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- Beral, V, et al.
(author)
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Alcohol, tobacco and breast cancer - collaborative reanalysis of individual data from 53 epidemiological studies, including 58515 women with breast cancer and 95067 women without the disease
- 2002
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In: British Journal of Cancer. - : Springer Science and Business Media LLC. - 1532-1827 .- 0007-0920. ; 87, s. 1234-45
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Journal article (peer-reviewed)abstract
- Alcohol and tobacco consumption are closely correlated and published results on their association with breast cancer have not always allowed adequately for confounding between these exposures. Over 80% of the relevant information worldwide on alcohol and tobacco consumption and breast cancer were collated, checked and analysed centrally. Analyses included 58515 women with invasive breast cancer and 95067 controls from 53 studies. Relative risks of breast cancer were estimated, after stratifying by study, age, parity and, where appropriate, women's age when their first child was born and consumption of alcohol and tobacco. The average consumption of alcohol reported by controls from developed countries was 6.0 g per day, i.e. about half a unit/drink of alcohol per day, and was greater in ever-smokers than never-smokers, (8.4 g per day and 5.0 g per day, respectively). Compared with women who reported drinking no alcohol, the relative risk of breast cancer was 1.32 (1.19 - 1.45, P < 0.00001) for an intake of 35 - 44 g per day alcohol, and 1.46 (1.33 - 1.61, P < 0.00001) for greater than or equal to 45 g per day alcohol. The relative risk of breast cancer increased by 7.1% (95% CI 5.5-8.7%; P<0.00001) for each additional 10 g per day intake of alcohol, i.e. for each extra unit or drink of alcohol consumed on a daily basis. This increase was the same in ever-smokers and never-smokers (7.1 % per 10 g per day, P < 0.00001, in each group). By contrast, the relationship between smoking and breast cancer was substantially confounded by the effect of alcohol. When analyses were restricted to 22 255 women with breast cancer and 40 832 controls who reported drinking no alcohol, smoking was not associated with breast cancer (compared to never-smokers, relative risk for ever-smokers= 1.03, 95% CI 0.98 - 1.07, and for current smokers=0.99, 0.92 - 1.05). The results for alcohol and for tobacco did not vary substantially across studies, study designs, or according to 15 personal characteristics of the women; nor were the findings materially confounded by any of these factors. If the observed relationship for alcohol is causal, these results suggest that about 4% of the breast cancers in developed countries are attributable to alcohol. In developing countries, where alcohol consumption among controls averaged only 0.4 g per day, alcohol would have a negligible effect on the incidence of breast cancer. In conclusion, smoking has little or no independent effect on the risk of developing breast cancer; the effect of alcohol on breast cancer needs to be interpreted in the context of its beneficial effects, in moderation, on cardiovascular disease and its harmful effects on cirrhosis and cancers of the mouth, larynx, oesophagus and liver. (C) 2002 Cancer Research UK.
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- Kinyoki, DK, et al.
(author)
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Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017
- 2020
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In: Nature medicine. - : Springer Science and Business Media LLC. - 1546-170X .- 1078-8956. ; 26:5, s. 750-759
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Journal article (peer-reviewed)abstract
- A double burden of malnutrition occurs when individuals, household members or communities experience both undernutrition and overweight. Here, we show geospatial estimates of overweight and wasting prevalence among children under 5 years of age in 105 low- and middle-income countries (LMICs) from 2000 to 2017 and aggregate these to policy-relevant administrative units. Wasting decreased overall across LMICs between 2000 and 2017, from 8.4% (62.3 (55.1–70.8) million) to 6.4% (58.3 (47.6–70.7) million), but is predicted to remain above the World Health Organization’s Global Nutrition Target of <5% in over half of LMICs by 2025. Prevalence of overweight increased from 5.2% (30 (22.8–38.5) million) in 2000 to 6.0% (55.5 (44.8–67.9) million) children aged under 5 years in 2017. Areas most affected by double burden of malnutrition were located in Indonesia, Thailand, southeastern China, Botswana, Cameroon and central Nigeria. Our estimates provide a new perspective to researchers, policy makers and public health agencies in their efforts to address this global childhood syndemic.
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- Stanaway, Jeffrey D., et al.
(author)
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Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990-2017: A systematic analysis for the Global Burden of Disease Study 2017
- 2018
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In: The Lancet. - 1474-547X .- 0140-6736. ; 392:10159, s. 1923-1994
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Journal article (peer-reviewed)abstract
- Background The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 comparative risk assessment (CRA) is a comprehensive approach to risk factor quantification that offers a useful tool for synthesising evidence on risks and risk-outcome associations. With each annual GBD study, we update the GBD CRA to incorporate improved methods, new risks and risk-outcome pairs, and new data on risk exposure levels and risk- outcome associations. Methods We used the CRA framework developed for previous iterations of GBD to estimate levels and trends in exposure, attributable deaths, and attributable disability-adjusted life-years (DALYs), by age group, sex, year, and location for 84 behavioural, environmental and occupational, and metabolic risks or groups of risks from 1990 to 2017. This study included 476 risk-outcome pairs that met the GBD study criteria for convincing or probable evidence of causation. We extracted relative risk and exposure estimates from 46 749 randomised controlled trials, cohort studies, household surveys, census data, satellite data, and other sources. We used statistical models to pool data, adjust for bias, and incorporate covariates. Using the counterfactual scenario of theoretical minimum risk exposure level (TMREL), we estimated the portion of deaths and DALYs that could be attributed to a given risk. We explored the relationship between development and risk exposure by modelling the relationship between the Socio-demographic Index (SDI) and risk-weighted exposure prevalence and estimated expected levels of exposure and risk-attributable burden by SDI. Finally, we explored temporal changes in risk-attributable DALYs by decomposing those changes into six main component drivers of change as follows: (1) population growth; (2) changes in population age structures; (3) changes in exposure to environmental and occupational risks; (4) changes in exposure to behavioural risks; (5) changes in exposure to metabolic risks; and (6) changes due to all other factors, approximated as the risk-deleted death and DALY rates, where the risk-deleted rate is the rate that would be observed had we reduced the exposure levels to the TMREL for all risk factors included in GBD 2017.
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- ASZTALOS, SJ, et al.
(author)
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CONFIRMATION OF THE SUPERDEFORMED BAND IN PB-192
- 1995
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In: Zeitschrift für Physik A Hadrons and Nuclei. - 0939-7922 .- 1431-5831. ; 352:3, s. 239-240
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Journal article (peer-reviewed)abstract
- High-spin states in Pb-192 were populated via the reaction Yb-173(Mg-24,5n) at a beam energy of 140 MeV, and the resulting gamma-rays were deteced using GAMMA-SPHERE. A previously observed superdeformed band in Pb-192 has been confirmed.
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| 23. |
- BERNSTEIN, LA, et al.
(author)
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ONSET OF COLLECTIVITY IN NEUTRON-DEFICIENT PO-196,PO-198
- 1995
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In: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 52:2, s. 621-627
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Journal article (peer-reviewed)abstract
- We have studied via in-beam gamma-ray spectroscopy Po-196 and Po-198, which are the first neutron-deficient Po isotopes to exhibit a collective low-lying structure. The ratios of yrast state energies and the E2 branching ratios of transitions from non-yrast to yrast states are indicative of a low-lying vibrational structure. The onset of collective motion in these isotopes can be attributed to the opening of the neutron i(13/2) orbital at N approximate to 112 and the resulting large overlap between the two valence protons in the h(9/2) orbital and the valence neutrons in the i(13/2) orbital.
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| 24. |
- BERNSTEIN, LA, et al.
(author)
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SUPERDEFORMATION IN ER-154
- 1995
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In: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 52:3, s. R1171-R1174
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Journal article (peer-reviewed)abstract
- A superdeformed (SD) band consisting of 13 gamma-ray transitions has been observed in Er-154, an isotone of Dy-152(66). The experiment was performed using the Sn-118(Ar-40,4n) reaction at E(Ar-40)=185 MeV and the early implementation of GAMMASPHERE. This is an observation of a SD band in the A approximate to 150 region with a proton number greater than 66. The J((2)) moment of inertia of the band is constant above ($) over bar h omega=0.45 MeV and shows a sharp rise below this value suggesting a paired band crossing. These results suggest that total Routhian surface calculations fail to accurately predict the deformation of the band.
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- HENRY, EA, et al.
(author)
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COLLECTIVE OBLATE BANDS IN PB NUCLEI
- 1993
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In: Abstracts of Papers of the American Chemical Society. - 0065-7727. ; 206, s. 58-NUCL
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Journal article (peer-reviewed)
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| 37. |
- HUGHES, JR, et al.
(author)
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EXCITATIONS IN DOUBLY-MAGIC SUPERDEFORMED PB-194
- 1994
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In: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 50:3, s. R1265-R1269
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Journal article (peer-reviewed)abstract
- A new superdeformed band with an intensity similar to 5% relative to the yrast superdeformed band has been observed in Pb-194. Evidence for a second new band corresponding to the signature partner is also presented. These bands were observed with GAMMASPHERE early implementation via the Yb-174(Mg-25, 5n) reaction at a beam energy of 130 MeV. The rotational characteristics of the new bands suggest an interpretation involving particle-hole excitations in the doubly-magic Pb-194 superdeformed core. The results are compared to neighboring nuclei and recent theoretical calculations, and possible configurations are suggested.
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| 38. |
- HUGHES, JR, et al.
(author)
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LIFETIME MEASUREMENTS IN THE REGULAR DELTA-I = 1 OBLATE BAND IN PB-197
- 1993
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In: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 48:5, s. R2135-R2139
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Journal article (peer-reviewed)abstract
- Lifetimes of states in the regular DELTAI = 1 band in 197Pb have been measured with the Doppler-shift attenuation method. Excited states in 197Pb were populated using the Sm-154(48Ca, 5n) reaction at E(b) = 210 MeV. The target consisted of 1 mg/cm2 Sm-154 evaporated onto a 10 mg/cm2 Au backing. Discernible lineshapes for gamma rays in the energy range 300 < E(gamma) < 500 keV in the regular band were observed in a spectroscopic study with the 20 Ge-detector array, HERA. Level lifetimes were obtained from a lineshape analysis. Averaged reduced transition strengths, B(M1) approximately 1.7 W.u. and B(E2) approximately 18 W.u., are deduced and these are compared with theoretical predictions for the suggested configuration of this band.
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