| 1. |
- Sano, Soichi, et al.
(author)
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Hematopoietic loss of Y chromosome leads to cardiac fibrosis and heart failure mortality
- 2022
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In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 377:6603, s. 292-297
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Journal article (peer-reviewed)abstract
- Hematopoietic mosaic loss of Y chromosome (mLOY) is associated with increased risk of mortality and age-related diseases in men, but the causal and mechanistic relationships have yet to be established. Here, we show that male mice reconstituted with bone marrow cells lacking the Y chromosome display increased mortality and age-related profibrotic pathologies including reduced cardiac function. Cardiac macrophages lacking the Y chromosome exhibited polarization toward a more fibrotic phenotype, and treatment with a transforming growth factor β1–neutralizing antibody ameliorated cardiac dysfunction in mLOY mice. A prospective study revealed that mLOY in blood is associated with an increased risk for cardiovascular disease and heart failure–associated mortality. Together, these results indicate that hematopoietic mLOY causally contributes to fibrosis, cardiac dysfunction, and mortality in men.
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| 2. |
- Kimberg, Victor, et al.
(author)
-
Rydberg-valence mixing and interchannel coupling in resonant oxygen 1s inelastic x-ray scattering of O_2
- 2012
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In: Physical Review A. Atomic, Molecular, and Optical Physics. - : American Physical Society. - 1050-2947 .- 1094-1622. ; 85:3
-
Journal article (peer-reviewed)abstract
- Rydberg-valence (RV) mixing and doublet-quartet (DQ) interchannel coupling in the core-excited states of triplet open-shell O2 are experimentally and theoretically unveiled through the resonant inelastic x-ray scattering around the O 1s→σ∗u resonance. Ab initio calculations explain complicated excitation energy dependence of the spectral profile by the interplay of the DQ interchannel coupling under the presence of the RV mixing. Complicated intermediate states with valence and/or Rydberg character are successfully analyzed through the filtering of pure valence and pure Rydberg final states.
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| 3. |
- Tokushima, Takashi, et al.
(author)
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Polarization dependent resonant x-ray emission spectroscopy of D2O and H2O water : Assignment of the local molecular orbital symmetry
- 2012
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In: Journal of Chemical Physics. - : AIP Publishing. - 0021-9606 .- 1089-7690. ; 136:4, s. 044517-
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Journal article (peer-reviewed)abstract
- The polarization dependence of the split two peaks in the lone-pair region in the x-ray emission spectra has been determined at several different excitation energies for both D2O and H2O water. In contrast to predictions based on a narrow range of local water structures where the two peaks would be of different molecular orbital symmetry and arise from, respectively, intact and dissociated molecules, we show that the two peaks in the lone-pair region are both of lone-pair 1b(1) orbital symmetry. The results support the interpretation that the two peaks appear due to fluctuations between two distinct different main structural environments.
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