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| 2. |
- Perera, Minoli A., et al.
(author)
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Genetic variants associated with warfarin dose in African-American individuals : a genome-wide association study
- 2013
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In: The Lancet. - 0140-6736 .- 1474-547X. ; 382:9894, s. 790-796
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Journal article (peer-reviewed)abstract
- Background VKORC1 and CYP2C9 are important contributors to warfarin dose variability, but explain less variability for individuals of African descent than for those of European or Asian descent. We aimed to identify additional variants contributing to warfarin dose requirements in African Americans. Methods We did a genome-wide association study of discovery and replication cohorts. Samples from African-American adults (aged >= 18 years) who were taking a stable maintenance dose of warfarin were obtained at International Warfarin Pharmacogenetics Consortium (IWPC) sites and the University of Alabama at Birmingham (Birmingham, AL, USA). Patients enrolled at IWPC sites but who were not used for discovery made up the independent replication cohort. All participants were genotyped. We did a stepwise conditional analysis, conditioning first for VKORC1 -1639G -> A, followed by the composite genotype of CYP2C9*2 and CYP2C9*3. We prespecified a genome-wide significance threshold of p<5x10(-8) in the discovery cohort and p<0.0038 in the replication cohort. Findings The discovery cohort contained 533 participants and the replication cohort 432 participants. After the prespecified conditioning in the discovery cohort, we identified an association between a novel single nucleotide polymorphism in the CYP2C cluster on chromosome 10 (rs12777823) and warfarin dose requirement that reached genome-wide significance (p=1.51x10(-8)). This association was confirmed in the replication cohort (p=5.04x10(-5)); analysis of the two cohorts together produced a p value of 4.5x10(-12). Individuals heterozygous for the rs12777823 A allele need a dose reduction of 6.92 mg/week and those homozygous 9.34 mg/week. Regression analysis showed that the inclusion of rs12777823 significantly improves warfarin dose variability explained by the IWPC dosing algorithm (21% relative improvement). Interpretation A novel CYP2C single nucleotide polymorphism exerts a clinically relevant effect on warfarin dose in African Americans, independent of CYP2C9*2 and CYP2C9*3. Incorporation of this variant into pharmacogenetic dosing algorithms could improve warfarin dose prediction in this population.
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| 3. |
- Anuar, S. A., et al.
(author)
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Effect of Carbon Supports on Oxygen Reduction Reaction of Iron/Cobalt Electrocatalyst
- 2020
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In: International Journal of Nanoelectronics and Materials. - : Unimap Press. - 1985-5761 .- 1997-4434. ; 13:Special Issue, s. 225-232
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Journal article (peer-reviewed)abstract
- Dual metal FeCo has great potential as Pt-free catalyst in various applications, such as cathodic catalyst for fuel cells, in order to reduce the cost significantly and make fuel cell commercialization, viable. In this study, dual metal FeCo catalyst supported on carbon Vulcan XC-72, carbon nanotubes (CNT), and reduced graphene oxide (rGO) were successfully prepared via facile co-precipitation method with varying weight ratios of Fe and Co. The structure of the as-prepared catalysts was characterized by powder X-ray diffraction (XRD), scanning electron micrographs (SEM), and X-ray photoelectron spectroscopy (XPS). The XPS analysis revealed that CoFe2O4 were present on the catalyst particle surface with different Fe to Co ratio. The emergence of the new peak at 530.5 eV is assigned to the deposition of CoFe2O4, which is enabled via Fe-O-Co bonds. The FeCo/rGO catalyst with weight ratio of 2:1 exhibited the optimum performance for oxygen reduction reaction (ORR), with reduction peak of 0.163 mA cm(-2) at 0.385 V vs. Ag/AgCl in an acidic media. The experimental result suggested that the dual metal FeCo catalyst display favourable electrocatalytic activity towards ORR and appears to be a promising cathodic electrocatalyst for an acidic fuel cell.
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| 5. |
- Heijtza, RD, et al.
(author)
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Normal gut microbiota modulates brain development and behavior
- 2011
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In: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 1091-6490. ; 108:7, s. 3047-3052
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Journal article (peer-reviewed)abstract
- Microbial colonization of mammals is an evolution-driven process that modulate host physiology, many of which are associated with immunity and nutrient intake. Here, we report that colonization by gut microbiota impacts mammalian brain development and subsequent adult behavior. Using measures of motor activity and anxiety-like behavior, we demonstrate that germ free (GF) mice display increased motor activity and reduced anxiety, compared with specific pathogen free (SPF) mice with a normal gut microbiota. This behavioral phenotype is associated with altered expression of genes known to be involved in second messenger pathways and synaptic long-term potentiation in brain regions implicated in motor control and anxiety-like behavior. GF mice exposed to gut microbiota early in life display similar characteristics as SPF mice, including reduced expression of PSD-95 and synaptophysin in the striatum. Hence, our results suggest that the microbial colonization process initiates signaling mechanisms that affect neuronal circuits involved in motor control and anxiety behavior.
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| 6. |
- Nor-Anuar, A., et al.
(author)
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Strength characteristics of aerobic granular sludge
- 2012
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In: Water Science and Technology. - : IWA Publishing. - 0273-1223 .- 1996-9732. ; 65:2, s. 309-316
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Journal article (peer-reviewed)abstract
- Aerobic granular sludge has a number of advantages over conventional activated sludge flocs, such as cohesive and strong matrix, fast settling characteristic, high biomass retention and ability to withstand high organic loadings, all aspects leading towards a compact reactor system. Still there are very few studies on the strength of aerobic granules. A procedure that has been used previously for anaerobic granular sludge strength analysis was adapted and used in this study. A new coefficient was introduced, called a stability coefficient (S), to quantify the strength of the aerobic granules. Indicators were also developed based on the strength analysis results, in order to categorize aerobic granules into three levels of strength, i.e. very strong (very stable), strong (stable) and not strong (not stable). The results indicated that aerobic granules grown on acetate were stronger (high density: >150 g T SSL(-1) and low S value: 5%) than granules developed on sewage as influent. A lower value of S indicates a higher stability of the granules.
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- Osman, Syaiful, et al.
(author)
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Variation of chemical properties, crystalline structure and calorific values of native Malaysian bamboo species
- 2022
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In: Wood and Fiber Science. - : Society of Wood Science and Technology. - 0735-6161. ; 54:3, s. 173-186
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Journal article (peer-reviewed)abstract
- The chemical properties of four common Malaysian bamboo species locally known as Beting (Gigantochloa levis), Semantan (Gigantochloa scortechinii), Lemang (Schizostachyum brachyladum) and Akar (Bambusa vulgaris) were studied. Chemical analysis shows that the alkaline extractive content for Malaysian bamboo species studied was within 24.4% to 25.6%, ethanol-toluene extractive content for Malaysian bamboo species was within 4.0% to 7.2% and water extractive content was within 10.4% to 12.8%. The average value of holocellulose content for Malaysian bamboo was between 64.5% to 70.67%, Klason lignin within 25.3% to 28.4%, cellulose content was between 28.5% to 33.8% and α-cellulose content for all bamboo species was within the range of 40.7% to 47.9%. The crystallinity of bamboo samples was between 42.0 to 44.4%, indicating their semi-crystalline structure. Heating value of bamboo ranged between 17.0 MJ/kg to 18.1 MJ/kg with G. scortechinii having the highest heating value.. The Inductive Couple Plasma Atomic Emission Spectroscopy (ICP-ES) analysis showed that Potassium (K) and Calcium (C) were the major elements in the ash of all bamboo samples. This study demonstrates the potential of native bamboo species as an alternative sustainable raw material to wood for a wide range of applications.
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