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- Glasbey, JC, et al.
(author)
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- 2021
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swepub:Mat__t
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- Anastasi, A., et al.
(author)
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Combination of KLOE sigma (e(+) e(-) -> pi(+)pi(-) gamma(gamma)) measurements and determination of a(mu)(pi+pi-) in the energy range 0.10 < s < 0.95 GeV2
- 2018
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In: Journal of High Energy Physics (JHEP). - : Springer. - 1126-6708 .- 1029-8479. ; :3
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Journal article (peer-reviewed)abstract
- The three precision measurements of the cross section sigma (e(+)e(-) -> pi(+)pi(-)gamma(gamma)) using initial state radiation by the KLOE collaboration provide an important input for the prediction of the hadronic contribution to the anomalous magnetic moment of the muon. These measurements are correlated for both statistical and systematic uncertainties and, therefore, the simultaneous use of these measurements requires covariance matrices that fully describe the correlations. We present the construction of these covariance matrices and use them to determine a combined KLOE measurement for sigma (e(+)e(-) -> pi(+)pi(-)gamma(gamma)). We find, from this combination, a two-pion contribution to the muon magnetic anomaly in the energy range 0.10 < s < 0.95 GeV2 of a(mu)(pi+pi-) (489.8 +/- 1.7(stat) +/- 4.8(sys)) x 10(-10).
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- Anastasi, A., et al.
(author)
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Combined limit on the production of a light gauge boson decaying into mu(+) mu(-) and pi(+) pi(-)
- 2018
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In: Physics Letters B. - : ELSEVIER SCIENCE BV. - 0370-2693 .- 1873-2445. ; 784, s. 336-341
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Journal article (peer-reviewed)abstract
- We searched for the mu(+) mu(-) decay of a light vector gauge boson, also known as dark photon, in the e(+) e(-) -> mu(+) mu(-) gamma(ISR) process by means of the Initial State Radiation (ISR) method. We used 1.93fb(-1) of data collected by the KLOE experiment at the DA Phi NE phi-factory. No structures have been observed over the irreducible mu(+) mu(-) background. A 90% CL limit on the ratio epsilon(2)= alpha'/alpha between the dark coupling constant and the fine structure constant of 3 x 10(-6)-2 x 10(-7) has been set in the dark photon mass region between 519 MeV and 973 MeV. This new limit has been combined with the published result obtained investigating the hypothesis of the dark photon decaying into hadrons in e(+) e(-) -> pi(+) pi(-) gamma(ISR) events. The combined 90% CL limit increases the sensitivity especially in the rho-omega interference region and excludes epsilon(2) greater than (13 - 2) x 10(-7). For dark photon masses greater than 600 MeV the combined limit is lower than 8 x 10(-7) resulting more stringent than present constraints from other experiments.
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- Anastasi, A., et al.
(author)
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Measurement of the charge asymmetry for the K-S -> pi e nu decay and test of CPT symmetry with the KLOE detector
- 2018
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In: Journal of High Energy Physics (JHEP). - : SPRINGER. - 1126-6708 .- 1029-8479. ; :9
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Journal article (peer-reviewed)abstract
- Using 1.63 fb(-1) of integrated luminosity collected by the KLOE experiment about 7 x 10(4) K-S -> pi(+/-)e(-/+)nu decays have been reconstructed. The measured value of the charge asymmetry for this decay is A(S) = (-4.9 +/- 5.7(stat) +/- 2.6(syst)) x 10(-3) which is almost twice more precise than the previous KLOE result. The combination of these two measurements gives A(S) = (3.8 +/- 5.0(stat) +/- 2.6(syst)) x 10(-3) and, together with the asymmetry of the K-L semileptonic decay, provides significant tests of the CPT symmetry. The obtained results are in agreement with CPT invariance.
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- Anastasi, A., et al.
(author)
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Limit on the production of a low-mass vector boson in e(+)e(-) -> U gamma, U -> e(+)e(-) with the KLOE experiment
- 2015
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In: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 750, s. 633-637
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Journal article (peer-reviewed)abstract
- The existence of a new force beyond the Standard Model is compelling because it could explain several striking astrophysical observations which fail standard interpretations. We searched for the light vector mediator of this dark force, the U boson, with the KLOE detector at the DA Phi NE e(+)e(-) collider. Using an integrated luminosity of 1.54 fb(-1), we studied the process e(+)e(-) -> U gamma, with U -> e(+)e(-), using radiative return to search for a resonant peak in the dielectron invariant-mass distribution. We did not find evidence for a signal, and set a 90% CL upper limit on the mixing strength between the Standard Model photon and the dark photon, epsilon(2), at 10(-6)-10(-4) in the 5-520 MeV/c(2) mass range.
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- Anastasi, A., et al.
(author)
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Limit on the production of a new vector boson in e+e− → Uγ, U → π+π− with the KLOE experiment
- 2016
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In: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 757, s. 356-361
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Journal article (peer-reviewed)abstract
- Abstract The recent interest in a light gauge boson in the framework of an extra U(1) symmetry motivates searches in the mass range below 1 GeV. We present a search for such a particle, the dark photon, in e + e − → U γ , U → π + π − based on 28 million e + e − → π + π − γ events collected at DAΦNE by the KLOE experiment. The π + π − production by initial-state radiation compensates for a loss of sensitivity of previous KLOE U → e + e − , μ + μ − searches due to the small branching ratios in the ρ – ω resonance region. We found no evidence for a signal and set a limit at 90% CL on the mixing strength between the photon and the dark photon, ε 2 , in the U mass range between 527 and 987 MeV . Above 700 MeV this new limit is more stringent than previous ones.
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- Anastasi, A., et al.
(author)
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Measurement of the running of the fine structure constant below 1 GeV with the KLOE detector
- 2017
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In: Physics Letters B. - : ELSEVIER SCIENCE BV. - 0370-2693 .- 1873-2445. ; 767, s. 485-492
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Journal article (peer-reviewed)abstract
- We have measured the running of the effective QED coupling constant alpha(s) in the time-like region 0.6 < root s < 0.975 GeV with the KLOE detector at DA Phi NE using the Initial-State Radiation process e(+) e(-) -> mu(+) mu(-)gamma. It represents the first measurement of the running of alpha(s) in this energy region. Our results show a more than 5 sigma significance of the hadronic contribution to the running of alpha(s), which is the strongest direct evidence both in time- and space-like regions achieved in a single measurement. By using the e(+) e(-) -> pi(+) pi(-) cross section measured by KLOE, the real and imaginary parts of the shift Delta alpha(s) have been extracted. From a fit of the real part of Delta alpha(s) and assuming the lepton universality the branching ratio BR(omega -> mu(+) mu(-)) = (6.6 +/- 1.4(stat) +/- 1.7(syst)) (.) 10 (5)has been determined.
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- Anastasi, A., et al.
(author)
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Precision measurement of the η → π + π − π 0 Dalitz plot distribution with the KLOE detector
- 2016
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In: Journal of High Energy Physics (JHEP). - 1126-6708 .- 1029-8479. ; :5
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Journal article (peer-reviewed)abstract
- Using 1.6 fb−1 of e + e − → ϕ → ηγ data collected with the KLOE detector at DAΦNE, the Dalitz plot distribution for the η → π + π − π 0 decay is studied with the world’s largest sample of ∼ 4.7 · 106 events. The Dalitz plot density is parametrized as a polynomial expansion up to cubic terms in the normalized dimensionless variables X and Y . The experiment is sensitive to all charge conjugation conserving terms of the expansion, including a gX 2 Y term. The statistical uncertainty of all parameters is improved by a factor two with respect to earlier measurements.
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- Anastasi, A., et al.
(author)
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Search for dark Higgsstrahlung in e(+0)e(-) -> mu(+)mu(-) and missing energy events with the KLOE experiment
- 2015
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In: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 747, s. 365-372
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Journal article (peer-reviewed)abstract
- We searched for evidence of a Higgsstrahlung process in a secluded sector, leading to a final state with a dark photon U and a dark Higgs boson h', with the KLOE detector at DA Phi NE. We investigated the case of h' lighter than U, with U decaying into a muon pair and h' producing a missing energy signature. We found no evidence of the process and set upper limits to its parameters in the range 2m(mu) < m(U) < 1000 MeV, m(h') < m(U). (C) 2015 The Authors. Published by Elsevier B.V.
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- Kohl, S, et al.
(author)
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CNGB3 mutations account for 50% of all cases with autosomal recessive achromatopsia
- 2005
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In: European Journal of Human Genetics. - : Springer Science and Business Media LLC. - 1476-5438 .- 1018-4813. ; 13:3, s. 302-308
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Journal article (peer-reviewed)abstract
- Achromatopsia is a congenital, autosomal recessively inherited disorder characterized by a lack of color discrimination, low visual acuity (<0.2), photophobia, and nystagmus. Mutations in the genes for CNGA3, CNGB3, and GNAT2 have been associated with this disorder. Here, we analyzed the spectrum and prevalence of CNGB3 gene mutations in a cohort of 341 independent patients with achromatopsia. In 163 patients, CNGB3 mutations could be identified. A total of 105 achromats carried apparent homozygous mutations, 44 were compound (double) heterozygotes, and 14 patients had only a single mutant allele. The derived CNGB3 mutation spectrum comprises 28 different mutations including 12 nonsense mutations, eight insertions and/or deletions, five putative splice site mutations, and three missense mutations. Thus, the majority of mutations in the CNGB3 gene result in significantly altered and/or truncated polypeptides. Several mutations were found recurrently, in particular a 1 bp deletion, c.1148delC, which accounts for over 70% of all CNGB3 mutant alleles. In conclusion, mutations in the CNGB3 gene are responsible for approximately 50% of all patients with achromatopsia. This indicates that the CNGB3/ACHM3 locus on chromosome 8q21 is the major locus for achromatopsia in patients of European origin or descent.
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- Zheng, Hou-Feng, et al.
(author)
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Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture
- 2015
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In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 526:7571, s. 112-
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Journal article (peer-reviewed)abstract
- The extent to which low-frequency (minor allele frequency (MAF) between 1-5%) and rare (MAF <= 1%) variants contribute to complex traits and disease in the general population is mainly unknown. Bone mineral density (BMD) is highly heritable, a major predictor of osteoporotic fractures, and has been previously associated with common genetic variants(1-8), as well as rare, population specific, coding variants(9). Here we identify novel non-coding genetic variants with large effects on BMD (n(total) = 53,236) and fracture (n(total) = 508,253) in individuals of European ancestry from the general population. Associations for BMD were derived from whole-genome sequencing (n = 2,882 from UK10K (ref. 10); a population-based genome sequencing consortium), whole-exome sequencing (n = 3,549), deep imputation of genotyped samples using a combined UK10K/1000 Genomes reference panel (n = 26,534), and de novo replication genotyping (n = 20,271). We identified a low-frequency non-coding variant near a novel locus, EN1, with an effect size fourfold larger than the mean of previously reported common variants for lumbar spine BMD8 (rs11692564(T), MAF51.6%, replication effect size510.20 s.d., P-meta = 2 x 10(-14)), which was also associated with a decreased risk of fracture (odds ratio = 0.85; P = 2 x 10(-11); ncases = 98,742 and ncontrols = 409,511). Using an En1cre/flox mouse model, we observed that conditional loss of En1 results in low bone mass, probably as a consequence of high bone turnover. We also identified a novel low frequency non-coding variant with large effects on BMD near WNT16 (rs148771817(T), MAF = 1.2%, replication effect size +10.41 s.d., P-meta = 1 x 10(-11)). In general, there was an excess of association signals arising from deleterious coding and conserved non-coding variants. These findings provide evidence that low-frequency non-coding variants have large effects on BMD and fracture, thereby providing rationale for whole-genome sequencing and improved imputation reference panels to study the genetic architecture of complex traits and disease in the general population.
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- Anastasi, E, et al.
(author)
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Expression of activated Notch3 in transgenic mice enhances generation of T regulatory cells and protects against experimental autoimmune diabetes
- 2003
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In: Journal of immunology (Baltimore, Md. : 1950). - : The American Association of Immunologists. - 0022-1767 .- 1550-6606. ; 171:9, s. 4504-4511
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Journal article (peer-reviewed)abstract
- Thymic-derived dysregulated tolerance has been suggested to occur in type 1 diabetes via impaired generation of CD4+CD25+ T regulatory cells, leading to autoimmune β cell destruction. In this study, we demonstrate that Notch3 expression is a characteristic feature of CD4+CD25+ cells. Furthermore, streptozotocin-induced autoimmune diabetes fails to develop in transgenic mice carrying the constitutively active intracellular domain of Notch3 in thymocytes and T cells. The failure to develop the disease is associated with an increase of CD4+CD25+ T regulatory cells, accumulating in lymphoid organs, in pancreas infiltrates and paralleled by increased expression of IL-4 and IL-10. Accordingly, CD4+ T cells from Notch3-transgenic mice inhibit the development of hyperglycemia and insulitis when injected into streptozotocin-treated wild-type mice and display in vitro suppressive activity. These observations, therefore, suggest that Notch3-mediated events regulate the expansion and function of T regulatory cells, leading to protection from experimental autoimmune diabetes and identify the Notch pathway as a potential target for therapeutic intervention in type 1 diabetes.
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- Batista, Vania, et al.
(author)
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Surface guided radiation therapy: : An international survey on current clinical practice
- 2022
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In: Technical Innovations and Patient Support in Radiation Oncology. - : Elsevier BV. - 2405-6324. ; 22, s. 1-8
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Journal article (peer-reviewed)abstract
- Introduction: Surface Guided Radiation Therapy (SGRT) is being increasingly implemented into clinical practiceacross a number of techniques and irradiation-sites. This technology, which is provided by different vendors, canbe used with most simulation- and delivery-systems. However, limited guidelines and the complexity of clinicalsettings have led to diverse patterns of operation. With the aim to understand current clinical practice a surveywas designed focusing on specifics of the clinical implementation and usage.Materials and methods: A 32-question survey covered: type and number of systems, quality assurance (QA),clinical workflows, and identification of strengths/limitations. Respondents from different professional groupsand countries were invited to participate. The survey was distributed internationally via ESTRO-membership,social media and vendors.Results: Of the 278 institutions responding, 172 had at least one SGRT-system and 136 use SGRT clinically.Implementation and QA were primarily based on the vendors’ recommendations and phantoms. SGRT wasmainly implemented in breast RT (116/136), with strong but diverse representation of other sites. Many (58/135) reported at least partial elimination of skin-marks and a third (43/126) used open-masks. The most commonimaging protocol reported included the combination of radiographic imaging with SGRT. Patient positioning(115/136), motion management (104/136) and DIBH (99/136) were the main applications.Main barriers to broader application were cost, system integration issues and lack of demonstrated clinical value.A lack of guidelines in terms of QA of the system was highlighted.Conclusions: This overview of the SGRT status has the potential to support users, vendors and organisations in thedevelopment of practices, products and guidelines.
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