SwePub - search: WFRF:(Andersen Steffen)

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1.	van As, Dirk, et al. (author) Katabatic winds and piteraq storms : observations from the Greenland ice sheet 2014 In: Geological Survey of Denmark and Greenland Bulletin. - 1811-4598 .- 1604-8156. ; 31, s. 83-86 Journal article (peer-reviewed)abstract In 2007 the Programme for Monitoring the Greenland Ice Sheet (PROMICE) was initiated to observe and gain insight into the mass budget of Greenland ice masses. By means of in situ observations and remote sensing, PROMICE assesses how much mass is gained as snow accumulation on the surface versus how much is lost by iceberg calving and surface ablation (Ahlstrøm et al. 2008). A key element of PROMICE is a network of automatic weather stations (AWSs) designed to quantify components of the surface mass balance, including the energy exchanges contributing to surface ablation (Van As et al. 2013).The use of these AWS observations is not limited to studies of ice-sheet mass balance. PROMICE contributes to CryoNet (www.globalcryospherewatch.org/cryonet), the core network of surface measurement sites of the World Meteorological Organization (WMO) Global Cryosphere Watch. By real-time delivery through WMO, PROMICE observations contribute to improve both operational forecasting and climate analysis in the data-sparse Arctic. The Greenlandic population, highly dependent on accurate forecasting of weather conditions, benefits directly from these real-time observations. For instance, extreme surface wind speeds are a high-risk element in Greenland. The third-highest wind speed observed at the surface of the Earth (93 m/s or 333 km/h), was recorded in a 8–9 March 1972 storm at Thule in North-West Greenland (Stansfield 1972).In this paper, we discuss the extent to which the Greenland ice sheet generates its own near-surface wind field. We use PROMICE data to gain insight into the interaction between air temperature, radiation and gravity-driven katabatic winds. We focus on a particularly powerful spring storm in 2013 that contributed to a fatality on an ice-sheet ski traverse attempt (Linden 2013).
2.	Wadt, Karin A W, et al. (author) Molecular characterization of melanoma cases in denmark suspected of genetic predisposition. 2015 In: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 10:3 Journal article (peer-reviewed)abstract Both environmental and host factors influence risk of cutaneous melanoma (CM), and worldwide, the incidence varies depending on constitutional determinants of skin type and pigmentation, latitude, and patterns of sun exposure. We performed genetic analysis of CDKN2A, CDK4, BAP1, MC1R, and MITFp.E318K in Danish high-risk melanoma cases and found CDKN2A germline mutations in 11.3% of CM families with three or more affected individuals, including four previously undescribed mutations. Rare mutations were also seen in CDK4 and BAP1, while MC1R variants were common, occurring at more than twice the frequency compared to Danish controls. The MITF p.E318K variant similarly occurred at an approximately three-fold higher frequency in melanoma cases than controls. To conclude, we propose that mutation screening of CDKN2A and CDK4 in Denmark should predominantly be performed in families with at least 3 cases of CM. In addition, we recommend that testing of BAP1 should not be conducted routinely in CM families but should be reserved for families with CM and uveal melanoma, or mesothelioma.
3.	2019 Journal article (peer-reviewed)
4.	Andersen, Steffen, et al. (author) Asset Integration and Attitudes to Risk : Theory and Evidence 2017 Reports (other academic/artistic)abstract Measures of risk attitudes derived from experiments are often questioned because they are based on small stakes bets and do not account for the extent to which the decision-maker integrates the prizes of the experimental tasks with personal wealth. We exploit the existence of detailed information on individual wealth of experimental subjects in Denmark, and directly estimate risk attitudes and the degree of asset integration consistent with observed behavior. The behavior of the adult Danes in our experiment is consistent with partial asset integration: they behave as if some fraction of personal wealth is combined with experimental prizes in a utility function, and that this combination entails less than perfect substitution. Our subjects do not perfectly asset integrate. The implied risk attitudes from estimating these specifications imply risk premia and certainty equivalents that are a priori plausible under expected utility theory or rank dependent utility models. These are reassuring and constructive solutions to payoff calibration paradoxes. In addition, the rigorous, structural modeling of partial asset integration points to a rich array of neglected questions in risk management and policy evaluation in important field settings.
5.	Andersen, Steffen, et al. (author) Asset Integration and Attitudes toward Risk : Theory and Evidence 2018 In: Review of Economics and Statistics. - : MIT Press. - 0034-6535 .- 1530-9142. ; 100:5, s. 816-830 Journal article (peer-reviewed)abstract We provide evidence that choices over small stakes bets are consistent with assumptions of some payoff calibration paradoxes. We then exploit the existence of detailed information on individual wealth of our experimental subjects in Denmark, and directly estimate risk attitudes and the degree of asset integration. We discover that behavior is consistent with partial, rather than full, asset integration. The implied risk attitudes from estimating these specifications indicate risk premia and certainty equivalents that are a priori plausible. This theory and evidence suggest one constructive solution to payoff calibration paradoxes.
6.	Andersen, Steffen, et al. (author) Discounting behavior : A reconsideration 2014 In: European Economic Review. - : Elsevier. - 0014-2921 .- 1873-572X. ; 71, s. 15-33 Journal article (peer-reviewed)abstract We re-evaluate the theory, experimental design and econometrics behind claims that individuals exhibit non-constant discounting behavior. Theory points to the importance of controlling for the non-linearity of the utility function of individuals, since the discount rate is defined over time-dated utility flows and not flows of money. It also points to a menagerie of functional forms to characterize different types of non-constant discounting behavior. The implied experimental design calls for individuals to undertake several tasks to allow us to identify these models, and to several treatments such as multiple horizons and the effect of allowing for a front end delay on earlier payments. The implied econometrics calls for structural estimation of th`e theoretical models, allowing for joint estimation of utility functions and discounting functions. Using data collected from a representative sample of 413 adult Danes in 2009, we draw surprising conclusions. Assuming an exponential discounting model we estimate discount rates to be 9% on average. We find no evidence to support quasi-hyperbolic discounting or "fixed cost" discounting, and only modest evidence to support other specifications of non-constant discounting. Furthermore, the evidence for non-constant discounting, while statistically significant, is not economically significant in terms of the size of the estimated discount rates. We undertake extensive robustness checks on these findings, including a detailed review of the previous, comparable literature.
7.	Andersen, Steffen, et al. (author) Discounting behaviour and the magnitude effect : Evidence from a field experiment in Denmark 2013 In: Economica. - : Blackwell Publishing. - 0013-0427 .- 1468-0335. ; 80:320, s. 670-697 Journal article (peer-reviewed)abstract We evaluate the claim that individuals exhibit a magnitude effect in their discounting behaviour, where higher discount rates are inferred from choices made with lower principals, all else being equal. If the magnitude effect is quantitatively significant, it is not appropriate to use one discount rate that is independent of the scale of the project for cost-benefit analysis and capital budgeting. Using data from a field experiment in Denmark, we find statistically significant evidence of a magnitude effect that is much smaller than is claimed. This evidence surfaces only if one controls for unobserved individual heterogeneity in the population.
8.	Andersen, Steffen, et al. (author) Dual criteria decisions 2014 In: Journal of Economic Psychology. - : Elsevier. - 0167-4870 .- 1872-7719. ; 41, s. 101-113 Journal article (peer-reviewed)abstract The most popular models of decision making use a single criterion to evaluate projects or lotteries. However, decision makers may actually consider multiple criteria when evaluating projects. We consider a dual criteria model from psychology. This model integrates the familiar tradeoffs between risk and utility that economists traditionally assume, allowance for rank-dependent decision weights, and consideration of income thresholds. We examine the issues involved in full maximum likelihood estimation of the model using observed choice data. We propose a general method for integrating the multiple criteria, using the logic of mixture models, which we believe is attractive from a decision-theoretic and statistical perspective. The model is applied to observed choices from a major natural experiment involving intrinsically dynamic choices over highly skewed outcomes. The evidence points to the clear role that income thresholds play in such decision making, but does not rule out a role for tradeoffs between risk and utility or probability weighting.
9.	Andersen, Steffen, et al. (author) Estimating subjective probabilities 2014 In: Journal of Risk and Uncertainty. - : Springer. - 0895-5646 .- 1573-0476. ; 48:3, s. 207-229 Journal article (peer-reviewed)abstract Subjective probabilities play a central role in many economic decisions and act as an immediate confound of inferences about behavior, unless controlled for. Several procedures to recover subjective probabilities have been proposed, but in order to recover the correct latent probability one must either construct elicitation mechanisms that control for risk aversion, or construct elicitation mechanisms which undertake "calibrating adjustments" to elicited reports. We illustrate how the joint estimation of risk attitudes and subjective probabilities can provide the calibration adjustments that theory calls for. We illustrate this approach using data from a controlled experiment with real monetary consequences to the subjects. This allows the observer to make inferences about the latent subjective probability, under virtually any well-specified model of choice under subjective risk, while still employing relatively simple elicitation mechanisms.
10.	Andersen, Steffen, et al. (author) Inferring beliefs as subjectively imprecise probabilities 2012 In: Theory and Decision. - : Springer Nature. - 0040-5833 .- 1573-7187. ; 73:1, s. 161-184 Journal article (peer-reviewed)abstract We propose a method for estimating subjective beliefs, viewed as a subjective probability distribution. The key insight is to characterize beliefs as a parameter to be estimated from observed choices in a well-defined experimental task and to estimate that parameter as a random coefficient. The experimental task consists of a series of standard lottery choices in which the subject is assumed to use conventional risk attitudes to select one lottery or the other and then a series of betting choices in which the subject is presented with a range of bookies offering odds on the outcome of some event that the subject has a belief over. Knowledge of the risk attitudes of subjects conditions the inferences about subjective beliefs. Maximum simulated likelihood methods are used to estimate a structural model in which subjects employ subjective beliefs to make bets. We present evidence that some subjective probabilities are indeed best characterized as probability distributions with non-zero variance.
11.	Andersen, Steffen, et al. (author) Multiattribute Utility Theory, Intertemporal Utility, and Correlation Aversion 2018 In: International Economic Review. - : Wiley-Blackwell Publishing Inc.. - 0020-6598 .- 1468-2354. ; 59:2, s. 537-555 Journal article (peer-reviewed)abstract Convenient assumptions about qualitative properties of the intertemporal utility function have generated counterintuitive implications for the relationship between atemporal risk aversion and the intertemporal elasticity of substitution. If the intertemporal utility function is additively separable, then the latter two concepts are the inverse of each other. We review a theoretical specification with a long lineage in the literature on multi-attribute utility and use this theoretical structure to guide the design of a series of experiments that allow us to identify and estimate intertemporal correlation aversion. Our results show that subjects are correlation averse over lotteries with intertemporal income profiles.
12.	Andersen, Steffen, et al. (author) Non-linear mixed logit 2012 In: Theory and Decision. - : Springer Nature. - 0040-5833 .- 1573-7187. ; 73:1, s. 77-96 Journal article (peer-reviewed)abstract We develop an extension of the familiar linear mixed logit model to allow for the direct estimation of parametric non-linear functions defined over structural parameters. Classic applications include the estimation of coefficients of utility functions to characterize risk attitudes and discounting functions to characterize impatience. There are several unexpected benefits of this extension, apart from the ability to directly estimate structural parameters of theoretical interest.
13.	Andersen, Steffen, et al. (author) Risk aversion in game shows 2008 In: Research in Experimental Economics. - : JAI Press Ltd. - 0193-2306 .- 1875-7537. ; 12, s. 359-404 Journal article (peer-reviewed)abstract We review the use of behavior from television game shows to infer risk attitudes. These shows provide evidence when contestants are making decisions over very large stakes, and in a replicated, structured way. Inferences are generally confounded by the subjective assessment of skill in some games, and the dynamic nature of the task in most games. We consider the game shows Card Sharks, Jeopardy!, Lingo, and finally Deal Or No Deal. We provide a detailed case study of the analyses of Deal Or No Deal, since it is suitable for inference about risk attitudes and has attracted considerable attention.
14.	Andersen, Steffen, et al. (author) When the Field Is Not Enough : Using Complementary Field and Lab Experiments to Investigate Congestion Pricing Responses 2014 Reports (other academic/artistic)abstract We use data from a field experiment collecting route choices using GPS recorders and a lab experiment eliciting risk attitude characteristics of drivers. We find that drivers behave in predicted ways in response to variations in average travel times, and in response to manipulations of route pricing. Demand functions are downward sloping in tolls and in travel times. We do not find that drivers respond to variations in the unreliability of travel times, but this is not due to their risk attitudes. Almost all drivers are risk averse, and express a revealed preference in favor of the relatively safe route that is increasing in risk aversion. Because the alternate routes are located at some distance apart, we suspect that the lack of response to travel time unreliability is to be found in biases in drivers expectations of unreliability.
15.	Bothmann, Enrico, et al. (author) A standard convention for particle-level Monte Carlo event-variation weights 2023 In: SciPost Physics Core. - 2666-9366. ; 6:1 Journal article (peer-reviewed)abstract Streams of event weights in particle-level Monte Carlo event generators are a convenient and immensely CPU-efficient approach to express systematic uncertainties in phenomenology calculations, providing systematic variations on the nominal prediction within a single event sample. But the lack of a common standard for labelling these variation streams across different tools has proven to be a major limitation for event-processing tools and analysers alike. Here we propose a well-defined, extensible community standard for the naming, ordering, and interpretation of weight streams that will serve as the basis for semantically correct parsing and combination of such variations in both theoretical and experimental studies.
16.	Brockmann, Sarah J., et al. (author) CHCHD10 mutations p.R15L and p.G66V cause motoneuron disease by haploinsufficiency 2018 In: Human Molecular Genetics. - : Oxford University Press. - 0964-6906 .- 1460-2083. ; 27:4, s. 706-715 Journal article (peer-reviewed)abstract Mutations in the mitochondrially located protein CHCHD10 cause motoneuron disease by an unknown mechanism. In this study, we investigate the mutations p. R15L and p. G66V in comparison to wild-type CHCHD10 and the non-pathogenic variant p. P34S in vitro, in patient cells as well as in the vertebrate in vivo model zebrafish. We demonstrate a reduction of CHCHD10 protein levels in p. R15L and p. G66V mutant patient cells to approximately 50%. Quantitative real-time PCR revealed that expression of CHCHD10 p. R15L, but not of CHCHD10 p. G66V, is already abrogated at the mRNA level. Altered secondary structure and rapid protein degradation are observed with regard to the CHCHD10 p. G66V mutant. In contrast, no significant differences in expression, degradation rate or secondary structure of non-pathogenic CHCHD10 p. P34S are detected when compared with wild-type protein. Knockdown of CHCHD10 expression in zebrafish to about 50% causes motoneuron pathology, abnormal myofibrillar structure and motility deficits in vivo. Thus, our data show that the CHCHD10 mutations p. R15L and p. G66V cause motoneuron disease primarily based on haploinsufficiency of CHCHD10.
17.	Bruno, Raphael Romano, et al. (author) Management and outcomes in critically ill nonagenarian versus octogenarian patients 2021 In: BMC Geriatrics. - : BMC. - 1471-2318. ; 21:1 Journal article (peer-reviewed)abstract Background: Intensive care unit (ICU) patients age 90 years or older represent a growing subgroup and place a huge financial burden on health care resources despite the benefit being unclear. This leads to ethical problems. The present investigation assessed the differences in outcome between nonagenarian and octogenarian ICU patients. Methods: We included 7900 acutely admitted older critically ill patients from two large, multinational studies. The primary outcome was 30-day-mortality, and the secondary outcome was ICU-mortality. Baseline characteristics consisted of frailty assessed by the Clinical Frailty Scale (CFS), ICU-management, and outcomes were compared between octogenarian (80-89.9 years) and nonagenarian (>= 90 years) patients. We used multilevel logistic regression to evaluate differences between octogenarians and nonagenarians. Results: The nonagenarians were 10% of the entire cohort. They experienced a higher percentage of frailty (58% vs 42%; p < 0.001), but lower SOFA scores at admission (6 +/- 5 vs. 7 +/- 6; p < 0.001). ICU-management strategies were different. Octogenarians required higher rates of organ support and nonagenarians received higher rates of life-sustaining treatment limitations (40% vs. 33%; p < 0.001). ICU mortality was comparable (27% vs. 27%; p = 0.973) but a higher 30-day-mortality (45% vs. 40%; p = 0.029) was seen in the nonagenarians. After multivariable adjustment nonagenarians had no significantly increased risk for 30-day-mortality (aOR 1.25 (95% CI 0.90-1.74; p = 0.19)). Conclusion: After adjustment for confounders, nonagenarians demonstrated no higher 30-day mortality than octogenarian patients. In this study, being age 90 years or more is no particular risk factor for an adverse outcome. This should be considered- together with illness severity and pre-existing functional capacity - to effectively guide triage decisions.
18.	Eriksson, Andrea, et al. (author) How is health promotion research undertaken in a Nordic context? : A scoping review on doctoral dissertations from 2008-2018 2020 In: Socialmedicinsk Tidskrift. - 0037-833X. ; 97:3, s. 488-502 Journal article (peer-reviewed)abstract This scoping review was commenced as a collaboration within the NordicHealth Promotion Research Network (NHPRN). The overall aim was to explore how research under the label ‘health promotion’ was undertaken in a Nordic context. The search for dissertations published in Denmark, Finland, Iceland, Norway and Sweden was limited to the years 2008 to 2018. Manual searches of university websites, as well as different databases in the Nordic countries, were required for collecting dissertations from all universities. The collection of dissertations was more difficult than expected. There were 56 published PhD dissertations from 6 universities in Denmark, 51 from 8 universities in Finland, 0 from Iceland, 53 from 7 universities in Norway and 193 from 22 universities in Sweden. Almost half of the analysed dissertations combined qualitative and quantitative methods. About one-third of the dissertations had a settings approach, followed by a societal approach and individual approach. Finland and Sweden presented more intervention studies than the other countries. A majority of the intervention studies included individual lifestyle issues. Based on the analysis of the research approaches, more dissertations embracing societal perspectives and broader determinants of health may be recommended for future Nordic dissertations.
19.	Eriksson, Andrea, 1977-, et al. (author) How is Health Promotion Research Undertaken in a Nordic Context? A Scoping Review of Doctoral Dissertations from 2008–2018 2020 In: Socialmedicinsk Tidskrift. - 0037-833X. ; 97:3, s. 488-502 Journal article (peer-reviewed)
20.	Fronczek, Jakub, et al. (author) Relationship between the Clinical Frailty Scale and short-term mortality in patients ≥ 80 years old acutely admitted to the ICU : a prospective cohort study 2021 In: Critical Care. - : BioMed Central (BMC). - 1364-8535 .- 1466-609X. ; 25:1 Journal article (peer-reviewed)abstract BACKGROUND: The Clinical Frailty Scale (CFS) is frequently used to measure frailty in critically ill adults. There is wide variation in the approach to analysing the relationship between the CFS score and mortality after admission to the ICU. This study aimed to evaluate the influence of modelling approach on the association between the CFS score and short-term mortality and quantify the prognostic value of frailty in this context.METHODS: We analysed data from two multicentre prospective cohort studies which enrolled intensive care unit patients ≥ 80 years old in 26 countries. The primary outcome was mortality within 30-days from admission to the ICU. Logistic regression models for both ICU and 30-day mortality included the CFS score as either a categorical, continuous or dichotomous variable and were adjusted for patient's age, sex, reason for admission to the ICU, and admission Sequential Organ Failure Assessment score.RESULTS: The median age in the sample of 7487 consecutive patients was 84 years (IQR 81-87). The highest fraction of new prognostic information from frailty in the context of 30-day mortality was observed when the CFS score was treated as either a categorical variable using all original levels of frailty or a nonlinear continuous variable and was equal to 9% using these modelling approaches (p < 0.001). The relationship between the CFS score and mortality was nonlinear (p < 0.01).CONCLUSION: Knowledge about a patient's frailty status adds a substantial amount of new prognostic information at the moment of admission to the ICU. Arbitrary simplification of the CFS score into fewer groups than originally intended leads to a loss of information and should be avoided. Trial registration NCT03134807 (VIP1), NCT03370692 (VIP2).
21.	Fronczek, Jakub, et al. (author) Short-term mortality or patients >= 80 years old admitted to European intensive care units: an international observational study 2022 In: British Journal of Anaesthesia. - : ELSEVIER SCI LTD. - 0007-0912 .- 1471-6771. ; 129:1, s. 58-66 Journal article (peer-reviewed)abstract Background: Limited evidence suggests variation in mortality of older critically ill adults across Europe. We aimed to investigate regional differences in mortality among very old ICU patients. Methods: Multilevel analysis of two international prospective cohort studies. We included patients >= 80 yr old from 322 ICUs located in 16 European countries. The primary outcome was mortality within 30 days from admission to the ICU. Results are presented as n (%) with 95% confidence intervals and odds ratios (ORs). Results: Of 8457 patients, 2944 (36.9% [35.9-38.0%]) died within 30 days. Crude mortality rates varied widely between participating countries (from 10.1% [6.4-15.6%] to 45.1% [41.1-49.2%] in the ICU and from 21.3% [16.3-28.9%] to 55.3% [51.1-59.5%] within 30 days). After adjustment for confounding variables, the variation in 30-day mortality between countries was substantially smaller than between ICUs (median OR 1.14 vs 1.58). Healthcare expenditure per capita (OR=0.84 per $1000 [0.75-0.94]) and social health insurance framework (OR=1.43 [1.01-2.01]) were associated with ICU mortality, but the direction and magnitude of these relationships was uncertain in 30-day follow-up. Volume of admissions was associated with lower mortality both in the ICU (OR=0.81 per 1000 annual ICU admissions [0.71-0.94]) and in 30-day follow-up (OR=0.86 [0.76-0.97]). Conclusion: The apparent variation in short-term mortality rates of older adults hospitalised in ICUs across Europe can be largely attributed to differences in the clinical profile of patients admitted. The volume-outcome relationship identified in this population requires further investigation.
22.	Gjelstrup, Louise Carstensen, et al. (author) The role of higher-order protein structure in supporting binding by heteroclitic monoclonal antibodies: The monoclonal antibody KIM185 to CD18 also binds C4-binding protein 2011 In: Molecular Immunology. - : Elsevier BV. - 1872-9142 .- 0161-5890. ; 49:1-2, s. 38-47 Journal article (peer-reviewed)abstract Heteroclitic monoclonal antibodies are characterized by the ability to bind multiple epitopes with little or no similarity. Such antibodies have been reported earlier, but insight into to the molecular basis of this propensity is limited. Here we report that the KIM185 antibody to human CD18 reacts with the plasma protein C4b-binding protein (C4BP). This was revealed during affinity purification procedures where human serum was incubated with surfaces coated with monoclonal antibodies to CD18. Other monoclonal antibodies to CD18 (KIM127 and TS1/18) showed no such interaction with C4BP. We constructed a sandwich-type time-resolved immunofluorometric assay using KIM185 both as capture and developing antibody. By use of proteolytic fragments of KIM185 and recombinant deletion mutants of C4BP the interaction sites were mapped to the variable region of KIM185 and the oligomerization domain of C4BP, respectively. C4BP is a large oligomeric plasma protein that binds activated complement factor C4b and other endogenous ligands as well as microorganisms. By use of the recent crystallographic data on the structure of CD11c/CD18 and prediction of the secondary structure of the C4BP oligomerization domain, we show that epitopes bound by KIM185 in these proteins are unlikely to share any major structural similarity. However, both antigens may form oligomers that would enable avid binding by the antibody. Our report points to the astonishing ability of heteroclitic antibodies to accommodate the binding of multiple proteins with no or little structural similarity within the confined space of the variable regions. (C) 2011 Elsevier Ltd. All rights reserved.
23.	Guidet, Bertrand, et al. (author) Withholding or withdrawing of life-sustaining therapy in older adults (≥ 80 years) admitted to the intensive care unit 2018 In: Intensive Care Medicine. - : Springer Science and Business Media LLC. - 0342-4642 .- 1432-1238. ; 44:7, s. 1027-1038 Journal article (peer-reviewed)abstract PURPOSE: To document and analyse the decision to withhold or withdraw life-sustaining treatment (LST) in a population of very old patients admitted to the ICU.METHODS: This prospective study included intensive care patients aged ≥ 80 years in 309 ICUs from 21 European countries with 30-day mortality follow-up.RESULTS: LST limitation was identified in 1356/5021 (27.2%) of patients: 15% had a withholding decision and 12.2% a withdrawal decision (including those with a previous withholding decision). Patients with LST limitation were older, more frail, more severely ill and less frequently electively admitted. Patients with withdrawal of LST were more frequently male and had a longer ICU length of stay. The ICU and 30-day mortality were, respectively, 29.1 and 53.1% in the withholding group and 82.2% and 93.1% in the withdrawal group. LST was less frequently limited in eastern and southern European countries than in northern Europe. The patient-independent factors associated with LST limitation were: acute ICU admission (OR 5.77, 95% CI 4.32-7.7), Clinical Frailty Scale (CFS) score (OR 2.08, 95% CI 1.78-2.42), increased age (each 5 years of increase in age had a OR of 1.22 (95% CI 1.12-1.34) and SOFA score [OR of 1.07 (95% CI 1.05-1.09 per point)]. The frequency of LST limitation was higher in countries with high GDP and was lower in religious countries.CONCLUSIONS: The most important patient variables associated with the instigation of LST limitation were acute admission, frailty, age, admission SOFA score and country.TRIAL REGISTRATION: ClinicalTrials.gov (ID: NTC03134807).
24.	Helferich, Anika M., et al. (author) Dysregulation of a novel miR-1825/TBCB/TUBA4A pathway in sporadic and familial ALS 2018 In: Cellular and Molecular Life Sciences (CMLS). - : Springer. - 1420-682X .- 1420-9071. ; 75:23, s. 4301-4319 Journal article (peer-reviewed)abstract Genetic and functional studies suggest diverse pathways being affected in the neurodegenerative disease amyotrophic lateral sclerosis (ALS), while knowledge about converging disease mechanisms is rare. We detected a downregulation of microRNA-1825 in CNS and extra-CNS system organs of both sporadic (sALS) and familial ALS (fALS) patients. Combined transcriptomic and proteomic analysis revealed that reduced levels of microRNA-1825 caused a translational upregulation of tubulin-folding cofactor b (TBCB). Moreover, we found that excess TBCB led to depolymerization and degradation of tubulin alpha-4A (TUBA4A), which is encoded by a known ALS gene. Importantly, the increase in TBCB and reduction of TUBA4A protein was confirmed in brain cortex tissue of fALS and sALS patients, and led to motor axon defects in an in vivo model. Our discovery of a microRNA-1825/TBCB/TUBA4A pathway reveals a putative pathogenic cascade in both fALS and sALS extending the relevance of TUBA4A to a large proportion of ALS cases.
25.	Hindelang, Steffen, et al. (author) The Day after : Alternatives to intra-EU BITs 2016 In: Journal of World Investment & Trade. - : Brill. - 1660-7112 .- 2211-9000. ; 17:6, s. 984-1014 Journal article (peer-reviewed)abstract Intra-EU bilateral investment treaties (BITs) are the dinosaurs in the multi-level legal system of the European Union (EU). They sit uneasily with EU law, yet they provide an important tool for foreign investors to manage political risk in some EU Member States. This paper suggests, that alternatives to intra-EU BITs should best be developed from existing functional equivalents in EU law, ie substantive standards of protection in EU law should be made more transparent by the way of a ‘restatement’ of the pertinent legal practice. On principle, foreign investors should make use of functioning domestic courts. Where such institutions lack quality, the EU and the EU Member States should work towards their improvement. Meanwhile, a ‘safety net’ should be provided for foreign investors in case domestic courts fail to dispense justice. This ‘safety net’ may take the form of a PCA-administered arbitral forum or that of a ‘Unified Investment Court’.
26.	Ibarz, Mercedes, et al. (author) Sepsis at ICU admission does not decrease 30-day survival in very old patients : a post-hoc analysis of the VIP1 multinational cohort study 2020 In: Annals of Intensive Care. - : Springer. - 2110-5820. ; 10:1 Journal article (peer-reviewed)abstract BACKGROUND: The number of intensive care patients aged ≥ 80 years (Very old Intensive Care Patients; VIPs) is growing. VIPs have high mortality and morbidity and the benefits of ICU admission are frequently questioned. Sepsis incidence has risen in recent years and identification of outcomes is of considerable public importance. We aimed to determine whether VIPs admitted for sepsis had different outcomes than those admitted for other acute reasons and identify potential prognostic factors for 30-day survival.RESULTS: This prospective study included VIPs with Sequential Organ Failure Assessment (SOFA) scores ≥ 2 acutely admitted to 307 ICUs in 21 European countries. Of 3869 acutely admitted VIPs, 493 (12.7%) [53.8% male, median age 83 (81-86) years] were admitted for sepsis. Sepsis was defined according to clinical criteria; suspected or demonstrated focus of infection and SOFA score ≥ 2 points. Compared to VIPs admitted for other acute reasons, VIPs admitted for sepsis were younger, had a higher SOFA score (9 vs. 7, p < 0.0001), required more vasoactive drugs [82.2% vs. 55.1%, p < 0.0001] and renal replacement therapies [17.4% vs. 9.9%; p < 0.0001], and had more life-sustaining treatment limitations [37.3% vs. 32.1%; p = 0.02]. Frailty was similar in both groups. Unadjusted 30-day survival was not significantly different between the two groups. After adjustment for age, gender, frailty, and SOFA score, sepsis had no impact on 30-day survival [HR 0.99 (95% CI 0.86-1.15), p = 0.917]. Inverse-probability weight (IPW)-adjusted survival curves for the first 30 days after ICU admission were similar for acute septic and non-septic patients [HR: 1.00 (95% CI 0.87-1.17), p = 0.95]. A matched-pair analysis in which patients with sepsis were matched with two control patients of the same gender with the same age, SOFA score, and level of frailty was also performed. A Cox proportional hazard regression model stratified on the matched pairs showed that 30-day survival was similar in both groups [57.2% (95% CI 52.7-60.7) vs. 57.1% (95% CI 53.7-60.1), p = 0.85].CONCLUSIONS: After adjusting for organ dysfunction, sepsis at admission was not independently associated with decreased 30-day survival in this multinational study of 3869 VIPs. Age, frailty, and SOFA score were independently associated with survival.
27.	Jung, Christian, et al. (author) A comparison of very old patients admitted to intensive care unit after acute versus elective surgery or intervention 2019 In: Journal of critical care. - : W B SAUNDERS CO-ELSEVIER INC. - 0883-9441 .- 1557-8615. ; 52, s. 141-148 Journal article (peer-reviewed)abstract Background: We aimed to evaluate differences in outcome between patients admitted to intensive care unit (ICU) after elective versus acute surgery in a multinational cohort of very old patients (80 years; VIP). Predictors of mortality, with special emphasis on frailty, were assessed.Methods: In total, 5063 VIPs were induded in this analysis, 922 were admitted after elective surgery or intervention, 4141 acutely, with 402 after acute surgery. Differences were calculated using Mann-Whitney-U test and Wilcoxon test. Univariate and multivariable logistic regression were used to assess associations with mortality.Results: Compared patients admitted after acute surgery, patients admitted after elective surgery suffered less often from frailty as defined as CFS (28% vs 46%; p < 0.001), evidenced lower SOFA scores (4 +/- 5 vs 7 +/- 7; p < 0.001). Presence of frailty (CFS >4) was associated with significantly increased mortality both in elective surgery patients (7% vs 12%; p = 0.01), in acute surgery (7% vs 12%; p = 0.02).Conclusions: VIPs admitted to ICU after elective surgery evidenced favorable outcome over patients after acute surgery even after correction for relevant confounders. Frailty might be used to guide clinicians in risk stratification in both patients admitted after elective and acute surgery.
28.	Kaislahti Tillman, Päivi, 1958-, et al. (author) Stable isotope records of Sphagnum fuscum peat as late Holocene climate proxies in north-eastern European Russia Other publication (other academic/artistic)
29.	Kaislahti Tillman, Päivi, et al. (author) Stable isotopes in Sphagnum fuscum peat as late-Holocene climate proxies in northeastern European Russia 2013 In: The Holocene. - : SAGE Publications. - 0959-6836 .- 1477-0911. ; 23:10, s. 1381-1390 Journal article (peer-reviewed)abstract The environment of the northern taiga to tundra transition is highly sensitive to climate fluctuations. In this study from northeastern European Russia, stable carbon and oxygen isotope ratios (δ13C, δ18O) in α-cellulose of Sphagnum fuscum stems subsampled from hummocks and peat plateau profiles have been used as climate proxies. The entire isotope time series, dated by lead (210Pb), caesium (137Cs) and AMS-radiocarbon (14C) dating, spans the past 2500 years. Plant macrofossil analyses were used as an aid in single species selection, but are also helpful in identifying past surface moisture conditions. The most significant relationships were found between the recent δ13C record and summer (July–August) temperatures (R 2 = 0.58, p < 0.01), and the recent δ18O record and winter (October–May) precipitation anomalies in the tundra region (R 2 = 0.36, p < 0.01). The study demonstrates that stable isotopes preserved in northern peat deposits are useful indicators for summer temperature and winter precipitation at decadal to millennial timescales.
30.	Karottki, Dorina Gabriela, et al. (author) An indoor air filtration study in homes of elderly: cardiovascular and respiratory effects of exposure to particulate matter. 2013 In: Environmental health : a global access science source. - 1476-069X. ; 12:1 Journal article (peer-reviewed)abstract Exposure to particulate air pollution increases respiratory and cardiovascular morbidity and mortality, especially in elderly, possibly through inflammation and vascular dysfunction.
31.	Persson, Peter, et al. (author) Analysis of wind-induced vibrations in high-rise buildings 2016 In: Proceedings of the INTER-NOISE 2016 - 45th International Congress and Exposition on Noise Control Engineering: Towards a Quieter Future. ; , s. 7650-7661 Conference paper (peer-reviewed)abstract Buildings are getting taller due to increased urbanisation and densification of cities. More advanced construction methods and the desire to construct impressive buildings is also supporting the trend. Due to their inherent slenderness resulting in low eigenfrequencies, these buildings are susceptible to wind-induced vibrations which can be highly disturbing for occupants. Already barely perceivable acceleration levels within the low-frequency range relevant to whole-body vibrations can cause nausea and discomfort, while high acceleration levels can cause alarm and fear amongst the occupants. The paper summarises acceptable acceleration levels in high-rise buildings (here referred to as buildings over 200 m in height) stated in different building codes and previous work on the subject. Accelerations of a high-rise building subjected to wind-loads are evaluated using a full numerical model and one reduced with Ritz-vectors and the results are compared. The paper focusses on wind-load dynamics in early stages of the design process, with an intent to give an indication of the dynamic properties of a building.
32.	Rasmussen, Sune Olander, et al. (author) Ice-core data used for the construction of the Greenland Ice-Core Chronology 2005 and 2021 (GICC05 and GICC21) 2023 In: Earth System Science Data. - 1866-3508 .- 1866-3516. ; 15:8, s. 3351-3364 Journal article (peer-reviewed)abstract We here describe, document, and make available a wide range of data sets used for annual-layer identification in ice cores from DYE-3, GRIP, NGRIP, NEEM, and EGRIP. The data stem from detailed measurements performed both on the main deep cores and shallow cores over more than 40 years using many different setups developed by research groups in several countries and comprise both discrete measurements from cut ice samples and continuous-flow analysis data.The data series were used for counting annual layers 60 000 years back in time during the construction of the Greenland Ice-Core Chronology 2005 (GICC05) and/or the revised GICC21, which currently only reaches 3800 years back. Now that the underlying data are made available (listed in Table 1) we also release the individual annual-layer positions of the GICC05 timescale which are based on these data sets.We hope that the release of the data sets will stimulate further studies of the past climate taking advantage of these highly resolved data series covering a large part of the interior of the Greenland ice sheet.
33.	Rayner, Manny, et al. (author) Recycling Lingware in a Multilingual MT System 1997 In: Proceedings of ACL/EACL Workshop From Research to Commercial Applications. ; , s. 65-70 Conference paper (peer-reviewed)abstract We describe two methods relevant to multilingual machine translation systems, which can be used to port linguistic data (grammars, lexicons and transfer rules) between systems used for processing related languages. The methods are fully implemented within the Spoken Language Translator system, and were used to create versions of the systems for two new language pairs using only a month of expert effort.

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