| 1. |
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| 2. |
- Glasbey, JC, et al.
(author)
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- 2021
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swepub:Mat__t
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| 3. |
- Tabiri, S, et al.
(author)
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- 2021
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swepub:Mat__t
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| 4. |
- Bravo, L, et al.
(author)
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- 2021
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swepub:Mat__t
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| 5. |
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| 6. |
- Tran, K. B., et al.
(author)
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The global burden of cancer attributable to risk factors, 2010-19: a systematic analysis for the Global Burden of Disease Study 2019
- 2022
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In: Lancet. - 0140-6736. ; 400:10352, s. 563-591
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Journal article (peer-reviewed)abstract
- Background Understanding the magnitude of cancer burden attributable to potentially modifiable risk factors is crucial for development of effective prevention and mitigation strategies. We analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 to inform cancer control planning efforts globally. Methods The GBD 2019 comparative risk assessment framework was used to estimate cancer burden attributable to behavioural, environmental and occupational, and metabolic risk factors. A total of 82 risk-outcome pairs were included on the basis of the World Cancer Research Fund criteria. Estimated cancer deaths and disability-adjusted life-years (DALYs) in 2019 and change in these measures between 2010 and 2019 are presented. Findings Globally, in 2019, the risk factors included in this analysis accounted for 4.45 million (95% uncertainty interval 4.01-4.94) deaths and 105 million (95.0-116) DALYs for both sexes combined, representing 44.4% (41.3-48.4) of all cancer deaths and 42.0% (39.1-45.6) of all DALYs. There were 2.88 million (2.60-3.18) risk-attributable cancer deaths in males (50.6% [47.8-54.1] of all male cancer deaths) and 1.58 million (1.36-1.84) risk-attributable cancer deaths in females (36.3% [32.5-41.3] of all female cancer deaths). The leading risk factors at the most detailed level globally for risk-attributable cancer deaths and DALYs in 2019 for both sexes combined were smoking, followed by alcohol use and high BMI. Risk-attributable cancer burden varied by world region and Socio-demographic Index (SDI), with smoking, unsafe sex, and alcohol use being the three leading risk factors for risk-attributable cancer DALYs in low SDI locations in 2019, whereas DALYs in high SDI locations mirrored the top three global risk factor rankings. From 2010 to 2019, global risk-attributable cancer deaths increased by 20.4% (12.6-28.4) and DALYs by 16.8% (8.8-25.0), with the greatest percentage increase in metabolic risks (34.7% [27.9-42.8] and 33.3% [25.8-42.0]). Interpretation The leading risk factors contributing to global cancer burden in 2019 were behavioural, whereas metabolic risk factors saw the largest increases between 2010 and 2019. Reducing exposure to these modifiable risk factors would decrease cancer mortality and DALY rates worldwide, and policies should be tailored appropriately to local cancer risk factor burden. Copyright (C) 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.
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| 7. |
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| 8. |
- Bryazka, D., et al.
(author)
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Population-level risks of alcohol consumption by amount, geography, age, sex, and year: a systematic analysis for the Global Burden of Disease Study 2020
- 2022
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In: Lancet. - 0140-6736. ; 400:10347, s. 185-235
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Journal article (peer-reviewed)abstract
- Background The health risks associated with moderate alcohol consumption continue to be debated. Small amounts of alcohol might lower the risk of some health outcomes but increase the risk of others, suggesting that the overall risk depends, in part, on background disease rates, which vary by region, age, sex, and year. Methods For this analysis, we constructed burden-weighted dose-response relative risk curves across 22 health outcomes to estimate the theoretical minimum risk exposure level (TMREL) and non-drinker equivalence (NDE), the consumption level at which the health risk is equivalent to that of a non-drinker, using disease rates from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2020 for 21 regions, including 204 countries and territories, by 5-year age group, sex, and year for individuals aged 15-95 years and older from 1990 to 2020. Based on the NDE, we quantified the population consuming harmful amounts of alcohol. Findings The burden-weighted relative risk curves for alcohol use varied by region and age. Among individuals aged 15-39 years in 2020, the TMREL varied between 0 (95% uncertainty interval 0-0) and 0.603 (0.400-1.00) standard drinks per day, and the NDE varied between 0.002 (0-0) and 1.75 (0.698-4.30) standard drinks per day. Among individuals aged 40 years and older, the burden-weighted relative risk curve was J-shaped for all regions, with a 2020 TMREL that ranged from 0.114 (0-0.403) to 1.87 (0.500-3.30) standard drinks per day and an NDE that ranged between 0.193 (0-0.900) and 6.94 (3.40-8.30) standard drinks per day. Among individuals consuming harmful amounts of alcohol in 2020, 59.1% (54.3-65.4) were aged 15-39 years and 76.9% (7.0-81.3) were male. Interpretation There is strong evidence to support recommendations on alcohol consumption varying by age and location. Stronger interventions, particularly those tailored towards younger individuals, are needed to reduce the substantial global health loss attributable to alcohol. Copyright (C) 2022 The Author(s). Published by Elsevier Ltd.
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| 9. |
- Khatri, C, et al.
(author)
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Outcomes after perioperative SARS-CoV-2 infection in patients with proximal femoral fractures: an international cohort study
- 2021
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In: BMJ open. - : BMJ. - 2044-6055. ; 11:11, s. e050830-
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Journal article (peer-reviewed)abstract
- Studies have demonstrated high rates of mortality in people with proximal femoral fracture and SARS-CoV-2, but there is limited published data on the factors that influence mortality for clinicians to make informed treatment decisions. This study aims to report the 30-day mortality associated with perioperative infection of patients undergoing surgery for proximal femoral fractures and to examine the factors that influence mortality in a multivariate analysis.SettingProspective, international, multicentre, observational cohort study.ParticipantsPatients undergoing any operation for a proximal femoral fracture from 1 February to 30 April 2020 and with perioperative SARS-CoV-2 infection (either 7 days prior or 30-day postoperative).Primary outcome30-day mortality. Multivariate modelling was performed to identify factors associated with 30-day mortality.ResultsThis study reports included 1063 patients from 174 hospitals in 19 countries. Overall 30-day mortality was 29.4% (313/1063). In an adjusted model, 30-day mortality was associated with male gender (OR 2.29, 95% CI 1.68 to 3.13, p<0.001), age >80 years (OR 1.60, 95% CI 1.1 to 2.31, p=0.013), preoperative diagnosis of dementia (OR 1.57, 95% CI 1.15 to 2.16, p=0.005), kidney disease (OR 1.73, 95% CI 1.18 to 2.55, p=0.005) and congestive heart failure (OR 1.62, 95% CI 1.06 to 2.48, p=0.025). Mortality at 30 days was lower in patients with a preoperative diagnosis of SARS-CoV-2 (OR 0.6, 95% CI 0.6 (0.42 to 0.85), p=0.004). There was no difference in mortality in patients with an increase to delay in surgery (p=0.220) or type of anaesthetic given (p=0.787).ConclusionsPatients undergoing surgery for a proximal femoral fracture with a perioperative infection of SARS-CoV-2 have a high rate of mortality. This study would support the need for providing these patients with individualised medical and anaesthetic care, including medical optimisation before theatre. Careful preoperative counselling is needed for those with a proximal femoral fracture and SARS-CoV-2, especially those in the highest risk groups.Trial registration numberNCT04323644
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| 10. |
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| 11. |
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| 12. |
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| 13. |
- James, SL, et al.
(author)
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Global injury morbidity and mortality from 1990 to 2017: results from the Global Burden of Disease Study 2017
- 2020
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In: Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention. - : BMJ. - 1475-5785. ; 26:SUPP_1Supp 1, s. 96-114
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Journal article (peer-reviewed)abstract
- Past research in population health trends has shown that injuries form a substantial burden of population health loss. Regular updates to injury burden assessments are critical. We report Global Burden of Disease (GBD) 2017 Study estimates on morbidity and mortality for all injuries.MethodsWe reviewed results for injuries from the GBD 2017 study. GBD 2017 measured injury-specific mortality and years of life lost (YLLs) using the Cause of Death Ensemble model. To measure non-fatal injuries, GBD 2017 modelled injury-specific incidence and converted this to prevalence and years lived with disability (YLDs). YLLs and YLDs were summed to calculate disability-adjusted life years (DALYs).FindingsIn 1990, there were 4 260 493 (4 085 700 to 4 396 138) injury deaths, which increased to 4 484 722 (4 332 010 to 4 585 554) deaths in 2017, while age-standardised mortality decreased from 1079 (1073 to 1086) to 738 (730 to 745) per 100 000. In 1990, there were 354 064 302 (95% uncertainty interval: 338 174 876 to 371 610 802) new cases of injury globally, which increased to 520 710 288 (493 430 247 to 547 988 635) new cases in 2017. During this time, age-standardised incidence decreased non-significantly from 6824 (6534 to 7147) to 6763 (6412 to 7118) per 100 000. Between 1990 and 2017, age-standardised DALYs decreased from 4947 (4655 to 5233) per 100 000 to 3267 (3058 to 3505).InterpretationInjuries are an important cause of health loss globally, though mortality has declined between 1990 and 2017. Future research in injury burden should focus on prevention in high-burden populations, improving data collection and ensuring access to medical care.
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| 14. |
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| 15. |
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| 16. |
- Abbafati, Cristiana, et al.
(author)
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- 2020
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Journal article (peer-reviewed)
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| 17. |
- James, SL, et al.
(author)
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Estimating global injuries morbidity and mortality: methods and data used in the Global Burden of Disease 2017 study
- 2020
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In: Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention. - : BMJ. - 1475-5785. ; 26:SUPP_1Supp 1, s. 125-153
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Journal article (peer-reviewed)abstract
- While there is a long history of measuring death and disability from injuries, modern research methods must account for the wide spectrum of disability that can occur in an injury, and must provide estimates with sufficient demographic, geographical and temporal detail to be useful for policy makers. The Global Burden of Disease (GBD) 2017 study used methods to provide highly detailed estimates of global injury burden that meet these criteria.MethodsIn this study, we report and discuss the methods used in GBD 2017 for injury morbidity and mortality burden estimation. In summary, these methods included estimating cause-specific mortality for every cause of injury, and then estimating incidence for every cause of injury. Non-fatal disability for each cause is then calculated based on the probabilities of suffering from different types of bodily injury experienced.ResultsGBD 2017 produced morbidity and mortality estimates for 38 causes of injury. Estimates were produced in terms of incidence, prevalence, years lived with disability, cause-specific mortality, years of life lost and disability-adjusted life-years for a 28-year period for 22 age groups, 195 countries and both sexes.ConclusionsGBD 2017 demonstrated a complex and sophisticated series of analytical steps using the largest known database of morbidity and mortality data on injuries. GBD 2017 results should be used to help inform injury prevention policy making and resource allocation. We also identify important avenues for improving injury burden estimation in the future.
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| 18. |
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| 19. |
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| 20. |
- Burney, Peter, et al.
(author)
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Prevalence and Population-Attributable Risk for Chronic Airflow Obstruction in a Large Multinational Study
- 2021
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In: American Journal of Respiratory and Critical Care Medicine. - 1073-449X .- 1535-4970. ; 203:11, s. 1353-1365
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Journal article (peer-reviewed)abstract
- Rationale: The Global Burden of Disease program identified smoking and ambient and household air pollution as the main drivers of death and disability from chronic obstructive pulmonary disease (COPD).Objectives: To estimate the attributable risk of chronic airflow obstruction (CAO), a quantifiable characteristic of COPD, due to several risk factors.Methods: The Burden of Obstructive Lung Disease study is a cross-sectional study of adults, aged ≥40, in a globally distributed sample of 41 urban and rural sites. Based on data from 28,459 participants, we estimated the prevalence of CAO, defined as a postbronchodilator FEV1-to-FVC ratio less than the lower limit of normal, and the relative risks associated with different risk factors. Local relative risks were estimated using a Bayesian hierarchical model borrowing information from across sites. From these relative risks and the prevalence of risk factors, we estimated local population attributable risks.Measurements and Main Results: The mean prevalence of CAO was 11.2% in men and 8.6% in women. The mean population attributable risk for smoking was 5.1% in men and 2.2% in women. The next most influential risk factors were poor education levels, working in a dusty job for ≥10 years, low body mass index, and a history of tuberculosis. The risk of CAO attributable to the different risk factors varied across sites.Conclusions: Although smoking remains the most important risk factor for CAO, in some areas, poor education, low body mass index, and passive smoking are of greater importance. Dusty occupations and tuberculosis are important risk factors at some sites.
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| 21. |
- Homod, R. Z., et al.
(author)
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Effect of different building envelope materials on thermal comfort and air-conditioning energy savings : A case study in Basra city, Iraq
- 2021
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In: Journal of Energy Storage. - : Elsevier. - 2352-152X .- 2352-1538. ; 34
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Journal article (peer-reviewed)abstract
- Recently, a numerous number of houses has been built using AAC materials, which consume the most amount of energy in the building sector by Heating, ventilation, and air -conditioning (HVAC) systems. Thus, the most significant factor affecting the energy consumed by HVAC systems is the materials used in the building. Building models are important tools in determining the energy efficiency of buildings. Numerous strategies have been established to construct building models, such as the weight, gray, and black boxes, as well as hybrid models. Hybrid models have not been researched extensively, although they provide a reasonable representation of actual indoor conditions. Therefore, this study employs a hybrid calculation model for the analysis of physical and empirical correlations to evaluate thermal comfort in buildings, which reflects their energy consumption. The residential load factor (RLF) technique is adopted owing to its systematic organization and ease of use, which is achieved by dividing the model into submodels. The model is verified and validated by drawing a comparison with field measurements and the output obtained from ANSYS software. The actual field measurements and ANSYS outputs match the outputs of the proposed model; the results show small residual errors, indicating a well-defined model structure. The cost and energy savings of vernacular buildings and autoclaved aerated concrete (AAC) (or low-cost) buildings have been highly debated in Basra city. Models of these two different building materials are simulated within the MATLAB/Simulink environment. Their results indicate that the vernacular building has the highest energy saving potential up to 47.83% over 24 h a day. These results provide an excellent argument to realize the benefits of vernacular buildings by reducing the dependency on powered cooling.
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| 22. |
- Knox-Brown, Ben, et al.
(author)
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Small airways obstruction and its risk factors in the Burden of Obstructive Lung Disease (BOLD) study : a multinational cross-sectional study
- 2023
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In: The Lancet Global Health. - : Elsevier. - 2214-109X. ; 11:1, s. E69-E82
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Journal article (peer-reviewed)abstract
- Background: Small airways obstruction is a common feature of obstructive lung diseases. Research is scarce on small airways obstruction, its global prevalence, and risk factors. We aimed to estimate the prevalence of small airways obstruction, examine the associated risk factors, and compare the findings for two different spirometry parameters.Methods: The Burden of Obstructive Lung Disease study is a multinational cross-sectional study of 41 municipalities in 34 countries across all WHO regions. Adults aged 40 years or older who were not living in an institution were eligible to participate. To ensure a representative sample, participants were selected from a random sample of the population according to a predefined site-specific sampling strategy. We included participants' data in this study if they completed the core study questionnaire and had acceptable spirometry according to predefined quality criteria. We excluded participants with a contraindication for lung function testing. We defined small airways obstruction as either mean forced expiratory flow rate between 25% and 75% of the forced vital capacity (FEF25-75) less than the lower limit of normal or forced expiratory volume in 3 s to forced vital capacity ratio (FEV3/FVC ratio) less than the lower limit of normal. We estimated the prevalence of pre-bronchodilator (ie, before administration of 200 mu g salbutamol) and post-bronchodilator (ie, after administration of 200 mu g salbutamol) small airways obstruction for each site. To identify risk factors for small airways obstruction, we performed multivariable regression analyses within each site and pooled estimates using random-effects meta-analysis.Findings: 36 618 participants were recruited between Jan 2, 2003, and Dec 26, 2016. Data were collected from participants at recruitment. Of the recruited participants, 28 604 participants had acceptable spirometry and completed the core study questionnaire. Data were available for 26 443 participants for FEV3/FVC ratio and 25 961 participants for FEF25-75. Of the 26 443 participants included, 12 490 were men and 13 953 were women. Prevalence of pre-bronchodilator small airways obstruction ranged from 5% (34 of 624 participants) in Tartu, Estonia, to 34% (189 of 555 participants) in Mysore, India, for FEF25-75, and for FEV 3/FVC ratio it ranged from 5% (31 of 684) in Riyadh, Saudi Arabia, to 31% (287 of 924) in Salzburg, Austria. Prevalence of post-bronchodilator small airways obstruction was universally lower. Risk factors significantly associated with FEV 3/FVC ratio less than the lower limit of normal included increasing age, low BMI, active and passive smoking, low level of education, working in a dusty job for more than 10 years, previous tuberculosis, and family history of chronic obstructive pulmonary disease. Results were similar for FEF25-75, except for increasing age, which was associated with reduced odds of small airways obstruction.Interpretation: Despite the wide geographical variation, small airways obstruction is common and more prevalent than chronic airflow obstruction worldwide. Small airways obstruction shows the same risk factors as chronic airflow obstruction. However, further research is required to investigate whether small airways obstruction is also associated with respiratory symptoms and lung function decline.
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| 23. |
- Knox-Brown, Ben, et al.
(author)
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The association of spirometric small airways obstruction with respiratory symptoms, cardiometabolic diseases, and quality of life : results from the Burden of Obstructive Lung Disease (BOLD) study
- 2023
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In: Respiratory Research. - : BioMed Central (BMC). - 1465-9921 .- 1465-993X. ; 24:1
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Journal article (peer-reviewed)abstract
- BackgroundSpirometric small airways obstruction (SAO) is common in the general population. Whether spirometric SAO is associated with respiratory symptoms, cardiometabolic diseases, and quality of life (QoL) is unknown.MethodsUsing data from the Burden of Obstructive Lung Disease study (N = 21,594), we defined spirometric SAO as the mean forced expiratory flow rate between 25 and 75% of the FVC (FEF25-75) less than the lower limit of normal (LLN) or the forced expiratory volume in 3 s to FVC ratio (FEV3/FVC) less than the LLN. We analysed data on respiratory symptoms, cardiometabolic diseases, and QoL collected using standardised questionnaires. We assessed the associations with spirometric SAO using multivariable regression models, and pooled site estimates using random effects meta-analysis. We conducted identical analyses for isolated spirometric SAO (i.e. with FEV1/FVC ≥ LLN).ResultsAlmost a fifth of the participants had spirometric SAO (19% for FEF25-75; 17% for FEV3/FVC). Using FEF25-75, spirometric SAO was associated with dyspnoea (OR = 2.16, 95% CI 1.77–2.70), chronic cough (OR = 2.56, 95% CI 2.08–3.15), chronic phlegm (OR = 2.29, 95% CI 1.77–4.05), wheeze (OR = 2.87, 95% CI 2.50–3.40) and cardiovascular disease (OR = 1.30, 95% CI 1.11–1.52), but not hypertension or diabetes. Spirometric SAO was associated with worse physical and mental QoL. These associations were similar for FEV3/FVC. Isolated spirometric SAO (10% for FEF25-75; 6% for FEV3/FVC), was also associated with respiratory symptoms and cardiovascular disease.ConclusionSpirometric SAO is associated with respiratory symptoms, cardiovascular disease, and QoL. Consideration should be given to the measurement of FEF25-75 and FEV3/FVC, in addition to traditional spirometry parameters.
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| 24. |
- Abozid, Hazim, et al.
(author)
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Prevalence of chronic cough, its risk factors and population attributable risk in the Burden of Obstructive Lung Disease (BOLD) study : a multinational cross-sectional study
- 2024
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In: eClinicalMedicine. - : Elsevier. - 2589-5370. ; 68
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Journal article (peer-reviewed)abstract
- Background Chronic cough is a common respiratory symptom with an impact on daily activities and quality of life. Global prevalence data are scarce and derive mainly from European and Asian countries and studies with outcomes other than chronic cough. In this study, we aimed to estimate the prevalence of chronic cough across a large number of study sites as well as to identify its main risk factors using a standardised protocol and definition. Methods We analysed cross-sectional data from 33,983 adults (>= 40 years), recruited between Jan 2, 2003 and Dec 26, 2016, in 41 sites (34 countries) from the Burden of Obstructive Lung Disease (BOLD) study. We estimated the prevalence of chronic cough for each site accounting for sampling design. To identify risk factors, we conducted multivariable logistic regression analysis within each site and then pooled estimates using random -effects metaanalysis. We also calculated the population attributable risk (PAR) associated with each of the identifed risk factors. Findings The prevalence of chronic cough varied from 3% in India (rural Pune) to 24% in the United States of America (Lexington,KY). Chronic cough was more common among females, both current and passive smokers, those working in a dusty job, those with a history of tuberculosis, those who were obese, those with a low level of education and those with hypertension or airflow limitation. The most influential risk factors were current smoking and working in a dusty job. Interpretation Our findings suggested that the prevalence of chronic cough varies widely across sites in different world regions. Cigarette smoking and exposure to dust in the workplace are its major risk factors.
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| 25. |
- Abuzeid, Nadir, et al.
(author)
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Antimycobacterial activity of selected medicinal plants traditionally used in Sudan to treat infectious diseases
- 2014
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In: Journal of Ethnopharmacology. - : Elsevier. - 0378-8741 .- 1872-7573. ; 157, s. 134-139
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Journal article (peer-reviewed)abstract
- Ethnopharmacological relevance: The emergence of multidrug-resistant strains of Mycobacterium tuberculosis underscores the need for continuous development of new and efficient methods to determine the susceptibility of isolates of Mycobacterium tuberculosis in the search for novel antimycobacterial agents. Natural products constitute an important source of new drugs, and design and implementation of antimycobacterial susceptibility testing methods are necessary to evaluate the different extracts and compounds. In this study we have explored the antimycobacterial properties of 50 ethanolic extracts from different parts of 46 selected medicinal plants traditionally used in Sudan to treat infectious diseases. Materials and methods: Plants were harvested and ethanolic extracts were prepared. For selected extracts, fractionation with hydrophilic and hydrophobic solvents was undertaken. A luminometry-based assay was used for determination of mycobacterial growth in broth cultures and inside primary human macrophages in the presence or absence of plant extracts and fractions of extracts. Cytotoxicity was also assessed for active fractions of plant extracts. Results: Of the tested extracts, three exhibited a significant inhibitory effect on an avirulent strain of Mycobacterium tubercluosis (H37Ra) at the initial screening doses (125 and 6.25 mu g/ml). These were bark and leaf extracts of Khaya senegalensis and the leaf extract of Rosmarinus officinalis L. Further fractions of these plant extracts were prepared with n-hexane, chloroform, ethyl acetate, n-butanol, ethanol and water, and the activity of these extracts was retained in hydrophobic fractions. Cytotoxicity assays revealed that the chloroform fraction of Khaya senegalensis bark was non-toxic to human monocyte-derived macrophages and other cell types at the concentrations used and hence, further analysis, including assessment of IC50 and intracellular activity was done with this fraction. Conclusion: These results encourage further investigations to identify the active compound(s) within the chloroform fraction of Khaya senegalensis bark. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
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| 26. |
- Amaral, Andre F. S., et al.
(author)
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Chronic airflow obstruction and ambient particulate air pollution
- 2021
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In: Thorax. - : BMJ Publishing Group Ltd. - 0040-6376 .- 1468-3296. ; 76:12, s. 1236-1241
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Journal article (peer-reviewed)abstract
- Smoking is the most well-established cause of chronic airflow obstruction (CAO) but particulate air pollution and poverty have also been implicated. We regressed sex-specific prevalence of CAO from 41 Burden of Obstructive Lung Disease study sites against smoking prevalence from the same study, the gross national income per capita and the local annual mean level of ambient particulate matter (PM2.5) using negative binomial regression. The prevalence of CAO was not independently associated with PM2.5 but was strongly associated with smoking and was also associated with poverty. Strengthening tobacco control and improved understanding of the link between CAO and poverty should be prioritised.
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| 27. |
- Almusaed, Amjad, 1967-, et al.
(author)
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Shading Effects Upon Cooling House Strategy In Iraq
- 2007
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In: Building Low Energy Cooling and Advanced Ventilation Technologies in the 21st Century: 2<sup>nd</sup> PALENC Conference 28<sup>th</sup> AIVC Conference. - Crete island : University of Athens. - 9789606746031 ; , s. 40-44
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Conference paper (peer-reviewed)abstract
- Macroclimatic forces have been important factors ever since man first constructed shelter. Throughout architectural history, local buildings have used great in providing the most comfortable internal conditions possible within the exigencies and constraints of local climate. The habitual living way in Iraq is accurately reflected in the households’ organization, in their volumetric configuration, in the forms of useful locations they engender. Houses are compact with interior courtyard; the streets are sinuous and pass through houses volumes. The shady interior courtyard has the effect that the rooms do not communicate directly with the overheated air outside, but through intermediate buffer spaces. In the mean time between courtyard and street at least a wall or a building is always interposed. This isolation from the street indicates concerns for defense. The architectural elements are strongly decorated, reproducing special typologies and traditional houses. The socials relations are strong, a situation which leads to personal-social spaces. The shadow is wanted to create both by means of architectural details and volumes, which have become a landmark of the local architecture specific character, and by means of natural elements (vegetation, water, etc.). The northern orientation is perfect for the summer functional rooms.
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| 28. |
- Armanuos, Asaad M., et al.
(author)
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Assessing the Effectiveness of Using Recharge Wells for Controlling the Saltwater Intrusion in Unconfined Coastal Aquifers with Sloping Beds : Numerical Study
- 2020
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In: Sustainability. - Switzerland : MDPI. - 2071-1050. ; 12:7
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Journal article (peer-reviewed)abstract
- Groundwater systems are considered major freshwater sources for many coastal aquifers worldwide. Seawater intrusion (SWI) inland into freshwater coastal aquifers is a common environmental problem that causes deterioration of the groundwater quality. This research investigates the effectiveness of using an injection through a well to mitigate the SWI in sloping beds of unconfined coastal aquifers. The interface was simulated using SEAWAT code. The repulsion ratios due to the length of the SWI wedge (RL) and the area of the saltwater wedge (RA) were computed. A sensitivity analysis was conducted to recognize the change in the confining layer bed slope (horizontal, positive, and negative) and hydraulic parameters of the value of the SWI repulsion ratio. Injection at the toe itself achieved higher repulsion ratios. RL and RA declined if the injection point was located remotely and higher than the toe of the seawater wedge. Installation at the toe achieved a higher RL in positive sloping followed by horizontal and negative slopes. Moreover, the highest value of RA could be reached by injecting at the toe itself with a horizontal bed aquifer, followed by negative and positive slopes. The recharge well is confirmed as one of the most effective applications for the mitigation of SWI in sloping bed aquifers. The Akrotiri case study shows that the proposed recharging water method has a significant impact on controlling SWI and declines in both SWI wedge length and area.
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| 29. |
- Armanuos, Asaad M., et al.
(author)
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Cross Assessment of Twenty-One Different Methods for Missing Precipitation Data Estimation
- 2020
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In: Atmosphere. - Switzerland : MDPI. - 2073-4433. ; 11:4, s. 1-35
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Journal article (peer-reviewed)abstract
- The results of metrological, hydrological, and environmental data analyses are mainlydependent on the reliable estimation of missing data. In this study, 21 classical methods were evaluated to determine the best method for infilling the missing precipitation data in Ethiopia. The monthly data collected from 15 different stations over 34 years from 1980 to 2013 were considered. Homogeneity and trend tests were performed to check the data. The results of the different methods were compared using the mean absolute error (MAE), root-mean-square error (RMSE), coefficient of efficiency (CE), similarity index (S-index), skill score (SS), and Pearson correlation coefficient (rPearson). The results of this paper confirmed that the normal ratio (NR), multiple linear regression (MLR), inverse distance weighting (IDW), correlation coefficient weighting (CCW), and arithmetic average (AA) methods are the most reliable methods of those studied. The NR method provides the most accurate estimations with rPearson of 0.945, mean absolute error of 22.90 mm, RMSE of 33.695 mm, similarity index of 0.999, CE index of 0.998, and skill score of 0.998. When comparing the observed results and the estimated results from the NR, MLR, IDW, CCW, and AA methods, the MAE and RMSE were found to be low, and high values of CE, S-index, SS, and rPearson were achieved. On the other hand, using the closet station (CS), UK traditional, linear regression (LR), expectation maximization (EM), and multiple imputations (MI) methods gave the lowest accuracy, with MAE and RMSE values varying from 30.424 to 47.641 mm and from 49.564 to 58.765 mm, respectively. The results of this study suggest that the recommended methods are applicable for different types of climatic data in Ethiopia and arid regions in other countries around the world.
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| 30. |
- Armanuos, Asaad M., et al.
(author)
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Underground Barrier Wall Evaluation for Controlling Saltwater Intrusion in Sloping Unconfined Coastal Aquifers
- 2020
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In: Water. - Switzerland : MDPI. - 2073-4441. ; 12:9
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Journal article (peer-reviewed)abstract
- Barrier walls are considered one of the most effective methods for facilitating the retreat of saltwater intrusion (SWI). This research plans to examine the effect of using barrier walls for controlling of SWI in sloped unconfined aquifers. The sloping unconfined aquifer is considered with three different bed slopes. The SEAWAT model is implemented to simulate the SWI. For model validation, the numerical results of the seawater wedge at steady state were compared with the analytical solution. Increasing the ratio of flow barrier depth (db/d) forced the saltwater interface to move seaward and increased the repulsion ratio (R). With a positive sloping bed, further embedding the barrier wall from 0.2 to 0.7 caused R to increase from 0.3% to 59%, while it increased from 1.8% to 41.7% and from 3.4% to 46.9% in the case of negative and horizontal slopes, respectively. Embedding the barrier wall to a db/d value of more than 0.4 achieved a greater R value in the three bed-sloping cases. Installing the barrier wall near the saltwater side with greater depth contributed to the retreat of the SWI. With a negative bed slope, moving the barrier wall from Xb/Lo = 1.0 toward the saltwater side (Xb/Lo = 0.2) increased R from 7.21% to 68.75%, whereas R increased from 5.3% to 67% for the horizontal sloping bed and from 5.1% to 64% for the positive sloping bed. The numerical results for the Akrotiri coastal aquifer confirm that the embedment of the barrier wall significantly affects the controlling of SWI by increasing the repulsion ratio (R) and decreasing the SWI length ratio (L/La). Cost-benefit analysis is recommended to determine the optimal design of barrier walls for increasing the cost-effectiveness of the application of barrier walls as a countermeasure for controlling and preventing SWI in sloped unconfined aquifers.
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| 31. |
- Borges Manna, Luiza, et al.
(author)
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Ursodeoxycholic acid improves feto-placental and offspring metabolic outcomes in hypercholanemic pregnancy.
- 2020
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In: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 10:1
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Journal article (peer-reviewed)abstract
- Perturbations in the intrauterine environment can result in lifelong consequences for metabolic health during postnatal life. Intrahepatic cholestasis of pregnancy (ICP) can predispose offspring to metabolic disease in adulthood, likely due to a combination of the effects of increased bile acids, maternal dyslipidemia and deranged maternal and fetal lipid homeostasis. Whereas ursodeoxycholic acid (UDCA) is a commonly used treatment for ICP, no studies have yet addressed whether it can also prevent the metabolic effects of ICP in the offspring and fetoplacental unit. We therefore analyzed the lipid profile of fetal serum from untreated ICP, UDCA-treated ICP and uncomplicated pregnancies and found that UDCA ameliorates ICP-associated fetal dyslipidemia. We then investigated the effects of UDCA in a mouse model of hypercholanemic pregnancy and showed that it induces hepatoprotective mechanisms in the fetal liver, reduces hepatic fatty acid synthase (Fas) expression and improves glucose tolerance in the adult offspring. Finally, we showed that ICP leads to epigenetic changes in pathways of relevance to the offspring phenotype. We therefore conclude that UDCA can be used as an intervention in pregnancy to reduce features of metabolic disease in the offspring of hypercholanemic mothers.
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| 32. |
- Farronato, Davide, et al.
(author)
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Failed Blade Implant After 25 Years in Function: Case Description and Histologic Analysis.
- 2018
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In: The International journal of periodontics & restorative dentistry. - 1945-3388. ; 38:2
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Journal article (peer-reviewed)abstract
- This report describes a failed blade implant after 25 years in function in the left maxilla and the results of histologic analysis of peri-implant tissues. The blade was retrieved, and histologic findings revealed that it was not osseointegrated despite being successfully in function for so many years. The long-term function of blade implants without osseointegration can be attributed to biotolerance exhibited by the implant rather than actual osseointegration.
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| 33. |
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| 34. |
- Knox-Brown, Ben, et al.
(author)
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Isolated small airways obstruction predicts future chronic airflow obstruction : a multinational longitudinal study
- 2023
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In: BMJ open respiratory research. - : BMJ Publishing Group Ltd. - 2052-4439. ; 10:1
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Journal article (peer-reviewed)abstract
- BACKGROUND: Chronic airflow obstruction is a key characteristic of chronic obstructive pulmonary disease. We investigated whether isolated small airways obstruction is associated with chronic airflow obstruction later in life.METHODS: We used longitudinal data from 3957 participants of the multinational Burden of Obstructive Lung Disease study. We defined isolated small airways obstruction using the prebronchodilator mean forced expiratory flow rate between 25% and 75% of the forced vital capacity (FVC) (FEF25-75) if a result was less than the lower limit of normal (1/FVC). We also used the forced expiratory volume in 3 s to FVC ratio (FEV3/FVC) to define small airways obstruction. We defined chronic airflow obstruction as post-bronchodilator FEV1/FVCRESULTS: Median follow-up time was 8.3 years. Chronic airflow obstruction was more likely to develop in participants with isolated small airways obstruction at baseline (FEF25-75 less than the LLN, OR: 2.95, 95% CI 1.02 to 8.54; FEV3/FVC less than the LLN, OR: 1.94, 95% CI 1.05 to 3.62). FEF25-75 was better than the FEV3/FVC ratio to discriminate future chronic airflow obstruction (AUC: 0.764 vs 0.692). Results were similar among participants of the UK Biobank study.CONCLUSION: Measurements of small airways obstruction can be used as early markers of future obstructive lung disease.
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| 35. |
- Larsson, Lena, 1969, et al.
(author)
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Understanding the role of endotoxin tolerance in chronic inflammatory conditions and periodontal disease.
- 2021
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In: Journal of clinical periodontology. - : Wiley. - 1600-051X .- 0303-6979. ; 49:3, s. 270-279
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Journal article (peer-reviewed)abstract
- This review aims to present the current understanding of endotoxin tolerance (ET) in chronic inflammatory diseases and explores the potential connection with periodontitis.Subsequent exposure to lipopolysaccharides (LPS) triggers ET, a phenomenon regulated by different mechanisms and pathways, including toll-like receptors (TLRs), nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB), apoptosis of immune cells, epigenetics, and microRNAs (miRNAs). These mechanisms interconnect ET with chronic inflammatory diseases that include periodontitis. While the direct correlation between ET and periodontal destruction has not been fully elucidated, emerging reports point towards the potential tolerization of human periodontal ligament cells (hPDLCs) and gingival tissues with a significant reduction of TLR levels.There is a potential link between ET and periodontal diseases. Future studies should explore the crucial role of ET in the pathogenesis of periodontal diseases as evidence of a tolerized oral mucosa may represent an intrinsic mechanism capable of regulating the oral immune response. A clear understanding of this host immune regulatory mechanism might lead to effective and more predictable therapeutic strategies to treat chronic inflammatory diseases and periodontitis. This article is protected by copyright. All rights reserved.
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| 36. |
- Mgaieth, Farah, et al.
(author)
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Exploring semantic verbal fluency patterns and their relationship to age and Alzheimer's disease in adults with Down syndrome.
- 2023
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In: Alzheimer's & dementia : the journal of the Alzheimer's Association. - 1552-5279. ; 19:11, s. 5129-37
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Journal article (peer-reviewed)abstract
- Adults with Down syndrome (DS) are at ultra-high risk of developing Alzheimer's disease (AD), characterized by poor episodic memory and semantic fluency in the preclinical phase in the general population. We explored semantic fluency performance in DS and its relationship to age, AD, and blood biomarkers.A total of 302 adults with DS at baseline and 87 at follow-up from the London Down Syndrome Consortium cohort completed neuropsychological assessments. Blood biomarkers were measured with the single molecule array technique in a subset of 94 participants.Poorer verbal fluency performance was observed as age increases. Number of correct words declined in those with AD compared to those without over 2 years and was negatively correlated with neurofilament light (r=-0.37, P=.001) and glial fibrillary acidic protein (r=-0.31, P=.012).Semantic fluency may be useful as an early indicator of cognitive decline and provide additional information on AD-related change, showing associations with biomarkers in DS.
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| 37. |
- Pilipchuk, Sophia P, et al.
(author)
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Micropatterned Scaffolds with Immobilized Growth Factor Genes Regenerate Bone and Periodontal Ligament-Like Tissues.
- 2018
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In: Advanced healthcare materials. - : Wiley. - 2192-2659 .- 2192-2640. ; 7:22
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Journal article (peer-reviewed)abstract
- Periodontal disease destroys supporting structures of teeth. However, tissue engineering strategies offer potential to enhance regeneration. Here, the strategies of patterned topography, spatiotemporally controlled growth factor gene delivery, and cell-based therapy to repair bone-periodontal ligament (PDL) interfaces are combined. Micropatterned scaffolds are fabricated for the ligament regions using polycaprolactone (PCL)/polylactic-co-glycolic acid and combined with amorphous PCL scaffolds for the bone region. Scaffolds are modified using chemical vapor deposition, followed by spatially controlled immobilization of vectors encoding either platelet-derived growth factor-BB or bone morphogenetic protein-7, respectively. The scaffolds are seeded with human cells and delivered to large alveolar bone defects in athymic rats. The effects of dual and single gene delivery with and without micropatterning are assessed after 3, 6, and 9 weeks. Gene delivery results in greater bone formation at three weeks. Micropatterning results in regenerated ligamentous tissues similar to native PDL. The combination results in more mature expression of collagen III and periostin, and with elastic moduli of regenerated tissues that are statistically indistinguishable from those of native tissue, while controls are less stiff than native tissues. Thus, controlled scaffold microtopography combined with localized growth factor gene delivery improves the regeneration of periodontal bone-PDL interfaces.
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| 38. |
- Ratanachina, Jate, et al.
(author)
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Association of respiratory symptoms and lung function with occupation in the multinational Burden of Obstructive Lung Disease (BOLD) study
- 2023
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In: European Respiratory Journal. - : European Respiratory Society. - 0903-1936 .- 1399-3003. ; 61:1
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Journal article (peer-reviewed)abstract
- Background Chronic obstructive pulmonary disease has been associated with exposures in the workplace. We aimed to assess the association of respiratory symptoms and lung function with occupation in the Burden of Obstructive Lung Disease study.Methods We analysed cross-sectional data from 28 823 adults (≥40 years) in 34 countries. We considered 11 occupations and grouped them by likelihood of exposure to organic dusts, inorganic dusts and fumes. The association of chronic cough, chronic phlegm, wheeze, dyspnoea, forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1)/FVC with occupation was assessed, per study site, using multivariable regression. These estimates were then meta-analysed. Sensitivity analyses explored differences between sexes and gross national income.Results Overall, working in settings with potentially high exposure to dusts or fumes was associated with respiratory symptoms but not lung function differences. The most common occupation was farming. Compared to people not working in any of the 11 considered occupations, those who were farmers for ≥20 years were more likely to have chronic cough (OR 1.52, 95% CI 1.19–1.94), wheeze (OR 1.37, 95% CI 1.16–1.63) and dyspnoea (OR 1.83, 95% CI 1.53–2.20), but not lower FVC (β=0.02 L, 95% CI −0.02–0.06 L) or lower FEV1/FVC (β=0.04%, 95% CI −0.49–0.58%). Some findings differed by sex and gross national income.Conclusion At a population level, the occupational exposures considered in this study do not appear to be major determinants of differences in lung function, although they are associated with more respiratory symptoms. Because not all work settings were included in this study, respiratory surveillance should still be encouraged among high-risk dusty and fume job workers, especially in low- and middle-income countries.
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| 39. |
- Salih, Sinan Q., et al.
(author)
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Viability of the advanced adaptive neuro-fuzzy inference system model on reservoir evaporation process simulation : case study of Nasser Lake in Egypt
- 2019
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In: Engineering Applications of Computational Fluid Mechanics. - UK : Taylor & Francis. - 1994-2060 .- 1997-003X. ; 13:1, s. 878-891
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Journal article (peer-reviewed)abstract
- Reliable prediction of evaporative losses from reservoirs is an essential component of reservoir management and operation. Conventional models generally used for evaporation prediction have a number of drawbacks as they are based on several assumptions. A novel approach called the co-active neuro-fuzzy inference system (CANFIS) is proposed in this study for the modeling of evaporation from meteorological variables. CANFIS provides a center-weighted set rather than global weight sets for predictor–predictand relationship mapping and thus it can provide a higher prediction accuracy. In the present study, adjustments are made in the back-propagation algorithm of CANFIS for automatic updating of membership rules and further enhancement of its prediction accuracy. The predictive ability of the CANFIS model is validated with three well-established artificial intelligence (AI) models. Different statistical metrics are computed to investigate the prediction efficacy. The results reveal higher accuracy of the CANFIS model in predicting evaporation compared to the other AI models. CANFIS is found to be capable of modeling evaporation from mean temperature and relative humidity only, with a Nash–Sutcliffe efficiency of 0.93, which is much higher than that of the other models. Furthermore, CANFIS improves the prediction accuracy by 9.2–55.4% compared to the other AI models.
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| 40. |
- Salmeron, C., et al.
(author)
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Roles of leptin and ghrelin in adipogenesis and lipid metabolism of rainbow trout adipocytes in vitro
- 2015
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In: Comparative Biochemistry and Physiology a-Molecular & Integrative Physiology. - : Elsevier BV. - 1095-6433. ; 188, s. 40-48
-
Journal article (peer-reviewed)abstract
- Leptin and ghrelin are important regulators of energy homeostasis in mammals, whereas their physiological-roles in fish have not been fully elucidated. In the present study, the effects of leptin and ghrelin on adipogenesis, lipolysis and on expression of lipid metabolism-related genes were examined in rainbow trout adipocytes in vitro. Leptin expression and release increased from preadipocytes to mature adipocytes in culture, but did not affect the process of adipogenesis. While ghrelin and its receptor were identified in cultured differentiated adipocytes, ghrelin did not influence either preadipocyte proliferation or differentiation, indicating that it may have other adipose-related roles. Leptin and ghrelin increased lipolysis in mature freshly isolated adipocytes, but mRNA expression of lipolysis markers was not significantly modified. Leptin significantly suppressed the fatty acid transporter-1 expression, suggesting a decrease in fatty acid uptake and storage, but did not affect expression of any of the lipogenesis or beta-oxidation genes studied. Ghrelin significantly increased the mRNA levels of lipoprotein lipase, fatty acid synthase and peroxisome proliferator-activated receptor-beta, and thus appears to stimulate synthesis of triglycerides as well as their mobilization. Overall, the study indicates that ghrelin, but not leptin seems to be an enhancer of lipid turn-over in adipose tissue of rainbow trout, and this regulation may at least partly be mediated through autocrine/paracrine mechanisms. The mode of action of both hormones needs to be further explored to better understand their roles in regulating adiposity in fish. (C) 2015 Elsevier Inc. All rights reserved.
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| 41. |
- Tao, Hai, et al.
(author)
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Global solar radiation prediction over North Dakota using air temperature : Development of novel hybrid intelligence model
- 2021
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In: Energy Reports. - Netherland : Elsevier. - 2352-4847. ; 7, s. 136-157
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Journal article (peer-reviewed)abstract
- Accurate solar radiation (SR) prediction is one of the essential prerequisites of harvesting solar energy. The current study proposed a novel intelligence model through hybridization of Adaptive Neuro-Fuzzy Inference System (ANFIS) with two metaheuristic optimization algorithms, Salp Swarm Algorithm (SSA) and Grasshopper Optimization Algorithm (GOA) (ANFIS-muSG) for global SR prediction at different locations of North Dakota, USA. The performance of the proposed ANFIS-muSG model was compared with classical ANFIS, ANFIS-GOA, ANFIS-SSA, ANFIS-Grey Wolf Optimizer (ANFIS-GWO), ANFIS-Particle Swarm Optimization (ANFIS-PSO), ANFIS-Genetic Algorithm (ANFIS-GA) and ANFISDragonfly Algorithm (ANFIS-DA). Consistent maximum, mean and minimum air temperature data for nine years (2010–2018) were used to build the models. ANFIS-muSG showed 25.7%–54.8% higher performance accuracy in terms of root mean square error compared to other models at different locations of the study areas. The model developed in this study can be employed for SR prediction from temperature only. The results indicate the potential of hybridization of ANFIS with the metaheuristic optimization algorithms for improvement of prediction ccuracy.
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