (4)

Research subject (UKÄ/SCB): Medical and Health Sciences (1)

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