| 1. |
- Ageron, M., et al.
(author)
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ANTARES : The first undersea neutrino telescope
- 2011
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In: Nuclear Instruments and Methods in Physics Research Section A. - : Elsevier. - 0168-9002 .- 1872-9576. ; 656:1, s. 11-38
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Journal article (peer-reviewed)abstract
- The ANTARES Neutrino Telescope was completed in May 2008 and is the first operational Neutrino Telescope in the Mediterranean Sea. The main purpose of the detector is to perform neutrino astronomy and the apparatus also offers facilities for marine and Earth sciences. This paper describes the design, the construction and the installation of the telescope in the deep sea, offshore from Toulon in France. An illustration of the detector performance is given. (C) 2011 Elsevier B.V. All rights reserved.
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| 2. |
- André, Ph., et al.
(author)
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Probing the cold magnetised Universe with SPICA-POL (B-BOP)
- 2019
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In: Publications Astronomical Society of Australia. - : Cambridge University Press (CUP). - 1323-3580 .- 1448-6083. ; 36
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Research review (peer-reviewed)abstract
- Space Infrared Telescope for Cosmology and Astrophysics (SPICA), the cryogenic infrared space telescope recently pre-selected for a 'Phase A' concept study as one of the three remaining candidates for European Space Agency (ESA's) fifth medium class (M5) mission, is foreseen to include a far-infrared polarimetric imager [SPICA-POL, now called B-fields with BOlometers and Polarizers (B-BOP)], which would offer a unique opportunity to resolve major issues in our understanding of the nearby, cold magnetised Universe. This paper presents an overview of the main science drivers for B-BOP, including high dynamic range polarimetric imaging of the cold interstellar medium (ISM) in both our Milky Way and nearby galaxies. Thanks to a cooled telescope, B-BOP will deliver wide-field 100-350 mu m images of linearly polarised dust emission in Stokes Q and U with a resolution, signal-to-noise ratio, and both intensity and spatial dynamic ranges comparable to those achieved by Herschel images of the cold ISM in total intensity (Stokes I). The B-BOP 200 mu m images will also have a factor similar to 30 higher resolution than Planck polarisation data. This will make B-BOP a unique tool for characterising the statistical properties of the magnetised ISM and probing the role of magnetic fields in the formation and evolution of the interstellar web of dusty molecular filaments giving birth to most stars in our Galaxy. B-BOP will also be a powerful instrument for studying the magnetism of nearby galaxies and testing Galactic dynamo models, constraining the physics of dust grain alignment, informing the problem of the interaction of cosmic rays with molecular clouds, tracing magnetic fields in the inner layers of protoplanetary disks, and monitoring accretion bursts in embedded protostars.
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| 3. |
- Hennemann, M., et al.
(author)
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Herschel observations of embedded protostellar clusters in the Rosette molecular cloud
- 2010
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In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 518, s. L84-
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Journal article (peer-reviewed)abstract
- The Herschel OB young stellar objects survey (HOBYS) has observed the Rosette molecular cloud, providing an unprecedented view of its star formation activity. These new far-infrared data reveal a population of compact young stellar objects whose physical properties we aim to characterise. We compiled a sample of protostars and their spectral energy distributions that covers the near-infrared to submillimetre wavelength range. These were used to constrain key properties in the protostellar evolution, bolometric luminosity, and envelope mass and to build an evolutionary diagram. Several clusters are distinguished including the cloud centre, the embedded clusters in the vicinity of luminous infrared sources, and the interaction region. The analysed protostellar population in Rosette ranges from 0.1 to about 15 M-circle dot with luminosities between 1 and 150 L-circle dot, which extends the evolutionary diagram from low-mass protostars into the high-mass regime. Some sources lack counterparts at near-to mid-infrared wavelengths, indicating extreme youth. The central cluster and the Phelps & Lada 7 cluster appear less evolved than the remainder of the analysed protostellar population. For the central cluster, we find indications that about 25% of the protostars classified as Class I from near-to mid-infrared data are actually candidate Class 0 objects. As a showcase for protostellar evolution, we analysed four protostars of low-to intermediate-mass in a single dense core, and they represent different evolutionary stages from Class 0 to Class I. Their mid-to far-infrared spectral slopes flatten towards the Class I stage, and the 160 to 70 mu m flux ratio is greatest for the presumed Class 0 source. This shows that the Herschel observations characterise the earliest stages of protostellar evolution in detail.
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| 4. |
- Lee, San, et al.
(author)
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Impact of data extraction errors in meta-analyses on the association between depression and peripheral inflammatory biomarkers : an umbrella review
- 2023
-
In: Psychological Medicine. - : Cambridge University Press. - 0033-2917 .- 1469-8978. ; 53:5, s. 2017-2030
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Research review (peer-reviewed)abstract
- BACKGROUND: Accumulating evidence suggests that alterations in inflammatory biomarkers are important in depression. However, previous meta-analyses disagree on these associations, and errors in data extraction may account for these discrepancies.METHODS: PubMed/MEDLINE, Embase, PsycINFO, and the Cochrane Library were searched from database inception to 14 January 2020. Meta-analyses of observational studies examining the association between depression and levels of tumor necrosis factor-α (TNF-α), interleukin 1-β (IL-1β), interleukin-6 (IL-6), and C-reactive protein (CRP) were eligible. Errors were classified as follows: incorrect sample sizes, incorrectly used standard deviation, incorrect participant inclusion, calculation error, or analysis with insufficient data. We determined their impact on the results after correction thereof.RESULTS: Errors were noted in 14 of the 15 meta-analyses included. Across 521 primary studies, 118 (22.6%) showed the following errors: incorrect sample sizes (20 studies, 16.9%), incorrect use of standard deviation (35 studies, 29.7%), incorrect participant inclusion (7 studies, 5.9%), calculation errors (33 studies, 28.0%), and analysis with insufficient data (23 studies, 19.5%). After correcting these errors, 11 (29.7%) out of 37 pooled effect sizes changed by a magnitude of more than 0.1, ranging from 0.11 to 1.15. The updated meta-analyses showed that elevated levels of TNF- α, IL-6, CRP, but not IL-1β, are associated with depression.CONCLUSIONS: These findings show that data extraction errors in meta-analyses can impact findings. Efforts to reduce such errors are important in studies of the association between depression and peripheral inflammatory biomarkers, for which high heterogeneity and conflicting results have been continuously reported.
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| 5. |
- Men'shchikov, A., et al.
(author)
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Filamentary structures and compact objects in the Aquila and Polaris clouds observed by Herschel
- 2010
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In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 518, s. L103-
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Journal article (peer-reviewed)abstract
- Our PACS and SPIRE images of the Aquila Rift and part of the Polaris Flare regions, taken during the science demonstration phase of Herschel discovered fascinating, omnipresent filamentary structures that appear to be physically related to compact cores. We briefly describe a new multi-scale, multi-wavelength source extraction method used to detect objects and measure their parameters in our Herschel images. All of the extracted starless cores (541 in Aquila and 302 in Polaris) appear to form in the long and very narrow filaments. With its combination of the far-IR resolution and sensitivity, Herschel directly reveals the filaments in which the dense cores are embedded; the filaments are resolved and have deconvolved widths of similar to 35 '' in Aquila and similar to 59 '' in Polaris (similar to 9000 AU in both regions). Our first results of observations with Herschel enable us to suggest that in general dense cores may originate in a process of fragmentation of complex networks of long, thin filaments, likely formed as a result of an interplay between gravity, interstellar turbulence, and magnetic fields. To unravel the roles of the processes, one has to obtain additional kinematic and polarization information; these follow-up observations are planned.
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| 6. |
- Motte, F., et al.
(author)
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Initial highlights of the HOBYS key program, the Herschel imaging survey of OB young stellar objects
- 2010
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In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 518, s. L77-
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Journal article (peer-reviewed)abstract
- We present the initial highlights of the HOBYS key program, which are based on Herschel images of the Rosette molecular complex and maps of the RCW120 H II region. Using both SPIRE at 250/350/500 mu m and PACS at 70/160 mu m or 100/160 mu m, the HOBYS survey provides an unbiased and complete census of intermediate-to high-mass young stellar objects, some of which are not detected by Spitzer. Key core properties, such as bolometric luminosity and mass (as derived from spectral energy distributions), are used to constrain their evolutionary stages. We identify a handful of high-mass prestellar cores and show that their lifetimes could be shorter in the Rosette molecular complex than in nearby low-mass star-forming regions. We also quantify the impact of expanding H II regions on the star formation process acting in both Rosette and RCW 120.
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| 7. |
- Schneider, N., et al.
(author)
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The Herschel view of star formation in the Rosette molecular cloud under the influence of NGC 2244
- 2010
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In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 518, s. L83-
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Journal article (peer-reviewed)abstract
- Context. The Rosette molecular cloud is promoted as the archetype of a triggered star-formation site. This is mainly due to its morphology, because the central OB cluster NGC 2244 has blown a circular-shaped cavity into the cloud and the expanding H II-region now interacts with the cloud. Aims. Studying the spatial distribution of the different evolutionary states of all star-forming sites in Rosette and investigating possible gradients of the dust temperature will help to test the "triggered star-formation" scenario in Rosette. Methods. We use continuum data obtained with the PACS (70 and 160 mu m) and SPIRE instruments (250, 350, 500 mu m) of the Herschel telescope during the science demonstration phase of HOBYS. Results. Three-color images of Rosette impressively show how the molecular gas is heated by the radiative impact of the NGC 2244 cluster. A clear negative temperature gradient and a positive density gradient (running from the H II-region/molecular cloud interface into the cloud) are detected. Studying the spatial distribution of the most massive dense cores (size scale 0.05 to 0.3 pc), we find an age-sequence (from more evolved to younger) with increasing distance to the cluster NGC 2244. No clear gradient is found for the clump (size-scale up to 1 pc) distribution. Conclusions. The existence of temperature and density gradients and the observed age-sequence imply that star formation in Rosette may indeed be influenced by the radiative impact of the central NGC 2244 cluster. A more complete overview of the prestellar and protostellar population in Rosette is required to obtain a firmer result.
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| 8. |
- Solmi, Marco, et al.
(author)
-
Physical and mental health impact of COVID-19 on children, adolescents, and their families :
- 2022
-
In: Journal of Affective Disorders. - : Elsevier. - 0165-0327 .- 1573-2517. ; 299, s. 367-376
-
Journal article (peer-reviewed)abstract
- Background: The COVID-19 pandemic has altered daily routines and family functioning, led to closing schools, and dramatically limited social interactions worldwide. Measuring its impact on mental health of vulnerable children and adolescents is crucial. Methods: The Collaborative Outcomes study on Health and Functioning during Infection Times (COH-FIT - www. coh-fit.com) is an on-line anonymous survey, available in 30 languages, involving >230 investigators from 49 countries supported by national/international professional associations. COH-FIT has thee waves (until the pandemic is declared over by the WHO, and 6-18 months plus 24-36 months after its end). In addition to adults, COH-FIT also includes adolescents (age 14-17 years), and children (age 6-13 years), recruited via nonprobability/snowball and representative sampling and assessed via self-rating and parental rating. Nonmodifiable/modifiable risk factors/treatment targets to inform prevention/intervention programs to promote health and prevent mental and physical illness in children and adolescents will be generated by COH-FIT. Co primary outcomes are changes in well-being (WHO-5) and a composite psychopathology P-Score. Multiple behavioral, family, coping strategy and service utilization factors are also assessed, including functioning and quality of life. Results: Up to June 2021, over 13,000 children and adolescents from 59 countries have participated in the COHFIT project, with representative samples from eleven countries. Limitations: Cross-sectional and anonymous design. Conclusions: Evidence generated by COH-FIT will provide an international estimate of the COVID-19 effect on childrens, adolescents and families, mental and physical health, well-being, functioning and quality of life, informing the formulation of present and future evidence-based interventions and policies to minimize adverse effects of the present and future pandemics on youth.
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| 9. |
- Solmi, Marco, et al.
(author)
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The collaborative outcomes study on health and functioning during infection times in adults (COH-FIT-Adults) : Design and methods of an international online survey targeting physical and mental health effects of the COVID-19 pandemic
- 2022
-
In: Journal of Affective Disorders. - : Elsevier. - 0165-0327 .- 1573-2517. ; 299, s. 393-407
-
Journal article (peer-reviewed)abstract
- Background: . High-quality comprehensive data on short-/long-term physical/mental health effects of the COVID-19 pandemic are needed. Methods: . The Collaborative Outcomes study on Health and Functioning during Infection Times (COH-FIT) is an international, multi-language (n=30) project involving >230 investigators from 49 countries/territories/regions, endorsed by national/international professional associations. COH-FIT is a multi-wave, on-line anonymous, cross-sectional survey [wave 1: 04/2020 until the end of the pandemic, 12 months waves 2/3 starting 6/24 months threreafter] for adults, adolescents (14-17), and children (6-13), utilizing non-probability/snowball and representative sampling. COH-FIT aims to identify non-modifiable/modifiable risk factors/treatment targets to inform prevention/intervention programs to improve social/health outcomes in the general population/vulnerable subgrous during/after COVID-19. In adults, co-primary outcomes are change from pre-COVID-19 to intra-COVID-19 in well-being (WHO-5) and a composite psychopathology P-Score. Key secondary outcomes are a P-extended score, global mental and physical health. Secondary outcomes include health-service utilization/ functioning, treatment adherence, functioning, symptoms/behaviors/emotions, substance use, violence, among others. Results: . Starting 04/26/2020, up to 14/07/2021 >151,000 people from 155 countries/territories/regions and six continents have participated. Representative samples of >= 1,000 adults have been collected in 15 countries. Overall, 43.0% had prior physical disorders, 16.3% had prior mental disorders, 26.5% were health care workers, 8.2% were aged >= 65 years, 19.3% were exposed to someone infected with COVID-19, 76.1% had been in quarantine, and 2.1% had been COVID 19-positive. Limitations: . Cross-sectional survey, preponderance of non-representative participants. Conclusions: . Results from COH-FIT will comprehensively quantify the impact of COVID-19, seeking to identify high-risk groups in need for acute and long-term intervention, and inform evidence-based health policies/strategies during this/future pandemics.
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| 10. |
- Adrian-Martinez, S., et al.
(author)
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A first search for coincident gravitational waves and high energy neutrinos using LIGO, Virgo and ANTARES data from 2007
- 2013
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In: Journal of Cosmology and Astroparticle Physics. - : IOP Publishing. - 1475-7516. ; :6
-
Journal article (peer-reviewed)abstract
- We present the results of the first search for gravitational wave bursts associated with high energy neutrinos. Together, these messengers could reveal new, hidden sources that are not observed by conventional photon astronomy, particularly at high energy. Our search uses neutrinos detected by the underwater neutrino telescope ANTARES in its 5 line configuration during the period January - September 2007, which coincided with the fifth and first science runs of LIGO and Virgo, respectively. The LIGO-Virgo data were analysed for candidate gravitational-wave signals coincident in time and direction with the neutrino events. No significant coincident events were observed. We place limits on the density of joint high energy neutrino - gravitational wave emission events in the local universe, and compare them with densities of merger and core-collapse events.
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| 11. |
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| 12. |
- De Simone, M., et al.
(author)
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Glycolaldehyde in Perseus young solar analogs
- 2017
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In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 599
-
Journal article (peer-reviewed)abstract
- © ESO 2017. Context. The earliest evolutionary stages of low-mass protostars are characterised by the so-called hot-corino stage, when the newly born star heats the surrounding material and enrich the gas chemically. Studying this evolutionary phase of solar protostars may help understand the evolution of prebiotic complex molecules in the development of planetary systems. Aims. In this paper we focus on the occurrence of glycolaldehyde (HCOCH 2 OH) in young solar analogs by performing the first homogeneous and unbiased study of this molecule in the Class 0 protostars of the nearby Perseus star forming region. Methods. We obtained sub-arcsec angular resolution maps at 1.3 mm and 1.4 mm of glycolaldehyde emission lines using the IRAM Plateau de Bure (PdB) interferometer in the framework of the CALYPSO IRAM large program. Results. Glycolaldehyde has been detected towards 3 Class 0 and 1 Class I protostars out of the 13 continuum sources targeted in Perseus: NGC1333-IRAS2A1, NGC1333-IRAS4A2, NGC1333-IRAS4B1, and SVS13-A. The NGC1333 star forming region looks particularly glycolaldehyde rich, with a rate of occurrence up to 60%. The glycolaldehyde spatial distribution overlaps with the continuum one, tracing the inner 100 au around the protostar. A large number of lines (up to 18), with upper-level energies E u from 37 K up to 375 K has been detected. We derived column densities ≥10 15 cm -2 and rotational temperatures T rot between 115 K and 236 K, imaging for the first time hot-corinos around NGC1333-IRAS4B1 and SVS13-A. Conclusions. In multiple systems glycolaldehyde emission is detected only in one component. The case of the SVS13-A+B and IRAS4-A1+A2 systems support that the detection of glycolaldehyde (at least in the present Perseus sample) indicates older protostars (i.e. SVS13-A and IRAS4-A2), evolved enough to develop the hot-corino region (i.e. 100 K in the inner 100 au). However, only two systems do not allow us to firmly conclude whether the primary factor leading to the detection of glycolaldehyde emission is the environments hosting the protostars, evolution (e.g. low value of L submm /L int ), or accretion luminosity (high L int ).
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| 13. |
- Dragioti, Elena, Ph.D., et al.
(author)
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A large-scale meta-analytic atlas of mental health problems prevalence during the COVID-19 early pandemic
- 2022
-
In: Journal of Medical Virology. - : WILEY. - 0146-6615 .- 1096-9071. ; 94:5, s. 1935-1949
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Journal article (peer-reviewed)abstract
- The COVID-19 pandemic and related restrictions can impact mental health. To quantify the mental health burden of COVID-19 pandemic, we conducted a systematic review and meta-analysis, searching World Health Organization COVID-19/PsycInfo/PubMed databases (09/29/2020), including observational studies reporting on mental health outcomes in any population affected by COVID-19. Primary outcomes were the prevalence of anxiety, depression, stress, sleep problems, posttraumatic symptoms. Sensitivity analyses were conducted on severe mental health problems, in high-quality studies, and in representative samples. Subgroup analyses were conducted stratified by age, sex, country income level, and COVID-19 infection status. One-hundred-seventy-three studies from February to July 2020 were included (n = 502,261, median sample = 948, age = 34.4 years, females = 63%). Ninety-one percent were cross-sectional studies, and 18.5%/57.2% were of high/moderate quality. The highest prevalence emerged for posttraumatic symptoms in COVID-19 infected people (94%), followed by behavioral problems in those with prior mental disorders (77%), fear in healthcare workers (71%), anxiety in caregivers/family members of people with COVID-19 (42%), general health/social contact/passive coping style in the general population (38%), depression in those with prior somatic disorders (37%), and fear in other-than-healthcare workers (29%). Females and people with COVID-19 infection had higher rates of almost all outcomes; college students/young adults of anxiety, depression, sleep problems, suicidal ideation; adults of fear and posttraumatic symptoms. Anxiety, depression, and posttraumatic symptoms were more prevalent in low-/middle-income countries, sleep problems in high-income countries. The COVID-19 pandemic adversely impacts mental health in a unique manner across population subgroups. Our results inform tailored preventive strategies and interventions to mitigate current, future, and transgenerational adverse mental health of the COVID-19 pandemic.
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| 14. |
- Dragioti, Elena, Ph.D., et al.
(author)
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Association of Antidepressant Use With Adverse Health Outcomes A Systematic Umbrella Review
- 2019
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In: JAMA psychiatry. - Chicago, IL, United States : AMER MEDICAL ASSOC. - 2168-6238 .- 2168-622X. ; 76:12, s. 1241-1255
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Research review (peer-reviewed)abstract
- This umbrella review searches PubMed, Scopus, and PsycINFO to summarize and grade the strength of evidence of the associations between antidepressants and adverse outcomes reported in multiple meta-analyses. Importance Antidepressant use is increasing worldwide. Yet, contrasting evidence on the safety of antidepressants is available from meta-analyses, and the credibility of these findings has not been quantified. Objective To grade the evidence from published meta-analyses of observational studies that assessed the association between antidepressant use or exposure and adverse health outcomes. Data Sources PubMed, Scopus, and PsycINFO were searched from database inception to April 5, 2019. Evidence Review Only meta-analyses of observational studies with a cohort or case-control study design were eligible. Two independent reviewers recorded the data and assessed the methodological quality of the included meta-analyses. Evidence of association was ranked according to established criteria as follows: convincing, highly suggestive, suggestive, weak, or not significant. Results Forty-five meta-analyses (17.9%) from 4471 studies identified and 252 full-text articles scrutinized were selected that described 120 associations, including data from 1012 individual effect size estimates. Seventy-four (61.7%) of the 120 associations were nominally statistically significant at P <= .05 using random-effects models. Fifty-two associations (43.4%) had large heterogeneity (I-2 > 50%), whereas small-study effects were found for 17 associations (14.2%) and excess significance bias was found for 9 associations (7.5%). Convincing evidence emerged from both main and sensitivity analyses for the association between antidepressant use and risk of suicide attempt or completion among children and adolescents, autism spectrum disorders with antidepressant exposure before and during pregnancy, preterm birth, and low Apgar scores. None of these associations remained supported by convincing evidence after sensitivity analysis, which adjusted for confounding by indication. Conclusions and Relevance This studys findings suggest that most putative adverse health outcomes associated with antidepressant use may not be supported by convincing evidence, and confounding by indication may alter the few associations with convincing evidence. Antidepressant use appears to be safe for the treatment of psychiatric disorders, but more studies matching for underlying disease are needed to clarify the degree of confounding by indication and other biases. No absolute contraindication to antidepressants emerged from this umbrella review. Question Is antidepressant use associated with adverse health outcomes, and how credible is the evidence behind this association in published meta-analyses of real-world data? Findings In this systematic umbrella review of 45 meta-analyses of observational studies, convincing evidence was found for the associations between antidepressant use and suicide attempt or completion among individuals younger than 19 years and between antidepressant use and autism risk among the offspring. However, none of these associations remained at the convincing evidence level after a sensitivity analysis that adjusted for confounding by indication. Meaning This studys findings suggest that claimed adverse health outcomes associated with antidepressants may not be supported by strong evidence and may be exaggerated by confounding by indication; no absolute contraindication to the use of antidepressants was found to be currently supported by convincing evidence.
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| 15. |
- Löfgren, André
(author)
-
Stability of the free-surface problem arising in ice-sheet- and glacier modeling : Numerical investigation and stabilization
- 2023
-
Licentiate thesis (other academic/artistic)abstract
- This thesis consists of two papers dealing with a stabilization method for free-surface flows. The method was initially developed to stabilize mantle-convection simulations, but is in this work extended to ice-sheet- and glacier modeling. The objective of this thesis is to assess the method when applied glaciological simulations, with regards to stability and accuracy. It is shown that the method works well and increases stable time-step sizes substantially both for ice-sheet- and glacier simulations, without loss of accuracy. The increased stability properties might be useful for performing long-term simulations and increasing sea-level-rise predictions on a centennial time scale.
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| 16. |
- Minier, V., et al.
(author)
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Evidence of triggered star formation in G327.3-0.6. Dust-continuum mapping of an infrared dark cloud with P-ArTéMiS
- 2009
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In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 501, s. L1-L4
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Journal article (peer-reviewed)abstract
- Aims: Expanding HII regions and propagating shocks are common in the environment of young high-mass star-forming complexes. They can compress a pre-existing molecular cloud and trigger the formation of dense cores. We investigate whether these phenomena can explain the formation of high-mass protostars within an infrared dark cloud located at the position of G327.3-0.6 in the Galactic plane, in between two large infrared bubbles and two HII regions. Methods: The region of G327.3-0.6 was imaged at 450 μ m with the CEA P-ArTéMiS bolometer array on the Atacama Pathfinder EXperiment telescope in Chile. APEX/LABOCA and APEX-2A, and Spitzer/IRAC and MIPS archives data were used in this study. Results: Ten massive cores were detected in the P-ArTéMiS image, embedded within the infrared dark cloud seen in absorption at both 8 and 24 μm. Their luminosities and masses indicate that they form high-mass stars. The kinematical study of the region suggests that the infrared bubbles expand toward the infrared dark cloud. Conclusions: Under the influence of expanding bubbles, star formation occurs in the infrared dark areas at the border of HII regions and infrared bubbles.
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| 17. |
- Sbarra, AN, et al.
(author)
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Mapping routine measles vaccination in low- and middle-income countries
- 2021
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In: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 589:7842, s. 415-
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Journal article (peer-reviewed)abstract
- The safe, highly effective measles vaccine has been recommended globally since 1974, yet in 2017 there were more than 17 million cases of measles and 83,400 deaths in children under 5 years old, and more than 99% of both occurred in low- and middle-income countries (LMICs)1–4. Globally comparable, annual, local estimates of routine first-dose measles-containing vaccine (MCV1) coverage are critical for understanding geographically precise immunity patterns, progress towards the targets of the Global Vaccine Action Plan (GVAP), and high-risk areas amid disruptions to vaccination programmes caused by coronavirus disease 2019 (COVID-19)5–8. Here we generated annual estimates of routine childhood MCV1 coverage at 5 × 5-km2pixel and second administrative levels from 2000 to 2019 in 101 LMICs, quantified geographical inequality and assessed vaccination status by geographical remoteness. After widespread MCV1 gains from 2000 to 2010, coverage regressed in more than half of the districts between 2010 and 2019, leaving many LMICs far from the GVAP goal of 80% coverage in all districts by 2019. MCV1 coverage was lower in rural than in urban locations, although a larger proportion of unvaccinated children overall lived in urban locations; strategies to provide essential vaccination services should address both geographical contexts. These results provide a tool for decision-makers to strengthen routine MCV1 immunization programmes and provide equitable disease protection for all children.
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| 18. |
- Shimajiri, Y., et al.
(author)
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Probing accretion of ambient cloud material into the Taurus B211/B213 filament
- 2019
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In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 623
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Journal article (peer-reviewed)abstract
- Context. Herschel observations have emphasized the role of molecular filaments in star formation. However, the origin and evolution of these filaments are not yet well understood, partly because of the lack of kinematic information. Aims. We confirm from a kinematic viewpoint that the Taurus B211/B213 filament is accreting background cloud material, and we investigate the potential influence of large-scale external effects on the formation of the filament. Methods. To examine whether the B211/B213 filament is accreting background gas because of its gravitational potential, we produced a toy accretion model and compared its predictions to the velocity patterns observed in (CO)-C-12 (1-0) and (CO)-C-13 (1-0). We also examined the spatial distributions of H alpha, Planck 857 GHz dust continuum, and HI emission to search for evidence of large-scale external effects. Results. We estimate that the depth of the Taurus cloud around the B211/B213 filament is similar to 0.3-0.7 pc under the assumption that the density of the gas is the same as the critical density of (CO)-C-13 (1-0). Compared to a linear extent of >10 pc in the plane of the sky, this suggests that the 3D morphology of the cloud surrounding the B211/B213 filament is sheet-like. Position-velocity (PV) diagrams observed in (CO)-C-12 (1-0) and (CO)-C-13 (1-0) perpendicular to the filament axis show that the emission from the gas surrounding B211/B213 is redshifted to the northeast of the filament and blueshifted to the southwest, and that the velocities of both components approach the velocity of the B211/B213 filament as the line of sight approaches the crest of the filament. The PV diagrams predicted by our accretion model are in good agreement with the observed (CO)-C-12 (1-0) and (CO)-C-13 (1-0) PV diagrams, supporting the previously proposed scenario of mass accretion into the filament. Moreover, inspection of the spatial distribution of the H alpha and Planck 857 GHz emission in the Taurus-California-Perseus region on scales up to >200 pc suggests that the B211/B213 filament may have formed as a result of an expanding supershell generated by the Per OB2 association. Conclusions. Based on these results, we propose a scenario in which the B211/B213 filament was initially formed by large-scale compression of HI gas and is now growing in mass by gravitationally accreting molecular gas of the ambient cloud.
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| 19. |
- Solmi, Marco, et al.
(author)
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Disparities in cancer screening in people with mental illness across the world versus the general population: prevalence and comparative meta-analysis including 4717 839 people
- 2020
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In: Lancet psychiatry. - : ELSEVIER SCI LTD. - 2215-0374 .- 2215-0366. ; 7:1, s. 52-63
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Journal article (peer-reviewed)abstract
- Background Since people with mental illness are more likely to die from cancer, we assessed whether people with mental illness undergo less cancer screening compared with the general population. Methods In this systematic review and meta-analysis, we searched PubMed and PsycINFO, without a language restriction, and hand-searched the reference lists of induded studies and previous reviews for observational studies from database inception until May 5, 2019. We included all published studies focusing on any type of cancer screening in patients with mental illness; and studies that reported prevalence of cancer screening in patients, or comparative measures between patients and the general population. The primary outcome was odds ratio (OR) of cancer screening in people with mental illness versus the general population. The Newcastle-Ottawa Scale was used to assess study quality and I-2 to assess study heterogeneity. This study is registered with PROSPERO, CRD42018114781. Findings 47 publications provided data from 46 samples including 4 717 839 individuals (501559 patients with mental illness, and 4 216 280 controls), of whom 69.85% were women, for screening for breast cancer (k=35; 296 699 individuals with mental illness, 1 023 288 in the general population), cervical cancer (k=29; 295 688 with mental illness, 3 540408 in general population), colorectal cancer (k=12; 153 283 with mental illness, 2 228 966 in general population), lung and gastric cancer (both k=1; 420 with mental illness, none in general population), ovarian cancer (k=1; 37 with mental illness, none in general population), and prostate cancer (k=6; 52 803 with mental illness, 2 038 916 in general population). Median quality of the included studies was high at 7 (IQR 6-8). Screening was significantly less frequent in people with any mental disease compared with the general population for any cancer (k=37; OR 0.76 [95% CI 0.72-0.79]; I-2=98.53% with publication bias of Eggers p value=0.025), breast cancer (k=27; 0.65 [0. 60-0.71]; I-2=97.58% and no publication bias), cervical cancer (k=23; 0.89 [O. 84-0. 95]; I-2 =98.47% and no publication bias), and prostate cancer (k=4; 0.78 [0.70-0.86]; I-2=79.68% and no publication bias), but not for colorectal cancer (k=8; 1.02 [0.90-1.15]; I-2=97.84% and no publication bias). Interpretation Despite the increased mortality from cancer in people with mental illness, this population receives less cancer screening compared with that of the general population. Specific approaches should be developed to assist people with mental illness to undergo appropriate cancer screening, especially women with schizophrenia. Copyright (C) 2019 Elsevier Ltd. All rights reserved.
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| 20. |
- Solmi, Marco, et al.
(author)
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Risk factors for eating disorders : an umbrella review of published meta-analyses.
- 2021
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In: Revista Brasileira de Psiquiatria. - : Associação Brasileira de Psiquiatria. - 1516-4446 .- 1809-452X. ; 43:3, s. 314-323
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Journal article (peer-reviewed)abstract
- OBJECTIVE: To grade the evidence about risk factors for eating disorders (anorexia nervosa, bulimia nervosa, and binge eating disorder) with an umbrella review approach.METHODS: This was a systematic review of observational studies on risk factors for eating disorders published in PubMed/PsycInfo/Embase until December 11th, 2019. We recalculated random-effect meta-analyses, heterogeneity, small-study effect, excess significance bias and 95% prediction intervals, grading significant evidence (p < 0.05) from convincing to weak according to established criteria. Quality was assessed with the Assessment of Multiple Systematic Reviews 2 (AMSTAR-2) tool.RESULTS: Of 2,197 meta-analyses, nine were included, providing evidence on 50 risk factors, 29,272 subjects with eating disorders, and 1,679,385 controls. Although no association was supported by convincing evidence, highly suggestive evidence supported the association between childhood sexual abuse and bulimia nervosa (k = 29, 1,103 cases with eating disorders, 8,496 controls, OR, 2.73, 95%CI 1.96-3.79, p = 2.1 x 10-9, AMSTAR-2 moderate quality) and between appearance-related teasing victimization and any eating disorder (k = 10, 1,341 cases with eating disorders, 3,295 controls, OR 2.91, 95%CI 2.05-4.12, p = 1.8x10-9, AMSTAR-2 moderate quality). Suggestive, weak, or no evidence supported 11, 29, and 8 associations, respectively.CONCLUSIONS: The most credible evidence indicates that early traumatic and stressful events are risk factors for eating disorders. Larger collaborative prospective cohort studies are needed to identify risk factors for eating disorders, particularly anorexia nervosa.
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| 21. |
- Ward-Thompson, D., et al.
(author)
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A Herschel study of the properties of starless cores in the Polaris Flare dark cloud region using PACS and SPIRE
- 2010
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In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 518, s. L92-
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Journal article (peer-reviewed)abstract
- The Polaris Flare cloud region contains a great deal of extended emission. It is at high declination and high Galactic latitude. It was previously seen strongly in IRAS Cirrus emission at 100 microns. We have detected it with both PACS and SPIRE on Herschel. We see filamentary and low-level structure. We identify the five densest cores within this structure. We present the results of a temperature, mass and density analysis of these cores. We compare their observed masses to their virial masses, and see that in all cases the observed masses lie close to the lower end of the range of estimated virial masses. Therefore, we cannot say whether they are gravitationally bound prestellar cores. Nevertheless, these are the best candidates to be potential prestellar cores in the Polaris cloud region.
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