| 1. |
- Tran, K. B., et al.
(author)
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The global burden of cancer attributable to risk factors, 2010-19: a systematic analysis for the Global Burden of Disease Study 2019
- 2022
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In: Lancet. - 0140-6736. ; 400:10352, s. 563-591
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Journal article (peer-reviewed)abstract
- Background Understanding the magnitude of cancer burden attributable to potentially modifiable risk factors is crucial for development of effective prevention and mitigation strategies. We analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 to inform cancer control planning efforts globally. Methods The GBD 2019 comparative risk assessment framework was used to estimate cancer burden attributable to behavioural, environmental and occupational, and metabolic risk factors. A total of 82 risk-outcome pairs were included on the basis of the World Cancer Research Fund criteria. Estimated cancer deaths and disability-adjusted life-years (DALYs) in 2019 and change in these measures between 2010 and 2019 are presented. Findings Globally, in 2019, the risk factors included in this analysis accounted for 4.45 million (95% uncertainty interval 4.01-4.94) deaths and 105 million (95.0-116) DALYs for both sexes combined, representing 44.4% (41.3-48.4) of all cancer deaths and 42.0% (39.1-45.6) of all DALYs. There were 2.88 million (2.60-3.18) risk-attributable cancer deaths in males (50.6% [47.8-54.1] of all male cancer deaths) and 1.58 million (1.36-1.84) risk-attributable cancer deaths in females (36.3% [32.5-41.3] of all female cancer deaths). The leading risk factors at the most detailed level globally for risk-attributable cancer deaths and DALYs in 2019 for both sexes combined were smoking, followed by alcohol use and high BMI. Risk-attributable cancer burden varied by world region and Socio-demographic Index (SDI), with smoking, unsafe sex, and alcohol use being the three leading risk factors for risk-attributable cancer DALYs in low SDI locations in 2019, whereas DALYs in high SDI locations mirrored the top three global risk factor rankings. From 2010 to 2019, global risk-attributable cancer deaths increased by 20.4% (12.6-28.4) and DALYs by 16.8% (8.8-25.0), with the greatest percentage increase in metabolic risks (34.7% [27.9-42.8] and 33.3% [25.8-42.0]). Interpretation The leading risk factors contributing to global cancer burden in 2019 were behavioural, whereas metabolic risk factors saw the largest increases between 2010 and 2019. Reducing exposure to these modifiable risk factors would decrease cancer mortality and DALY rates worldwide, and policies should be tailored appropriately to local cancer risk factor burden. Copyright (C) 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.
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| 4. |
- Bryazka, D., et al.
(author)
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Population-level risks of alcohol consumption by amount, geography, age, sex, and year: a systematic analysis for the Global Burden of Disease Study 2020
- 2022
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In: Lancet. - 0140-6736. ; 400:10347, s. 185-235
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Journal article (peer-reviewed)abstract
- Background The health risks associated with moderate alcohol consumption continue to be debated. Small amounts of alcohol might lower the risk of some health outcomes but increase the risk of others, suggesting that the overall risk depends, in part, on background disease rates, which vary by region, age, sex, and year. Methods For this analysis, we constructed burden-weighted dose-response relative risk curves across 22 health outcomes to estimate the theoretical minimum risk exposure level (TMREL) and non-drinker equivalence (NDE), the consumption level at which the health risk is equivalent to that of a non-drinker, using disease rates from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2020 for 21 regions, including 204 countries and territories, by 5-year age group, sex, and year for individuals aged 15-95 years and older from 1990 to 2020. Based on the NDE, we quantified the population consuming harmful amounts of alcohol. Findings The burden-weighted relative risk curves for alcohol use varied by region and age. Among individuals aged 15-39 years in 2020, the TMREL varied between 0 (95% uncertainty interval 0-0) and 0.603 (0.400-1.00) standard drinks per day, and the NDE varied between 0.002 (0-0) and 1.75 (0.698-4.30) standard drinks per day. Among individuals aged 40 years and older, the burden-weighted relative risk curve was J-shaped for all regions, with a 2020 TMREL that ranged from 0.114 (0-0.403) to 1.87 (0.500-3.30) standard drinks per day and an NDE that ranged between 0.193 (0-0.900) and 6.94 (3.40-8.30) standard drinks per day. Among individuals consuming harmful amounts of alcohol in 2020, 59.1% (54.3-65.4) were aged 15-39 years and 76.9% (7.0-81.3) were male. Interpretation There is strong evidence to support recommendations on alcohol consumption varying by age and location. Stronger interventions, particularly those tailored towards younger individuals, are needed to reduce the substantial global health loss attributable to alcohol. Copyright (C) 2022 The Author(s). Published by Elsevier Ltd.
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| 7. |
- Sheena, B. S., et al.
(author)
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Global, regional, and national burden of hepatitis B, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019
- 2022
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In: Lancet Gastroenterology & Hepatology. - : Elsevier BV. - 2468-1253. ; 7:9, s. 796-829
-
Journal article (peer-reviewed)abstract
- Background Combating viral hepatitis is part of the UN Sustainable Development Goals (SDGs), and WHO has put forth hepatitis B elimination targets in its Global Health Sector Strategy on Viral Hepatitis (WHO-GHSS) and Interim Guidance for Country Validation of Viral Hepatitis Elimination (WHO Interim Guidance). We estimated the global, regional, and national prevalence of hepatitis B virus (HBV), as well as mortality and disability-adjusted life-years (DALYs) due to HBV, as part of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019. This included estimates for 194 WHO member states, for which we compared our estimates to WHO elimination targets. Methods The primary data sources were population-based serosurveys, claims and hospital discharges, cancer registries, vital registration systems, and published case series. We estimated chronic HBV infection and the burden of HBV-related diseases, defined as an aggregate of cirrhosis due to hepatitis B, liver cancer due to hepatitis B, and acute hepatitis B. We used DisMod-MR 2.1, a Bayesian mixed-effects meta-regression tool, to estimate the prevalence of chronic HBV infection, cirrhosis, and aetiological proportions of cirrhosis. We used mortality-to-incidence ratios modelled with spatiotemporal Gaussian process regression to estimate the incidence of liver cancer. We used the Cause of Death Ensemble modelling (CODEm) model, a tool that selects models and covariates on the basis of out-ofsample performance, to estimate mortality due to cirrhosis, liver cancer, and acute hepatitis B. Findings In 2019, the estimated global, all-age prevalence of chronic HBV infection was 4 center dot 1% (95% uncertainty interval [UI] 3 center dot 7 to 4 center dot 5), corresponding to 316 million (284 to 351) infected people. There was a 31 center dot 3% (29 center dot 0 to 33 center dot 9) decline in all-age prevalence between 1990 and 2019, with a more marked decline of 76 center dot 8% (76 center dot 2 to 77 center dot 5) in prevalence in children younger than 5 years. HBV-related diseases resulted in 555 000 global deaths (487 000 to 630 000) in 2019. The number of HBV-related deaths increased between 1990 and 2019 (by 5 center dot 9% [-5 center dot 6 to 19 center dot 2]) and between 2015 and 2019 (by 2 center dot 9% [-5 center dot 9 to 11 center dot 3]). By contrast, all-age and age-standardised death rates due to HBV-related diseases decreased during these periods. We compared estimates for 2019 in 194 WHO locations to WHO-GHSS 2020 targets, and found that four countries achieved a 10% reduction in deaths, 15 countries achieved a 30% reduction in new cases, and 147 countries achieved a 1% prevalence in children younger than 5 years. As of 2019, 68 of 194 countries had already achieved the 2030 target proposed in WHO Interim Guidance of an all-age HBV-related death rate of four per 100 000. Interpretation The prevalence of chronic HBV infection declined over time, particularly in children younger than 5 years, since the introduction of hepatitis B vaccination. HBV-related death rates also decreased, but HBV-related death counts increased as a result of population growth, ageing, and cohort effects. By 2019, many countries had met the interim seroprevalence target for children younger than 5 years, but few countries had met the WHO-GHSS interim targets for deaths and new cases. Progress according to all indicators must be accelerated to meet 2030 targets, and there are marked disparities in burden and progress across the world. HBV interventions, such as vaccination, testing, and treatment, must be strategically supported and scaled up to achieve elimination.
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| 8. |
- Burstein, R., et al.
(author)
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Mapping 123 million neonatal, infant and child deaths between 2000 and 2017
- 2019
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In: Nature. - : Nature Publishing Group. - 0028-0836 .- 1476-4687. ; 574:7778, s. 353-358
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Journal article (peer-reviewed)abstract
- Since 2000, many countries have achieved considerable success in improving child survival, but localized progress remains unclear. To inform efforts towards United Nations Sustainable Development Goal 3.2—to end preventable child deaths by 2030—we need consistently estimated data at the subnational level regarding child mortality rates and trends. Here we quantified, for the period 2000–2017, the subnational variation in mortality rates and number of deaths of neonates, infants and children under 5 years of age within 99 low- and middle-income countries using a geostatistical survival model. We estimated that 32% of children under 5 in these countries lived in districts that had attained rates of 25 or fewer child deaths per 1,000 live births by 2017, and that 58% of child deaths between 2000 and 2017 in these countries could have been averted in the absence of geographical inequality. This study enables the identification of high-mortality clusters, patterns of progress and geographical inequalities to inform appropriate investments and implementations that will help to improve the health of all populations. © 2019, The Author(s).
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| 13. |
- Menden, MP, et al.
(author)
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Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen
- 2019
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In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1, s. 2674-
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Journal article (peer-reviewed)abstract
- The effectiveness of most cancer targeted therapies is short-lived. Tumors often develop resistance that might be overcome with drug combinations. However, the number of possible combinations is vast, necessitating data-driven approaches to find optimal patient-specific treatments. Here we report AstraZeneca’s large drug combination dataset, consisting of 11,576 experiments from 910 combinations across 85 molecularly characterized cancer cell lines, and results of a DREAM Challenge to evaluate computational strategies for predicting synergistic drug pairs and biomarkers. 160 teams participated to provide a comprehensive methodological development and benchmarking. Winning methods incorporate prior knowledge of drug-target interactions. Synergy is predicted with an accuracy matching biological replicates for >60% of combinations. However, 20% of drug combinations are poorly predicted by all methods. Genomic rationale for synergy predictions are identified, including ADAM17 inhibitor antagonism when combined with PIK3CB/D inhibition contrasting to synergy when combined with other PI3K-pathway inhibitors in PIK3CA mutant cells.
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| 16. |
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| 17. |
- Ruggeri, Kai, et al.
(author)
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The globalizability of temporal discounting
- 2022
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In: Nature Human Behaviour. - : Springer Nature. - 2397-3374. ; 6:10, s. 1386-1397
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Journal article (peer-reviewed)abstract
- Economic inequality is associated with preferences for smaller, immediate gains over larger, delayed ones. Such temporal discounting may feed into rising global inequality, yet it is unclear whether it is a function of choice preferences or norms, or rather the absence of sufficient resources for immediate needs. It is also not clear whether these reflect true differences in choice patterns between income groups. We tested temporal discounting and five intertemporal choice anomalies using local currencies and value standards in 61 countries (N = 13,629). Across a diverse sample, we found consistent, robust rates of choice anomalies. Lower-income groups were not significantly different, but economic inequality and broader financial circumstances were clearly correlated with population choice patterns. Ruggeri et al. find in a study of 61 countries that temporal discounting patterns are globally generalizable. Worse financial environments, greater inequality and high inflation are associated with extreme or inconsistent long-term decisions.
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| 18. |
- Bagheri, Z., et al.
(author)
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Cross-cultural measurement invariance of the Quality of Life Enjoyment and Satisfaction Questionnaire-Short form across ten countries: the application of Bayesian approximate measurement invariance
- 2022
-
In: Bmc Psychology. - : Springer Science and Business Media LLC. - 2050-7283. ; 10:1
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Journal article (peer-reviewed)abstract
- Background: The Quality of Life Enjoyment and Satisfaction Questionnaire-Short Form (Q-LES-Q-SF) is the most frequently used generic quality of life (QOL) measure in many countries and cultures worldwide. However, no single study has been carried out to investigate whether this questionnaire performs similarly across diverse cultures/countries. Accordingly, this study aimed to assess the cross-cultural measurement invariance of the Q-LES-Q-SF across ten different countries. Methods: The Q-LES-Q-SF was administrated to a sample of 2822 university students from ten countries: Bangladesh, Brazil, Croatia, India, Nepal, Poland, Serbia, Turkey, the United Arab Emirates, and Vietnam. The Bayesian approximate measurement invariance approach was used to assess the measurement invariance of the Q-LES-Q-SF. Results: Approximate measurement invariance did not hold across the countries for the Q-LES-Q-SF, with only two out of 14 items being non-invariant; namely items related to doing household and leisure time activities. Conclusions: Our findings did not support the cross-cultural measurement invariance of the Q-LES-Q-SF; thus, considerable caution is warranted when comparing QOL scores across different countries with this measure. Item rewording and adaptation along with calibrating non-invariant items may narrow these differences and help researchers to create an invariant questionnaire for reliable and valid QOL comparisons across different countries.
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| 23. |
- Bafekry, A., et al.
(author)
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A novel two-dimensional boron-carbon-nitride (BCN) monolayer: A first-principles insight
- 2021
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In: Journal of Applied Physics. - : AIP Publishing. - 0021-8979 .- 1089-7550. ; 130:11
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Journal article (peer-reviewed)abstract
- The optical, electronic, and structural properties of a theoretically predicted new boron-carbon-nitride (BCN) two-dimensional monolayer have been explored using density functional theory calculations. The phonon dispersion, molecular dynamics simulation, the cohesive energy, and the Born criteria of elastic constant calculations of the BCN monolayer confirm its stability. The phonon spectrum illustrates an out-of-plane flexure mode with quadratic dispersion in the long-wavelength limit. The BCN monolayer is a semiconductor with a direct bandgap of 0.9 (1.63) eV determined via the Perdew-Burke-Ernzerhof (Heyd-Scuseria-Ernzerhof) functional. The same electron and hole effective masses and mobility values indicate the high recombination rate of electrons and holes. Meanwhile, the BCN monolayer can absorb ultraviolet radiation more effectively than visible light. Due to its interesting physical properties, the novel BCN monolayer could be a rather good candidate material for electro-optical applications.& nbsp;Published under an exclusive license by AIP Publishing
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| 24. |
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| 25. |
- Bafekry, A., et al.
(author)
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Tunable electronic properties of porous graphitic carbon nitride (C6N7) monolayer by atomic doping and embedding: A first-principle study
- 2022
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In: Applied Surface Science. - : ELSEVIER. - 0169-4332 .- 1873-5584. ; 583
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Journal article (peer-reviewed)abstract
- Motivated by the successful synthesis of the porous graphitic carbon nitride (C6N7) monolayer very recently, we investigate the structural and electronic properties of C6N7 with doped and embedded with various atoms by means of spin-polarized density functional theory calculations. C6N7 monolayers doped with B, N, C, and O atoms have been revealed as stable and predicted to be feasible for experimental fabrication as free-standing monolayers based on the energy and thermal stability. Our computations demonstrate that while the C6N7 is a semiconductor, the doped C6N7 monolayers can be metal, dilute-magnetic semiconductor or half-metal. Further, a non magnetic moment is discovered in three of the doped C6N7 models and their electronic properties are disclosed to depend strongly on the spin configurations. The electronic properties of C6N7 depend on the doping atoms and doping sites. Furthermore, the effect of embedding of common nonmetal atoms such as B, C, N, S, O, Al, Si and P as well as transition metal including Sc, Ti, V, Cr, Mn, Fe, Co, Ni, Cu and Zn atoms on the electronic and magnetic behavior of the C6N7 are studied. The charge transfer analysis shows that all embedded atoms act as electron donors, expect N, O and S atoms which act as electron acceptors when interacting with C6N7. The modification of the electronic band structure of C6N7 as the underlying mechanism for the changes in its electronic properties has been investigated. The intention is to demonstrate how entering the above mentioned impurities changes the nature of C6N7 into a metal, ferromagnetic-metal or dilute-magnetic semiconductor. These findings give not only an insight into the physical properties of doped and embedded C6N7 monolayer by different atoms, but also can serve as a guide to discover future possible applications of this novel material.
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| 26. |
- Bafekry, A., et al.
(author)
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Van der Waals heterostructure of graphene and germanane: tuning the ohmic contact by electrostatic gating and mechanical strain
- 2021
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In: Physical Chemistry, Chemical Physics - PCCP. - : Royal Society of Chemistry. - 1463-9076 .- 1463-9084. ; 23:37, s. 21196-21206
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Journal article (peer-reviewed)abstract
- Recent exciting developments in synthesis and properties study of the Germanane (GeH) monolayer have inspired us to investigate the structural and electronic properties of the van der Waals GeH/Graphene (Gr) heterostructure by the first-principle approach. The stability of the GeH/Gr heterostructure is verified by calculating the phonon dispersion curves as well as by thermodynamic binding energy calculations. According to the band structure calculation, the GeH/Gr interface is n-type Ohmic. The effects of different interlayer distances and strains between the layers and the applied electric field on the interface have been investigated to gain insight into the van der Waals heterostructure modifications. An interlayer distance of 2.11 angstrom and compressive strain of 6% alter the contact from Ohmic to Schottky status, while the electric field can tune the GeH/Gr contact as p- or n-type, Ohmic, or Schottky. The average electrostatic potential of GeH/Gr and the Bader charge analysis have been used to explain the results obtained. Our theoretical study could provide a promising approach for improving the electronic performance of GeH/Gr-based nano-rectifiers.
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| 27. |
- Baghbanan, A., et al.
(author)
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Block stability analysis around a large cavern using probabilistic approach
- 2010
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In: Rock Engineering in Difficult Ground Conditions - Soft Rocks and Karst - Proceedings of the Regional Symposium of the International Society for Rock Mechanics, EUROCK 2009. - 9780415804813 ; , s. 435-440
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Conference paper (peer-reviewed)abstract
- Block stability analysis around a large excavation is analyzed with both Probabilistic Kinematics Limit Equilibrium (PKLE) and Discrete Fracture Network-Distinct Element Method (DFNDEM) approaches. Different combination of geometric parameters of fracture sets are selected in PKLE method and a series of numerical DEM modeling are performed on generated and validated DFN models in DFN-DEM approach to measure volume of potential unstable blocks and also minimum required support patterns. The mean volume of unstable blocks for PKLE with limited joint length assumption is fairly close to DFN models and they are far from mean value of PKLE when the joint length is extended infinitely. The minimum required support pattern for PKLE is smaller than DEM models which means that the PKLE design tool is underestimated compared with DFN-DEM method which benefits more realistic conceptual model and facilitates more sophisticate simulation tool.
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| 28. |
- Bagheri, M., et al.
(author)
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Runtime compositional analysis of track-based traffic control systems
- 2017
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In: ACM SIGBED Review. - : Association for Computing Machinery (ACM). - 1551-3688. ; 14:3, s. 38-39
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Journal article (peer-reviewed)abstract
- In this paper we address the development of dependable self-adaptive systems focusing on the specific domain of track-based traffic control systems where timing issues are critical.
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| 29. |
- Bagheri, Shervin, et al.
(author)
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Spontaneous symmetry breaking of a hinged flapping filament generates lift
- 2012
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In: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 109:15, s. 154502-
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Journal article (peer-reviewed)abstract
- Elastic filamentous structures found on swimming and flying organisms are versatile in function, rendering their precise contribution to locomotion difficult to assess. We show in this Letter that a single passive filament hinged on the rear of a bluff body placed in a stream can generate a net lift force without increasing the mean drag force on the body. This is a consequence of spontaneous symmetry breaking in the filament's flapping dynamics. The phenomenon is related to a resonance between the frequency associated with the von Kármán vortex street developing behind the bluff body and the natural frequency of the free bending vibrations of the filament.
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| 35. |
- Abdelraheem, Mohamed Ahmed, et al.
(author)
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Improved Linear Cryptanalysis of reduced-round SIMON-32 and SIMON-48
- 2015
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In: Progress in Cryptology - INDOCRYPT 2015. - Cham : Springer International Publishing. - 9783319266169 - 9783319266176 ; , s. 153-179
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Conference paper (peer-reviewed)abstract
- In this paper we analyse two variants of SIMON family of light-weight block ciphers against linear cryptanalysis and present the best linear cryptanalytic results on these variants of reduced-round SIMON to date. We propose a time-memory trade-off method that finds differential/linear trails for any permutation allowing low Hamming weight differential/linear trails. Our method combines low Hamming weight trails found by the correlation matrix representing the target permutation with heavy Hamming weight trails found using a Mixed Integer Programming model representing the target differential/linear trail. Our method enables us to find a 17-round linear approximation for SIMON-48 which is the best current linear approximation for SIMON-48. Using only the correlation matrix method, we are able to find a 14-round linear approximation for SIMON-32 which is also the current best linear approximation for SIMON-32. The presented linear approximations allow us to mount a 23-round key recovery attack on SIMON-32 and a 24-round Key recovery attack on SIMON-48/96 which are the current best results on SIMON-32 and SIMON-48. In addition we have an attack on 24 rounds of SIMON-32 with marginal complexity.
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| 36. |
- Alinejad, M., et al.
(author)
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Lignin-based polyurethanes : Opportunities for bio-based foams, elastomers, coatings and adhesives
- 2019
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In: Polymers. - : MDPI. - 2073-4360. ; 11:7
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Journal article (peer-reviewed)abstract
- Polyurethane chemistry can yield diverse sets of polymeric materials exhibiting a widerange of properties for various applications and market segments. Utilizing lignin as a polyol presentsan opportunity to incorporate a currently underutilized renewable aromatic polymer into theseproducts. In this work, we will review the current state of technology for utilizing lignin as a polyolreplacement in different polyurethane products. This will include a discussion of lignin structure,diversity, and modification during chemical pulping and cellulosic biofuels processes, approachesfor lignin extraction, recovery, fractionation, and modification/functionalization. We will discussthe potential of incorporation of lignins into polyurethane products that include rigid and flexiblefoams, adhesives, coatings, and elastomers. Finally, we will discuss challenges in incorporating ligninin polyurethane formulations, potential solutions and approaches that have been taken to resolvethose issues.
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| 37. |
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| 38. |
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| 39. |
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| 40. |
- Bagheri, B., et al.
(author)
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Comparsion study of different simulation codes for positive streamers
- 2017
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In: Proceedings of the International Conference on Phenomena in Ionized Gases (ICPIG).
-
Conference paper (other academic/artistic)abstract
- For streamer simulations a range of computational models have been developed by various groups for various purposes. These models differ in dimensionality (2D, 3D), model type (particle, fluid or hybrid approach and further differentiation), their numerical implementation, type of grid and its refinement, and their spatial/temporal discretization. The aim of the present study is to benchmark the results of different simulation codes for axisymmetric single positive streamers in air at 1 bar and 300 K using a fluid model.
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| 41. |
- Bagheri, Maryam, et al.
(author)
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Coordinated actor model of self-adaptive track-based traffic control systems
- 2018
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In: Journal of Systems and Software. - : Elsevier. - 0164-1212 .- 1873-1228. ; 143, s. 116-139
-
Journal article (peer-reviewed)abstract
- Self-adaptation is a well-known technique to handle growing complexities of software systems, where a system autonomously adapts itself in response to changes in a dynamic and unpredictable environment. With the increasing need for developing self-adaptive systems, providing a model and an implementation platform to facilitate integration of adaptation mechanisms into the systems and assuring their safety and quality is crucial. In this paper, we target Track-based Traffic Control Systems (TTCSs) in which the traffic flows through pre-specified sub-tracks and is coordinated by a traffic controller. We introduce a coordinated actor model to design self-adaptive TTCSs and provide a general mapping between various TTCSs and the coordinated actor model. The coordinated actor model is extended to build large-scale self-adaptive TTCSs in a decentralized setting. We also discuss the benefits of using Ptolemy II as a framework for model-based development of large-scale self-adaptive systems that supports designing multiple hierarchical MAPE-K feedback loops interacting with each other. We propose a template based on the coordinated actor model to design a self-adaptive TTCS in Ptolemy II that can be instantiated for various TTCSs. We enhance the proposed template with a predictive adaptation feature. We illustrate applicability of the coordinated actor model and consequently the proposed template by designing two real-life case studies in the domains of air traffic control systems and railway traffic control systems in Ptolemy II.
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| 42. |
- Bagheri, Maryam, et al.
(author)
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Coordinated actors for reliable self-adaptive systems
- 2017
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In: FACS 2016. - Cham : Springer. - 9783319576657 - 9783319576664 ; , s. 241-259
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Conference paper (peer-reviewed)abstract
- Self-adaptive systems are systems that automatically adapt in response to environmental and internal changes, such as possible failures and variations in resource availability. Such systems are often realized by a MAPE-K feedback loop, where Monitor, Analyze, Plan and Execute components have access to a runtime model of the system and environment which is kept in the Knowledge component. In order to provide guarantees on the correctness of a self-adaptive system at runtime, the MAPE-K feedback loop needs to be extended with assurance techniques. To address this issue, we propose a coordinated actor-based approach to build a reusable and scalable model@runtime for self-adaptive systems in the domain of track-based traffic control systems. We demonstrate the approach by implementing an automated Air Traffic Control system (ATC) using Ptolemy tool.We compare different adaptation policies on the ATC model based on performance metrics and analyze combination of policies in different configurations of the model. We enriched our framework with runtime performance analysis such that for any unexpected change, subsequent behavior of the model is predicted and results are used for adaptation at the change-point. Moreover, the developed framework enables checking safety properties at runtime. © Springer International Publishing AG 2017.
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| 43. |
- Bagheri, Maryam, et al.
(author)
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Lightweight Formal Method for Robust Routing in Track-based Traffic Control Systems
- 2020
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In: 2020 18TH ACM-IEEE INTERNATIONAL CONFERENCE ON FORMAL METHODS AND MODELS FOR SYSTEM DESIGN (MEMOCODE). - : IEEE. ; , s. 115-124
-
Conference paper (peer-reviewed)abstract
- In this paper, we propose a robust solution for the path planning and scheduling of the moving objects in a Track-based Traffic Control System (TTCS). The moving objects in a TTCS pass over pre-specified sub-tracks. Each sub-track accommodates at most one moving object in-transit. Due to the uncertainties in the context of a TTCS, we assign an arrival time window to each moving object for each sub-track in its route, instead of an exact value. The moving object can safely enter into the sub-track in the mentioned time window. To develop a safe plan, we adapt the tagged-signal model and provide a rigorous mathematical formalism for the actor model of a TTCS. To illustrate the applicability of the provided semantics, we provide a formal model of TTCSs in the Alloy language and use its analyzer to verify the developed model against system safety properties.
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| 44. |
- Bagheri, M., et al.
(author)
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Partial Order Reduction for Timed Actors
- 2022
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In: Lect. Notes Comput. Sci.. - Cham : Springer Science and Business Media Deutschland GmbH. - 9783030955601 ; , s. 43-60
-
Conference paper (peer-reviewed)abstract
- We propose a compositional approach for the Partial Order Reduction (POR) in the state space generation of asynchronous timed actors. We define the concept of independent actors as the actors that do not send messages to a common actor. The approach avoids exploring unnecessary interleaving of executions of independent actors. It performs on a component-based model where actors from different components, except for the actors on borders, are independent. To alleviate the effect of the cross-border messages, we enforce a delay condition, ensuring that an actor introduces a delay in its execution before sending a message across the border of its component. Within each time unit, our technique generates the state space of each individual component by taking its received messages into account. It then composes the state spaces of all components. We prove that our POR approach preserves the properties defined on timed states (states where the only outgoing transition shows the progress of time). We generate the state space of a case study in the domain of air traffic control systems based on the proposed POR. The results on our benchmarks illustrate that our POR method, on average, reduces the time and memory consumption by 76 and 34%, respectively.
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| 45. |
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| 46. |
- Bagheri, Y, et al.
(author)
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The Heterogeneous Pathogenesis of Selective Immunoglobulin A Deficiency
- 2019
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In: International archives of allergy and immunology. - : S. Karger AG. - 1423-0097 .- 1018-2438. ; 179:3, s. 231-245
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Journal article (peer-reviewed)abstract
- Selective immunoglobulin A deficiency (SIgAD) is the most prevalent type of primary immunodeficiency disorder. The phenotypic feature of SIgAD is related to a defect in B lymphocyte differentiation into plasma cell-producing immunoglobulin A (IgA). In this review, we summarize the recent advances in this regard. Genetic (including major histocompatibility complex [MHC] and non-MHC genes), immunologic (including B and T lymphocyte subsets abnormality), cytokines/chemokines and their related receptors, apoptosis and microbiota defects are reviewed. The mechanisms leading to SIgAD are most likely multifactorial and it can be speculated that several pathways controlling B cells functions or regulating epigenetic of the <i>IGHA</i> gene encoding constant region of IgA heavy chain and long-term survival of IgA switched memory B cells and plasma cells may be defective in different SIgAD patients.
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| 47. |
- Bhowmick, T., et al.
(author)
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Inertia Induces Strong Orientation Fluctuations of Nonspherical Atmospheric Particles
- 2024
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In: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 132:3
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Journal article (peer-reviewed)abstract
- The orientation of nonspherical particles in the atmosphere, such as volcanic ash and ice crystals, influences their residence times and the radiative properties of the atmosphere. Here, we demonstrate experimentally that the orientation of heavy submillimeter spheroids settling in still air exhibits decaying oscillations, whereas it relaxes monotonically in liquids. Theoretical analysis shows that these oscillations are due to particle inertia, caused by the large particle-fluid mass-density ratio. This effect must be accounted for to model solid particles in the atmosphere.
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| 48. |
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| 49. |
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| 50. |
- Keshmiri, F., et al.
(author)
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Contextualization and validation of the interprofessional collaborator assessment rubric (ICAR) through simulation : Pilot investigation.
- 2016
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In: Medical journal of the Islamic Republic of Iran. - : Iran University of Medical Sciences. - 1016-1430 .- 2251-6840. ; 30, s. 742-749
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Journal article (peer-reviewed)abstract
- BACKGROUND:Simulation can be used for educating, evaluating and assessing psychometric properties of an instrument. The aim of this study was to contextualize and assess the validity and reliability of the Interprofessional Collaborative Assessment tool (ICAR) in an Iranian context using simulation.METHODS:In this descriptive study, contextualization of the ICAR was assessed through several steps. Firstly, validity assessment was approved through expert panels and Delphi rounds. Secondly, reliability assessment was done by arranging a simulation video and assessing reproducibility, test-retest (ICC), internal consistency (Cronbach's Alpha) and inter-rater reliability (Kappa).The participants included 26 experts, 27 students and 6 staff of the Standardized Simulation Office of Teheran University of Medical Sciences.RESULTS:Contextualization and validity of the ICAR were approved in an Iranian context. The reliability of the tool was computed to be 0.71 according to Cronbach´s Alpha. The test-retest was calculated to be 0.76.CONCLUSION:The Iranian ICAR can be a useful tool for evaluating interprofessional collaborative competencies. The development of the instrument through a simulation scenario has been a positive prospect for researchers.
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