| 1. |
- Ahmad, Shahzad, et al.
(author)
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CDH6 and HAGH protein levels in plasma associate with Alzheimer’s disease in APOE ε4 carriers
- 2020
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In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 10:1
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Journal article (peer-reviewed)abstract
- Many Alzheimer’s disease (AD) genes including Apolipoprotein E (APOE) are found to be expressed in blood-derived macrophages and thus may alter blood protein levels. We measured 91 neuro-proteins in plasma from 316 participants of the Rotterdam Study (incident AD = 161) using Proximity Extension Ligation assay. We studied the association of plasma proteins with AD in the overall sample and stratified by APOE. Findings from the Rotterdam study were replicated in 186 AD patients of the BioFINDER study. We further evaluated the correlation of these protein biomarkers with total tau (t-tau), phosphorylated tau (p-tau) and amyloid-beta (Aβ) 42 levels in cerebrospinal fluid (CSF) in the Amsterdam Dementia Cohort (N = 441). Finally, we conducted a genome-wide association study (GWAS) to identify the genetic variants determining the blood levels of AD-associated proteins. Plasma levels of the proteins, CDH6 (β = 0.638, P = 3.33 × 10−4) and HAGH (β = 0.481, P = 7.20 × 10−4), were significantly elevated in APOE ε4 carrier AD patients. The findings in the Rotterdam Study were replicated in the BioFINDER study for both CDH6 (β = 1.365, P = 3.97 × 10−3) and HAGH proteins (β = 0.506, P = 9.31 × 10−7) when comparing cases and controls in APOE ε4 carriers. In the CSF, CDH6 levels were positively correlated with t-tau and p-tau in the total sample as well as in APOE ε4 stratum (P < 1 × 10−3). The HAGH protein was not detected in CSF. GWAS of plasma CDH6 protein levels showed significant association with a cis-regulatory locus (rs111283466, P = 1.92 × 10−9). CDH6 protein is implicated in cell adhesion and synaptogenesis while HAGH protein is related to the oxidative stress pathway. Our findings suggest that these pathways may be altered during presymptomatic AD and that CDH6 and HAGH may be new blood-based biomarkers.
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| 2. |
- Bakker, Marta, et al.
(author)
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Development of social perception : A conversation study of 6-, 12-and 36-month-old children
- 2011
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In: Infant Behavior and Development. - : Elsevier BV. - 0163-6383 .- 1879-0453. ; 34:2, s. 363-370
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Journal article (peer-reviewed)abstract
- A conversation is made up of visual and auditory signals in a complex flow of events. What is the relative importance of these components for young children's ability to maintain attention on a conversation? In the present set of experiments the visual and auditory signals were disentangled in four filmed events. The visual events were either accompanied by the speech sounds of the conversation or by matched motor sounds and the auditory events by either the natural visual turn taking of the conversation or a matched turn taking of toy trucks. A cornea-reflection technique was used to record the gaze-pattern of subjects while they were looking at the films. Three age groups of typically developing children were studied; 6-month-olds, 1-year-olds and 3-year-olds. The results show that the children are more attracted by the social component of the conversation independent of the kind of sound used. Older children find spoken language more interesting than motor sound. Children look longer at the speaking agent when humans maintain the conversation. The study revealed that children are more attracted to the mouth than to the eyes area. The ability to make more predictive gaze shifts develops gradually over age.
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| 3. |
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| 4. |
- Bakker, Marta, et al.
(author)
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Enhanced neural processing of goal-directed actions during active training in 4-month-old infants
- 2016
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In: Journal of cognitive neuroscience. - : MIT Press - Journals. - 0898-929X .- 1530-8898. ; 28:3, s. 472-482
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Journal article (peer-reviewed)abstract
- The current study explores the neural correlates of action perception and its relation to infants' active experience performing goal-directed actions. Study 1 provided active training with sticky mittens that enables grasping and object manipulation in prereaching 4-month-olds. After training, EEG was recorded while infants observed images of hands grasping toward (congruent) or away from (incongruent) objects. We demonstrate that brief active training facilitates social perception as indexed by larger amplitude of the P400 ERP component to congruent compared with incongruent trials. Study 2 presented 4-month-old infants with passive training in which they observed an experimenter perform goal-directed reaching actions, followed by an identical ERP session to that used in Study 1. The second study did not demonstrate any differentiation between congruent and incongruent trials. These results suggest that (1) active experience alters the brains' response to goal-directed actions performed by others and (2) visual exposure alone is not sufficient in developing the neural networks subserving goal processing during action observation in infancy.
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| 5. |
- Bakker, Marta, 1980-
(author)
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How hands shape the mind : The P400 as an index of manual actions and gesture perception
- 2018
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Doctoral thesis (other academic/artistic)abstract
- Being able to perform and understand actions is crucial for proper functioning in the social world. From birth, we use our bodies to act and to promote learning about ourselves, our environment and other people’s actions and intentions. Our mind is embodied; thus, our actions play a crucial role in cognitive and social development.This thesis focuses on the close interrelation between action and perception and the role of our hands in this link. Three empirical studies on action processing are presented in a framework of embodied cognition that emphasises the role of bodily experience in social development. All three studies were designed to measure event-related potentials (ERPs) in infants 4 to 9 months old, when they observed manual actions, grasping and the give-me gesture.Study I demonstrates the neural underpinnings of infants’ action–perception link at the age when their ability to grasp for objects in a functional manner emerges. Neural processing has been found to be influenced by infants’ own manual experience of exactly the same grasping action.Study II reveals that brief active motor training with goal-directed actions, even before the solid motor plans for grasping are developed, facilitates processing of others’ goal-directed actions.Study III shows that the same neural correlate that indexes processing of reaching actions is involved in encoding of the give-me gesture, a type of non-verbal communication that conveys a request. This ability was found not to be directly dependent on the infants’ own ability to respond behaviourally to another person’s gesture.This thesis pinpoints the neural correlate, P400, involved in the processing of goal-directed actions and gestures. The findings highlight the importance of motor experience, as well as the involvement of attentional processes in action processing. Additionally, the data from Study III may suggest a possible involvement of grasping skills in encoding non-verbal communicative gestures.
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| 6. |
- Bakker, Marta, et al.
(author)
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Neural correlates of action perception at the onset of functional grasping
- 2015
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In: Social Cognitive & Affective Neuroscience. - : Oxford University Press (OUP). - 1749-5016 .- 1749-5024. ; 10:6, s. 769-796
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Journal article (peer-reviewed)abstract
- Event-related potentials were recorded while infants observe congruent or incongruent grasping actions at the age when organized grasping first emerges (4-6 months of age). We demonstrate that the event-related potential component P400 encodes the congruency of power grasps at the age of 6 months (Experiment 1) and in 5-month-old infants that have developed the ability to use power grasps (Experiment 2). This effect does not extend to precision grasps, which infants cannot perform (Experiment 3). Our findings suggest that infants' encoding of the relationship between an object and a grasping hand (the action-perception link) is highly specialized to actions and manual configurations of actions that infants are able to perform.
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| 7. |
- Bakker, Marta, et al.
(author)
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The neural basis of non-verbal communication - enhanced processing of perceived give-me gestures in 9-month-old girls
- 2015
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In: Frontiers in Psychology. - : Frontiers Media SA. - 1664-1078. ; 6, s. 59-
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Journal article (peer-reviewed)abstract
- This study investigated the neural basis of non-verbal communication. Event-related potentials were recorded while 29 nine-month-old infants were presented with a give me gesture (experimental condition) and the same hand shape but rotated 90 degrees, resulting in a non-communicative hand configuration (control condition). We found different responses in amplitude between the two conditions, captured in the P400 ERR component. Moreover, the size of this effect was modulated by participants' sex, with girls generally demonstrating a larger relative difference between the two conditions than boys.
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| 8. |
- Chambers, John C., et al.
(author)
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Genetic loci influencing kidney function and chronic kidney disease
- 2010
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 42:5, s. 373-375
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Journal article (peer-reviewed)abstract
- Using genome-wide association, we identify common variants at 2p12-p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P = 10(-10) to 10(-15)). Of these, rs10206899 (near NAT8, 2p12-p13) and rs4805834 (near SLC7A9, 19q13) were also associated with chronic kidney disease (P = 5.0 x 10(-5) and P = 3.6 x 10(-4), respectively). Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease.
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| 9. |
- Elsner, Claudia, et al.
(author)
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Infants' online perception of give-and-take interactions
- 2014
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In: Journal of experimental child psychology (Print). - Elsevier : Elsevier BV. - 0022-0965 .- 1096-0457. ; 126, s. 280-294
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Journal article (peer-reviewed)abstract
- This research investigated infants’ online perception of give-me gestures during observation of a social interaction. In the first experiment, goal-directed eye movements of 12-month-olds were recorded as they observed a give-and-take interaction in which an object is passed from one individual to another. Infants’ gaze shifts from the passing hand to the receiving hand were significantly faster when the receiving hand formed a give-me gesture relative to when it was presented as an inverted hand shape. Experiment 2 revealed that infants’ goal-directed gaze shifts were not based on different affordances of the two receiving hands. Two additional control experiments further demonstrated that differences in infants’ online gaze behavior were not mediated by an attentional preference for the give-me gesture. Together, our findings provide evidence that properties of social action goals influence infants’ online gaze during action observation. The current studies demonstrate that infants have expectations about well-formed object transfer actions between social agents. We suggest that 12-month-olds are sensitive to social goals within the context of give-and-take interactions while observing from a third-party perspective.
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| 10. |
- Falck-Ytter, Terje, et al.
(author)
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Human infants orient to biological motion rather than audiovisual synchrony
- 2011
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In: Neuropsychologia. - : Elsevier BV. - 0028-3932 .- 1873-3514. ; 49:7, s. 2131-2135
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Journal article (peer-reviewed)abstract
- Both orienting to audiovisual synchrony and to biological motion are adaptive responses. The ability to integrate correlated information from multiple senses reduces processing load and underlies the perception of a multimodal and unified world. Perceiving biological motion facilitates filial attachment and detection of predators/prey. In the literature, these mechanisms are discussed in isolation. In this eye-tracking study, we tested their relative strengths in young human infants. We showed five-month-old infants point-light animation pairs of human motion, accompanied by a soundtrack. We found that audiovisual synchrony was a strong determinant of attention when it was embedded in biological motion (two upright animations). However, when biological motion was shown together with distorted biological motion (upright animation and inverted animation, respectively), infants looked at the upright animation and disregarded audiovisual synchrony. Thus, infants oriented to biological motion rather than multimodally unified physical events. These findings have important implications for understanding the developmental trajectory of brain specialization in early human infancy.
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| 11. |
- Galazka, Martyna, et al.
(author)
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How social is the chaser? : Neural correlates of chasing perception in 9-month-old infants
- 2016
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In: Developmental Cognitive Neuroscience. - 1878-9293 .- 1878-9307. ; 19, s. 270-278
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Journal article (peer-reviewed)abstract
- We investigated the neural correlates of chasing perception in infancy to determine whether animated interactions are processed as social events. By using EEG and an ERP design with animations of simple geometric shapes, we examined whether the positive posterior (P400) component, previously found in response to social stimuli, as well as the attention related negative fronto-central component (Nc), differs when infants observed a chaser versus a non-chaser. In Study 1, the chaser was compared to an inanimate object. In Study 2, the chaser was compared to an animate but not chasing agent (randomly moving agent). Results demonstrate no difference in the Nc component, but statistically higher P400 amplitude when the chasing agent was compared to either an inanimate object or a random object. We also find a difference in the N290 component in both studies and in the P200 component in Study 2, when the chasing agent is compared to the randomly moving agent. The present studies demonstrate for the first time that infants' process correlated motion such as chasing as a social interaction. The perception of the chasing agent elicits stronger time-locked responses, denoting a link between motion perception and social cognition.
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| 12. |
- Gredeback, Gustaf, et al.
(author)
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The neuropsychology of infants' pro-social preferences
- 2015
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In: Developmental Cognitive Neuroscience. - : Elsevier BV. - 1878-9293 .- 1878-9307. ; 12, s. 106-113
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Journal article (peer-reviewed)abstract
- The current study is the first to investigate neural correlates of infants' detection of pro-and antisocial agents. Differences in ERP component P400 over posterior temporal areas were found during 6-month-olds' observation of helping and hindering agents (Experiment 1), but not during observation of identically moving agents that did not help or hinder (Experiment 2). The results demonstrate that the P400 component indexes activation of infants' memories of previously perceived interactions between social agents. This leads to suggest that similar processes might be involved in infants' processing of pro-and antisocial agents and other social perception processes (encoding gaze direction, goal directed grasping and pointing).
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| 13. |
- Hilt, Sabine, et al.
(author)
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Response of submerged macrophyte communities to external and internal restoration measures in north temperate shallow lakes
- 2018
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In: Frontiers in Plant Science. - : Frontiers Media SA. - 1664-462X. ; 9
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Journal article (peer-reviewed)abstract
- Submerged macrophytes play a key role in north temperate shallow lakes by stabilizing clear-water conditions. Eutrophication has resulted in macrophyte loss and shifts to turbid conditions in many lakes. Considerable efforts have been devoted to shallow lake restoration in many countries, but long-term success depends on a stable recovery of submerged macrophytes. However, recovery patterns vary widely and remain to be fully understood. We hypothesize that reduced external nutrient loading leads to an intermediate recovery state with clear spring and turbid summer conditions similar to the pattern described for eutrophication. In contrast, lake internal restoration measures can result in transient clear-water conditions both in spring and summer and reversals to turbid conditions. Furthermore, we hypothesize that these contrasting restoration measures result in different macrophyte species composition, with added implications for seasonal dynamics due to differences in plant traits. To test these hypotheses, we analyzed data on water quality and submerged macrophytes from 49 north temperate shallow lakes that were in a turbid state and subjected to restoration measures. To study the dynamics of macrophytes during nutrient load reduction, we adapted the ecosystem model PCLake. Our survey and model simulations revealed the existence of an intermediate recovery state upon reduced external nutrient loading, characterized by spring clear-water phases and turbid summers, whereas internal lake restoration measures often resulted in clear-water conditions in spring and summer with returns to turbid conditions after some years. External and internal lake restoration measures resulted in different macrophyte communities. The intermediate recovery state following reduced nutrient loading is characterized by a few macrophyte species (mainly pondweeds) that can resist wave action allowing survival in shallowareas, germinate early in spring, have energy-rich vegetative propagules facilitating rapid initial growth and that can complete their life cycle by early summer. Later in the growing season these plants are, according to our simulations, outcompeted by periphyton, leading to late-summer phytoplankton blooms. Internal lake restoration measures often coincide with a rapid but transient colonization by hornworts, waterweeds or charophytes. Stable clear-water conditions and a diverse macrophyte flora only occurred decades after external nutrient load reduction or when measures were combined.
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| 14. |
- Juvrud, Joshua, 1987-, et al.
(author)
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Context dependent perception of apparent motion in 12-month-old infants and adults
-
In: Scientific Reports. - 2045-2322.
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Journal article (other academic/artistic)abstract
- The current study examines if 12-month-old infants and adults perceptions of apparent motion stimuli are context dependent by measuring sensitivity to possible and impossible apparent motion performed by a human figure. In Study 1, infants and adults viewed an apparent motion stimulus comprising of an arm moving from one side of a leg to the other. Results showed that both infants and adults reacted with larger pupil dilation when observing an impossible apparent motion, that is, larger pupil dilation when it appears that a hand passed through the leg as opposed to moving around the leg. Study 2 found no such effect when 12-month-old infants observed an object control stimulus with perceptually similar properties. These findings suggest that apparent motion perception is context dependent and that the constraints of the human body and human actions are taken into account when perceiving rapidly changing static images as fluid motion.
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| 15. |
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| 16. |
- Juvrud, Joshua, et al.
(author)
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Longitudinal Continuity in Understanding and Production of Giving-Related Behavior From Infancy to Childhood
- 2019
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In: Child Development. - : Wiley. - 0009-3920 .- 1467-8624. ; 90:2, s. e182-e191
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Journal article (peer-reviewed)abstract
- Infants have an early understanding of giving (the transfer of an item by one agent to another), but little is known about individual differences in these abilities or their developmental outcomes. Here, 9-month-olds (N = 59) showing clearer neural processing (Event-related potential, ERP) of a give-me gesture also evidenced a stronger reaction (pupil dilation) to an inappropriate response to a give-me gesture, and at 2 years were more likely to give in response to a give-me gesture. None of the differences in understanding and production of giving-related behaviors were associated with other sociocognitive variables investigated: language, gaze-following, and nongiving helping. The early developmental continuity in understanding and production of giving behavior is consistent with the great importance of giving for humans throughout the life span.
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| 17. |
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| 18. |
- Kaduk, Katharina, et al.
(author)
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Semantic processing of actions at 9months is linked to language proficiency at 9 and 18months.
- 2016
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In: Journal of experimental child psychology (Print). - : Elsevier BV. - 0022-0965 .- 1096-0457. ; 151
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Journal article (peer-reviewed)abstract
- The current study uses event-related potential methodologies to investigate how social-cognitive processes in preverbal infants relate to language performance. We assessed 9-month-olds' understanding of the semantic structure of actions via an N400 event-related potential (ERP) response to action sequences that contained expected and unexpected outcomes. At 9 and 18months of age, infants' language abilities were measured using the Swedish Early Communicative Development Inventory (SECDI). Here we show that 9-month-olds' understanding of the semantic structure of actions, evidenced in an N400 ERP response to action sequences with unexpected outcomes, is related to language comprehension scores at 9months and is related to language production scores at 18months of age. Infants who showed a selective N400 response to unexpected action outcomes are those who are classed as above mean in their language proficiency. The results provide evidence that language performance is related to the ability to detect and interpret human actions at 9months of age. This study suggests that some basic cognitive mechanisms are involved in the processing of sequential events that are shared between two conceptually different cognitive domains and that pre-linguistic social understanding skills and language proficiency are linked to one another.
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| 19. |
- Kattge, Jens, et al.
(author)
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TRY plant trait database - enhanced coverage and open access
- 2020
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In: Global Change Biology. - : Wiley-Blackwell. - 1354-1013 .- 1365-2486. ; 26:1, s. 119-188
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Journal article (peer-reviewed)abstract
- Plant traits-the morphological, anatomical, physiological, biochemical and phenological characteristics of plants-determine how plants respond to environmental factors, affect other trophic levels, and influence ecosystem properties and their benefits and detriments to people. Plant trait data thus represent the basis for a vast area of research spanning from evolutionary biology, community and functional ecology, to biodiversity conservation, ecosystem and landscape management, restoration, biogeography and earth system modelling. Since its foundation in 2007, the TRY database of plant traits has grown continuously. It now provides unprecedented data coverage under an open access data policy and is the main plant trait database used by the research community worldwide. Increasingly, the TRY database also supports new frontiers of trait-based plant research, including the identification of data gaps and the subsequent mobilization or measurement of new data. To support this development, in this article we evaluate the extent of the trait data compiled in TRY and analyse emerging patterns of data coverage and representativeness. Best species coverage is achieved for categorical traits-almost complete coverage for 'plant growth form'. However, most traits relevant for ecology and vegetation modelling are characterized by continuous intraspecific variation and trait-environmental relationships. These traits have to be measured on individual plants in their respective environment. Despite unprecedented data coverage, we observe a humbling lack of completeness and representativeness of these continuous traits in many aspects. We, therefore, conclude that reducing data gaps and biases in the TRY database remains a key challenge and requires a coordinated approach to data mobilization and trait measurements. This can only be achieved in collaboration with other initiatives.
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| 20. |
- Puerta, Adrián, et al.
(author)
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Early pharmacological profiling of isatin derivatives as potent and selective cytotoxic agents
- 2024
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In: Biochemical Pharmacology. - : Elsevier. - 0006-2952 .- 1356-1839. ; 222
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Journal article (peer-reviewed)abstract
- Isatin derivatives have attracted a lot of interest for their potential in the development of new anticancer drugs. A library of 38 isatin derivatives, created through an Ugi four-component reaction, underwent an initial screening in a panel of six human solid tumor cell lines. The four most active derivatives were then selected for further testing. These compounds showed selectivity towards the non-small cell lung cancer (NSCLC) cell line SW1573, whilst NSCLC A549 cells were barely affected. The combination of phenotypic assays, including wound healing, clonogenic and continuous live cell imaging provided a deeper understanding of the compounds’ mode of action. In particular, the latter demonstrated that isatin derivatives were able to induce necroptosis in SW1573 cells. The kinetics of cell death showed that necroptosis appeared after 2.5 h of exposure, which could be delayed to 7 h when co-treated with necrostatin-1. Interaction between the isatin derivatives and the KRAS G12C protein variant was discarded after in silico studies. Further studies are warranted to identify the cellular target responsible for the observed selectivity among cell lines.
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| 21. |
- Roczniewska, Marta, et al.
(author)
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How Should Job Crafting Interventions Be Implemented to Make Their Effects Last? : Protocol for a Group Concept Mapping Study
- 2022
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In: International Journal of Environmental Research and Public Health. - : MDPI. - 1661-7827 .- 1660-4601. ; 19:21
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Journal article (peer-reviewed)abstract
- Background: By means of job crafting (JC) employees shape and customize their job design to align it with their preferences. Research has so far shown that such bottom-up proactivity can be stimulated via JC interventions. While the overall effectiveness behind these interventions has been supported, it is unclear how to implement these interventions to make their effects lasting. Methods: The overall aim of this project will be to investigate how to implement JC interventions with lasting effects. We will apply a group concept mapping (GCM) methodology, which is a mixed methods approach of exploratory nature for engaging stakeholder groups in a structured conceptualization process. As part of concept mapping procedures, brainstorming sessions will be conducted with experts in job crafting to identify factors expected to make job crafting intervention effects lasting. These factors will be sorted by similarity and rated by each participant in regard to their perceived importance and feasibility to ensure lasting, sustainable effects. The data will be analyzed using multidimensional scaling (MDS), hierarchical cluster analysis, and descriptive and inferential statistics, resulting in a visual representation of conceptually distinguished clusters representing the factors influencing the sustainability of JC interventions. In the final step, a workshop will be conducted with the participants to facilitate the interpretation of the results. Results and conclusion: This study will provide knowledge relevant to organizational practitioners and scholars who want to implement JC interventions with lasting effects. Although data collected following the group concept mapping procedure is self-reported and at risk of being simplified, the method allows for a structured conceptualization process integrating different perspectives and uncovering implicit knowledge making it suitable for studying complex phenomena. The results will not only enrich the current literature concerning the effectiveness of JC interventions but also be used to develop a practitioner-oriented toolkit outlining evidence-based recommendations concerning designing and implementing, as well as evaluating JC interventions.
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| 22. |
- Sosnicka, Marta, et al.
(author)
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Fluid types and their genetic meaning for the BIF-hosted iron ores, Krivoy Rog, Ukraine
- 2015
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In: Ore Geology Reviews. - : Elsevier BV. - 0169-1368 .- 1872-7360. ; 68, s. 171-194
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Journal article (peer-reviewed)abstract
- This paper contributes to the understanding of the genesis of epigenetic, hypogene BIF-hosted iron deposits situated in the eastern part of Ukrainian Shield. It presents new data from the Krivoy Rog iron mining district (Skelevatske-Magnetitove deposit, Frunze underground mine and Balka Severnaya Krasnaya outcrop) and focuses on the investigation of ore genesis through application of fluid inclusion petrography, micro-thermometry, Raman spectroscopy and baro-acoustic decrepitation of fluid inclusions. The study investigates inclusions preserved in quartz and magnetite associated with the low-grade iron ores (31-37% Fe) and iron-rich quartzites (38-45% Fe) of the Saksaganskaya Suite, as well as magnetite from the locally named high-grade iron ores (52-56% Fe). These high-grade ores resulted from alteration of iron quartzites in the Saksaganskiy thrust footwall (Saksaganskiy tectonic block) and were a precursor to supergene martite, high-grade ores (60-70% Fe). Based on the new data two stages of iron ore formation (metamorphic and metasomatic) are proposed. The metamorphic stage, resulting in formation of quartz veins within the low-grade iron ore and iron-rich quartzites, involved fluids of four different compositions: CO2-rich, H2O, H2O-CO2(+/- N-2-CH4)-NaCl(+/- NaHCO3) and H2O-CO2(+/- N-2-CH4)-NaCl. The salinities of these fluids were relatively low (up to 7 mass% NaCl equiv.) as these fluids were derived from dehydration and decarbonation of the BIF rocks, however the origin of the nahcolite (NaHCO3) remains unresolved. The minimum P-T conditions for the formation of these veins, inferred from microthermometry are T-min = 219-246 degrees C and P-min = 130-158 MPa. The baro-acoustic decrepitation analyses of magnetite bands indicated that the low-grade iron ore from the Skelevatske-Magnetitove deposit was metamorphosed at T = similar to 530 degrees C. The metasomatic stage post-dated and partially overlapped the metamorphic stage and led to the upgrade of iron quartzites to the high-grade iron ores. The genesis of these ores, which are located in the Saksaganskiy tectonic block (Saksaganskiy ore field), and the factors controlling iron ore-forming processes are highly controversial. According to the study of quartz-hosted fluid inclusions from the thrust zone the metasomatic stage involved at least three different episodes of the fluid flow, simultaneous with thrusting and deformation. During the 1st episode three types of fluids were introduced: CO2-CH4-N-2(+/- C), CO2(+/- N-2-CH4) and low salinity H2O-N-2-CH4-NaCl (6.38-7.1 mass% NaCl equiv.). The 2nd episode included expulsion of the aqueous fluids H2O-N2CH4-NaCl(+/- CO2, +/- C) of moderate salinities (15.22-16.76 mass% NaCl equiv.), whereas the 3rd event involved high salinity fluids H2O-NaCl(+/- C) (20-35 mass% NaCl equiv.). The fluids most probably interacted with country rocks (e.g. schists) supplying them with CH4 and N-2. The high salinity fluids were most likely either magmatic-hydrothermal fluids derived from the Saksaganskiy igneous body or heated basinal brines, and they may have caused pervasive leaching of Fe from metavolcanic and/or the BIF rocks. The baro-acoustic decrepitation analyses of magnetite comprising the high-grade iron ore showed formation T = similar to 430-500 degrees C. The fluid inclusion data suggest that the upgrade to high-grade Fe ores might be a result of the Krivoy Rog BIF alteration by multiple flows of structurally controlled, metamorphic and magmatic-hydrothermal fluids or heated basinal brines.
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| 23. |
- van den Akker, Olmo R., et al.
(author)
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Increasing the transparency of systematic reviews : presenting a generalized registration form
- 2023
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In: Systematic Reviews. - : BioMed Central (BMC). - 2046-4053. ; 12
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Journal article (peer-reviewed)abstract
- This paper presents a generalized registration form for systematic reviews that can be used when currently available forms are not adequate. The form is designed to be applicable across disciplines (i.e., psychology, economics, law, physics, or any other field) and across review types (i.e., scoping review, review of qualitative studies, meta-analysis, or any other type of review). That means that the reviewed records may include research reports as well as archive documents, case law, books, poems, etc. Items were selected and formulated to optimize broad applicability instead of specificity, forgoing some benefits afforded by a tighter focus. This PRISMA 2020 compliant form is a fallback for more specialized forms and can be used if no specialized form or registration platform is available. When accessing this form on the Open Science Framework website, users will therefore first be guided to specialized forms when they exist. In addition to this use case, the form can also serve as a starting point for creating registration forms that cater to specific fields or review types.
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